2006 業績紹介

2006年

1. 成人および高齢者の精神・神経疾患の認知神経科学的研究

－著書－

  1. Maeda M, Maruoka T, Maeda H: Psychological consequences for students who survived the Ehime Maru Accident: A26-month follow study. PTSD Brain Mechanisms and Clinical Implications. Kato N, Kawata M, R.K.Pitman (Eds.) Tokyo, Springer 2006:193-202.
  2. Shigemori M： Recent Projects on Neurotrauma in Japan．Minimally Invasive Neurosurgery and Multidisciplinary Neurotraumatology　T. Kanno（Editor in Chife）　Springer　2006;268-73.

－論文－

  1. Uchimura N, Nakajima T, Hayashi K, Nose I, Hashizume Y, Ohyama T, Habukawa M, Kotorii N, Kuwahara H, Maeda H: Related Articles, Links: Effect of zolpidem on sleep architecture and its next-morning residual effect in insomniac patients: a randomized crossover comparative study with brotizolam. Prog Neuropsychopharmacol Biol Psychiatry 2006; 30(1):22-9.
  2. Yamamoto K, Uchimura N, Habukawa M, Takeuchi N, Oshima H, Oshima M, Maeda H: Evaluation of the effects of paroxetine in the treatment of REM sleep behavior disoder. Sleep Biol Rhythms 2006;4:190-2.
  3. Maeda M, Kato S, Fukushima S, Kaneyuki U, Fujii T, Kazanietz MG, Oshima K, Shigemori M: Regulation of vascular smooth muscle proliferation and migration by β2-chimaerin,a non-protein kinase C phorbol ester receptor. Int J Mol Me 2006;17(4)559-66.
  4. Tsuchiya S,Tsuchiya K,Tsuchiya K, Kaku Y,Uchimura N： Familial development of narcolepsy and periodic limb movement disorder.　Sleep Biol Rhythms　2006;4:179-82.

