2009 業績紹介

2009年

1. 成人および高齢者の精神・神経疾患の認知神経科学的研究

－著書－

  1. Miyagi T, Shigemori M: V.Head Trauma 6.Extended decompression and neuroprotection for traumatic brain injury(TBI). Essential Practice of Neurosurgery. Kazadi K.N.Kalangu(Editor-in-chief) 2009;724-30.
  2. Tokutomi T: V.Head Trauma 7.Therapeutic hypothermia for traumatic brain injury. Essential Practice of Neurosurgery. Kazadi K.N.Kalangu(Editor-in-chief) 2009;731-3.

－論文－

  1. Inoue Y, Hirata K, Kuroda K, Fujita M, Shimizu T, Emura N, Uchimura N, Kagimura T, Sha K, Nozawa T : Efficacy and safety of pramipexole in Japanese patients with primary restless legs syndrome: A polysomnographic randomized, double-blind, placebo-controlled study. Sleep Med 2010 Jan;11(1):11-6.
  2. Uchimura N, Kotorii N: [Insufficient sleep syndrome and QOL] Nippon Rinsho 2009 Aug;67(8):1621-5.
  3. Suzuki M, Takahashi S, Matsushima E, Tsunoda M, Kurachi M, Okada T, Hayashi T, Ishii Y, Morita K, Maeda H, Katayama S, Kawahara R, Otsuka T, Hirayasu Y, Sekine M, Okubo Y, Motoshita M, Ohta K, Uchiyama M, Kojima T: Exploratory eye movement dysfunction as a discriminator for schizophrenia. -A large sample study using a newly developed digital computerized system- Eur Arch Psychiatry Clin Neurosci 2009:259(3):186-94.
  4. Nishiura S, Morita K, Ishii Y, Igimi H, Maeda H: Characteristics of the left and right scanning in schizophrenia patients using exploratory eye movements: comparison with healthy subjects. Seishin Shinkeigaku Zasshi 2009;111(10):1183-90.
  5. Egami C, Morita K, Ohya T, Ishii Y, Yamashita Y, Matsuishi T: Developmental characteristics of visual cognitive function during childhood according to exploratory eye movements. Brain Dev 2009 Nov;31(10):750-7.
  6. Ujike H, Katsu T, Okahisa Y, Takaki M, Kodama M, Inada T, Uchimura N, Yamada M, Iwata N,Sora I, SIyo M, Ozaki N, Kuroda S: Genetic variants of but not D3 or D4 dopamine receptor geneare associated with rapid onset and poor prognosis of methamphetamine psychosis. Prog Neuropsychopharmacol Biol Psychiatry 2009;33(5):903-5.
  7. Haraguchi K, Maeda M, XM Yan, Uchimura N: Stigma associated with schizophrenia: Cultural comparison of social distance in Japan and China. Psychiatry Clin Neurosci 2009;63(2):153-60.
  8. Kotaka T, UjikeH, Okahisa Y, Takaki M, Nakata K, Kodama M, Inada T, Yamada M, Uchimura N, Iwata N, Sora I, Iyo M, Kuroda S: G72 gene is associated with suseptibility to methamphetamine psychosis. Prog Neuropsychopharmacol Biol Psychiatry 2009;33(6):1046-9.
  9. Kishi T, Ikeda M, Kitajima T, Yamanouchi Y, Kinoshita Y, Kawashima K, Okochi T, Tsunoka T, Okumura T, Inada T, Ujike H, Yamada M, Uchimura N, Sora I, Iyo M, Ozaki N, Iwata N: A functional polymorphism in estrogen receptor alpha gene(ESR1) is associated with Japanese methamphetamine induced psychosis. Prog Neuropsychopharmacol Biol Psychiatry 2009;33(5):895-989.
  10. Kishi T, Ikeda M, Kitajima T, Yamanouchi Y, Kinoshita Y, Kawashima K, Okochi T, Tsunoka T, Okumura T, Inada T, Ujike H, Yamada M, Uchimura N, Sora I, Iyo M, Ozaki N, Iwata N: Serotonin 1A receptor gene(HTR1A) was associated with Japanese methamphetamine-induced psychosis patients.Neuropharmacology 2010 Feb;58(2):452-6.
  11. Hiejima H, Nishi Y; Hosoda H, Yoh J, Mifune H, Satoh M, Sugimoto H, Chiba S; Kawahara Y, Tanaka E, Yoshimatsu H, Uchimura N, Kangawa K, Kojima M: Regional distribution and the dynamics of n-decanoyl ghrelin, another acyl-form of ghrelin, upon fasting in rodents. Regul Pept 2009;156:47-56.
  12. Yamashita S, Hasuo H, Tokutomi T, Shigemori M, Akasu T: Edaravone attenuates impairment of synaptic plasticity in granule cell layer of the dentate gyrus following traumatic brain injury. Neurosci Res 2009 (in press)
  13. Ooba S, Hasuo H, Shigemori M, Yamashita S, Akasu T: Mild hypothermia prevents post-traumatic hyperactivity of excitatory synapses in rat hippocampal CA1 pyramidal neurons. Kurume Med J 2009;56(3,4):49-59.
  14. Ishimatsu M, Tanaka E, Ishitake T, Akasu T: Making educational DVD for the faculty development in the PBL tutorial. The 2nd International PBL symposium 2009 "What are we learning about learning?" 2009:634-40.
  15. Hayashi T, Kondo T, Ishimatsu M, Yamada S, Nakamura K, Matsuoka K, Akasu T: Expression of the TRPM8-immunoreactivity in dorsal root ganglion neurons innervating the rat urinary bladder. Neurosci Res 2009;Nov;65(3):245-51.
