2005 業績紹介

2005年

1. 成人および高齢者の精神・神経疾患の認知神経科学的研究

－著書－

  1. Morita K, Shoji H, Yamamoto H, Nishiura S,Shoji Y, Matsuoka T, Maeda H: Characteristics of cognitive function in patients with Parkinson’s disease: a comparison with healthy subjects. Unveiling the Mystery of the Brain ?Neurophysiological Investigation of the Brain Function- 　Tsuji S、Tobimatsu S、Kakigi R、Uozumi T、Akamatsu N. eds.　The Netherlands Int Congress Series 1278 Elsevier　2005;344-7.
  2. Shoji Y, Morita K, Shigemori M, Yamamoto H, Nishiura S, Maeda H： Characteristics of cognitive function in patients with higher brain dysfunction after brain injury : an event-related potential study. 　 Unveiling the Mystery of the Brain ?Neurophysiological Investigation of the Brain Function- 　Tsuji S、Tobimatsu S、Kakigi R、 Uozumi T、Akamatsu N. eds.　The Netherlands Int Congress Series 1278 Elsevier　2005;352-5.
  3. Nishiura S, Morita K, Habukawa M,Yamamoto H, Shoji Y, Uchimura N, Maeda H: Characteristics of cognitive function in patients with sleep apnea syndrome : an event?related potential study. Unveiling the Mystery of the Brain ?Neurophysiological Investigation of the Brain Function- Tsuji S、Tobimatsu S、Kakigi R、Uozumi T、Akamatsu N. eds. The Netherlands Int Congress Series 1278 Elsevier 2005;356-8.
  4. Yamamoto H, Morita K, Shoji Y, Nishiura S, Maeda H： The improvement of cognitive function reflected by event-related potentials in drug-naive schizophrenia with atypical antipsycotics. Unveiling the Mystery of the Brain ?Neurophysiological Investigation of the Brain Function- Tsuji S、Tobimatsu S、Kakigi R、Uozumi T、Akamatsu N. eds. The Netherlands Int Congress Series 1278 Elsevier 2005;348-51.