2. 成人および高齢者の精神・神経疾患の分子生物学的研究

－論文－

  1. Suzuki A, Nakamura K, Sekine Y, Minabe Y, Takei N, Suzuki K, Iwata Y, Kawai M, Takebayashi K, Matsuzaki H, Iyo M, Ozaki N, Inada T, Iwata N, Harano M, Komiyama T, Yamada M, Sora I, Ujike H, Mori N: An association study between catechol-O-methyl transferase gene polymorphism and methamphetamine psychotic disorder. Psychiat Genet 2006;16(4):133-8.
  2. Nakamura K, Chen CK, Sekine Y, Iwata Y, Anitha A, Loh EW, Takei N, Suzuki A, Kawai M, Takebayashi K, Suzuki K, Minabe Y, Tsuchiya K, Yamada K, Iyo M, Ozaki N, Inada T, Iwata N, Harano M, Komiyama T, Yamada M, Sora I, Ujike H, Ball DM, Yoshikawa T, Lin SK, Mori N: Association analysis of SOD2 variants with methamphetamine psychosis in Japanese and Taiwanese populations. Hum Genet 2006;120:243-52.
  3. Kobayashi H, Hata H, Ujike H, Harano M, Inada T, Komiyama T, Yamada M, Sekine Y, Iwata N, Iyo M, Ozaki N, Itokawa M, Naka M, Ide S, Ikeda K, Numachi Y, Sora I: Association analysis of delta-opioid receptor gene polymorphisms in methamphetamine dependence/psychosis. Am J Med Genet B Neuropsychiatr Genet 2006;141(5):482-6.
  4. Nomura A, Ujike H, Tanaka Y, Otani K, Morita Y, Kishimoto M, Morio A, Harano M, Inada T, Yamada M, Komiyama T, Sekine Y, Iwata N, Sora I, Iyo M, Ozaki N, Kuroda S: Genetic variant of prodynorphin gene is risk factor for methamphetamine dependence. Neurosci Lett 2006;400(1-2):158-62.
  5. Ide S, Kobayashi H, Ujike H, Ozaki N, Sekine Y, Inada T, Harano M, Komiyama T, Yamada M, Iyo M, Iwata N, Tanaka K, Shen H, Iwahashi K, Itokawa M, Minami M, Satoh M, Ikeda K, Sora I: Linkage disequilibrium and association with methamphetamine dependence/psychosis of mu-opioid receptor gene polymorphisms. Pharmacogenomics J 2006;6(3):179-88.
  6. Ikeda M, Iwata N, Suzuki T, Kitajima T, Yamanouchi Y, Kinoshiya Y, Sekine Y, Iyo M, Harano M, Komiyama T, Yamada M, Sora I, Ujike H, Inada,Shuto T, Kuroiwa M, Hamamura M, Yabuuchi K, Shimazoe T, Watanabe S, Nishi A, Yamamoto T. ：　Reversal of methamphetamine-induced behavioral sensitization by repeated administration of a dopamine D1 receptor agonist. Neuropharmacology 　200;50:991-7.
  7. Wing-Sze Lo, Harano M, M Gawlik, Zhiliang Yu, J Chen, F.W. Pun, K-L Tong, C Zhao, S-K Ng, S-Y Tsang, Uchimura N, G Stober, H Xue ： GABRB2 Association with Schizophrenia: Commonalities and Differences Between Ethnic Groups and Clinical Subtypes　 Biol Psychiatry 2006;61:653-30.
  8. Yabuuchi K, Kuroiwa M, Shuto T, Sotogaku N, Snyder GL, Higashi H, Tanaka M, Greengard P, Nishi A. ：　Role of adenosine A1 receptors in the modulation of dopamine D1 and adenosine A2A receptor signaling in the neostriatum. Neuroscience 　2006;141:19-25.
  9. Takagi K, Fukunaga S, Nishi A, Shojima T, Yoshikawa K, Hori H, Akashi H, Aoyagi S. ：　In vivo recellularization of plain decellularized xenografts with specific cell characterization in the systemic circulation: histological and immunohistochemical study. 　 Artif Organs 　2006;30:233-41.
  10. Shojima T, Hayashida N, Nishi A, Takagi K, Hori H, Yoshikawa K, Aoyagi S. Effects of nicorandil preconditioning on membrane dystrophin. Eur J Cardiothorac Surg 　2006;30(3):472-9.
  11. Gama CI, Tully SE, Sotogaku N, Clark PM, Rawat M, Vaidehi N, William A. Goddard III WA, Nishi A, Hsieh-Wilson LC. Sulfation patterns of glycosaminoglycans encode molecular recognition and activity. Nat Chem Biol 2006;2:467-73.
  12. Shuto T, Kuroiwa M, Hamamura M, Yabuuchi K, Shimazoe T, Watanabe S, Nishi A, Yamamoto T.: Reversal of methamphetamine-induced behavioral sensitization by repeated administration of a dopamine D1 receptor agonist. Neuropharmacology　　2006;50:991-7
  13. Hamer M, Tanaka G, Okamura H, Tsuda A, Steptoe A: The Effects of depressive symptpms on cardiovascular and catecholamine responses to the induction of deoressive mood. Biol Psychol 2006;74:205.
  14. Akaiwa K, Akashi H,　Harada H, Sakashita H, Hiromatsu, Kano T, Aoyagi S：Moderate cerebral venous congestion induces rapid cerebral protection via adenosine A1 receptor activation. 　Brain Res 　2006;1122:47-55.
  15. Kano T, Ueda N, Harada H, Watanabe S：　　Intra-operative monitoring of EEG. Jpn J Anesthesiology 2006;55(3):269-79.
  16. Ando M, Tsuda A : Preliminary study of reminiscence therapy on depression and self-esteem in cancer patients. Psychol Rep 2006;98: 339-46.
  17. Asaumi Y, Hasuo H、Akasu T ： Dopamine presynaptically depresses fast inhibitory synaptic transmission via D4 receptor-protein kinase A pathway in the rat dorsolateral septal nucleus.　J Neurophysiol 　2006;96:591-601.
  18. Cao R, Hasuo H, Ooba S, Akasu T, Zhang X: Facilitation of glutamatergic synaptic transmission in hippocampal CA1 area of rats with traumatic brain injury. Neurosci Lett 　2006:401(1-2):136-41.