  16. Shin M-C, Kim C-J, Min B-I, Ogawa S, Tanaka E, Akaike N: A selective T-type Ca2+ channel blocker R(-) efonidipine. Naunyn-Schmiedeberg’s Arch Pharmacol 2008; 377:411-21.
  17. Maeda M, Tanak E, Shoudai K, Nonaka K, Murayama N, Ito Y, Akaike N: Differential effects of divalent cations on spontaneous and evoked glycine release from spinal interneurons. J Neurophysiol 2009;101:1103-13.
  18. Kawahara Y, Kawahara H, Kaneko F, Yamada M, Nishi Y, Tanaka E, Nishi A: Peripherally administered ghrelin induces bimodal effects on the mesolimbic dopamine system depending on food-consumptive states. Neuroscience 2009;161:855-64.
  19. Tanaka E, Tobita T, Murai Y, Okabe Y, Yamada A, KanoT, Higashi H. Shimoji K: Thiamylal antagonizes the inhibitory effects of column stimulation on dorsal horn activities in humans. Neuosci Res 2009; 64:391-6.
  20. Tokutomi T, Miyagi T, Takeuchi Y, Karukaya T, Katsuki H, Shigemori M: Effect of 35℃ hypothermia on intracranial pressure and clinical outcome in patients with severe traumatic brain injury. J Trauma 2009;66(1):166-73.
  21. Miura S, Noda K, Shiramizu N, Muraoka N, Hirohata M, Ayabe M, Abe T, Aizawa H, Taniwaki T: Parkinsonism and ataxia associated with an intracranial dural arteriovenous fistula presenting with hyperintense basal ganglia in T1-weighted MRI. J Clin Neurosci 2009;16(2):341-3.
  22. Fukushima S, Terasaki M, Sakata K, Miyagi N, Kato S, Sugita Y, Shigemori M: Sensitivity and usefulness of anti-phosphohistone-H3 antibody immunostaining for counting mitotic figures in meningioma cases. Brain Tumor Pathol 2009;26(2):51-7.
  23. Sugita Y, Ohshima K, Shigemori M, Arakawa M, Kuramoto T, Nakayama K:The tumor of the third ventricle. Neuropathology 2010 Feb 1;30(1):97-100.
  24. Kikuchi K, Tancharoen S, Matsuda F, Biswas KK, Ito T, Morimoto Y, Oyama Y, Takenouchi K, Miura N, Arimura N, Nawa Y, Meng X, Shrestha B, Arimura S, Iwata M, Mera K, Sameshima H, Ohno Y, Maenosono R, Tajima Y, Uchikado H, Kuramoto T, Nakayama K, Shigemori M, Yoshida Y, Hashiguchi T, Maruyama I, Kawahara K: Edaravone attenuates cerebral ischemic injury by suppressing aquaporin-4. Biochem Biophys Res Commun 2009 Dec 25;390(4):1121-5.
  25. Kikuchi K, Kawahara K, Biswas KK, Ito T, Tancharoen S, Morimoto Y, Matsuda F, Oyama Y, Takenouchi K, Miura N, Arimura N, Nawa Y, Meng X, Shrestha B, Arimura S, Iwata M, Mera K, Sameshima H, Ohno Y, Maenosono R, Yoshida Y, Tajima Y, Uchikado H, Kuramoto T, Nakayama K, Shigemori M, Hashiguchi T, Maruyama I: Minocycline attenuates both OGD-induced HMGB1 release and HMGB1-induced cell death in ischemic neuronal injury in PC12 cells. Biochem Biophys Res Commun 2009 Jul 24;385(2):132-6.
  26. Kikuchi K, Kawahara K, Tancharoen S, Matsuda F, Morimoto Y, Ito T, Biswas KK, Takenouchi K, Miura N, Oyama Y, Nawa Y, Arimura N, Iwata M, Tajima Y, Kuramoto T, Nakayama K, Shigemori M, Yoshida Y, Hashiguchi T, Maruyama I: The free radical scavenger edaravone rescues rats from cerebral infarction by attenuating the release of high-mobility group box-1in neuronalcells. J PharmacolExpTher 2009 Jun;329(3):865-74.
  27. Tanaka E, Tobita T, Murai Y, Okabe Y, Yamada A, Kano T, Higashi H, Shimoji K: Thiamylal antagonizes the inhibitory effects of dorsal column stimulation on dorsal horn activities in humans. Neurosci Res 2009 Aug;64(4):391-6.
  28. Fukushima S, Hirohata M, Okamoto Y, Yamashita S, Ishida S, Shigemori M: Anterior inferior cerebellar artery dissecting aneurysm in a juvenile ―Case Report―. Neurologia Medico-Chirurgica 2009;49(2):81-4.
  29. Komatani H, Sugita Y, Arakawa F, Ohshima K, Shigemori M: Expression of CXCL12 on pseudopalisading cells and proliferating microvessels in glioblastomas: An accelerated growth factor in glioblastomas. Int J Oncol 2009;34(3):665-72.
  30. Terasaki M, Tokutomi T, Shigemori M: Salvage therapy with temozolomide for recurrent or progressive high-grade gliomas refractory to ACNU [1-(4-amino-2-methyl -5-pyrimidynyl) methyl-3- (2-chloroethyl) -3-nitrosourea hydrochloride]. MolMed Report 2009;2(3):417-21.
  31. Hagihara N, Abe T, Inoue K, Watanabe M, Tabuchi K: Rapid resolusion of hydrocephalus due to simultaneous movements of hematoma in the trigono-occipital horn and the aqueduct. Neurology India 2009;57(3):357-8.
