Achievement List 業績リスト




1997　がんワクチン分子 Selected Publications in 1997-1998 l. Sudo, T., Kuramoto, T., Komiya, S., Inoue, A., Itoh, K., Expression of MAGE genes in osteosarcoma. J. Orthopaedic Research 15; 128-132, 1997. 2. Miyajima, J., Imai, Y., Nakao, M., Noda, N., Itoh, K., Higher susceptibility of erythropoietin-producing renal cell carcinomas to lysis by lymphokine-activated killer cells. J. Immunotherapy 19; 399-404, 1997. 3. Iwamoto, O., Nagao, Y., Shichijo, S., Eura, M., Kameyama, T., Itoh, K., Detection of MAGE-4 protein in sera of patients with head and neck squamous cell carcinoma. Int. J. Can. 70; 287-290, 1997. 4. Tamai, M., Yokouchi, M., Komiya, S., Mochizuki, K., Hidaka, S., Narita, S., Inoue, A., Itoh, K., Correlation between Vitamin D receptor genotypes and bone mineral density in Japanease patients with osteoporosis. CALCIFIED TISSUE INTRENATIONAL. 60; 229-232, 1997. 5. Seki, N., Hoshino, T,, Iwamoto., Hayashi, A., Itoh, K., HLA-A locus-restricted and tumor-specific CTL in tumor infiltrating lymphocytes of patients with lung cancer. Cell. Immunol. 175; 101-110, 1997. 6. Yamada, A., Hara, A., Inoue, M., Kamizono, S., Higuchi, H., Itoh, K., ~i2- integrin-mediated signal up-regulates counter recepter ICAM-1 expression on human monocyte cell line THP-1 through tyrosine phosphorylation. Cell. Immunol. 178; 9-16, 1997. 7. Hoshino, T., Suzuki, R., Tsuruta, Y., Matsutani, T., Kikuchi, M., Kawamoto, M., Gouhara, R., Shiraishi, T., Mochizuki, M., Itoh, K., Oizumi, K., Non-restricted T cell receptor-Va and -V~3 gene usage in patients with pulmonary sarcoidosis. Clin. Exp. Immunol. 108; 529-538, 1997. 8. Gouhara, R., Nakao, M., Ogata, Y., Isomato, H., Oizumi, K., Itoh, K.,_ Histocompatibility leukocyte antigen-2402-restricted cytotoxic T lymphocytes recognizing adenocarcinomas in tumor-infiltrating lymphocytes of patients with colon cancer. JJCR. 88; 198-204, 1997. 9. Hoshino, T., Seki, N., Kikuchi, M., kuramoto, T., Kodama, K., Koufuji, K., Iwamoto, O., Takeda, J., and Itoh, K., HLA-class I-restricted and tumor-specific CTL in tumor-infiltrating lymphocytes of patients with gastric cancer. Int. J. Cancer. 70; 631- 638, 1997. 10. Nakao, M., Sata, M., Saitsu, H., Yutani, S., Kawamoto, M., Koujiro M., Itoh, K., CD4~ heaptic cancer-specific cytotoxic T lymphocytes in patients with hepatocellular arcinoma. Cell. Immunol. 177; 176-181, 1997. 1 1. Toh, U., Yamana, H., Nakao, M., Imai Y., Seki, N., Takasu, H., Kaneshige, T., Fujita, H., Shirouzu, K., Itoh, K., HLA-class-I-restricted and tumor- specific cytotoxic T lymphocytes from metastatic lymphocytes from metastatic lympho nodes of esophageal cancers. Cell. Immunol. 177, 137-143, 1997. 1?. Shichijo, S., Hoshino, H., Koufuji, K., Hayashi, A., Kawamoto, M., Kikuchi, M., Higuchi, T., Ichiki, M., Oizumi, K., Itoh, K., Detection of MAGE-4 protein in sera of lung cancer patients. JJCR. 88; 414-419, 1997. 13. Nagai, K., Yamada, A., Eguchi, H., Kato, H., Itoh, K., HLA-A2402-restricted and tumor-specific cytotoxic T lymphocytes from tumor infiltrating lymphocytes of a child with Wilms' tumor. Pediatric Reseach. 42; 122-127, 1997. 14. Noguchi, M., Miyajima, J., Itoh, K., Noda, S., Detection of circulating tumor cells in patients with prostatic cancer using prostate specific membrane-derived primers in the polymerase chain reaction. Int. J. Urol. 4; 374-379, 1997. 