3. 小児の精神・神経疾患の分子基盤解明と遺伝子治療に関する研究

－著書－

  1. Takizawa Y, Takashima S, Itoh M: A histopathological study of premature and mature infants with pontosubicular neuron necrosis: Neuronal cell death in perinatal brain damage. Brain Res 2006;1095:200-6.

－論文－

  1. Takahashi T, Kawai T, Ushikoshi H, Nagano S, Oshika H, Inoue M, Kunisada T, Takemura G, Fujiwara H, Kosai K.: Identification and isolation of embryonic stem cell-derived target cells by adenoviral conditional targeting. Mol Ther 2006;14:673-83.
  2. Murofushi Y, Nagano S, Kamizono J, Takahashi T, Fujiwara H, Komiya S, Matsuishi T, Kosai K.:Cell cycle-specific changes in hTERT promoter activity in normal and cancerous cells in adenoviral gene therapy: A promising implication of telomerase-dependent targeting cancer gene therapy. Int J Oncol 2006;29:681-8.
  3. Kuge H, Ohashi K, Yokoyama T, Kanehiro H, Hisanaga M, Koyama F, Bumgardner GL, Kosai K, Nakajima Y.: Genetic modification of hepatocytes towards hepatocyte transplantation and liver tissue engineering. Cell Transplant 2006;15:1-12.
  4. Khai NC, Takahashi T, Ushikoshi H, Nagano S, Yuge K, Esaki M, Kawai T, Goto K, Murofushi Y, Fujiwara T, Fujiwara H, Kosai K: In vivo hepatic HB-EGF gene transduction inhibits Fas-induced liver injury and induces liver regeneration in mice: A comparative study to HGF. J Hepatol 2006; 44:1046-54.
  5. Misao Y, Takemura G, Arai M, Sato S, Suzuki K, Miyata S, Kosai K, Minatoguchi S, Fujiwara T, Fujiwara H.: Bone marrow-derived myocyte-like cells and regulation of repair-related cytokines after bone marrow cell transplantation. Cardiovasc Res 2006；69: 476-90.
  6. Kagawa T, Takemura G, Kosai K, Murata I. Ohno T, Takahashi T, Esaki M, Maruyama R, Fujiwara T, Ohashi H, Fujiwara H: Hepatocyte growth factor gene therapy slows down the progression of diabetic nephropathy in db/db mice. Nephron Physiol 2006；102: 92-102.
  7. Nagamitsu S, Nagano M, Yamashita Y, Takashima S, Matsuishi T: Prefrontal cerebral blood volume patterns while playing video games ?A near-infrared spectroscopy study. Brain Dev 2006;28:315-21.
  8. Matsuda K, Nishi Y, Okamatsu Y, Kojima M, Matsuishi T:Ghrelin and Leptin: a link between obesity and allergy ? J Allergy Clin Immunol 2006;117:705-6.
  9. Koga Y, Akita Y, Nishioka J, et al. Endothelial dysfunction in MELAS improved by L-arginine supplementation. Neurology 　2006;66:1766-9.
  10. Ueki I, Koga Y, Povalko N, Akita Y, Nishioka J, Yatsuga S, Fukiyama R, Matsuishi T: Mitochondrial tRNA gene mutation in patients having mitochondrial disease with lactic acidosis. Mitochondrion 2006;6(1):39-48.
  11. Mitsuda N, Yamahgata H, Zhong W,Aoto M, Akatsu H, Uekawa n, Kimino K, Taguchi K, Yamamoto T, Maruyama M, Kohara K, Takeda M, Kondo I, Miki T: 　　A novel alternative splicevariation of nicastrin and its implication in Alzheimer disease. Life Sci 2006;78(2):2444-8.
  12. Waragai M, Nagamitsu S, Xu, W, Li Yujiang, Lin Xi, Ashizawa T: ATAXIN 10 induces neuritogenesis via interaction with G-protein b2 subunit. J Neurosci Res 2006:83(7):1170-8.
  13. Masuyama T, Matsuo M, Jing JJ, Tabara Y, Kitsuki K, Yamagata H, Kan Y, Miki T, Ishii K, Kondo I. Classic Rett syndrome in a boy with R133C mutation of MECP2.　Brain Dev 2005；(6):439-42.