  32. Uchida M, Sakoda J, Arikawa S, Kunou Y, Ishibashi M, Abe T, Hayabuchi N: Comparison of dynamic MRI at 3.0T and MDCT of pancreatobiliary disease: Evaluation with source, hepatic arterial and portal venous vessel conspicuity. J Magn Reson Imaging 2009;29:846-52.
  33. Ma L, Ohyagi Y, Miyoshi K, Sakae N, Motomura K, Taniwaki T, Furuya H, Takeda K, Tabira T, Kira J : Increase in p53 Protein Levels by Presenilin 1 Gene Mutations and its Inhibition by Secretase Inhibitors. J Alzheimers Dis 2009;16(3):565-75.
  34. Miura S, Nakagawara H, Kaida H, Sugita M, Noda K, Motomura K, Ohyagi Y, Ayabe M, Aizawa H, Ishibashi M, Taniwaki T: Expansion of the phenotypic spectrum of SCA14 caused by the Gly128Asp mutation in PRKCG. Clin Neurol Neurosurg 2009;111(2): 211-5.
  35. Miyoshi K, Ohyagi Y, Sakae N, Motomura K, Ma L, Taniwaki T, Furuya H, Tabira T, Kira J: Enhancement of activation of caspases by presenilin 1 gene mutations and its inhibition by secretase inhibitors. J Alzheimers Dis 2009;16(3):551-64.
  36. Miura S, Ohyagi Y, Miike T, Noda K, Motomura K, Ayabe M, Aizawa H, Taniwaki T: Machado-Joseph disease/SCA3 and myotonic dystrophy type 1 in a single patient.: Clin Neurol Neurosurg 2009;111(10):791-4.
  37. Miyake Y, Sasaki S, Tanaka K, Fukushima W, Kiyohara C, Tsuboi Y, Yamada T, Oeda T, Miki T, Kawamura N, Sakae N, Fukuyama H, Hirota Y, Nagai M: Fukuoka Kinki Parkinson's Disease Study Group (including Taniwaki T): Dietary fat intake and risk of Parkinson's disease: a case-control study in Japan. J Neurol Sci 2010;288(1-2):117-22.
  38. Miura S, Kurita T, Noda K, Ayabe M, Aizawa H, Taniwaki T: Symmetrical brainstem encephalitis caused by herpes simplex virus. J Clin Neurosci 2009;16(4):589-90.
  39. Hagihara N, Abe T, Yoshioka F, Watanabe M, Tabuchi K: Photophobia as the visual manifestation of chiasmal compression by unruptured anterior communicating artery aneurysm. Neurol Med Chir (Tokyo) 2009;49(4):159-61.
  40. Kiyosue H, Mori H, Sagara Y, Hori Y, Okahara M, Nagatomi H, Abe T: Basal cerebral venous drainage from cavernous sinus dural arteriovenous fistulas. Neuroradiology 2009;51(3):175-81.
  41. Suzuki S, Furui S, Yamaguchi I, Yamagishi M, Watanabe A, Abe T, Kobayashi I: Effective Dose during Abdominal Three-dimensional Imaging with a Flat-Panel Detector Angiography System. Radiology 2009;250(2):545-50.
  42. Brydon L, Walker C, Wawrzyniak A, Whitehead D, Okamura H, Yajima J, Tsuda A, Steptoe A: Synergistic effects of psychological and immune stressors on inflammatory cytokine and sickness responses in humans. Brain Behav Immun 2009;23:217-24.
  43. Komatsu H, Nagamitsu S, Ozono S, Yamashita Y, Ishibashi M, Matsuishi T: Regional cerebral blood flow changes in early-onset anorexia nervosa before and after weight gain. Brain Dev 2009 (in press)
  44. Yamaguchi R, Futamata Y, Yoshimura F, Murakami N, Koufuji K, Kutami R, Kojima K, Ohki S, Kurata S, Kaida H, Ishibashi M, Yano H: Mastopathic-type fibroadenoma and ductal adenoma of the breast with false-positive fluorodeoxyglucose positron emission tomography. Jpn J Radiol 2009 Aug;27(7):280-4.
  45. Kaida H, Ishibashi M, Kurata S, Uchiyama Y, Tanaka N, Abe T, Kobayashi M, Kaibara H, Uchida M, Nakashima T, Fujita H, Hayabuchi N: The utility of FDG-PET for detecting multiple primary cancers in hypopharyngeal cancer patients. Nuklearmedizin 2009;48(5):179-84.
  46. Uchida M, Sakoda J, Arikawa S, Kunou Y, Ishibashi M, Abe T, Hayabuchi N: Comparison of dynamic MRI at 3.0 T and MDCT of pancreatobiliary disease: evaluation with source, MPR, CPR, and MIP images for image quality and hepatic arterial and portal venous vessel conspicuity. J Magn Reson Imaging 2009 Apr;29(4):846-52.
  47. Kaibara H, Kaida H, Ishibashi M, Kurata S, Otsubo K, Fujimoto K, Uchida M, Abe T, Kobayashi M, Doi R, Kunou Y, Okamura T, Oshima K, Hayabuchi N: 18F-FDG-PET findings of rare case of nonsecretory plasmablastic myeloma. Ann Nucl Med 2009 Nov;23(9):807-11.
  48. Tani S, Homma T, Uchikado H, Nagashima H, Isoshima A, Ohhashi H, Tochigi S, Abe T: New surgical technique to secure the bone strut during anterior cervical corpectomy and fusion: Kusabi fixation technique―Technical Note―. Neurologia Medico-Chirurgica. 2010;50(1):83-6.
  49. Sugita Y, Ohshima K, Shigemori M, Arakawa M, Kuramoto T, Nakayama K: The tumor of the third ventricle. Neuropathology. 2010;30(1):97-100.

