Inhibition of STAT-mediated cytokine responses to chemically-induced colitis prevents inflammation-associated neurobehavioral impairments.
Brain Behav Immun. 2023 Nov:114:173-186. doi: 10.1016/j.bbi.2023.08.019. Epub 2023 Aug 23. [PubMed]
Forebrain-specific conditional calcineurin deficiency induces dentate gyrus immaturity and hyper-dopaminergic signaling in mice.
Mol Brain. 2022 Nov 22;15(1):94. doi: 10.1186/s13041-022-00981-0. PMID: 36414974. [PubMed]
Kuroiwa M, Shuto T, Nagai T, Amano M, Kaibuchi K, Nairn AC, Nishi A.
DARPP-32/protein phosphatase 1 regulates Rasgrp2 as a novel component of dopamine D1 receptor signaling in striatum.
Neurochem Int. 2022 Nov 6;162:105438. doi: 10.1016/j.neuint.2022.105438. Online ahead of print. PMID: 36351540. [PubMed]
Hatayama M, Katayama KI, Kawahara Y, Matsunaga H, Takashima N, Iwayama Y, Matsumoto Y, Nishi A, Yoshikawa T, Aruga J.
SLITRK1-mediated noradrenergic projection suppression in the neonatal prefrontal cortex.
Commun Biol. 2022 Sep 9;5(1):935. doi: 10.1038/s42003-022-03891-y. PMID: 36085162. [PubMed]
Kishikawa Y, Kawahara Y, Ohnishi YN, Sotogaku N, Koeda T, Kawahara H, Nishi A.
Dysregulation of dopamine neurotransmission in the nucleus accumbens in immobilization-induced hypersensitivity.
Front Pharmacol. 2022 Sep 8;13:988178. doi: 10.3389/fphar.2022.988178. eCollection 2022. PMID: 36160381. [PubMed]
Kobayashi K, Shikano K, Kuroiwa M, Horikawa M, Ito W, Nishi A, Segi-Nishida E, Suzuki H.
Noradrenaline activation of hippocampal dopamine D1 receptors promotes antidepressant effects.
Proc Natl Acad Sci USA. 2022 Aug 16;119(33):e2117903119. doi: 10.1073/pnas.2117903119. Epub 2022 Aug 8. PMID: 35939697. [PubMed]
Distinct Role of Dopamine in the PFC and NAc During Exposure to Cocaine-Associated Cues.
Int J Neuropsychopharmacol. 2021 Dec 8;24(12):988-1001. [PubMed]
Naoki Hashizume, Ryusuke Shin, Jun Akiba, Naoki Sotogaku, Kimio Asagiri, Shigeki Hikida, Suguru Fukahori, Shinji Ishii, Nobuyuki Saikusa, Yoshinori Koga, Hideaki Egami, Yoshiaki Tanaka, Akinori Nishi, Minoru Yagi.
The herbal medicines Inchinkoto and Saireito improved hepatic fibrosis via aquaporin 9 in the liver of a rat bile duct ligation model.
Pediatr Surg Int. 2021 Aug;37(8):1079-1088. [PubMed]
Yukari Nakamura, Sophie Longueville, Akinori Nishi, Denis Herv_, Jean-Antoine Girault, Yuki Nakamura.
Dopamine D1 receptor-expressing neurons activity is essential for locomotor and sensitizing effects of a single injection of cocaine.
Eur J Neurosci. 2021 Aug;54(4):5327-5340. [PubMed]
Keita Sugiyama, Mahomi Kuroiwa, Takahide Shuto, Yoshinori N Ohnishi, Yukie Kawahara, Yuta Miyamoto, Takaichi Fukuda, Akinori Nishi.
Subregion-Specific Regulation of Dopamine D1 Receptor Signaling in the Striatum: Implication for L-DOPA-Induced Dyskinesia.
J Neurosci. 2021 Jul 28;41(30):6388-6414. [PubMed]
M, Sawa A, Nishi A.
Adolescent psychosocial stress enhances sensitization to cocaine exposure in genetically vulnerable mice.