－論文－

  1. Egami H, Goto N,Chikama K,Fukuyama H, Tsujimaru S, Maeda H： A case of affective dysregulation、 impulsivity and depressive mood of a borderline personality disorder successfully treated with olanzapine. 　Int Clin Psychopharmacol　2005;20:A8.
  2. Egami H, Goto N, Chikama K, Uchimura N, Maeda H ： A case of irregular sleep-wake pattern with post-traumatic stress disorder and depressive state treated successfully with fluvoxamine、triazolam and mecobalamin combination. Int Clin Psychopharmacol 2005;20:A8.
  3. Yoshimura R, Nakamura J, Shinkai H, Goto M, Yamada Y, Kaji K, Kakihara K, Ueda N, Kohara K, Ninomiya H, Egami H, Maeda H　：　An open study of risperidone liquid in the acute phase of schizophrenia.　Hum Psychopharmacol Clin Exp　2005;20:243-8.
  4. Habukawa M, Uchimura N, Nose I,Kotorii N, Yamamoto K, Matsuyama S, Hashimoto T,Demizu S, Maeda M : Emotional states and quality of life in patients with obstructive sleep apnea. Sleep Biol Rhythms　 2005;3:99-105.
  5. Uchimura N, Nakajima T, Hayashi K, Nose I, Hashizume Y, Ohyama T, Habukawa M, Kotorii N, Kuwahara ,Maeda H： Effect of zolpidem on sleep architecture and itsy next-morning residual effect ininsomniacpatients : A randomized crossover comparative study with brotizolam. Prog Neuropsychopharmacol Biol Psychiatry 2005;30(1):22-9.
  6. Tomita M, J.Loughead, RC.Gur, A.Brennan, W.Snyder, K.Lesko, K.Ruparel, RE.Gur ： Brain activities associating face memory deficits in schizophrenia. Schizophr Bul 2005;31:437.
  7. Nishiyori　A, Shibata A,Ogimoto I, Uchimura N, Egami H, Nakamura J,Sakata R, Fukuda K： Alcohol drinking frequency is more directly associated with alcohol use disorder than alcohol metabolizing enzymes among male Japanese. Psychiat Clin Neurosci 　2005;59:38-44.
  8. Uematsu K,Futter M,Linda C. Hsieh-Wilson, Higashi H, Maeda H,Angus C. Nairn,Paul Greengard, Nishi A ： Regulation of spinophilin Ser94 phosphorylation in neostriatal neurons involves DARPP-32-dependent and -independent pathways.　 J Neurochem 　2005;95:1642-52.
  9. Ishii H, Yoshida M,Morinaga D,Annou N,Tanaka M : An α２ adrenoceptor inhibits noradrenaline (NA) release in the locus coeruleus (LC) of the rat brain assessed by in vivo microdialysis. Biog Amines 　　2005;19:69-77.
  10. Hirohata M, Abe T, Fujimura N, Takeuchi Y, Shigemori M: Preoperative Embolization of Brain Tumor with Pial Artery or Dural Branch of Internal Carotid Artery as Feeding Artery.　 Intervent Neuroradiol 2006:12(suppl 1):246-51.
  11. Nishida H, Ishibashi M, Hiromatsu Y, Kaida H, Baba K, Miyake I, Ikedo H, Kato S, Fukami K, Iida S, Okuda S: Comparison of histological finfings and parathyroid scintigraphy in hemodialysis patients with secondary hyperparathyroid glands. Endor J 2005;52(2):223-8.
  12. Kaida H, Ishibashi M, Nishida H, Baba K, Hayabuchi N: Rahabdomyolysis induced by psychotropic drugs. Clin Nucl Med 2005;30:569.
  13. Nishida H、Kaida H, Ishibashi M, Hiromatsu Y, Baba K, Iida S, Okuda S:　Usefulness of bone uptake ratio of bone scintingraphy in hemodialysis patients. Ann Nucl Med 2005;19(2):91-4.
  14. Kaida H, Ishibashi M, Nishida H, Baba K, Hiromatsu Y, Okuda S, Hayabuchi N: Usefulness of whole PTH assay in patients with renal osteodystrophy-Correlation with bone scintingraphy. Ann Nucl Med 2005;19(3):179-84.
  15. Nishida H, Kaida H, Ishibashi M, Baba K, Kouno K,Okuda S: Evaluation of exercise-induced acte real failure in renal hypouricemia using Tc-99m DTPA renography. Ann Nucl Med 2005；19(4), 325-9.
  16. Kaida H, Ishibashi M, Nishida H, Baba K, Hiromatsu Y, Okuda S, Hayabuchi N:　Assessment of therapeutic effect in patients with secondary hyperparathyroidism using bone scintigraphy. Ann Nucl Med 2005;19(5): 367-72.
  17. Uchida M, Ishibashi M, Tomita N, Shinagawa M, Hayabuchi N, Okuda K:　Hilar and suprapancreatic cholagiocarcinoma; Value of 3D angiography and multiphase fusion images using MDCT. Am J Roentgenol 2005;184:1572-7.
  18. Imaizumi T, Nishizaka S, Ayabe M, Shoji H, Ichiyama T, Sugita T: Chronic viral encephalitis with microglial nodules in the whole brain. Med Sci Monit 　2005;11:CS23-6.
  19. Tokito T, Tajiri M, Ayabe M, Shoji H, Maeyama Y, Hirohashi N: A clinical trial of ribavirin administraion for Japanese encephalitis : a case report. Neuroinfection 2005;10:94-7.
  20. Sato R, Ayabe M, Shoji H, Ichiyama T, Saito Y, Hondo R, Eizuru Y: Herpes simplex virus type2 recurrent meningitis (Mollaret’ s meningitis): a consideration for the recurrent pathogenesis. J Infect 2005; 51:e217-20.
    22. Hirai R, Ayabe M, Shoji H, Kaji M, Ichiyama T, Sakai K: Herpes simplex encephalitis presenting with bilateral hippocampal lesions on magnetic resonance imaging, simultaneously complicated by small cell lung carcinoma: a case report. Intern Med 2005;44:1006-8.