2. 成人および高齢者の精神・神経疾患の分子生物学的研究

－著書－

  1. Saitoh M, Itoh M, Takashima S, Mizuguchi M, Iwamori M: Phosphatidyl ethanolamine with increased polyunsaturated fatty acids in compensation for plasmalogen defect in the Zellweger syndrome brain. Neurosci Lett 2009;449:164-7.

－総説－

  1. Nishi A : Role of Cdk5 in dopamine signaling and addiction. Tanpakushitsu Kakusan Koso. 2009 Jun;54(7):813-9.

－論文－

  1. Kawahara Y, Kawahara H, Kaneko F, Yamada M, Nishi Y, Tanaka E, Nishi A: Peripherally administered ghrelin induces bimodal effects on the mesolimbic dopamine system depending on food-consumptive states. Neuroscience 2009;161:855-64.
  2. Rebholz H, Nishi A, Liebscher S, Nairn AC, Flajolet M, Greengard P: PCK2 negatively regulates Galphas signaling. Proc Natl Acad Sci USA 2009 Aug 18;106(33):14096-101.
  3. Tanda K, Nishi A, Matsuo N, Nakanishi K, Yamasaki N, Sugimoto T, Toyama K, Takao K, Miyakawa T: Abnormal social behavior, hyperactivity, impaired remote spatial memory, and increased D1-mediated dopaminergic signaling in neuronal nitric oxide synthase knockout mice. Mol Brain 2009;Jun 18;2(1):19.
  4. Hiejima H, Nishi Y, Hosoda H, Yoh J, Mifune H, Satoh M, Sugimoto H, Chiba S, Kawahara Y, Tanaka E, Yoshimatsu H, Uchimura N, Kangawa K, Kojima M: Regional distribution and the dynamics of n-decanoyl ghrelin, another acyl-form of ghrelin, upon fasting in rodents. Regul Pept 2009;156:47-56.
  5. Kotaka T, Ujike H, Okahisa Y, Takaki M, Nakata K, Kodama M, Inada T, Yamada M, Uchimura N, Iwata N, Sora I, Iyo M, Ozaki N, Kuroda S: G72 gene is associated with susceptibility to methamphetamine psychosis. Prog Neuropsychopharmacol Biol Psychiatry 2009;Aug 31;33(6):1046-9.
  6. Okochi T, Kishi T, Ikeda M, Kitajima T, Kinoshita Y, Kawashima K, Okumura T, Tsunoka T, Inada T, Yamada M, Uchimura N, Iyo M, Sora I, Ozaki N, Ujike H, Iwata N: Genetic association analysis of NRG1 with methamphetamine-induced psychosis in a Japanese population. Prog Neuropsychopharmacol Biol Psychiatry 2009 Aug 1;33(5):895-8.
  7. Kishi T, Ikeda M, Kitajima T, Yamanouchi Y, Kinoshita Y, Kawashima K, Okochi T, Tsunoka T, Okumura T, Inada T, Ujike H, Yamada M,Uchimura N, Sora I, Iyo M, Ozaki N, Iwata N : A functional polymorphism in estrogen receptor alpha gene is associated with Japanese methamphetamine induced psychosis. Prog Neuropsychopharmacol Biol Psychiatry 2009 Aug 1;33(5):903-5.
  8. Miura S, Noda K, Shiramizu N, Muraoka N, Horohata M, Ayabe M,Abe T, Aizawa H, Taniwaki T: Parkinsonism and ataxia associated with an intracranial dural arteriovenous fistula presenting with heperintense basal ganglia in T1- weighted MRI. J Clin Neurosci 2009;16(2):341-3.
  9. Miura S, Ohyagi Y, Miike T, Noda K, Motomura K, Ayabe M, Aizawa H, Taniwaki T : Machado-Joseph disease/SCA3 and myotonic dystrophy type 1 in a single patient. Clin Neurol Neurosurg 2009; Dec;111(10):791-4.
  10. Miura S, Kurita T, Noda K, Ayabe M, Aizawa H, Taniwaki T: Symmetrical brainstem encephalitis caused by herpes simplex virus.　 J Clin Neurosci 2009 Apr;16(4):　589-90.
  11. Miyoshi K, Ohyagi Y, Sakae N, Motomura K, Ma L, Taniwaki T, Furuya H, Tabira T, Kira J: Enhancement of activation of caspases by presenilin 1 gene mutations and its inhibition by secretase inhibitors. J Alzheimers Dis 2009;16 (3): 551-64.
  12. Miura S, Nakagawara H, Kaida H, Sugita M, Noda K, Motomura K, Ohyagi Y, Ayabe M, Aizawa H, Ishibashi M, Taniwaki T: Expansion of the phenotypic spectrum of SCA14 caused by the Gly128Asp mutation in PRKCG. Clin Neurol Neurosurg 2009;111(2): 211-5.
  13. Ma L, Ohyagi Y, Miyoshi K, Sakae N, Motomura K, Taniwaki T, Furuya H, Takeda K, Tabira T, Kira J: Increase in p53 Protein Levels by Presenilin 1 Gene Mutations and its Inhibition by Secretase Inhibitors. J Alzheimers Dis 2009;16 (3): 565-75.
  14. Miyake Y, Sasaki S, Tanaka K, Fukushima W, Kiyohara C, Tsuboi Y, Yamada T, Oeda T, Miki T, Kawamura N, Sakae N, Fukuyama H, Hirota Y, Nagai M: Fukuoka Kinki Parkinson's Disease Study Group (including Taniwaki T): Dietary fat intake and risk of Parkinson's disease: a case-control study in Japan. J Neurol Sci 2010;288(1-2):117-22.
  15. Kanemaru T, Hirata K, Takasu S, Isobe S, Mizuki K, Mataka S, Nakamura K: A fluorescence scanning electron Microscope. Ultramicroscopy 200;109:344-9.
