2002 業績紹介

2002年

1.　成人および高齢者の精神・神経疾患の認知神経科学的研究

－論文－

  1. 1. Uchimura N, Takeuchi N, Kuwahara H, Nose I, Hashizume Y, Shirakawa S, Ohyama T, Maeda H ：　Situation and problem of administration methods and the intermission of hypnotics. Psychiatr　Clin　Neurosci　2002;56:295-6.
  2. Nose I, Ookawa T, Tanaka J, Yamamoto T, Uchimura N, Maeda H, Kuwahara H　：　Decreased blood flow of the left thalamus during somnolent episodes in a case of recurrent hypersomnia.　 Psychiatr　Clin　Neurosci 2002;56:277-8.
  3. Shirakawa S, Takeuchi N, Uchimura N, Ohyama T, Maeda H, Abe T, Ishibashi M, Ohshima Y, Ohshima H　： Study of image findings in rapid eye movement sleep behavioural disorder. Psychiatr Clin Neurosci 　2002;56:291-2.
  4. Tanaka J, Uchimura N, Hashizume Y, Shirakawa S, Satomura T, Ohyama T, Takeuchi N, Kuwahara H, Maeda H　：　Effects of aroma on sleep and biological rhythms.　Psychiatr Clin Neurosci 2002;56:299-300.
  5. Shigemori M, Tokutomi T ： Result of nationwide survey of the management of severe head injury in Japan．　Neurol Res 2002;24:41-4.
  6. Nakamura N, Yamaura A, Shigemori M, Ono J, Kawamata T, Sakamoto T　：　Epidemiology, prevention and countermeasures against severe traumatic brain injury in Japan and abroad． Neurol Res　2002;24:45-53.
  7. Abe T, Hirohata M, Tanaka N, Uchiyama Y, Kojima K, Fujimoto K, Alexander M, Norbash, Hayabuchi N： Clinical benefits of rotational 3D angiography in endovascular treatment of ruptured cerebral aneurysm．　AJNR　2002;23:686-8.
  8. Sugita Y, Terasaki M , Shigemori M, Morimatsu M, Honda E, Oshima Y ： Astroblastoma with unusual signet-ring-like cell components ： A case report and literature review．　Neuropathology　2002;22:200-5.
  9. Fujimura N, Sugita Y, Hirohata M, Miyagi N, Terasaki M, Tokutomi T, Shigemori M： Primary intracerebral malignant fibrous histiocytoma in a child．　Pediatr Neurosurg　2002;37:271-4.
  10. Sakata K, Kato S, Jonathan C. Fox, Shigemori M, Morimatsu M ： Autocrine signaling through ras regulates cell survival activity in human glioma cells ： Potential cross-talk between ras and the phosphatidylinositol 3-kinase-akt pathway． J Neuropathol Exp Neurol　2002;61:975-83.
  11. Shigemori M, Yamaura A, Nagao S, Katayama Y, Sugiura K, Aruga T, Onuma T, Yamaki T, Ono J, Ogawa T, Tomita H, Shiogai T, Tokutomi T, Kawamata T, Abe H, Yoshimoti T, Kirino T, Hayakawa T, Omoto T, Fukui H, The Japan Society of Neurotraumatology　： The Japanese guideline for the management of severe head injury．　ICRAN 2002 2002:49-56.
  12. Niiyama S, Tanaka E, Yamamoto S, Yasumoto S, Kano T, Higashi H ： Bupivacaine, but not tetracaine, protects against the in vitro ischemic insult of rat hippocampal CA1 neurons. Neurosci Res 　2002;42:231-41.
  13. Tanaka E, Uchikado H, Niiyama S, Uematsu K, Higashi H　： Extrusion of intracellular calcium ion after in vitro ischemia in the rat hippocampal CA1 region. J Neurophysiol 2002;88:879-87.
  14. Shoji, H, Wakasugi, K, Miura, Y, Imaizumi, T, Kazuyama, Y. : Herpesvirus infections of the central nervous system.　Jpn J Infect Dis 　2002;55:6-13.
  15. Shoji, H, Azuma K, Nishimura Y, Fujimoto H, Sugita Y, Eizuru Y：　Acute viral encephalitis. : The recent progress. Intern Med 　2002;41:420-8.
  16. Iijima H, Wakasugi K, Ayabe M, Shoji, H, Abe T : An adult case of influenza A virus-associated encephalitis: Magnetic Resonance Imaging findings.　 J Neuroimaging 2002;12:1-3.
  17. Ichiyama T, Shoji, H, Kato M, Sawaishi Y, Ozawa H, Matsubara T, Furukawa S: Cerebrospinal fluid levels of cytokines and soluble tumour necrosis factor receptor in acute disseminated encephalomyelitis. 　Eur J Pediatr 2002;161:133-7.
  18. Miura Y, Susuki K, Yuki N, Ayabe M, Shoji, H : Guillair-Barre syndrome presenting pharyngeal-cenvical-brachial weakness in the recovery phase. 　Eur Neurol 2002;48:53-4.
  19. Kojima Y, Hashiguchi H, Hashimoto T, Tsuji S, Shoji, H, Kazuyama Y : Recurrent herpes simplex virus type 2 meningitis.　 Jpn J Infect Dis 　2002;55:85-8.
  20. Aoki T, Kato S, Jonathan C. Fox, Okamoto K, Sakata K, Morimatsu M, Shigemori M ：Inhibition of autocrine fibroblast growth factor signaling by the adenovirus-mediated expression of an antisense transgene or a dominant negative receptor in human glioma cells n vitro． Int J Oncol　 2002;21:629-36.

