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The inhibition of evoked excitatory postsynaptic potentials produced by ammonium chloride in rat hippocampal CA1 neurons
Heliyon 6: e05830
doi: 10.1016/j.neulet.2016.11.006.


Activation of chathepsin L contributes to the irreversible depolarization induced by oxygen and glucose deprivation in rat hippocampal CA1 neurons.
Neuroscience Letters :636:120-126
doi: 10.1016/j.neulet.2016.11.006.

久留米医会誌 :80:264-275


A natural therapeutic approach for the treatment of periodontitis by MK615.
Med Hypotheses :85(5):618-21

Voluntary exercise contributed to an amelioration of abnormal feeding behavior, locomotor activity and ghrelin production concomitantly with a weight reduction in high fat diet-induced obese rats.
Peptides :71:49-55
doi: 10.1016/j.peptides.2015.06.007

Cleavage of host cytokeratin-6 by lysine-specific gingipain induces gingival inflammation in periodontitis patients.
PLoS One 17:10(2):e0117775
doi: 10.1371/journal.pone.0117775

Secondhand smoke exposure-induced nucleocytoplasmic shuttling of HMGB1 in a rat premature skin aging model.
Biochem Biophys Res Commun. 2:456(1):92-7
doi: 10.1016/j.bbrc.2014.11.040

Surface vacuolar ATPase in ameloblastoma contributes to tumor invasion of the jaw bone.
International Journal of Oncology 48(3):1258-70
doi: 10.3892/ijo.2016.3350

Effects of back massages on stress observed in students preparing for the national license examination.
Health 7:430-438

Identification of activated protein C as a ghrelin endopeptidase in bovine plasma.
Journal of Endocrinology 224: 61-73
doi: 10.1530/JOE-14-0529


久留米大学医学部附属臨床検査専門学校紀要 22: 27-29

Relation between circulating levels of GH, IGF-1, ghrelin and somatic growth in Rett syndrome.
Brain and Development 36: 794-800

Changes in the nitric oxide-soluble guanylate cyclase system and natriuretic peptide receptor system in placentas of pregnant Dahl salt-sensitive rats.
The Journal of Obstetrics and Gynaecology Research 41(4): 540-50
doi: 10.1111/jog.12602

Correction: Potential of the Angiotensin Receptor Blockers (ARBs) Telmisartan, Irbesartan, and Candesartan for Inhibiting the HMGB1/RAGE Axis in Prevention and Acute Treatment of Stroke.
International Journal of Molecular Sciences15: 5410-5411


The efficacy of edaravone (redicut), a free radical scavenger, for cardiovascular disease.
International Journal of Molecular Sciences14: 13909-13930

Edaravone (Radicut), a free radical scavenger, is a potentially useful addition to thrombolytic therapy in patients with acute ischemic stroke (review)
Biomedical Reports 1: 7-12

Relation between circulating levels of GH, IGF-1, ghrelin and somatic growth in Rett syndrome.
Brain and Development
doi: 10.1016/j.braindev.2013.11.007

Potential of the Angiotensin Receptor Blockers(ARBs) Telmisartan, Irbesartan, and Candesartan for Inhibiting the HMGB1/RAGE Axis in Prevention and Acute Treatment of Stroke
International Journal of Molecular Sciences14:18899-18924

Preventive effects of Morus alba L. anthocyanins on diabetes in Zucker diabetic fatty rats
Experimental and therapeutic medicine 6:689-695

Development of transcranial sonothrombolysis as an alternative stroke therapy: incremental scientific advances toward overcoming substantial barriers.
Expert Rev Med Devices 10(2):201-213

Changes in subcellular distribution of n-octanoyl or n-decanoyl ghrelin in ghrelin-producing cells.
Frontiers in Experimental Endocrinology 4:84,
doi: 10.3389/fendo.2013.00084


Ghrelin acylation by ingestion of medium-chain fatty acids.
Methods in Enzymology 514:303-315

Periodontal disease and type 2 diabetes mellitus: Is the HMGB1-RAGE axis the missing link?
Medical Hypotheses 79(4):452-455

Activation of protein kinase A and C prevents recovery from persistent depolarization produced by oxygen and glucose deprivation in rat hippocampal neurons.
Journal of Neurophysiology 107:2517-2525

Methylseleninic acid is a novel suppressor of aromatase expression.
Journal of Endocrinology 212:199-205