  16. Fujimura T, Yamagishi S, Ueda S, Fukami K, Shibata R, Matsumoto Y, Kaida Y, Hayashida A, Koike K, Matsui T, Nakamura K, Okuda S : Administration of pigment epithelium-derived factor(PEDF) reduces proteinuria by suppressing decreased nephrin and increased VEGF expression in the glomeruli of adriamycin-injected rats. Nephrol Dial Transplant 2009;24(5):1397-406.
  17. Takayama T, Kondo T, Kobayashi M, Ohta K, Ishibashi Y, Kanemaru T, Shimazu H, Ishikawa F, Nakamura T, Kinoshita S, Nakamura K: Characterstic Morphology and Distribution of Bone Marrow Derived Cells in the Cornea. Anat Rec 2009;292(5):756-63.
  18. Hayashi T, Kondo T, Ishimatsu M, Yamada S, Nakamura K, Matsuoka K, Akasu T: Expression of the TRPM8-immunoreactivity in dorsal root ganglion neurons innervating the rat urinary bladder. Neurosci Res 2009 Nov;65(3):245-51.
  19. Kanemaru T, Hirata K, Takasu S, Isobe S, Mizuki K, Mataka S, Nakamura K: A fluorescence scanning electron Microscope. Ultramicroscopy 2009:109;344-9.
  20. Fujimura T, Yamagishi S, Ueda S, Fukami K, Shibata R, Matsumoto Y, Kaida Y, Hayashida A, Koike K, Matsui T, Nakamura K, Okuda S: Administration of pigment epithelium-derived factor(PEDF) reduces proteinuria by suppressing decreased nephrin and increased VEGF expression in the glomeruli of adriamycin-injected rats. Nephrol Dial Transplant 2009;24(5):1397-406.
  21. Nomura Y, Kimura H, Karube K, Aoki R, Yoshida S, Sugita Y, Niino D, Kimura Y, Shimizu K,Kimura Y, Aoki R, Kiyasu J,Takeuchi M, Hashikawa K, Hirose S, Ohshima K: Hepatocellular apoptosis associated with cytotoxic T/natural killer-cell infiltration in chronic active EBV infection. Pathol Int 2009;59:438-42.
  22. Nomura Y, Takeuchi M, Yoshida S, Sugita Y, Niino D, Kimura H, Karube K, Aoki R, Shimizu K, Kimura Y, Aoki R, Kiyasu J, Hashikawa K, Hirose S, Ohshima K: Phenotype for activated tissue macrophage in histiocytic necrotizing lymphadenitis. Pathol Int 2009;59:631-5.
  23. Sugita Y, Irie K, Ohshima K, Hitotsumatsu T, Sato O, Arimura K: Pleomorphic xanthastrocytoma as a componentof temporal lobe cystic ganglioglioma. Brain Tumor Pathol 2009;26:31-6.
  24. Kobayashi K, Sugita Y, Shojo H, Sumida T: Brain germinoma in a young adult man with suspcion of fatal neglec. Am J Forensic Med Pathol 2009;30:180-2.
  25. Komatani H,Sugita Y, Arakawa F, Ohshima K, Shigemori M: Expression of CXCL12 on pseudopalisading cells and proliferating microvessels in glioblastomas: An accelerated growth factor in glioblastomas. Int J Oncol 2009;34(3):665-72.
  26. Bryon L, Walker C, Wawrzyniak A, Whitehead D, Okamura H, Yajima J, Tsuda A, Steptoe､ A: Synergistic effects of psychological and immune stressors on inflammatory cytokine and sickness responses in humans. Brain Behav Immun 2009;23(2):217-24.
  27. Park Y, Tsuda A, Kim U, Han K, Kim E, Horiuchi S: Factors influencing stress and depression among Korean and Japanese Students: With specific focus on parental social support､ resiliency of efficacy and stress management behavior. Korean Journal of Psychological and Social Issues 2009;15;1-28.
  28. Maeda M, Tanaka E, Shoudai K, Nonaka K, Murayama N, Ito Y, Akaike N: Differential effects of divalent cations on spontaneous and evoked glycine release from spinal interneurons. J Neurophysiol 2009;Feb;101(2):1103-13.
  29. Nagamitsu S, Yamashita F, Araki Y, Iizuka C, Ozono S, Komatsu H, Ohya T,Yamashita Y, Kakuma T, Tsuda A, Matsuishi T: Characteristic prefrontal blood volume patterns when imaging body type､ high-calorie food､ and mother-child attachment in childhood anorexia nervosa: A near infrared spectroscopy study. 2010 Feb;32(2):162-7.
  30. Fukushima S, Terasaki M, Sakata K, Miyagi N, Kato S, Sugita Y, Shigemori M: Sensivity and usefulness of anti-phosphohistone-H3 antibody immunostaining for counting mitotic figures in meningioma cases. Brain Tumor Pathol 2009;26(2):51-7.
  31. Sugita Y, Ohshima K, Shigemori M, Arakawa M, Kuramoto T, Nakayama K: The tumor of the third ventricle. Neuropathology 2010;30:97-100.
  32. Kimura Y, Sato K, Arakawa F, Karube K, Nomura Y, Shimizu K, Aoki R, Hashikawa K, Yoshida S, Kiyasu J, Takeuchi M, Nino D, Sugita Y, Morito T, Yoshino T, Nakamura S, Kikuchi M, Ohshima K: Mantle cell lymphoma shows three morphorogical evaluations of classical, intermediate, and aggressive forms, which occur parallel with increased labeling index of cyclin D1 and Li-67 Cancer Sci 2010;101:806-14.