Neurosci Res. 2019 Mar 1. pii: S0168-0102(19)30021-5. [Epub ahead of print] [PubMed]
Obligatory roles of dopamine D1 receptors in the dentate gyrus in antidepressant actions of a selective serotonin reuptake inhibitor, fluoxetine.
Mol Psychiatry. 2018 Dec 10. [Epub ahead of print] [PubMed]
Hanada Y, Kawahara Y, Ohnishi YN, Shuto T, Kuroiwa M, Sotogaku N, Greengard P, Sagi Y, Nishi A.
p11 in Cholinergic Interneurons of the Nucleus Accumbens Is Essential for Dopamine Responses to Rewarding Stimuli.
eNeuro. 2018 Nov 8;5(5). pii: ENEURO.0332-18.2018. [PubMed]
Hagiwara A, Kitahara Y, Grabner CP, Vogl C, Abe M, Kitta R, Ohta K, Nakamura K, Sakimura K, Moser T, Nishi A, Ohtsuka T.
Cytomatrix proteins CAST and ELKS regulate retinal photoreceptor development and maintenance.
J Cell Biol. 2018 Nov 5;217(11):3993-4006. [PubMed]
Miyamoto Y, Katayama S, Shigematsu N, Nishi A, Fukuda T.
Striosome-based map of the mouse striatum that is conformable to both cortical afferent topography and uneven distributions of dopamine D1 and D2 receptor-expressing cells.
Brain Struct Funct. 2018 Sep 10. [PubMed]
Shigematsu N, Nishi A, Fukuda T.
Gap Junctions Interconnect Different Subtypes of Parvalbumin-Positive Interneurons in Barrels and Septa with Connectivity Unique to Each Subtype.
Cereb Cortex. 2018 Feb 27. [PubMed]
Potential for targeting dopamine/DARPP-32 signaling in neuropsychiatric and neurodegenerative disorders.
Expert Opin Ther Targets. 2017 Mar;21(3):259-272. [PubMed]
Nishi A, Matamales M, Musante V, Valjent E, Kuroiwa M, Kitahara Y, Rebholz H, Greengard P, Girault JA, Nairn AC.
Glutamate Counteracts Dopamine/PKA Signaling via Dephosphorylation of DARPP-32 Ser-97 and Alteration of Its Cytonuclear Distribution.
J Biol Chem. 2017 Jan 27;292(4):1462-1476. [PubMed]
Neuronal circuits and physiological roles of the basal ganglia in terms of transmitters, receptors and related disorders.
J Physiol Sci. 2016 Nov;66(6):435-446. [PubMed]
Heckman PR, van Duinen MA, Bollen EP, Nishi A, Wennogle L, Blokland A, Prickaerts J. Phosphodiesterase inhibition and regulation of dopaminergic frontal and striatal functioning: clinical implications.
Int J Neuropsychopharmacol. 2016 Apr 2. pii: pyw030. [PubMed]
Kitahara Y, Ohta K, Hasuo H, Shuto T, Kuroiwa M, Sotogaku N, Togo A, Nakamura K, Nishi A.: Chronic Fluoxetine Induces the Enlargement of Perforant Path-Granule Cell Synapses in the Mouse Dentate Gyrus.
PLoS One. 2016 Jan 20;11(1):e0147307. [PubMed]
Nagai T, Nakamuta S, Kuroda K, Nakauchi S, Nishioka T, Takano T, Zhang X, Tsuboi D, Funahashi Y, Nakano T, Yoshimoto J, Kobayashi K, Uchigashima M, Watanabe M, Miura M, Nishi A, Kobayashi K, Yamada K, Amano M, Kaibuchi K.
Phosphoproteomics of the Dopamine Pathway Enables Discovery of Rap1 Activation as a Reward Signal In Vivo.
Neuron. 2016 Feb 3;89(3):550-65. [PubMed]
Kaneko F, Kawahara Y, Kishikawa Y, Hanada Y, Yamada M, Kakuma T, Kawahara H, Nishi A.
Long-term citalopram treatment alters the stress responses of the cortical dopamine and noradrenaline systems: the role of cortical 5-HT1A receptors.