2. 成人および高齢者の精神・神経疾患の分子生物学的研究

－論文－

  1. Itoh K, Hashimoto K, Shimizu E, Sekine Y, Ozaki N, Inada T, Harano M, Iwata N, Komiyama T、 Yamada M, Sora I, Nakata K, Ujike H, Iyo M： Association study between brain-derived neurotrophic factor gene polymorphisms and methamphetamine abusers in Japan.　 Am J Med Genet B Neuropsychiatr Genet 　2005；132： 70-3.
  2. Morita Y, Ujike H, Tanaka Y, Uchida N, Nomura A, Ohtani K, Kishimoto M, Morio A,Imamura T, Sakai A, Inada T, Harano M, Komiyama T, Yamada M, Sekine Y, Iwata N, Iyo I. Sora I, Ozaki N, Kuroda S： A nonsynonymous polymorphism in the human fatty acid amide hydrolase gene did not associate with either methamphetamine dependence or schizophrenia.　 Neurosci Lett　 2005;376: 182-7.
  3. Hashimoto T, Hashimoto K, Matsuzawa D, Shimizu E, Sekine Y, Inada T, Ozaki N, Iwata N, Harano M, Komiyama T, Yamada M, Sora I, Ujike H, Iyo M ： A functional glutathione S-transferase P1 gene polymorphism is associated with methamphetamine-induced psychosis in Japanese population. 　Am J Med Genet B Neuropsychiatr Genet　 2005;135:5-9.
  4. Ohgake S, Hashimoto K, Shimizu E, Koizumi H, Okamura N, Koike K, Matsuzawa D, Sekine Y, Inada T, Ozaki N, Iwata N, Harano M, Komiyama T, Yamada M, Sora I, Ujike H, Shirayama Y, Iyo M ： Functional polymorphism of the NQO2 gene is associated with methamphetamine psychosis.　 Addict Biol 　2005;10: 145-8.
  5. Ikeda M, Iwata N, Suzuki T, Kitajima T, Yamanouchi Y. Kinoshiya Y, Sekine Y, Iyo M, Harano M, Komiyama T, Yamada M, Sora I, Ujike H, Inada I,Ozaki N： Positive association of AKT1 haplotype to Japanese methamphetamine use disorder.　Int J Neuropsychopharmacol 　2005;28:1-5.
  6. Morita Y, Ujike H, Tanaka Y, Uchida N, Nomura A, Otani K, Kishimoto M, Morio A, Inada T, Harano M, Komiyama T, Yamada M, Sekine Y, Iwata N, Iyo M, Sora I, Ozaki N ： The X-box binding protein 1 (XBP1) gene is not associated with methamphetamine dependence.　 Neurosci Lett　 2005;383: 194-8.
  7. Nishiyama T, Ikeda M, Iwata N, Suzuki T, Kitajima T, Yamanouchi Y, Sekine Y, Iyo M, Harano M, Komiyama T, Yamada M, Sora I, Ujike H, Inada T, Furukawa T, Ozaki N：　Haplotype association between GABAA receptor gamma2 subunit gene (GABRG2) and methamphetamine use disorder.　Pharmacogenomics J 　2005;5:89-95.
  8. Nishi A, Watanabe Y, Higashi H, Tanaka M, Nairn AC, Greengard P : Glutamate regulation of DARPP-32 phosphorylation in neostriatal neurons involves activation of multiple signaling cascades. Proc Natl Acad Sci USA 2005;102:1194-204.
  9. Futter M, Uematsu K, S. A. Bullock, Y Kim, H. C. Hemmings,Jr. Nishi A, P Greengard、 A. C.Nairn ： Phosphorylation of spinophilin by ERK and cyclin -dependent PK5(Cdk5).　Proceeding of the National Academy of Science of the United States of America 　2005;102:3489-94.