2. 成人および高齢者の精神・神経疾患の分子生物学的研究

－著書－

  1. Matsubara-Tsutsui M, Yamagata H, Morishima A, Nakura J, Mitsuda N, Kamino K, Kondo I, Miki T ： The-4,752 C/T polymorphism in the Presenilin 1 Gene Increases the Risk of Alzheimer's Disease in Apolipoprotein E4 Carriers Internal Medicine 2002;41(10):823-8.
  2. Tanaka M, Yamada S, Yoshida M, Emoto H, Ishii H. : Brain norepinephrine system and anxiety. In: Nagatsu T, Nabeshima T, McCarty R, Goldstein S, eds. : Advances in Behavioral Biology, Vol.53. Catecholamine Research. From Molecular Insights to Clinical Medicine. New York　: Kluwer Academic /Plenum Publishers,　 2002;337-40.

－論文－

  1. Matsuyama S, Higashi H, Maeda H, Greengard P, Nishi A ：　Neurotensin regulates DARPP-32 Thr34 phosphorylation in neostriatal neurons by activation of dopamine D1-type receptors.　J Neurochem　2002;81:325-34.
  2. Yasumoto S, Tanaka E, Hattori G, Maeda H, Higashi H　：　Direct and indirect actions of dopamine on the membrane potential in medium spiny neurons of the mouse neostriatum.　J Neurophysiol　2002;87:1234-43.
  3. Watanabe Y, Benson DW, Yano S, Akagi T, Yoshino M, Murray JC ： Two novel frameshift mutations inNKX2.5. Resultinnovel features including visceral inversus and sinus venosus type ASD. J Med Genet 　2002;39:807-11.
  4. Kubota T, Waki K, Nakamura T, Ohashi H, Watanabe Y, Yoshino M, Kida T, Okamoto N, Matsumura M, Muroya K, Ogata T, Goto Y, Fukushima Y　:　 The proportion of cells with functional X disomy is associated with the severity of mental retardation in mosaic ring X Turner syndrome females.　Cytogenet Genome Res 　2002;99:276-84.
  5. Kaneko M, Yamashita Y, Nagamitsu S, Nakayama T, Matsuishi T ：　Severe Infantile Measles Encephalitis Occurred Three Months after Neonatal Measles. Neuropediatrics 2002;33:274-7.
  6. Kondo S, Schutte BC, Richardson RJ, Bjork BC, Knight AS, Watanabe Y, Howard E, Ferreira De Lima RL, Daack-Hirsch S, Sander A, McDonald-McGinn DM, Zackai EH, Lammer EJ, Aylsworth AS, Ardinger HH, Lidral AC, Pober BR, Moreno L, Arcos-Burgos M, Valencia C, Houdayer C, Bahuau M, Moretti-Ferreira D, Richieri-Costa A, Dixon MJ, Murray JC：Mutations in IRF6 cause Van der Woude and　popliteal pterygium syndromes. Nat Genet 2002;32:285-9.
  7. Matsuyama S, Higashi H, Maeda H, Greengard P, Nishi A ： Neurotensin regulates DARPP-32 Thr34 phosphorylation in neostriatal neurons by activation of dopamine D1-type receptors. J Neurochem　2002;81:325-34.
  8. Nishi A, Bibb J.A, Matsuyama S, Hamada M, Higashi H, Nairn A.C, Greengard P ： Regulation of DARPP-32 dephosphorylation at PKA- and Cdk5-sites by NMDA and AMPA receptors　: 　distinct roles of calcineurin and protein phosphatase-2A J Neurochem　2002;81:832-41.