15. Hoshino, T., Ohta, A., Yang, D., Kawamoto, M., Kikuchi, M., Inoue,Y., Kamizono, S., Ota, T., Itoh, K., Oizumi, K. Elevated serum IL-6, IFN-y and TNF-a levels in patients with adult Still's disease. J. Rheumatology 23; 124-129, 1997. 16. Nagao, Y., Sata, M., Itoh, K., Chiba, L, Komiyama, K., Yanoma, K., Eura, M., Tanikawa, K., Kameyama, T., High prevalence of hepatitis C virus antibody and RNA in patients with head and neck squamous cell carcinoma. Hepatology Reseach 7; 206- 212, 1997. 17. Tsuzurahara, S., Sata, M., Iwamoto, S., Shichijo, S., Kojiro, M., Tanikawa, K., Itoh, K., Detection of MAGE-4 protein in the sera of Patients with hepatitis-C virus- associated hepatocellular carcinoma and liver cirrhosis. JJCR. 88; 915-918, 1997. 18. Suekane, S., Nakao, M., moue, M., Noda, S., Itoh, K., Histocompatibility leukocyte antigen-2-restricted and tumor-specific cytotoxic T lymphocytes from tumor- infiltrating lymphocytes of a patient with testicular embryonal cancer. JJCR. 88; 1180- 1189, 1998. 19. Shichijo, S., Nakao, T., Imai, Y., Takasu, H., Kawamoto, M., Niiya, F., Yang, D., Toh, Y., Yamana, H., Itoh, K., A Gene encoding antigenic peptides of human squamous cell carcinoma recognized by cytotoxic T lymphocytes. J. Exp. Med. 187; 277-288, 1998. 20. Eton, O., Kharkevitch, D. D., Gianan, M. A., Ross, L, Mansfield, P. F., Lee, J. E., Itoh, K., Pride, M., Bedikian, A. C., Papadopoulos, N. E., Plager, C., Legha, S., Benjamin, R. S., and Balch, C. M., Active immunotherapy with ultraviolet-B irradiated autologous whole melanoma cells plus DetoxTM in patients with metastatic melanoma. Clinical Cancer Research. in press, 1998. 21. Higuchi, T., Seki, N., Kamizono, S., Yamada, A., Kimura, A., Kato, H., Itoh, K., Polymorphism of the 5'-flanking region of human tumor-necrosis factor (TNF)-a gene in Japanese. Tissue Antigen in press, 1998. 1997 肝癌研究 Publications l. Satoshi Shakado, Shotaro Sakisaka, Kazunori Noguchi, Masaru Harada, Ryuichiro Maekawa, Michio Sata, and Kyuichi Tanikawa., Effects of vascular endothelial growth factor (VEGF) on cultured rat sinusoidal endothelial cells. Cells of the hepatic sinusoid Vol. 6. p. 79-81, 1997. 2. Masaru Harada, Satoshi Shakado, Shotaro Sakisaka, Seishu Tamaki, Masahito Ohishi, Kurumi Sasatomi, Hironori Kola, Yoshihiro Mimura, Michio Sata, and Kyuichi Tanikawa., Role of vacuolar pH on the receptor-mediated endocytosis of horseradish peroxidase in isolated rat sinusoidal endothelial cells. Cells of the hepatic sinusoid Vol. 6. p. 384-385, 1997. 3. Masaru Harada, Satoshi Shakado, Shotaro Sakisaka, Seishu Tamaki, Masahito Ohishi, Kurumi Sasatomi, Hironori Koga, Michio Sata, Kyuichi Tanikawa., Bafilomycin A1, a specific inhibitor of V type H+-ATPases, inhibits the acidification of endocytic structures and inhibits horseradish peroxidase uptake in isolated rat sinudodal endothelial cells. Liver 17: 244-250, 1997. 4. Ryukichi Kumashiro, Shotaro Sakisaka, Kazunori Noguchi, Kazuya Sato, Yuriko Koga, Nobuhide Kusaba, Shimpei Tanaka, Hironori Koga, Kunihide Ishii, Jun Seo, Michio Sata and Kyuichi Tanikawa., Liver cell death in alcoholic hepatitis. Frontier in Hepatology '97. p. 67-79, 1997. 5. Morimasa Wada, Satoshi Toh, Ken Taniguchi, Takanori Nakamura, Takeshi Uchiumi, Kimitoshi Kohno, Ichiro Yoshida, Akihiko Kimura, Shotaro Sakisaka, Yukihiko Adachi and Michihiko Kuwano., Mutations in the canalicular multispecific organic anion transporter (cMOAT) gene, a novel ABC transporter, in patients with hyperbilirubinemia II / Dubin-Johnson syndrome. Human Molecular Genetics: 7: 203-207, 1998. 