  10. Asaumi Y, Hasuo H, Akasu T ： Properties of dopamine- induced outward current in neurons of the rat dorsolateral septal nucleus.　 Kurume Med J 2005;52:57-62.
  11. Ohshima T, Ogura H, Tomizawa K, Hayashi K, Suzuki H, Saito T, Kamei H, Nishi A, Bibb JA, Hisanaga S-I, Matsui H, Mikoshiba K: Impairment of hippocampal long-term depression and defective spatial learning and memory in p35-/- mice. J Neurochem 2005;94:917-25.
  12. Hamada M, Hendrick JP, Ryan GR, Kuroiwa M, Higashi H, Tanaka M, Nairn AC, Greengard P, Nishi A: Nicotine regulates DARPP-32 phosphorylation at multiple sites in neostriatal neurons. J Pharmacol Exp Ther 2005;315: 872-8.
  13. Uematsu K, Futter M, Hsieh-Wilson LC, Higashi H, Maeda H, Nairn AC, Greengard P, Nishi A: Regulation of spinophilin Ser94 phosphorylation in neostriatal neurons involves DARPP-32-dependent and -independent pathways. J Neurochem 2005;95:1642-52.
  14. The Japanese Schizophrenia Sib-Pair Group (JSSLG), Genomewide high-density SNP linkage analysis of 236 japanese families supports the existence of schizophrenia susceptibility loci on chromosomes 1p, 14q, and 20p Am J Hum Genet 2005;77:937-44.
  15. Yokomizo Y, Murai Y, Tanaka E, Inokuchi H, Kusukawa J, Higashi H: Excitatory GABAergic synaptic potentials in the mesencephalic trigeminal nucleus of adult rat in vitro. Neurosci Res 2005;51:463-74.
  16. Niiyama S, Tanaka E, Tsuji S, Murai Y, Satani M, Sakamoto H, Takahashi K, Kuroiwa M, Yamada A, Noguchi M, Higashi H: Neuroprotective mechanisms of lidocaine against in vitro ischemic insult of the rat hippocampal CA1 pyramidal neurons. Neurosci Res 2005;53:271-8.
  17. Harada H, Wang Y, Mishima Y, Uehara N, Makaya T, Kano : A novel method of detecting rCBF with laser-Doppler flowmetry without cranial window through the skull for a MCAO rat model.Brain ResProtoc 2005;14(3):165-70.
  18. Kakinohana M, Harada H, Mishima Y, Kano T, Sugahara K : Neuroprotective Effect of Epidural Electrical Stimulation against Ischemic Spinal Cord Injury in Rats: Electrical Preconditioning. Anesthesiology 2005;103(1): 84-92.
  19. Gu JW, Zheng CX, Zhang AH, Hasuo H, Akasu T, Yang WT, Yang LB, Xia X, Ma Y: Effects and wavelet spectral entropy analysis of rhubard extracts rhein on synaptic transmission in rat hippocampalcal area in vitro. Chin Med J 2005；118(10): 817-23.
  20. Asaumi Y, HasuoH, Akasu T: Properties of dopamine-inducedoutward current in neurons of the rat dorsolateral septal nucleus. Kurume Med J 2005;52(1,2):57-62.
  21. Gu J-W, Hasuo H, Takeya M, Akasu T: Effects of emodin on synaptic transmission in rat hippocampal CA1 pyramidal neurons in vitro. Neuropharmacology 2005;49(1):103-11.
  22. Mishima Y, Harada H, Sugiyama K, Miyagawa Y, Uehara N, Kano T: Induction of neuronal tolerance by electroconvulsive shock in rats subjected to forebrain ischemia. Kurume Med J 2005;52:153-60.