3. 小児の精神・神経疾患の分子基盤解明と遺伝子治療に関する研究

－著書－

  1. Yamashita Y: Congenital Infections In: Cognitive and Behavioral Abnormalities of Pediatric Diseases. Nass RD, Frank Y eds. Oxford University Press New York (in press)
  2. Saitoh M, Itoh M, Takashima S, Mizuguchi M, Iwamori M: Phosphatidyl ethanolamine with increased polyunsaturated fatty acids in compensation for plasmalogen defect in the Zellweger syndrome brain. Neurosci Lett 2009;449:164-7.

－総説－

  1. Koga Y: MELAS and L-arginine therapy. Review article. New York Academy of Science 2009 (in press)
  2. Nishi A: Role of Cdk5 in dopamine signaling and addiction. Tanpakushitsu Kakusan Koso 2009 Jun;54(7):813-9.

－論文－

  1. Muta H､Ishii M､Iemura M､Matsuishi T: Health-related quality of life in adolescents and young adults with a history of Kawasaki Disease.J Pediatr　2010;156(3): 439-43.
  2. Ohya T, Nagai T, Araki Y, Yanagawa T, Tanabe T, Iyoda K, Kurihara M, Yamamoto K, Masunaga K, Iizuka C, Nagamitsu S, Yamashita Y, Awaya Y, Maekawa K, Matsuishi T: A pilot study on the changes in immunity after ACTH therapy in patients with West syndrome. Brain Dev 2009 Nov;31(10):739-43.
  3. Komatsu H, Nagamitsu S, Ozono S, Yamashita Y, Ishibashi M, Matsuishi T : Regional cerebral blood flow changes in early-onset anorexia nervosa before and after weight gain. Brain Dev 2009 (in press)
  4. Iizuka C, Yamashita Y, Nagamitsu S, Yamashita T, Araki Y, Ohya T, Hara M, Shibuya I, Kakuma T,Matsuishi T: Comparison of the strengths and difficulties questionnaire (SDQ) scores between children with high-functioning autism spectrum disorder (HFASD) and attention-deficit/hyperactivity disorder (AD/HD). Brain Dev 2009 (in press)
  5. Kanbe T, Maeno Y, Fujino H, Kanda H, Hirose A, Okada J, Morikawa T, Iwata S, Iwata O, Matsuishi T : Brain-type natriuretic peptide at birth reflects foetal maturation and antenatal stress. Acta Paediatr 2009 Sep;98(9):1421-5.
  6. Tani H, Matsuda K, Matsumoto T, Hiramoto I, Okamatsu Y, Takehiro S, Kimura K, Higuchi S, Okazaki R,Matsuishi T : Extended-stay hospitalization for childhood asthma in Japan. Pediatr Int 2009 Aug;51(4):502-6.
  7. Egami C, Morita K, Ohya T, Ishii Y, Yamashita Y, Matsuishi T: Developmental characteristics of visual cognitive function during childhood according to exploratory eye movements. Brain Dev 2009 Nov;31(10):750-7.
  8. Suda K, Kudo Y, Higaki T, Nomura Y, Miura M, Matsumura M, Ayusawa M, Ogawa S, Matsuishi T: A Multi-center and retrospective case study of warfarin and aspirin combination therapy in patients with giant coronary aneurysms caused by Kawasaki disease. Circ J 2009 Jul;73(7):1319-23.
  9. Koteda Y, Suda K, Kishimoto S, Ito S, Kudo Y, Nishino H, Ishii H, Iemura M, Matsuishi T: Impact of intravenous Immunoglobulin Infusion on longitudinal left ventricular performance in patients with acute Kawasaki disease of usual course. J Cardiol 2009 Aug;54(1):45-51.
  10. Okamatsu Y, Matsuda K, Hiramoto I, Tani H, Kimura K, Yada Y, Kakuma T, Higuchi S, Kojima M, Matsuishi T: Ghrelin and leptin modulates immunoglobulin production and liver function in overweight children . Pediatr Int 2009 Feb;51(1):9-13.
  11. Ueki I, Kimura A, Chen HL, Yorifuji T, Mori J, Itoh S, Maruyama K, Ishige T, Takei H, Nittono H, Kurosawa T, Kage M,Matsuishi T: SRD5B1 gene analysis needed for the accurate diagnosis of primary 3-oxo-Delta4-steroid 5beta-reductase deficiency. J Gastroenterol Hepatol 2009 May;24(5):776-85.
  12. Nagamitsu S, Yamashita F, Iizuka C, Ozono S, Komatsu H, Ohya T, Yamashita Y, Tsuda A, Matsuishi T: Characteristic prefrontal blood volume patterns when imaging body type, high-calorie food, and mother-child attachment in childhood anorexia nervosa: a near infrared spectroscopy study. Brain Dev 2010 Feb;32(2):162-7.
  13. Povalko N. Yatsuga S, Katayama K, Koga Y: MELAS and arginine therapy. Therap Adv Neurol Disord 2009 (in press)
  14. Iwata O,Iwata S, Olson L, Kapetanakis A, Kato T, Evans S, Araki Y, Kakuma T, Matsuishi T, Setterwall F, Lagercrantz H, Robertson N: Therapeutic hypothermia can be induced and maintained using either commercial water bottles or a “ phase changing material “ matters in a newborn piglet model. Arch Dis Child 2009 May;94(5):387-91.
  15. Iwasaki M,Iwata S,IemuraA,Yamashita N,TominoY,AnmeT,Yamagata Z,Iwata O,Matsuishi T: Utility of Ssubjective Ssleep Aasssessment Ttools for Hhealthy Ppreschool Cchildren: A Ccomparative Sstudy Bbetween Ssleep Llogs,Qquestionnaires and Aactigraphy. J Epidemiol 2010 Mar 5;20(2):143-9.
  16. Eshima N, Iwata O, Iwata S, Tabata M, Higuchi Y, Matsuishi T, Karukaya S: Age and gender specific prevalence of HTLV-1. J Clin Virol 2009 Jun;45(2):135-8.
  17. Okada H, Takemura G, Kosai K, Tsujimoto A, Esaki M, Takahashi T, Nagano S, Kanamori H, Miyata S, Li Y, Ohno T, Maruyama R, Ogino A, Li L, Nakagawa M, Nagashima K, Fujiwara T, Fujiwara H, Minatoguchi S: Combined therapy with cardioprotective cytokine administration and anti-apoptotic gene transfer in postinfarction heart failure. Am J Physiol Heart Circ Physiol 2009 Mar;296(3):H616-26.