Int J Neuropsychopharmacol. 2016 Aug 12;19(8). pii: pyw026. [PubMed]
首藤隆秀、西 昭徳
項目「DARPP-32」
脳科学辞典 (2016) DOI：10.14931/bsd.7033 https://bsd.neuroinf.jp/wiki/DARPP-32
The role of ventral striatal cAMP signaling in stress-induced behaviors.
Nat Neurosci 2015 Aug;18(8):1094-100. [PubMed]
Tassin TC, Benavides DR, Plattner F, Nishi A, Bibb JA.
Regulation of ERK Kinase by MEK1 Kinase Inhibition in the Brain.
J Biol Chem. 2015 Jun 26;290(26):16319-29. [PubMed]
Ohnishi YH, Ohnishi YN, Nakamura T, Ohno M, Kennedy PJ, Yasuyuki O, Nishi A, Neve R, Tsuzuki T, Nestler EJ.
PSMC5, a 19S Proteasomal ATPase, Regulates Cocaine Action in the Nucleus Accumbens.
PLoS One. 2015 May 11;10(5):e0126710. [PubMed]
Biever A, Puighermanal E, Nishi A, David A, Panciatici C, Longueville S, Xirodimas D, Gangarossa G, Meyuhas O, Herve D, Girault JA, Valjent E.
PKA-dependent phosphorylation of ribosomal protein S6 does not correlate with translation efficiency in striatonigral and striatopallidal medium-sized spiny neurons.
J Neurosci. 2015 Mar 11;35(10):4113-30. [PubMed]
Uematsu K, Heiman M, Zelenina M, Padovan J, Chait BT, Aperia A, Nishi A, Greengard P.
Protein kinase A directly phosphorylates metabotropic glutamate receptor 5 to modulate its function.
J Neurochem. 2015 Mar;132(6):677-86. [PubMed]
Ohnishi YN, Ohnishi YH, Vialou V, Mouzon E, LaPlant Q, Nishi A, Nestler EJ.
Functional role of the N-terminal domain of ΔFosB in response to stress and drugs of abuse.
Neuroscience. 2015 Jan 22;284:165-70. [PubMed]
The spontaneously hypertensive rat/Izm (SHR/Izm) shows attention deficit/hyperactivity disorder-like behaviors but without impulsive behavior: therapeutic implications of low-dose methylphenidate.
Behav Brain Res. 2014 Nov 1;274:235-42. [PubMed]
Plattner F, Hernandez A, Kistler TM, Pozo K, Zhong P, Yuen EY, Tan C, Hawasli AH, Cooke SF, Nishi A, Guo A, Wiederhold T, Yan Z, Bibb JA.
Memory enhancement by targeting Cdk5 regulation of NR2B.
Neuron. 2014 Mar 5;81(5):1070-83. [PubMed]
Upregulation of the dorsal raphe nucleus-prefrontal cortex serotonin system by chronic treatment with escitalopram in hyposerotonergic Wistar-Kyoto rats.
Neuropharmacology. 2013 Sep;72:169-78. [PubMed]
Shuto T, Kuroiwa M, Koga Y, Kawahara Y, Sotogaku N, Toyomasu K, Nishi A
Acute effects of resveratrol to enhance cocaine-induced dopamine neurotransmission in the striatum.
Neurosci Lett. 2013 May 10;542:107-112.[PubMed]
Takao K, Kobayashi K, Hagihara H, Ohira K, Shoji H, Hattori S, Koshimizu H, Umemori J, Toyama K, Nakamura HK, Kuroiwa M, Maeda J, Atsuzawa K, Esaki K, Yamaguchi S, Furuya S, Takagi T, Walton NM, Hayashi N, Suzuki H, Higuchi M, Usuda N, Suhara T, Nishi A, Matsumoto M, Ishii S, Miyakawa T.
Deficiency of Schnurri-2, an MHC Enhancer Binding Protein, Induces Mild Chronic Inflammation in the Brain and Confers Molecular, Neuronal, and Behavioral Phenotypes Related to Schizophrenia.
