2008 業績紹介

2008年

1. 成人および高齢者の精神・神経疾患の認知神経科学的研究

－論文－

  1. Oe　M, Maeda　M, Uchimura　N： Longitudinal psychological effects of the Garuda Indonesia air disaster in Japan.　Kurume Medical Journal　2008;55(1,2):1-6.
  2. Miura S, Noda K, Kusumoto M, Tomioka R, Honda S, Ayabe M, Aizawa H, Taniwaki T: Central sleep apnea in a patient with Japanese encephalitis. Neurology Asia 2008;13:77-81.
  3. Kuroki N, Ohyagi Y, Kawano Y, Yoshiura T, Taniwaki T, Kira J: Acute onset Facial numbness. J Clin Neurosci 2008;15(9):1049.
  4. Miura S, Shibata H, Kida H, Noda K, Tomiyasu K, Yamamoto K, Iwaki A, Ayabe M, Aizawa H, Taniwaki T, Fukumaki Y. Hereditary motor and sensory neuropathy with proximal dominancy in the lower extremities, urinary disturbance, and paroxysmal dry cough. J Neurol Sci 2008;273(1-2):88-92.
  5. Oishi A, Tobimatsu S, Ogata K, Taniwaki T, Kinukawa N, Toyoshiba H, Kira J: Differential contributions of spinal and cortical motoneurons to input-output properties of human small hand muscle. Neurol Res 2008;30(10):1106-13.
  6. Miura S, Noda K, Shiramizu N, Muraoka N, Horohata M, Ayabe M, Abe T, Aizawa H, Taniwaki T: Parkinsonism and ataxia associated with an intracranial dural arteriovenous fistula presenting with heperintense basal ganglia in T1- weighted MRI. J Clin Neurosci 2009;16(2):341-3.
  7. Miura S, Nakagawara H, Kaida H, Sugita M, Noda K, Motomura K, Ohyagi Y, Ayabe M, Aizawa H, Ishibashi M, Taniwaki T:Expansion of the phenotypic spectrum of SCA14 caused by the Gly128Asp mutation in PRKCG. Clin Neurol Neurosurg 2009;111(2): 211-5.
  8. Miyoshi K, Ohyagi Y, Sakae N, Motomura K, Ma L, Taniwaki T, Furuya H, Tabira T, Kira J: Enhancement of activation of caspases by presenilin 1 gene mutations and its inhibition by secretase inhibitors. J Alzheimers Dis 2009;16(3):551-64.
  9. Ma L, Ohyagi Y, Miyoshi K, Sakae N, Motomura K, Taniwaki T, Furuya H, Takeda K, Tabira T, Kira J: Increase in p53 Protein Levels by Presenilin 1 Gene Mutations and its Inhibition by Secretase Inhibitors. J Alzheimers Dis 2009;16(3): 565-75.
  10. Egami　C, Morita K, Oya T ,Ishii Y, Yamashita Y, Matuishi T: Developmental characteristics of visual cognitive function during childhood according to exploratory eye movements. Brain Dev 2008 (in press)
  11. Sugita Y, Nakamura Y, Yamamoto M, Ogasawara S, Ohshima K, Shigemori M: Expression of KIAA 0864 protein in neuroepithelial tumors: an analysis based on the presence of monoclonal antibody HFB-16. Journal of Neurooncology 2008; 89:151-158.
  12. Tokutomi T, Morimoto K, Miyagi T, Yamaguchi S, Ishikawa K, Shigemori M: Optimal temperature for the management of severe traumatic brain injury: Effect of hypothermia on intracranial pressure, systemic and intracranial hemodynamics, and metabolism. Neurosurgery 2008;61(supple 1):256-266.
  13. Ooba S, Hasuo H, Shigemori M, Akasu T: Diazepam attenuates the post-traumatic hyperactivity of excitatory synapses in rat hippocampal CA1 neurons. Neuroscience Research. 2008;62(3):195-205.
  14. Fukushima S, Terasaki M, Shigemori M: Chordoid meningioma arising in the pineal region: a case report. Brain Tumor Pathol 2008;25(2):91-95.
  15. Tokutomi T, Miyagi T, Ogawa T, Ono J, Kawamata T, Sakamoto T, Shigemori M, Nakamura N: Age-associated increases in poor outcomes after traumatic brain injury: A report from the Japan Neurotrauma Data Bank. Journal of Neurotrauma 2008;25(12):1407-1414.
  16. Tokutomi T, Miyagi T, Takeuchi Y, Karukaya T, Katsuki H, Shigemori M: Effect of 35℃ hypothermia on intracranial pressure and clinical outcome in patients with severe traumatic brain injury. Journal of Trauma 2009;66(1):166-173.
  17. Fukushima S, Hirohata M, Okamoto Y, Yamashita S, Ishida S, Shigemori M: Anterior inferior cerebellar artery dissecting aneurysm in a juvenile ―Case Report―. Neurologia Medico-Chirurgica 2009;49(2):81-84.
  18. Komatani H, Sugita Y, Arakawa F, Ohshima K, Shigemori M: Expression of CXCL12 on pseudopalisading cells and proliferating microvessels in glioblastomas: An accelerated growth factor in glioblastomas.　 Int J Oncol　2009;34(3):665-672.
  19. Terasaki M, Eric Bouffet, Katsuki H, Fukushima S, Shigemori M: Pilot trial of the rate of response, safety, and tolerability of temozolomide and oral VP-16 in patients with recurrent or treatment-induced malignant central nervous system tumors. Surgical Neurology.　 2008;69(1):46-50.
  20. Fukushima S, Kato S, Maeda M, Shigemori M: Caspase-9 pathway activation by inhibiting endogenous fibroblast growth factor signaling in human glioma cells. International Journal of Oncology. 2008; 32(2):467-473.
  21. Hagihara N, Abe T, Hirohata M, Inoue K, Watanabe M, Tabuchi K: Simultaneous occurrence of subarachnoid hemorrhage due to ruptured aneurysm and remote brainstem hematoma-Case report-. Neurologia medico-chirurgica. 2008; 48(2):64-67.