  18. Yamashita Y, Mukasa A, Honda Y, Anai C, Kunisaki C, Koutaki J, Motoyama S, Sugimoto A, Ohya T, Nakashima M, Nagamitsu S, Gnagy EM, Greiner AR, Pelham WE, Matsuishi T: Short-term effect of American summer treatment program for Japanese children with attention deficit hyperactivity disorder. Brain Dev 2010 Feb;32(2):115-22.
  19. Komaki H, Nishigaki Y, Fuku N, Hosoya H, Murayama K, Ohtake A, Goto Y, Wakamoto H, Koga Y, Tanaka M: Pyruvate therapy for Leigh syndrome due to cytochrome c oxidase deficiency. Biochim Biophys Acta 2009 Mar;1800(3):313-5.
  20. Yoshino M､ Ohira T､ Harada E､ Okada J､ Watanabe Y､ Takahashi M､ Ando T: Plasma amino acid concentrations and body mass index are prognostic factors in hyperammonemic crisis in male patients with late-onset OTC deficiency. Mol Genet Metab 2009
  21. Narumi S､ Numakura C､ Shiihara T､ Seiwa C､ Nozaki Y､ Yamagata T､ Momoi M､ Nishi E､ Kawame H､ Akabane T､ Watanabe Y､ Nishimura G､ Emi M､ Hasegawa T: Various types of LRP5 mutations in four patients with osteoporosis-pseudoglioma syndrome: identification of a 7.2-kb microdeletion by oligonucleotide tiling microarray. Am J Med Genet A 2010 Jan;152A(1):133-40.
  22. Edwards RL､ Moseley K､ Watanabe Y､ Wong LJ､ Ottina J､ Yano S: Long-term neurodevelopmental effects of early detection and treatment in 6-year old patient with argininemia diagnosed by newborn screening. J Inherit Metab Dis 2009 (in press)
  23. Muta H､Ishii M､Iemura M､Matsuishi T: Health-Related Quality of Life in Adolescents and Young Adults with a History ofKawasaki Disease.J Pediatr2010 Mar;156(3):439-43.
  24. Nishino H､ Suda K､ Teramachi Y､ Kishimoto S､ Goto K､ Iemura M､ Matsuishi T : Entrapment of the left coronary artery ostium by the aortic valve leaflet promoting myocardial ischemia. J Am Coll Cardiol (in press)
  25. Li L, Okada H, Takemura G, Kosai K, Kanamori H, Esaki M, Takahashi T, Goto K, Tsujimoto A, Maruyama R, Kawamura I, Kawaguchi T, Takeyama T, Fujiwara T, Fujiwara H, Minatoguchi S: Postinfarction gene therapy with adenoviral vector expressing decorin mitigates cardiac remodeling and dysfunction. Am J Physiol Heart Circ Physiol 2009 Oct;297(4):H1504-13.
  26. Umeno H, Chitose S, Murofushi Y, Kosai K, Sato K, Kawahara A, Nakashima T: Efficacy of autologous fat injection laryngoplasty with an adenoviral vector expressing hepatocyte growth factor in a canine model.J Laryngol Otol 2009 May;123 Suppl 31:24-9.
  27. Nomura Y, Kimura H, Karube K, Aoki R, Yoshida S, Sugita Y, Niino D, Kimura Y, Shimizu K, Kimura Y, Aoki R, Kiyasu J, Takeuchi M, Hashikawa K, Hirose S, Ohshima K: Hepatocellular apoptosis associated with cytotoxic T/natural killer-cell infiltration in chronic active EBV infection. Pathol Int 2009;59:438-42.
  28. Nomura Y,Takeuchi M,Yoshida S, Sugita Y, Niino D,Kimura H, Karube K, Aoki R, Shimizu K, Kimura Y,Aoki R, Kiyasu J,Hashikawa K, Hirose S, Ohshima K: Phenotype for activated tissue macrophage in histiocytic necrotizing lymphadenitis. Pathol Int 2009;59: 631-5.
  29. Sugita Y, Irie K, Ohshima K, Hitotsumatsu T, Sato O, Arimura K: Pleomorphic xanthastrocytoma as a componentof temporal lobe cystic ganglioglioma. Brain Tumor Pathol 2009;26:31-6.
  30. Kobayashi K, Sugita Y, Shojo H, Sumida T: Brain germinoma in a young adult man with suspcion of fatal neglec. Am J Forensic Med Pathol 2009;30:180-2.
  31. Komatani H, Sugita Y, Arakawa F, Ohshima K, Shigemori M: Expression of CXCL12 on pseudopalisading cells and proliferating microvessels in glioblastomas: An accelerated growth factor in glioblastomas. Int J Oncol 2009;34(3):665-72.
  32. Fukushima S, Terasaki M, Sakata K, Miyagi N, Kato S, Sugita Y, Shigemori M: Sensivity and usefulness of anti-phosphohistone-H3 antibody immunostaining for counting mitotic figures in meningioma cases. Brain Tumor Pathol 2009;26(2):51-7.
  33. Sugita Y, Ohshima K, Shigemori M, Arakawa M, Kuramoto T, Nakayama K: The tumor of the third ventricle. Neuropathology 2010;30:97-100.
  34. Kimura Y, Sato K, Arakawa F, Karube K, Nomura Y, Shimizu K, Aoki R, Hashikawa K, Yoshida S, Kiyasu J, Takeuchi M, Nino D, Sugita Y, Morito T, Yoshino T, Nakamura S, Kikuchi M, Ohshima K: Mantle cell lymphoma shows three morphorogical evaluations of classical, intermediate, and aggressive forms, which occur parallel with increased labeling index of cyclin D1 and Li-67 Cancer Sci 2010;101:806-14.
  35. Brydon L, Walker C,Wawrzyniak A,Whitehead D,Okamura H, Yajima J,Tsuda A,Steptoe A:Synergistic effects of psychological and immune stressors on inflammatory cytokine and sickness responses in humans. Brain Behav Immun 2009;23:217-24.
  36. Hagihara N, Abe T, Inoue K, Watanabe M, Tabuchi K: Rapid resolusion of hydrocephalus due to simultaneous movements of hematoma in the trigono-occipital horn and the aqueduct. Neurology India 2009;57(3):357-8.