Neuropsychopharmacology. 2013 Jul;38(8):1409-25. [PubMed]
Kawahara Y, Kaneko F, Yamada M, Kishikawa Y, Kawahara H, Nishi A.
Food reward-sensitive interaction of ghrelin and opioid receptor pathways in mesolimbic dopamine system.
Neuropharmacology. 2013 Apr;67:395-402.[PubMed]
Muscarinic receptors acting at pre- and post-synaptic sites differentially regulate dopamine/DARPP-32 signaling in striatonigral and striatopallidal neurons.
Neuropharmacology. 2012 Dec;63(7):1248-1257. [PubMed]
Koo JW, Mazei-Robison MS, Chaudhury D, Juarez B, LaPlant Q, Ferguson D, Feng J, Sun H, Scobie KN, Damez-Werno D, Crumiller M, Ohnishi YN, Ohnishi YH, Mouzon E, Dietz DM, Lobo MK, Neve RL, Russo SJ, Han MH, Nestler EJ.
BDNF is a negative modulator of morphine action.
Science. 2012 Oct 5;338(6103):124-128.[PubMed]
Cui H, Mason BL, Lee C, Nishi A, Elmquist JK, Lutter M.
Melanocortin 4 receptor signaling in dopamine 1 receptor neurons is required for procedural memory learning.
Physiol Behav. 2012 May 15;106(2):201-210.[PubMed]
Kuroiwa M, Snyder GL, Shuto T, Fukuda A, Yanagawa Y, Benavides DR, Nairn AC, Bibb JA, Greengard P, Nishi A.
Phosphodiesterase 4 inhibition enhances the dopamine D1 receptor/PKA/DARPP-32 signaling cascade in frontal cortex.
Psychopharmacology (Berl). 2012 Feb;219(4):1065-79. [PubMed]
Mechanisms for the modulation of dopamine d(1) receptor signaling in striatal neurons.
Front Neuroanat. 2011;5:43. doi: 10.3389/fnana.2011.00043. Epub 2011 Jul 18. [PubMed]
Mitsumori T, Furuyashiki T, Momiyama T, Nishi A, Shuto T, Hayakawa T, Ushikubi F, Kitaoka S, Aoki T, Inoue H, Matsuoka T, Narumiya S.
Thromboxane receptor activation enhances striatal dopamine release, leading to suppression of GABAergic transmission and enhanced sugar intake.
Eur J Neurosci. 2011 Aug;34(4):594-604. [PubMed]
Shuto T, Nishi A
Treatment of the Psychostimulant-Sensitized Animal Model of Schizophrenia.
CNS Neurosci Ther. 2011 Apr;17(2):133-139. [PubMed]
Advanced research on dopamine signaling to develop drugs for the treatment of mental disorders: biochemical and behavioral profiles of phosphodiesterase inhibition in dopaminergic neurotransmission.
J Pharmacol Sci. 2010 Sep 16;114(1):6-16. Epub 2010 Aug 12. [PubMed]
Hara M, Fukui R, Hieda E, Kuroiwa M, Bateup HS, Kano T, Greengard P, Nishi A.
Role of adrenoceptors in the regulation of dopamine/DARPP-32 signaling in neostriatal neurons.
J Neurochem. 2010 May;113(4):1046-59. Epub 2010 Mar 4. [PubMed]
CK2 negatively regulates Gαs signaling.
Proc Natl Acad Sci USA. 2009 Aug 18;106(33):14096-101. [PubMed]
Tanda K, Nishi A, Matsuo N, Nakanishi K, Yamasaki N, Sugimoto T, Toyama K, Takao K、 Miyakawa T.
Abnormal social behavior, hyperactivity, impaired remote spatial memory, and increased D1-mediated dopaminergic signaling in neuronal nitric oxide synthase knockout mice.
Molecular Brain. 2009 Jun 18;2(1):19. [PubMed]
Kawahara Y, Kawahara H, Kaneko F, Yamada M, Nishi Y, Tanaka E, Nishi A.
Peripherally administered ghrelin induces bimodal effects on mesolimbic dopamine system depending on food-consumptive states.
Neuroscience. 2009 Jul 7;161(3):855-64. [PubMed]
Regulation of DARPP-32 phosphorylation by three distinct dopamine D1-like receptor signaling pathways in the neostriatum.