2. 成人および高齢者の精神・神経疾患の分子生物学的研究

－総説－

  1. Ooba S, Hasuo H, Shigemori M, Akasu T: Diazepam attenuates the post-traumatic hyperactivity of excitatory synapses in rat hippocampal CA1 neurons. Neurosci Res 2008;62(3):195-205.
  2. Stipanovich A, Valjent E, Matamales M, Nishi A, Ahn J-H, Maroteaux M, Bertran-Gonzalez J, Brami-Cherrier K, Enslen H, Corbillé A-G, Filhol O, Nairn AC, Greengard P, Hervé D, Girault J-A: A phosphatase cascade by which rewarding stimuli control nucleosomal response. Nature 2008;453:879-884.
  3. Shuto T, Seeman P, Kuroiwa M, Nishi A: Repeated administration of a dopamine D1 receptor agonist reverses the increased proportions of striatal dopamine D1High and D2High receptors in methamphetamine-sensitized rats. Eur J Neurosci 2008;27:2551-2557.
  4. Bateup H, Svenningsson P, Kuroiwa M, Gong S, Nishi A, Heintz N, Greengard P: Cell type-specific regulation of DARPP-32 phosphorylation by psychostimulant and antipsychotic drugs. Nat Neurosci 2008;11:932-939.
  5. Nishi A, Kuroiwa M, Miller DB, O'Callaghan JP, Bateup HS, Shuto T, Sotogaku N, Fukuda T, Heintz N, Greengard P, Snyder GL. Distinct roles of PDE4 and PDE10A in the regulation of cAMP/PKA signaling in the striatum. J Neurosci 2008;28:10460-10471.
  6. Kuroiwa M, Bateup HS, Shuto T, Higashi H, Tanaka M, Nishi A: Regulation of DARPP-32 phosphorylation by three distinct dopamine D1-like receptor signaling pathways in the neostriatum. J Neurochem 2008;107:1014-1026.
  7. Kawahara Y, Kawahara H, Kaneko F, Yamada M, Nishi Y, Tanaka E, Nishi A: Peripherally administered ghrelin induces bimodal effects on mesolimbic dopamine system depending on food-consumptive states. Neuroscience 2009 (in press)