3. 小児の精神・神経疾患の分子基盤解明と遺伝子治療に関する研究

－論文－

  1. Fukuda T, Yamashita Y, Nagamitsu S, Miyamoto K, Jing-Ji Jin, Ohmori I, Ohtsuka Y, Kuwajima K, Endo S, Iwai T, Yamagata H, Tabata Y, Miki T, Matsuishi T, Kondo I:Methyl-CpG Binding protein 2 gene (MECP2) variations in Japanese patients with Rett syndrome: pathological mutations and polymorphisms. 　Brain Dev 2005;27(3):211-7.
  2. Ushikoshi H, Takahashi T, Chen X, Khai NC, Esaki M, Goto K, Takemura G, Maruyama R, Minatoguchi S, Fujiwara T, Nagano S, Yuge K, Kawai T, Murofushi Y, Fujiwara H, Kosai K : Local overexpression of HB-EGF exacerbates remodeling following myocardial infarction by activating non-cardiomyocytes. Lab Invest 　2005;85:862-73.
  3. Kamizono J, Nagano S, Murofushi Y, Komiya S, Fujiwara H, Matsuishi T, Kosai K: Survivin-responsive conditionally replicating adenovirus exhibits cancer-specific and efficient viral replication. Cancer Res 2005;65: 5284-91.
  4. Nagano S, Oshika H, Fujiwara H, Komiya S, Kosai K: An Efficient Construction of Conditionally Replicating Adenoviruses that Target Tumor Cells with Multiple Factors. Gene Ther 2005;12:1385-93.
  5. Yuge K, Takahashi T, Nagano S, Terazaki Y, Murofushi Y, Ushikoshi H, Kawai T, Khai NC, Nakamura T, Fujiwara H, Kosai K: Adenoviral Gene Transduction of Hepatocyte Growth Factor Elicits Inhibitory Effects for Hepatoma. Int J Oncol 2005;27:77-85.
  6. Tada T, Nguyen JB, Hitoshi Y, Watson NP, Dunn JF, Ohara S, Nagano S, Kosai K, Israel MA : Diffuse Encephaloventriculitis and Substantial Leukoencephalopathy after Intraventricular Administration of Recombinant Adenovirus. Neurol Res 2005;27:378-86.
  7. Okada H, Takemura G, Kosai K, Li Y, Takahashi T, Esaki M, Yuge K, Miyata S, Maruyama R, Mikami A, Minatoguchi S, Fujiwara T, Fujiwara H: Postinfarction gene therapy against transforming growth factor-beta signal modulates infarct tissue dynamics and attenuates left ventricular remodeling and heart failure. Circulation 2005;111:2430-7.
  8. Misao Y, Arai M, Ohno T, Ushikoshi H, Takahashi T, Takemura G, Minatoguchi S, Fujiwara T, Fujiwara H: Cyclophosphamide improves the function of post-infarct hearts by reducing old infarct area and accelerating the mobilization of CD34+ cells. Circ J 2005;69:763-5.
  9. Koga Y, Akita Y, Nishioka J, Yatsuga S, Povalko N, Tanabe Y, Fujimoto S, Matsuishi T: L-arginine improves the symptoms of stroke-like episodes in MELAS. Neurology 2005;64(4):710-2.
  10. Tsuneoka M, Teye K, Arima N, Soejima M, Otera H, Ohashi K, Koga Y, Fujita H, Shirouzu K, Kimura H, Koda Y: A novel MYC-Target gene, MIMITIN, that is involved in cell proliferation of esophageal squamous cell carcinoma. J Biol Chem 2005;280(20):19977-85.