J Neurochem. 2008; 107:1014-1026. [PubMed]
Nishi A, Kuroiwa M, Miller DB, O'Callaghan JP, Bateup HS, Shuto T, Sotogaku N, Fukuda T, Heintz N,
Greengard P, Snyder GL.
Distinct Roles of PDE4 and PDE10A in the Regulation of cAMP/PKA Signalingin the Striatum.
J Neurosci. 2008;28:10460-10471. [PubMed]
Bateup HS, Svenningsson P, Kuroiwa M, Gong S, Nishi A, Heintz N, Greengard P.
Cell type-specific regulation of DARPP-32 phosphorylation by psychostimulant and antipsychotic drugs.
Nat Neurosci. 2008 Aug;11(8):932-939. [PubMed]
Stipanovich A, Valjent E, Matamales M, Nishi A, Ahn J-H, Maroteaux M, Bertran-Gonzalez J, Brami-Cherrier K, Enslen H, Corbillé A-G, Filhol O, Nairn AC, Greengard P, Hervé D, Girault J-A.
A phosphatase cascade by which rewarding stimuli control nucleosomal response.
Nature. 2008 Jun 12;453(7197):879-84. [PubMed]
Shuto T, Seeman P, Kuroiwa M, Nishi A.
Repeated administration of a dopamine D1 receptor agonist reverses the increased proportions of striatal dopamine D1(High) and D2(High) receptors in methamphetamine-sensitized rats.
Eur J Neurosci. 2008 May;27(10):2551-7. [PubMed]
Miyasaka M, Greengard P, Narumiya S.
Prostaglandin E2 acts on EP1 receptor and amplifies both dopamine D1
and D2 receptor signaling in the striatum.
J Neurosci. 2007 Nov 21;27(47):12900-7. [PubMed]
Sonomura T, Nakamura K, Furuta T, Hioki H, Nishi A, Yamanaka A,
Uemura M, Kaneko T.
Expression of D1 but not D2 dopamine receptors in striatal neurons
producing neurokinin B in rats.
Eur J Neurosci. 2007 Dec;26(11):3093-103. [PubMed]
Nguyen C, Hosokawa T, Kuroiwa M, Ip NY, Nishi A, Hisanaga H, Bibb JA.
Differential regulation of the Cdk5-dependent phosphorylation sites of inhibitor-1 and DARPP-32 by depolarization.
J Neurochem. 2007 Nov;103(4):1582-93. [PubMed]
Sotogaku N, Tully SE, Gama CI, Higashi H, Tanaka M, Hsieh-Wilson LC, Nishi A.
Activation of phospholipase C pathways by a synthetic chondroitin sulfate-E
tetrasaccharide promotes neurite outgrowth of dopaminergic neurons.
J Neurochem. 2007 Oct;103(2):749-60. [PubMed]
Kawahara Y, Kawahara H, Kaneko F, Tanaka M.
Long-term administration of citalopram reduces basal and stress-induced extracellular noradrenaline levels in rat brain.
Psychopharmacology (Berl). 2007 Sep;194(1):73-81. [PubMed]
Ahn J-H, Sung JY, McAvoy T, Nishi A, Janssens V, Goris J, Greengard P, Nairn AC.
The B"/PR72 subunit mediates Ca2+-dependent dephosphorylation of DARPP-32 by protein phosphatase 2A.
Proc Natl Acad Sci U S A. 2007 Jun 5;104(23):9876-81. [PubMed]
Nguyen C, Nishi A, Kansy JW, Fernandez J, Hayashi K, Gillardon F, Hemmings HC Jr, Nairn AC, Bibb JA.
Regulation of protein phosphatase inhibitor-1 by cyclin-dependent kinase 5.
J Biol Chem. 2007 Jun 1;282(22):16511-20. [PubMed]
Ahn J-H, McAvoy T, Rakhilin SV, Nishi A, Greengard P, Nairn AC.
Protein kinase A activates protein phosphatase 2A by phosphorylation of the B56delta subunit.