－論文－

  1. Stipanovich A, Valjent E, Matamales M, Nishi A, Ahn J-H, Maroteaux M, Bertran-Gonzalez J, Brami-Cherrier K, Enslen H, Corbillé A-G, Filhol O, Nairn AC, Greengard P, Hervé D, Girault J-A: A phosphatase cascade by which rewarding stimuli control nucleosomal response. Nature 2008;453:879-884.
  2. Shuto T, Seeman P, Kuroiwa M, Nishi A: Repeated administration of a dopamine D1 receptor agonist reverses the increased proportions of striatal dopamine D1High and D2High receptors in methamphetamine-sensitized rats. Eur J Neurosci 2008;27:2551-2557.
  3. Bateup H, Svenningsson P, Kuroiwa M, Gong S, Nishi A, Heintz N, Greengard P: Cell type-specific regulation of DARPP-32 phosphorylation by psychostimulant and antipsychotic drugs. Nat Neurosci 2008;11:932-939.
  4. Nishi A, Kuroiwa M, Miller DB, O'Callaghan JP, Bateup HS, Shuto T, Sotogaku N, Fukuda T, Heintz N, Greengard P, Snyder GL: Distinct roles of PDE4 and PDE10A in the regulation of cAMP/PKA signaling in the striatum. J Neurosci 2008;28:10460-10471.
  5. Kuroiwa M, Bateup HS, Shuto T, Higashi H, Tanaka M, Nishi A: Regulation of DARPP-32 phosphorylation by three distinct dopamine D1-like receptor signaling pathways in the neostriatum. J Neurochem 2008;107:1014-1026.
  6. Kawahara Y, Kawahara H, Kaneko F, Yamada M, Nishi Y, Tanaka E, Nishi A: Peripherally administered ghrelin induces bimodal effects on mesolimbic dopamine system depending on food-consumptive states. Neuroscience 2009 (in press)
  7. Tsuruta T, Yang CN,Ueki H, Li GY, Maekawa A, Kamikawa H, Oku E, Somehara T, Fujito H, Tatebayashi H, Yamada S: Determination of Paroxetine in human saliva by reversed phase high-performance liquid chromatography with UV detection. JPN J neuropsychopharmacol 2007;27:9-12.
  8. Li G,Watanabe I, Kunitake Y, Sugataka K, Muraoka T,Kojima N, Kawashima T, Yamada S: Relationship between saliva level of 3-methoxy-4-hydroxyphenylglycol and mental health in the elderly general population. Psychiatry and Clinical Neurosciences 2008;62:162-167.
  9. Muraoka T,Oku E, Sugataka K,Yamada S: A Case of Severe Parkinsonism Associated With Short-term Treatment With Milnacipran; CLINICAL NEUROPHARMACOLOGY　2008;31:299-300.
  10. Maeda M, Tanaka E, Shoudai K, Nonaka K, Murayama N, Ito Y, Akaike N: Differential effects of divalent cations on spontaneous and evoked glycine release from spinal interneurons. J Neurophysiol 2009 ;Feb;101(2):1103-13.
  11. Brydon L, Walker C, Wawrzyniak A, Whitehead D, Okamura H, Yajima J, Tsuda A, Steptoe A：　Synergistic effects of psychological and immune stressors on inflammatory cytokine and sickness responses in humans. 　Brain Behavior and Immunity　　2009;23:217-224.