  37. Uchida M, Sakoda J, Arikawa S, Kunou Y, Ishibashi M, Abe T, Hayabuchi N: Comparison of dynamic MRI at 3.0T and MDCT of pancreatobiliary disease: Evaluation with source, hepatic arterial and portal venous vessel conspicuity. J Magn Reson Imaging 2009;29:846-52.
  38. Hagihara N, Abe T, Yoshioka F, Watanabe M, Tabuchi K: Photophobia as the visual manifestation of chiasmal compression by unruptured anterior communicating artery aneurysm. Neurol Med Chir (Tokyo) 2009;49(4):159-61.
  39. Miura S, Nakagawara H, Kaida H, Sugita M, Noda K, Motomura K, Ohyagi Y, Ayabe M, Aizawa H, Ishibashi M, Taniwaki T: Expansion of the phenotypic spectrum of SCA14 caused by the Gly128Asp mutation in PRKCG. Clin Neurol Neurosurg 2009;111(2): 211-5.
  40. Kaida H, Ishibashi M, Kurata S, Uchiyama Y, Tanaka N, Abe T, Kobayashi M, Kaibara H, Uchida M, Nakashima T, Fujita H, Hayabuchi N: The utility of FDG-PET for detecting multiple primary cancers in hypopharyngeal cancer patients. Nuklearmedizin 2009;48(5):179-84.
  41. Uchida M, Sakoda J, Arikawa S, Kunou Y, Ishibashi M, Abe T, Hayabuchi N:Comparison of dynamic MRI at 3.0 T and MDCT of pancreatobiliary disease: evaluation with source, MPR, CPR, and MIP images for image quality and hepatic arterial and portal venous vessel conspicuity. J Magn Reson Imaging 2009 Apr;29(4):846-52.
  42. Kaibara H, Kaida H, Ishibashi M, Kurata S, Otsubo K, Fujimoto K, Uchida M, Abe T, Kobayashi M, Doi R, Kunou Y, Okamura T, Oshima K, Hayabuchi N:18F-FDG-PET findings of rare case of nonsecretoryplasmablasticmyeloma.AnnNuclMed2009 Nov;23(9):807-11.
  43. Kiyosue H, Mori H, Sagara Y, Hori Y, Okahara M, Nagatomi H, Abe T: Basal cerebral venous drainage from cavernous sinus dural arteriovenous fistulas. Neuroradiology 2009;51(3):175-81.
  44. Miura S, Noda K, Shiramizu N, Muraoka N, Hirohata M, Ayabe M, Abe T, Aizawa H, Taniwaki T: Parkinsonism and ataxia associated with an intracranial dural arteriovenous fistula presenting with hyperintense basal ganglia in T1-weighted MRI. J Clin Neurosci 2009;16(2):341-3.
  45. Suzuki S, Furui S, Yamaguchi I, Yamagishi M, Watanabe A, Abe T, Kobayashi I: Effective Dose during Abdominal Three-dimensional Imaging with a Flat-Panel Detector Angiography System. Radiology 2009;250(2):545-50.
  46. Kawahara Y, Kawahara H, Kaneko F, Yamada M, Nishi Y,Tanaka E,Nishi A: Peripherally administered ghrelin induces bimodal effects on the mesolimbic dopamine system depending on food-consumptive states.Neuroscience 2009;161:855-64.
  47. Hiejima H, Nishi Y , Hosoda H, Yoh J, Mifune H, Satoh M, Sugimoto H, Chiba S, Kawahara Y, Tanaka E, Yoshimatsu H, Uchimura N, Kangawa K, Kojima M: Regional distribution and the dynamics of n-decanoyl ghrelin, another acyl-form of ghrelin, upon fasting in rodents. Regul Pept 2009;156:47-56.
  48. Hayashi T, Kondo T, Ishimatsu M, Yamada S, Nakamura K, Matsuoka K, Akasu T: Expression of the TRPM8-immunoreactivity in dorsal root ganglion neurons innervating the rat urinary bladder. Neurosci Res 2009 Nov;65(3):245-51.
  49. Ishimatsu M, Tanaka E, Ishitake T, Akasu T: Making educational DVD for the faculty development in the PBL tutorial. The 2nd International PBL symposium 2009 "What are we learning about learning?" 2009:634-40.
  50. Tanda K,Nishi A, Matsuo N, Nakanishi K, Yamasaki N, Sugimoto T, Toyama K, Takao K, Miyakawa T : Abnormal social behavior, hyperactivity, impaired remote spatial memory, and increased D1-mediated dopaminergic signaling in neuronal nitric oxide synthase knockout mice. Mol Brain 2009 Jun;18;2(1):19.
  51. Rebholz H, Nishi A, Liebscher S, Nairn AC, Flajolet M, Greengard P: PCK2 negatively regulates Galphas signaling. Proc Natl Acad Sci USA 2009 Aug 18;106(33):14096-101.
  52. Miyata S, Takemura G, Kosai K, Takahashi T, Esaki M, Li L, Kanamori H, Maruyama R, Goto K, Tsujimoto A, Takeyama T, Kawaguchi T, Ohno T, Nishigaki K, Fujiwara T, Fujiwara H, Minatoguchi S: Anti-Fas Gene Therapy Prevents Doxorubicin-induced Cardiotoxicity through Mechanisms Independent of Apoptosis. Am J Pathol 2010 Feb;176(2):687-98.
  53. Li L,Okada H,Takemura G,Kosai K, Kanamori H,Esaki M,Takahashi T,Goto K,Tsujimoto A, Maruyama R,Kawamura I,Kawaguchi T,Takeyama T,Fujiwara T,Fujiwara H,Minatoguchi S: Postinfarction gene therapy with adenoviral vector expressing decorin mitigates cardiac remodeling and dysfunction. Am J Physiol: Heart and Circulatory Physiology 2009;287(4):H1504-13.
  54. Okada H,Takemura G,Kosai K,Tsujimoto A,Esaki M,Takahashi T,Nagano S,Kanamori H, Miyata S,Li Y,Ohno T,Maruyama R, Ogino A,Li L,Nakagawa M,Nagashima K,Fujiwara T, Fujiwara H, Minatoguchi S: Combined therapy with cardioprotective cytokine administration and anti-apoptotic gene transfer in postinfarction heart failure. Am J Physiol: Heart and Circulatory Physiology 2009;296(3):H616-26.
  55. Tanaka E,Tobita T,Murai Y,Okabe Y,Yamada A,Kano T,Higashi H,Shimoji K: Thiamylal antagonizes the inhibitory effects of dorsal column stimulation on dorsal horn activities in humans. Neurosci Res 2009;64(4):391-6.