A-type natriuretic peptide level in angiotensin II type 1a receptor knockout mice.
Experimental Animals 61(2):131-138
Increased production of active ghrelin is relevant to hyperphagia in non-obese spontaneously diabetic Torii rat.
Metabolism 61:491-495
Secondary prevention of stroke: Pleiotropic effects of optimal oral pharmacotherapy.
Experimental and therapeutic medicine 4:3-7
Different A-type natriuretic peptide level in five strains of mice.
The Journal of Veterinary Medical Science 74:499-502
Disrupted regulation of ghrelin production under antihypertensive treatment in spontaneously hypertensive rats.
Circulation Journal 76:1423-1429
Ghrelin levels are reduced in Rett syndrome patients with eating difficulties.
Int J Devl Neurosci 29(8):899-902
Structures and molecular forms of the ghrelin-family peptides.
Peptides 32(11):2175-2182
Plasma levels of n-decanoyl ghrelin, another acyl- and active-form of ghrelin, in human subjects and the effect of glucose- or meal-ingestion on its dynamics.
Regulatory Peptides 167(1):140-148
Connexon-mediated cell adhesion drives microtissue self-assembly
The FADEB Journal 25(1): 255-264
Identification and characterization of acyl-protein thioesterase 1/lysophospholipase I as a ghrelin deacylation/lysophospholipid hydrolyzing enzyme in fetal bovine serum and conditioned medium.
Endocrinology 151(10):4765-4775
Homeobox A7 increases cell proliferation by upregulation of epidermal growth factor receptor expression in human granulosa cells.
Peproductive biology and endocrinology 8:61
Dihydrotestosterone suppresses foam cells formation and attenuates atherosclerosis development.
Endocrinology 151(7):3307-3316 [JCEM]
Dynamics of placental ghrelin production and its receptor expression in a Dahl salt-sensitive rat model of intrauterine growth restriction.
Placenta 31(5):358-364
生殖機能調節の新しい視点 6. グレリンと生殖機能の関連.
産科と婦人科 77(3):283-287
Peroxisome proliferator-activated receptor gamma mediates the endocrine disrupter bisphenol a inhibition of FSH-stimulated IGF-I, aromatase and Estradiol in human granulosa cells.
Environ Health Perspect 118:400-406
Regional distribution and the dynamics of n-decanoyl ghrelin, another acyl-form of ghrelin, upon fasting in rodents.
Regulatory Peptides 156:47-56
Peripherally administered ghrelin induces bimodal effects on mesolimbic dopamine system depending on food-consumptive states.
Neuroscience 161:855-864
TRAIL pathway components and their putative role in granulosa cell apoptosis in the human ovary.
Differentiation 77:369-376
Regulation of LH receptor and PGF2α receptor signaling by the regulator of G protein signaling 2 (RGS2) in human and mouse granulosa cells.
Chinese Journal of Physiology 51: 282-291
Functional potentiation of leptin-Stat3 signaling by the androgen receptor.
Endocrinology 149: 6028-6036
Characterization of recombinant human growth differentiation factor-9 signaling in ovarian granulosa cells.
Molecular and Cellular Endocrinology 283: 58-67
Inhibition of proteasome activity sensitizes human granulosa tumor cells to TRAIL-induced cell death.
Cancer Letters 260: 20-27
久留米医学会雑誌 71:327-340
Glutathione S-transferase theta 1 expressed in granulosa cells as a biomarker for oocyte quality in agerelated infertility.
Fertillity and Sterility 90: 1026-1035
ロゴスとパトスの脳 −意識とは何か─.
久留米医学会雑誌 70:47-53
ペリネイタルケア 26:89-93
A new cytochemical method for in situ detection of cholinergic synaptic transmission by staining of Cu2+ incorporated in frog neuromuscular junction during nerve stimulation.
Biomedical Research 27:125-130
Two opposing roles of 4-AP-sensitive K+ current in initiation and invasion of spikes in rat mesencephalic trigeminal neurons.
Journal of Neurophysiology 96:1887-1901
Immunohistochemical localization of ghrelin in rodent kidneys.
Histochemistry and Cell Biology 126:231-238
Ghrelin and leptin: A link between obesity and allergy?
Journal of Allergy and Clinical Immunology 117: 705-706
Role of adenosine A1 receptors in the modulation of dopamine D1 and adenosine A2A receptor signaling in the neostriatum.
Neuroscience 141: 19-25
久留米医学会雑誌 69:326-335
久留米医学会雑誌 69:343-350
九州動物実験雑誌 22:35-39
Excitatory GABAergic synaptic potentials in the mesencephalic trigeminal nucleus of adult rat in vitro.
Neurosci. Res. 51:463-474
Neuroprotective mechanisms of lidocaine against in vitro ischemic insult of the rat hippocampal CA1 pyramidal neurons.
Neurosci. Res. 53:271-278
Nicotine regulates DARPP-32 (Dopamine- and cAMP- regulated phosphoprotein of 32 kDa) phosphorylation at multiple sites in neostriatal neurons.