3. 小児の精神・神経疾患の分子基盤解明と遺伝子治療に関する研究

－論文－

  1. Matsuishi T, Nagano M, Araki Y, Tanaka Y, Iwasaki M, Yamashita Y, Nagamitsu S, Iizuka C, Ohya T, Shibuya K, Hara M, Matsuda K, Tsuda A, Kakuma T: Scale properties of the Japanese version of the Strengths and Difficulties Questionnaire (SDQ): A study of infant and school children in community samples. Brain Dev 2008;30: 410-415.
  2. Tanabe T, Awaya Y, Matsuishi T, Iyoda K, Nagai T, Kurihara M, Yamamoto K, Minagawa K, Maekawa K: Management of and prophylaxis against status epilepticus in children with severe myoclonic epilepsy in infancy (SMEI; Dravet syndrome)-A nationwide questionnaire survey in Japan. Brain Dev 2008;30:629-635.
  3. Matsushige T, Ichiyama T, Anlar B, Tohyama J, Nomura K, Yamashita Y, Furukawa S. CSF neurofilament and soluble TNF receptor 1 levels in subacute sclerosing panencephalitis. J Neuroimmunol 2008;205:155-159.
  4. Ohya T, Nagai T, Araki Y, Yanagawa T, Tanabe T, Iyoda K, Kurihara M, Yamamoto K, Masunaga K, Iizuka C, Nagamitsu S, Yamashita Y Awaya Y, Maekawa K, Matsuishi T: A pilot study on the changes in immunity after ACTH therapy in patients with West syndrome. Brain Dev 2008 (in press)
  5. Egami C, Morita K, Ohya T, Ishii Y, Yamashita Y, Matsuishi T: Developmental characteristics of visual cognitive function during childhood according to exploratory eye movements. Brain Dev 2008 (in press)
  6. Yamashita Y, Mukasa A, Honda Y, Anai C, Kunisaki C, Koutaki J, Motoyama S, Sugimoto A, Ohya T, Nakashima M, Nagamitsu S, Gnagy EM, Greiner AR, Pelham WE, Matsuishi T: Short-term effect of American summer treatment program for Japanese children with attention deficit hyperactivity disorder. Brain Dev 2008 (in press)
  7. Nishioka J, Akita Y, Yatsuga S, Katayama K, Matsuishi T, Ishibashi M, Koga Y: Inapprooriate intracranial hemodynamics in the natural course of MELAS. Brain Dev 2008;30(2):100-105.
  8. Hirata K, Akita Y, Yatsuga S, Katayama K, Koga Y: Effect of L-arginine on synaptosomal mitochondrial function. Brain Dev 2008;30:238-245.
  9. Povalko N. Yatsuga S, Katayama K, Koga Y. MELAS and arginine therapy. Ther Adv Neurol Disord 2009 (in press)
  10. Watanabe Y, Sakai H, Nishimura A, Miyake N, Saitsu H, Mizuguchi T, Matsumoto N. Paternal somatic mosaicism of a TGFBR2 mutation transmitting to an affected son with Loeys-Dietz syndrome. Am J Med Genet A 2008;146A:3070-3074.
  11. Numata S, Harada E, Maeno Y, Ueki I, Watanabe Y, Fujii C, Yanagawa T, Takenaka S, Inoue T, Inoue S, Goushi T, Yasutake T, Mizuta T, Yoshino M: Paternal transmission and slow elimination of mutant alleles associated with late-onset ornithine transcarbamylase deficiency in male patients. J Hum Genet 2008;53: 10-17.
  12. Cady EB, Iwata O, Bainbridge A, Wyatt JS, Robertson NJ：Phosphorus magnetic resonance spectroscopy 2 h after perinatal cerebral hypoxia-ischemia prognosticates outcome in the newborn piglet. J Neurochem 2008 Nov;107(4):1027-35.
  13. Robertson NJ, Nakakeeto M, Hagmann C, Cowan FM, Acolet D, Iwata O, Allen E, Elbourne D, Costello A, Jacobs I：Therapeutic hypothermia for birth asphyxia in low-resource settings: a pilot randomised controlled trial. Lancet 2008 Sep 6;372(9641):801-3.