Proc Natl Acad Sci USA. 2007 Feb 20;104(8):2979-84. [PubMed]
Sulfation patterns of glycosaminoglycans encode molecular recognition and activity.
Nat Chem Biol. 2006 Sep;2(9):467-73. [PubMed]
Shuto T, Kuroiwa M, Hamamura M, Yabuuchi K, Shimazoe T, Watanabe S, Nishi A, Yamamoto T.
Reversal of methamphetamine-induced behavioral sensitization by repeated administration of a dopamine D1 receptor agonist.
Neuropharmacology. 2006 Jun;50(8):991-7. [PubMed]
Yabuuchi K, Kuroiwa M, Shuto T, Sotogaku N, Snyder GL, Higashi H, Tanaka M, Greengard P, Nishi A.
Role of adenosine A1 receptors in the modulation of dopamine D1 and adenosine A2a receptor signaling in the neostriatum.
Neuroscience. 2006 Aug 11;141(1):19-25. [PubMed]
Glutamate regulation of DARPP-32 phosphorylation in neostriatal neurons involves activation of multiple signaling cascades.
Proc Natl Acad Sci U S A. 2005 Jan 25;102(4):1199-204. [PubMed]
Futter M, Uematsu K, Bullock SA, Kim Y, Hemmings HC Jr, Nishi A, Greengard P, Nairn AC.
Phosphorylation of spinophilin by ERK and cyclin-dependent PK 5 (Cdk5).
Proc Natl Acad Sci U S A. 2005 Mar 1;102(9):3489-94. [PubMed]
Ohshima T, Ogura H, Tomizawa K, Hayashi K, Suzuki H, Saito T, Kamei H, Nishi A, Bibb JA, Hisanaga S, Matsui H, Mikoshiba K.
Impairment of hippocampal long-term depression and defective spatial learning and memory in p35 mice.
J Neurochem. 2005 Aug;94(4):917-25. [PubMed]
Hamada M, Hendrick JP, Ryan GR, Kuroiwa M, Higashi H, Tanaka M, Nairn AC, Greengard P, Nishi A.
Nicotine regulates DARPP-32 (dopamine- and cAMP-regulated phosphoprotein of 32 kDa) phosphorylation at multiple sites in neostriatal neurons.
J Pharmacol Exp Ther. 2005 Nov;315(2):872-8. [PubMed]
Uematsu K, Futter M, Hsieh-Wilson LC, Higashi H, Maeda H, Nairn AC, Greengard P, Nishi A.
Regulation of spinophilin Ser94 phosphorylation in neostriatal neurons involves both DARPP-32-dependent and independent pathways.
J Neurochem. 2005 Dec;95(6):1642-52. [PubMed]
Differential regulation of dopamine D1 and D2 signaling by nicotine in neostriatal neurons.
J Neurochem. 2004 Sep;90(5):1094-103. [PubMed]
Kansy JW, Daubner SC, Nishi A, Sotogaku N, Lloyd MD, Nguyen C, Lu L, Haycock JW, Hope BT, Fitzpatrick PF, Bibb JA.
Identification of tyrosine hydroxylase as a physiological substrate for Cdk5.
J Neurochem. 2004 Oct;91(2):374-84. [PubMed]
Takaseya T, Ishimatsu M, Tayama E, Nishi A, Akasu T, Aoyagi S.
Mechanical unloading improves intracellular Ca2+ regulation in rats with doxorubicin-induced cardiomyopathy.
J Am Coll Cardiol. 2004 Dec 7;44(11):2239-46. [PubMed]
Rakhilin SV, Olson PA, Nishi A, Starkova NN, Fienberg AA, Nairn AC, Surmeier DJ, Greengard P.
A network of control mediated by regulator of calcium/calmodulin-dependent signaling.
Science. 2004 Oct 22;306(5696):698-701. [PubMed]
Kawahara Y, Hesselink MB, van Scharrenburg G, Westerink BH.
Tonic inhibition by orphanin FQ/nociceptin of noradrenaline neurotransmission in the amygdala.
Eur J Pharmacol. 2004 Feb 6;485(1-3):197-200. [PubMed]