JPET 315:872-878
Regulation of spinophilin Ser94 phosphorylation in neostriatal neurons involves both DARPP-32-dependent and independent pathways.
J Neurochem 95:1642-1652
Ingested medium-chain fatty acids are directly utilized for the acyl modification of ghrelin.
Endocrinology 146:2255-2264
Developmental changes in the pattern of ghrelin's acyl modification and the levels of acyl-modified ghrerins in murine stomach.
Endocrinology 146:2709-2715
A new cytochemical method for ultrastructural localization of Co2+ in rat hippocampal CA1 pyramidal neurons in vitro.
J Neurosci Methods 135: 1-8
Differential regulation of dopamine D1 and D2 signaling by nicotine in neostriatal neurons.
J Neurochem 90: 1094-1103
Protective actions of various local anesthetics against the membrane dysfunction produced by in vitro ischemia in rat hippocampal CA1 neurons.
Neurosci Res 50: 291-298
Glutamate regulation of DARPP-32 phosphorylation in neostriatal neurons involves activation of multiple signaling cascades.
Proc Natl Acad Sci USA 102(4): 1199-1204
DARPP-32: An integrator of neurotransmission.
Annu Rev Pharmacol Toxicol 44: 269-296
Mechanical unloading improves intracellular Ca2+ regulation in rats with doxorubicin-induced cardiomyopathy.
J Am Coll Cardiol 44(11): 2239-2246
Distinct profiles of refilling of inhibitory neurotransmitters into presynaptic terminals projecting to spinal neurones in immature rats.
J Physiol 560(2): 469-478
Electrical and pharmacological properties of the slow depolarization induced by Schaffer collateral stimulation in astrocytes of the rat hippocampal CA1 region.
Neurosci Lett 343: 85-88
Arachidonic acid metabolites contribute to the irreversible depolarization induced by in vitro ischemia.
J Neurophysiol 90:3213-3223
Effect of methylphenidate on dopamine/DARPP signalling in adult, but not young, mice.
J Neurochem 87:1391-1401
Metabotropic mGlu5 receptors regulate adenosine A2A receptor signaling.
Proc Natl Acad Sci USA 100:1322-1327
Regulation of DARPP-32 Thr75 phosphorylation by neurotensin in neostriatal neurons: involvement of glutamate signalling.
Eur J Neurosci 18:1247-1253
日本薬理学雑誌 122 (3):215-225
脳の科学 25:257-264
Bupivacaine, but not tetracaine, protects against the in vitro ischemic insult of rat hippocampal CA1 neurons.
Neurosci Res. 42:231-241
Direct and indirect actions of dopamine on the membrane potential in medium spiny neurons of the mouse neostriatum.
Neurophysiol. 87:1234-1243
Extrusion of intracellular calcium ion after in vitro ischemia in the rat hippocampal CA1 region.
J Neurophysiol. 88:879-887
Neurotensin regulates DARPP-32 Thr34 phosphorylation in neostriatal neurons by activation of dopamine D1-type receptors.
J Neurochem. 81:325-334
Regulation of DARPP-32 dephosphorylation at PKA-and Cdk5-sites by NMDA and AMPA receptors: distinct roles of calcineurin and protein phosphatase-2A.
J Neurochem. 81:832-841
The presynaptic modulation of glutamate release and the membrane dysfunction induced by in vitro ischemia in rat hippocampal CA1 neurons.
Life Sci. 72: 363-374
Postnatal changes in the overall postsynaptic currents evoked in CA1 pyramidal neurons of the rat hippocampus.
Life Sci. 72: 341-353
Phosphorylation of protein phosphatase inhibitor-1 by Cdk5.
J. Biol. Chem. 276:14490-11497
Mechanisms underlying the depression of evoked fast EPSCs following in vitro ischemia in rat hippocampal CA1 neurons.
J. Neurophysiol. 86:1095-1103
Correlation between electrophysiology and morphology of three groups of neuron in the dorsal commissural nucleus of lumbosacral spinal cord of mature rats studied in vitro.
J. Comp. Neurol. 437:156-169
Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5.
Nature 410:376-380
Regulation of cyclin-dependent kinase 5 and casein kinase 1 by metabotropic glutamate receptors.
Proc. Natl. Acad. Sci. USA 98:11062-11068
Functional reorganization of sensory pathways in the rat spinal dorsal horn following peripheral nerve injury.
J. Physiol. 532(1):241-250
Na+/Ca2+ exchanger activity induces a slow DC potential after in vitro ischamia in rat hippocampal CA1 region.
Neurosci Res 36: 129-140
A spinal cord slice preparation for analyzing synaptic responses to stimulation of pelvic and pudendal nerves in mature rats.
J Neurosci Methods 100: 71-78
Amplification of dopaminergic signaling by a positive feedback loop.
Proc Natl Acad Sci USA 97: 12840-12845
Phosphorylation of protein phosphatase-1 inhibitors, inhibitor-1 and DARPP-32, in renal medulla.
Eur J Pharmacol 408:107-116
臨床薬理の進歩2000: 146-150