  14. Iwata O, Iwata S, Bainbridge A, De Vita E, Matsuishi T, Cady EB, Robertson NJ：Supra- and sub-baseline phosphocreatine recovery in developing brain after transient hypoxia-ischaemia: relation to baseline energetics, insult severity and outcome.　Brain 2008 Aug;131(Pt 8):2220-6.
  15. Sato Y, Hayakawa M, Iwata O, Okumura A, Kato T, Hayakawa F, Kubota T, Maruyama K, Hasegawa M, Sato M, Oshiro M, Kito O, Kojima S：Delayed neurological signs following isolated parasagittal injury in asphyxia at term. Eur J Paediatr Neurol 2008 Sep;12(5):359-65.
  16. Nagamitsu S, Yamashita F, Iizuka C, Ozono S, Komatsu H, Ohya T , Yamashita Y, Tsuda A, Matsuishi T：Characteristic prefrontal blood volume patterns when imaging body type, high-calorie food, and mother-child attachment in childhood anorexia nervosa: a near infrared spectroscopy study. Brain Dev 2008 (in press)
  17. Okada H, Takemura G, Kosai K, Tsujimoto A, Esaki M, Takahashi T, Nagano S, Kanamori H, Miyata S, Li Y, Ohno T, Maruyama R, Ogino A, Li L, Nakagawa M, Nagashima K, Fujiwara T, Fujiwara H, Minatoguchi S.: Combined therapy with cardioprotective cytokine administration and antiapoptotic gene transfer in postinfarction heart failure. Am J Physiol Heart Circ Physiol 2009:296(3):H616-26.
  18. Kondo T, Takemura G, Kosai K, Ohno T, Takahashi T, Esaki M, Goto K, Maruyama R, Murata I, Minatoguchi S, Fujiwara T, Fujiwara H.: Application of an adenoviral vector encoding soluble transforming growth factor-beta type II receptor to the treatment of diabetic nephropathy in mice. Clin Exp Pharmacol Physiol 2008；35(11):1288-93.
  19. Esaki M, Takemura G, Kosai K, Takahashi T, Miyata S, Li L, Goto K, Maruyama R, Okada H, Kanamori H, Ogino A, Ushikoshi H, Minatoguchi S, Fujiwara T, Fujiwara H.: Treatment with an adenoviral vector encoding hepatosyte growth factor mitigates established cardiac dysfunction in doxorubicin -induced cardiomyopathy. Am J Physiol Heart Circ Physiol　2008;294(2): H1048-1057.
  20. Kanaumi T, Takashima S, Iwasaki H, Itoh M, Mitsudome A, Hirose : Developemntal changes in KCNQ2 and KCNQ3 expression in human brain: Possible contribution to the age-dependent etiology of benign familial enonatal convulsions. Brain Dev 2008;30:362-269.
  21. Saitoh M., Itoh M,, Takashima S, Mizuguchi M, Iwamori M: Phosphatidyl ethanolamine with increased polyunsaturated fatty acids in compensation for plasmalogen defect in the Zellweger syndrome brain. Neurosci Lett 2009;449:164-167.
  22. Lin JX, Ishikawa K, Sakamoto M, TsunemiT, IShiguri T, Amino T, Toru S, Kondo I, Mizuwsawa H: Direct and accurate measument of CAG repeat configuration in theataxin-1(ATXN-1) gene by "dual-fluorescence labeled PCR-restriction fragment length anakysis J Hum Genet 2008; 53(4) 287-295.
  23. Marshall CR, Young EJ, Pani AM, Freckmann ML, Lacassie Y, Howald C, Fitzgerald KK, Peippo M, Morris CA, Shane K, Priolo M, Morimoto M, Kondo I, Manguoglu E, Berker-Karauzum S, Edery P, Hobart HH, Mervis CB, Zuffardi O, Reymond A, Kaplan P, Tassabehji M, Gregg RG, Scherer SW, Osborne LR. :Infantile spasms is associated with deletion of the MAGI2 gene on chromosome 7q11.23-q21.11. Am J Hum Genet. 2008 Jul;83(1):106-11.
  24. Tsuda Y, Hasimoto T, Mori K, Ito T,Nishimura M, Fukumoto A, Kondo I: Neuroradiological studies in Rett syndrome. No to Hattatsu 2008:40(4) 313-318.