  9. Ishimatsu M, Kidani Y, Tsuda A, Akasu T ： Effects of methylphenidate on the membrane potential and current in neurons of the rat locus coeruleus. J Neurophysiol　2002;87(3):1206-12.
  10. Takeya M, Hasuo H, Akasu T ： Effects of temperature increase on the propagation of presynaptic action potentials in the pathway between the Schaffer collaterals and hippocampal CA1 neurons. Neurosci Res　2002;42(3):175-85.
  11. Hasuo H, Matsuoka T, Akasu T ： Activation of presynaptic 5-hydroxytryptamine 2A receptors facilitates excitatory synaptic transmission via protein kinase C in the dorsolateral septal nucleus. J Neurosci　2002:22(17):7509-17.
  12. Akasu T, Muraoka N, Hasuo H ： Hyperexcitability of hippocampal CA1 neurons after fluid percussion injury of the rat cerebral cortex. Neurosci Lett　2002;329(3):305-8.
  13. Kuwahata T, Ishimatsu M, Kidani Y, Akasu T ： Effects of methylphenidate on the inhibitory postsynaptic potential in rat locus coeruleus neurons. Kurume Med J　2002;49(4):185-90.
  14. Matsui-Okuno M, Yokoo H, Yoshida M, Emoto H, Ishii H, Annoh N, Morinaga D, Tanaka M ： Corticotropin releasing-factor(CRF) increases extracellular GABA levels in the rat hypothalamus. Biogenic Amines　2002;17(17):141-8.

3. 小児の精神・神経疾患の分子基盤解明と遺伝子治療に関する研究

－著書－

  1. Takashima S, Hirayama A, Okoshi Y, Itoh M. : Vascular , axonal and glial pathogenesis of periventricular leukomalacia in fetuses and neonates. Neuroembryology 2002；1：72-7.
  2. Ozawa Y, Takashima S. : Developmental neurotransmitter pathology in the brainstem of sudden infant death syndrome : a review and sleep position. Forensic Sci Int. 2002 Sep 14;130 Suppl:53.

－総説－

  1. Nagamitsu S, Ashizawa T, “Myotonic Dystrophies” 　In : Neuromuscular Disorders, eds Harati Yadoll ah Poumand Rahman. 2002;293-314.
  2. Kitamura K ,Yanazawa M, Sugiyama N, Miura H, Iizuka-Kogo A, Kusaka M, Omichi K, Suzuki R, Kato-Fukui Y, Kamiirisa K, Matsuo M, Kamijo S, Kasahara M, Yoshioka H, Ogata T, Fukuda T, Kondo I, Kato M, William B, Dobyns, Yokoyama　M, Morohashi　K　：　　　Mutation of ARX causes abnormal development of forebrain and testes in mice and X-linked lissencephaly with abnormal genitalia in humans Nature Genetics 　 2002;32:359-69.
  3. Yamaguchi N, Kobayashi K, Yasuda T, Nishi I, Iijima M, Nakagawa M, Osame M, Ikuko Kondo, Saheki T　　：　Screening of SLC25A13 Mutations in Early and Late Onset Patients With Citrin Deficiency and in Japanese Population: Identification of Two Novel Mutations and Establishiment of Multiple DNA Diagnosis Methods for Nine Mutations HUMAN MUTATION 　　2002;19:122-30.

