2004 業績紹介

2004年

1. 成人および高齢者の精神・神経疾患の認知神経科学的研究

－著書－

  1. Hirohata M, Fujimura N, Takeuchi Y, Tokutomi T, Shigemori M : Symptomatic vasospasm after early surgical and endovascular treatment of ruptured cerebral aneurysms. R. Loch macdonald, ed.　 New York, Thieme, 2004:249-51.

－総説－

  1. Kobayashi S, Ueno T, Kato K, Nose Y, Harada M : Peer-to-peer communication system for sharing electronic medical records. The Journal on information technology in healthcare, 2004;2(5):343-52.

－論文－

  1. Ueno T, Morita K, Shoji Y, Yamamoto M, Maeda H: Recognition of facial expression and visual P300 in schizophrenic patients : Differences between paranoid type patients and nonp-paranoid patients. Psychiat Clin Neurosci 2004;58(6):585-92.
  2. Ito H, Kono T, Ishida S, Maeda H： Gender Difference in QTc Prolongation of People with Mental Disorders. Ann Gen Hosp Psychiat　2004;3:3-8.
    3. Shoji H, Asaoka K, Ayabe M, Ichiyama T, Sakai K: 　Non-herpetic acute limbic encephalitis: a new subgroup of limbic encephalitis ? 　Intern Med 　2004;43:348.
  3. Ayukawa A, Fujimoto H, Ayabe M, Shoji H, Matsui R, Iwata Y, Fukuda H, Ochi K, Noda K, Ono Y, Sakai K, Takehisa Y, Yasui K: An unexpected outbreak of Japanese encephalitis in the Chugoku district of Japan, 2002. Jpn J Infect Dis 2004; 57:63-6.
  4. Takei S, Sato R, Nishizaka S, Imaizumi T, Ayabe M, Shoji H: Unilateral lower cranial nerve palsies due to varicella-zoster virus in the absence of rash: A report of two cases. Neuroinfection 　2004;9:89-91.
  5. Hamakawa S, Koda C, Umeno H, Yoshida Y, Nakashima T, Asaoka K, Shoji H: Oropharyngeal dysphagia in a case of Huntingon’s disease.　 Auris Nasus Larynx　　2004;31:171-6.
  6. Asaoka K, Shoji, H, Nishizaka S, Ayabe M, Abe T, Ohori N, Ichiyama T, Eizuru Y. ：　Non-herpetic acute limbic encephalitis. CSF cytokines and MRI findings. Intern Med 2004;43:42-8.
  7. Sugita Y, Tokunaga O, Nakashima A, Shigemori M : SHP-1 expression in primary central nervous system B-cell lymphomas in immunocompetent patients reflects maturation stage of normal B cell counterparts. Pathol Int 2004;54:659-66.
  8. Hirohata M, Abe T, Fujimura N, Takeuchi Y, Morimitsu H, Shigemori M : Clinical outcomes of coil embolization for acutely ruptured aneurysm Comparison with results of neck clipping when coil embolization is considered the first option. Interventional Neuroradiology 2004;10(suppl 2):49-53.
  9. Tokutomi T, Miyagi T, Takeuchi Y, Karukaya T, Shigemori M : Effects of hypothermia on systemic and intracranial hemodynamics and metabolism. 7th International Neurotrauma Symposium 2004;139-43.

2. 成人および高齢者の精神・神経疾患の分子生物学的研究

－総説－

  1. Svenningsson P, Nishi A, Fisone G, Girault J-A, Nairn AC, Greengard P: 　DARPP-32: an integrator of neurotransmission in striatal neurons. 　 Annu Rev Pharmacol Toxicol 　2004;44:269-96.
  2. Nairn AC, Svenningsson P, Nishi A, Fisone G, Girault J-A, Greengard P: The role of DARPP-32 in the actions of drugs of abuse. Neuropharmacol 　2004;47:14-23.