  11. Povalko N, Zakharova E, Rudenskaia G, Akita Y, Hirata K, Matsuishi T, Koga Y: A new sequence variant in mitochondrial DNA associated with high penetrance of Russian Leber hereditary optic neuropathy. Mitochondrion 　2005;5(3):194-9.
  12. Matsuda K, Nishi Y, Okamatsu Y, Kojima M, Matsuishi T: Ghrelin and Leptin: a link between obesity and allergy ? J Allergy Clin Immunol 2006;27:705-6.
  13. Matsuda K, Tani H, Okamatsu Y, Sakaguchi Y, Kimura K, Matsuishi T: Increment of IgE production in obese children. J Allergy Clin Immunol 2005；115: S169.
  14. Matsuda K, Sakata Y, Tani H, Kimura K, Matsuishi T: Transient Haemophilus influenzae Type b bacteremia in a healthy child. Kurume Med J 2005;52:53-6.
  15. Muta H, Ishii M, Egami K, Hayasaka S, Nakamura Y, Yanagawa H, Matsuishi T: Serum sodium levels in patients with Kawasaki disease. Pediatr Cardiol 2005;26(4):404-7.
  16. Masuyama T, Matsuo M, Jing JJ, Tabara Y, Kitsuki K, Yamagata H, Kan Y, Miki T, Ishii K, Kondo I. Classic Rett syndrome in a boy with R133C mutation of MECP2.　Brain Dev 2005;(6):439-42.
  17. Owada K, Ishikawa K, Toru S, Ishida G, Gomyoda M, Tao O, Noguchi Y, Kitamura K, Kondo I, Noguchi E, Arinami T, Mizusawa H.: A clinical, genetic, and neuropathologic study in a family with 16q-linked ADCA type III.　Neurology 2005；65(4): 629-32.
  18. Zhong W, Yamagata HD, Taguchi K, Akatsu H, Kamino K, Yamamoto T, Kosaka K, Takeda M, Kondo I, Miki T. Lymphocyte-specific protein tyrosine kinase is a novel risk gene for Alzheimer disease.　J Neurol Sci 2005;238(1-2): 53-7.
  19. Ishikawa K, Toru S, Tsunemi T, Li M, Kobayashi K, Yokota T, Amino T, Owada K, Fujigasaki H, Sakamoto M, Tomimitsu H, Takashima M, Kumagai J, Noguchi Y, Kawashima Y, Ohkoshi N, Ishida G, Gomyoda M, Yoshida M, Hashizume Y, Saito Y, Murayama S, Yamanouchi H, Mizutani T, Kondo I, Toda T, Mizusawa H.: An autosomal dominant cerebellar ataxia linked to chromosome 16q22.1 is associated with a single-nucleotide substitution in the 5' untranslated region of the gene encoding a protein with spectrin repeat and Rho guanine-nucleotide exchange-factor domains.　Am J Hum Genet 2005;77(2):280-96.
  20. Taguchi K, Yamagata HD, Zhong W, Kamino K, Akatsu H, Hata R, Yamamoto T, Kosaka K,Takeda M, Kondo I, Miki T. Identification of hippocampus-related candidate genes for Alzheimer's disease.　 Ann Neurol 2005;57(4):585-8.
  21. Fukuda T, Yamashita Y, Nagamitsu S, Miyamoto K, Jin JJ, Ohmori I, Ohtsuka Y, Kuwajima K, Endo S, Iwai T, Yamagata H, Tabara Y, Miki T, Matsuishi T, Kondo I.: Methyl-CpG binding protein 2 gene (MECP2) variations in Japanese patients with Rett syndrome: pathological mutations and polymorphisms.　 Brain Dev 2005;27(3):211-7.
  22. Kondo I, Shimizu A, Asakawa S, Miyamoto K, Yamagata H, Tabara Y, Shimizu N.: COH1 analysis and linkage study in two Japanese families with Cohen syndrome.　Clin Genet 2005;67(3):270-272.