－論文－

  1. Yoshida T, Hanada T, Tokuhisa T, Kosai K, Sata M, Kohara M, Yoshimura A : Activation of STAT3 by the Hepatitis C virus core protein leads to cellular transformation. 　J Exp Med　2002;196::641-53.
  2. Aoyama T, Takemura G, Maruyama R, Kosai K, Takahashi T, Koda M, Hayakawa K, Kawase Y, Minatoguchi S, Fujiwara H : Molecular mechanisms of non-apoptosis by Fas stimulation alone versus apoptosis with an additional actinomycin D in cultured cardiomyocytes. Cardiovasc Res 　2002;55:787-98.
  3. Fukunaga M, Takamori S, Hayashi A, Shirouzu K, Kosai K : Adenoviral herpes simplex virus thymidine kinase gene therapy in an orthotopic lung cancer model. 　　Ann Thorac Surg 2002;73:1740-6.
  4. Kusaga A, Yamashita Y, Koeda T, Hiratani M, Kaneko M, Yamada M, Matsuishi T : Increased urine phenylethylamine after methylphenidate treatment in children with ADHD. 　Ann Neurol 　2002;52:371-4.
  5. Kaneko M, Yamashita Y, Nagamitsu S, Nakayama T, Matsuishi T : Severe infantile easles encephalitis occurred three months after neonatal measles. Neuropediatrics 2002;33:274-7.
  6. Koga Y, Ishibashi M, Ueki I, Yatsuga S, Fukiyama R, Akita Y, Matsuishi T : Effects of L-arginine on the acute phase of strokes in three patients with MELAS. 　Neurology 　2002;58:827-8.
  7. Shimizu T, Matsuishi T, Iwamoto R, Handa K, Yoshioka H, Kato H, Ueda S, Hara H, Tabira T ： Mekada Elevated levels of anti-CD9 antibodies in the cerebrospinal fluid of patients with subacute sclerosing panencephalitis. 　J Infect Dis 2002;185:346-50.
  8. Yoshida T, Hanada T, Tokuhisa T, Kosai K, Sata M, Kohara M, Yoshimura A : Activation of STAT3 by the Hepatitis C virus core protein leads to cellular transformation. J Exp Med 2002;196:641-53.
  9. Kitamura K, Yanazawa M, Sugiyama N, Miura H, Iizuka-Kogo A, Kusaka M, Omichi K, Suzuki R, Kato-Fukui Y, Kamiirisa K, Matsuo M, Kamijo S-I, Kasahara M, Yoshioka H, Ogata T, Fukuda T, Kondo I, Kato M, Dobyns WB, Yoikoyama M, Morohashi K-i : Mutations of Arx/ARX causes abnormal development of forebrain and testes in mice and X-linked liccencephaly with abnormal genitalia in humans. 　 Nature Genet 　2002;32:359-69.
  10. Yamaguchi N, Kobayashi K, Yasuda T, Nishi I, Iijima M, Nakagawa M, Osame M, Kondo I, Saheki T ：　Screening of SLC25A13 mutations in early and late onset patients with citrin deficiency and in the Japanese population　: Identification of two novel mutations and establishment of multiple DNA diagnosis methods for nine mutations 　Hum Mut 　2002;19:122-30.
  11. Ishii M, Ueno T, Ikeda H, Iemura M, Sugimura T, Furui J, Sugahara Y, Muta H, Akagi T, Nomura Y, Homma T, Yokoi H, Nobuyoshi M, Matsuishi Y, Kato H : Sequential follow-Up results of catheter intervention for coronary artery lesions after Kawasaki disease quantitative coronary artery angiography and intravascular ultrasound imaging study. 　Circulation 　 2002;105:3004-10.
  12. Muta H, Ishii M, Matsuishi T : Coronary artery aneurysms after Kawasaki disease in a patient with a single coronary artery. 　Pediatr Cardiol 　2002;23:568-9.
  13. Furui J, Ishii M, Ikeda H, Muta H, Egami K, Sugahara Y, Himeno W, Akagi T, Kato H, Matsuishi T : Soluble form of the selectin family in children with kawasaki disease ; prediction for coronary artery lesion. Acta Paediatr　2002;91;1183-8.