－論文－

  1. Harada H, Wang Y, Mishima Y, Uehara N, Makaya T, Kano T: A novel method of detecting rCBF with laser-Doppler flowmetry without cranial window through the skull for a MCAO rat model. Brain Res Protoc 2004; 14：165-70.
  2. Koizumi H, Hashimoto K, Kumakiri C, Shimizu E, Sekine Y, Ozaki N, Inada T, Harano M, Komiyama T, Yamada M, Sora I, Ujike H, Takei N, Iyo M：　Association between the glutathione S-transferase M1 gene deletion and female methamphetamine abusers.　 Am J Med Genet　2004;126B:43-5.
  3. Harano M, Uchimura N, Ueno M, Abe H, Ishibashi M, Iida N, Tanaka T, Maeda H, Sora I, Iyo M, Komiyama T, Yamada M, Sekine Y, Inada T, Ozaki N, Iwata N, Ujike H：　Association Between TaqI A Polymorphism of DRD2 Gene and Cerebral Form in Methamphetamine Psychosis.　 Am J Med Genet 2004;130b:109.
  4. Nomura A, Ujike H, Tanaka Y, Harano M, Inada T, Yamada M, Komiyama T,Sekine Y, Iwata N, Sora I, Iyo M, Ozaki N, Kuroda S：　The prodynorphin gene promoter is associated with methamphetamine dependence in Japanese population.　Am J Med Genet　 2004;130b:111.
  5. Itoh K, Hashimoto K, Shimizu E, Sekine Y, Ozaki N, Inada T, Harano M, Iwata N, Komiyama T, Yamada M, Sora I, Nakata K, Ujike H, Iyo M.　：　Association study between brain-derived neurotrophic factor gene polymorphisms and methamphetamine abusers in Japan.　Am J Med Genet　2005;132(1):70-3.
  6. Matsuoka T,　Hasuo H,　Akasu T：　5-Hydroxytryptamine 1B receptors mediate presynaptic inhibition of monosynaptic IPSC in the rat dorsolateral septal nucleus. 　Neurosci Res　2004;48:229-38.
  7. Asaoka K, Shoji H, Nishizaka S, Ayabe M, Abe T, Ohori N, Ichiyama T, Eizuru Y：　 Non-herpetic acute limbic encephalitis. CSF cytokines and MRI findings. Intern Med 2004;43:42-8.
  8. Hamada M, Higashi H, Nairn AC, Greengard P, Nishi A : Differential regulation of dopamine D1 and D2 signaling by nicotine in neostriatal neurons. J Neurochem　 2004;90:1094-103.
  9. Kansy JW, Daubner SC, Nishi A, Sotogaku N, Lloyd MD, Nguyen C, Lu L, Haycock JW, Hope B, Fitzpatrick PF, Bibb JA : Identification of Tyrosine Hydroxylase as a Physiological Substrate for Cdk5. J Neurochem　 2004;91:374-84.
  10. Takaseya T, Ishimatsu M, Tayama E, Nishi A, Akasu T, Aoyagi S :　 Mechanical unloading improves intracellular Ca2+ regulation in rats with doxorubicin-induced cardiomyopathy. J Am Coll Cardiol　 2004;44:2239-46.
  11. Rakhilin SV, Olson PA, Nishi A, Starkova NN, Fienberg AA, Nairn, AC, Surmeier DJ, Greengard P : A novel regulator of calcium/ calmodulin -dependent signaling. Science　　 2004;306:698-701.
  12. Kuwahata T, Kidani Y, Ishimatsu M, Akasu T : Effects of milnacipran on the inhibitory postsynaptic potential in neurons of the rat locus coeruleus. Kurume Med J 2004;51(3,4):185-91.
  13. Takaseya T, Ishimatsu M, Tayama E, Nishi A, Akasu T, Aoyagi S : Mechanical unloading improves intracellular Ca2+ regulation in rats with doxorubicin-induced cardiomyopathy. J Am Coll Cardiol 2004;44(11):2239-46.
  14. Tanaka E, Ishii K, Akagi T, Hirai K, Motelica-Heino I, Katayama Y, Higashi H, Hashikawa T, Tsuji S : A new cytochemical method for ultrastructural localization of Co2+ in rat hippocampal CA1 pyramidal neurons in vitro. 　J Neurosci Methods 　2004;135:1-8.
  15. Yamada A, Tanaka E, Niiyama S, Yamamoto S, Hamada M, Higashi H : Protective Actions of Various Local Anesthetics against The Membrane Dysfunction Produced by In Vitro Ischemia in Rat Hippocampal CA1　Neurons Neurosci Res　2004;50(3):291-8.
  16. Li GY, Ueki H, Kawashima T, Sugataka K, Muraoka T, Yamada S : Involvement of the noradrenergic system in performance on a continuous task requiring effortful attention. Neuropsychobiology 2004;50:336-40.
  17. Kawashima T, Oda M, Kuno T, Ueki H, Hisatomi A, Yamada S ：　Metyrapone for delirium dueto Cushing’ssyndrome induced by occult ectopic adrenocorticotropine secretion.　　J　Clin Psychiatry 2004；65:1019-20.