6. Shotaro Sakisaka, Masaru Harada, Motonari Kawaguchi, Eitaro taniguchi, and K uichi Tanikawa., Congenital lipidosis. Liver Diseases and Hepatic Sinuosidal Cells. (in press) 1998. 7. S. Sakisaka, H. Koga, K. Sasatomi, Y Mimura, T. Kawaguchi, and K. Tanikawa., Biliary Secretion of Endotoxin and Pathogenesis of Primary Biliary Cirrhosis. Yale J Biol Med 1998 (in press) 8. Kurumi Sasatomi, Kazunori Noguchi, Shotaro Sakisaka, Michio Sata, and Kyuichi Tanikawa. , Abnormal Accumulation of Endotoxin in Biliary Epithelial Cells in Primary Biliary Cirrhosis and Primary Sclerosing Cholangitis. Journal of Hepatology 1998 (in press) 9. Hironori Kola, Shotaro Sakisaka, Masahito Ohishi, and Kyuichi Tanikawa., Nuclear DNA Fragmentation and Expression of Bcl-2 in Primary Biliary Cirrhosis. Hepatology 1997; 25: 1077- 1084. 10. Seiji Noguchi, Michio Sata, Hiroshi Suzuki, Yohsuke Yamakawa, Ken-ichi Ohoba, Masashi Mizokami, Kyuichi Tanikawa., GB virus C (GBV-C)/hepatitis G virus (HGV) infection among intravenous drug users in Japan. Virus Res. 49, 155-62, 1997. 11. Seiji Noguchia, Michio Sata, Hiroshi Suzuki, Kunitaka Fukuizumi, Yohsuke Yamakawa, Mild Shirachi, Tatsunori Nakano, Ken-ichi Ohba, Masashi Mizokami, Kyuichi Tanikawa., GB virus C (GBV-C)/hepatitis G virus (HGV) infection in a hepatitis C virus hyper-endemic area in Japan. Hepatology Research 7, 149-157, 1997. 12. Fuyuhiko Akiyoshi, Michio Sata,Yasuyo Uchimura, Hiroshi Suzuki, Kyuichi Tanikawa. , Hepatic Iron Stainings in Chronic Hepatitis C Patients with Low HCV RNA Levels : as a Predictive Marker for IFN Therapy. Am J gastroenterol 92, 9, 1463-1466, 1997. 13. Fuyuhiko Akiyoshi, Michio Sata, Katsuyuki Ono, Hiroshi Suzuki, Kyuichi Tanikawa. , Epidemiologic study of anti-HCV antibody reactivity with immunoblot assay. Hepatology research 7, 58-65, 1997. 14. Yasuyo Uchimura, Michio Sata, Hiroshi Suzuki, Fuyuhiko Akiyoshi, Kumi Tanaka, Noriyuki Ono, Masayoshi Kage, Masamichi Kojiro, Kyuichi Tanikawa., High prevalence of hepatitis C virus infection in schistosomiasis japonica patients associated with hepatocellular carcinoma. Int J oncol 11, 1103-1107, 1997. 15. Fuyuhiko Akiyoshi, Michio Sata, Hiroshi Suzuki, Yasuyo Uchimura, Keiichi Mitsuyama, Katsuhiko Matsuo and Kyuichi Tanikawa., Serum Vascular Endothelial Growth Factor Levels in Various Liver Diseases. Dig Dis Sci 43, 41-45, 1998. 16. Michio Sata, Seiji Noguchi, Kunitaka Fukuizumi, Hitoshi Nakano, Hiroshi Suzuki, Kyuichi Tanikawa., Sero-epidemiologic study of hepatitis C virus infection in Fukuoka, Japan. J Gastroenterol 1997. 17. Shinichi Tsuzurahara, Michio Sata, U Iwamoto, Shigeki Shichijo, Hiroshi Suzuki, Masamichi Kojiro, Kyuichi Tanikawa, Kyogo Itoh., Detection of MAGE-4 protein in the sera of patients with hepatitis C virus-associated hepatocelular carcinoma and liver cirrhosis. Jpn J Cancer Res 88: 915- 918, 1997. 18. Tatsuya Ide, Michio Sata, Hitoshi Nakano, Hiroshi Suzuki, Kyuichi Tanikawa., Increased serum IgM class anti-lipid A antibody and therapeutic effect of ursodeoxycholic acid in primary biliary cirrhosis. Hepatogastroenterology 44: 1569-1573, 1997. 19. Michio Sata, Hiroshi Suzuki, Ryukichi Kumashiro, Kyuichi Tanikawa., GB virus infection in acute and chronic cryptogenic liver disease. Am J Gastroentero192: 1404-1405, 1997. 