3. 小児の精神・神経疾患の分子基盤解明と遺伝子治療に関する研究

－論文－

  1. Muta H, Ishii M, Egami K, Furui J, Sugahara Y, Akagi T, Nakamura Y, Yanagawa H, Matsuishi T:　 Early intravenous gamma-globulin treatment for Kawasaki Disease: The nationwide surveys in Japan.　　J Pediatr 　2004;144:496-9.
  2. Muta H, Ishii M, Sakaue T, Egami K, Furui J, Sugahara Y, Akagi T, Nakamura Y, Yanagawa H, Matsuishi T: 　Older age is a risk factor for the development of cardiovascular sequelae in Kawasaki Disease.　 Pediatrics 　2004;114:1.
  3. Nagano S, Yuge K, Fukunaga M, Terazaki Y, Fujiwara H, Komiya S, Kosai K : Gene Therapy Eradicating Distant Disseminated Micro-Metastases by Optimal Cytokine Expression in the Primary Lesion Only -Novel concepts for successful cytokine gene therapy-. Int J Onol 2004;24:549-58.
  4. Hisaka Y, Ieda M, Nakamura T, Kosai K, Ogawa S, Fukuda K　: 　Powerful and controllable angiogenesis by using gene-modified cells expressing human hepatocyte growth factor and thymidine kinase. 　　J Am Coll Cardiol 2004;43:1915-22.
  5. Minatoguchi S, Takemura G, Chen XH, Wang N, Uno Y, Koda M, Arai M, Misao Y, Lu C, Suzuki K, Goto K, Komada A, Takahashi T, Kosai K, Fujiwara T, Fujiwara H: Acceleration of the Healing Process and Myocardial Regeneration May Be Important as a mechanism of mprovement of cardiac function and remodeling by postinfarction granulocyte colony-stimulating factor treatment. Circulation 2004;109:2572-80.
  6. Iida SI, Hirota T, Morisaki T, Marumoto T, Hara T, Kuninaka S, Honda S, Kosai KI, Kawasuji M, Pallas DC, Saya H　: Tumor suppressor WARTS ensures genomic integrity by regulating both mitotic progression and G(1) tetraploidy checkpoint function.　　Oncogene　2004;23(31):5266-74.
  7. Kawai T, Takahashi T, Fujiwara H, Esaki K, Ushikoshi H, Nagano S, Kosai K　: Efficient cardiomyogeneic differentiation of embryonic stem cell by FGF-2 and BMP-2. 　　Circ J　2004;68(7):691-702.
  8. Li Y, Takemura G, Kosai K, Takahashi T, Fujiwara H : Critical Roles for the Fas/Fas Ligand System in Postinfarction Ventricular Remodeling and Heart Failure. Circ Res 2004;95:627-36.
  9. Ikoma T, Takahashi T, Nagano S, Li Y-M, Ohno Y, Ando K, Fujiwara T, Fujiwara H, Kosai K : A Definitive Role of RhoC in Metastasis of Orthotopic Lung Cancer in Mice. Clin Cancer Res 2004;10:1192-200.
  10. Yamashita Y, Kusaga A, Koga Y, Nagamitsu S, Matsuishi T　: 　Noonan syndrome,　moyamoya-like vascular changes, and antiphospholipid syndrome.　 Pediatr Neurol 　2004;31(5):364-6.
  11. Yamashita Y, Isagai T, Seki Y, Ohya T, Ngamitsu S, Matsuishi T: West syndrome associated with administration of a histamine H1 antagonist. oxatomide Kurume Med J 2004;51(3,4):273-5.
  12. Koga Y: 　MELAS and L-arginine therapy.　　 Brain Dev 　　2004;26(7):480.
  13. Yamagata H, Chen Y, Akatsu H, Kamino K, Ito J-I, Yokoyama S, Yamamoto T, Kosaka K, Miki T, Kondo I: Promoter polymorphism in FGF1 gene increases risk of definite Alzheimer's disease. 　Biochem Biophys Res Commun 2004;321(2):320-3.
  14. Mizuguchi M, Mori M, Nozaki Y, Momoi MY, Itoh M, Takashima S, Hino O　: Absence of allelic loss in cytomegalic neurons of cortical tuber in the Ecker rat model of tuberous sclerosis. 　Acta Neuropathol 2004;107:47-52.
  15. Ozawa Y, Takashima S, Tada H : Alpha2-adrenergic recepter subtype alterations in the brainstem in the sudden infant death syndrome. 　Early Hum Dev 2004;75:Suppl:S129-38.
  16. Wada N, Matsuishi T, Nonaka M, Naito E, Yoshino M : Pyruvate dehydrogenase E1α subunit deficiency in a female patient: evidence of antenatal origin of brain damage and possible etiology of infantile spasms. Brain Dev　2004;26:57-60.