20. Kunitaka Fukuizumi, Michio Sata, Eisuke Tanaka, Hiroshi Suzuki, Kyuichi Tanikawa. , Hepatitis C virus seroconversion rate in hyperendemic area of HCV in Japan: a prospective study. Scand J Infect Dis 29: 345-347, 1997. 21. Michio Sata, Tatsuya Ide, M Hashimoto, Hiroshi Suzuki, Kyuichi Tanikawa., Timing of IFN therapy initiation for acute hepatitis C after accidental needlestick. J Hepatol 27: 425-426, 1997. 22. Michio Sata, Tatsuya Ide, Osamu Hashimoto, Hirofumi Fukushima, Norito Matsukuma, Hiroshi Suzuki, Kyuichi Tanikawa., Transmission route and clinical course in sporadic acute hepatitis C. J Viral Hepatitis 4: 273-278, 1997. 23. Tatsuya Ide, Michio Sata, Kunitaka Fukuizumi, Hiroshi Suzuki, Kyuichi Tanikawa. , Characteristics of complete responders to interferon among patients with chronic hepatitis C with high serum levels of HCV RNA. Hepatol Res 7: 19-27, 1997. 24. Yosuke Yamakawa, Michio Sata, Hiroshi Suzuki, Tatsuya Ide, Kyuichi Tanikawa., Monitoring of serum levels of HCV RNA in the early phase of IFN therapy; As a predictive marker of subsequent 25. Hiroshi Suzuki, Michio Sata, Masaru Sasaki, Eisuke Tanaka, Yohsuke Yamakawa, K uichi Tanikawa., Clinical usefulness of serum HBV DNA measurement with a non radioactive chemiluminescence method. Int Hepatol Commun 6: 324-331, 1997. 26. Seiji Noguchi, Michio Sata, Hiroshi Suzuki, Masashi Mizokami and Kyuichi Tanikawa., Routes of hepatitis C virus infection in an endemic rural area of Japan-Molecular epidemiological study of hepatitis C virus infection. Scand J Infect Dis 29: 23-28, 1997. 27. Seiji No~uchi, Michio Sata, Hiroshi Suzuki, Kenichi Ohoba, Masashi Mizokami, Kyuichi Tanikawa., Early interferon treatment of acute hepatitis C aquired by needle stick. Clin Infect Dis 24: 992-994, 1997. 28. Eisuke Tanaka, Michio Sata, Hitoshi Nakano, Hiroshi Suzuki, Kyuichi Tanikawa., Antibody response to inactivated hepatitis A vaccine. Hepatol Res 9: 103-112, 1998. 29. Masaru Sasaki, Michio Sata, Masatoshi Ishibashi, Naohisa Uchimura, Kyuichi Tanikawa. , Decreased regional cerebral blood flow during interferon therapy. Hepatol Res 9: 1-8, 1998. 30. Kunitaka Fukuizumi, Michio Sata, Hiroshi Suzuki, Ryukichi Kumashiro, Kyuichi Tanikawa., Natural disappearance of serum HCV RNA: prospective study in hyperendemic area. Hepatol Res 9: 144-151, 1998. 31. Michio Sata, Seiji Noguchi, Tatsuya Ide, Hiroshi Suzuki, Ryukichi Kumashiro, Yumiko Nagao, Masayoshi Kage, Hideki Saitsu, Toshihio Kurohiji, Kyuichi Tanikawa., Lack of detection of hepatitis C virus replicative intermediate in abdominal lymph nodes. Hepatol Res 10: 66-73, 1998. 32. Ichiro Miyajima, Michio Sata, Ryukichi Kumashiro, Yasuyo Uchimura, Tatsuya Ide, Hiroshi Suzuki and Kyuichi Tanikawa., The incidence of hepatocellular carcinoma in patients with chronic hepatitis C after interferon treatment. Oncol Rep 5: 201-204, 1998. 33. Kumi Tanaka, Michio Sata, Yasuyo Uchimura, Hiroshi Suzuki and Kyuichi Tanikawa., Long- term evaluation of interferon therapy in hepatitis C virus-associated cirrhosis: Does IFN prevent development of hepatocellular carcinoma ? Oncol Rep 5: 205-208, 1997. 34. Mild Shirachi, Michio Sata, Ichiro Miyajima, Masatoshi Tanaka and Kyuichi Tanikawa., Liver- associated natural killer activity in cirrhotic rats. Microbiol Immunol 42: 117-124, 1998. 35. Shigeru Tokeshi, Michio Sata, Hiroshi Suzuki, Kyuichi Tanikawa., Secretory IgA anti-HAV in bile of hepatitis A patients. Hepatol Res 10: 167-174, 1998. 36. Hiroshi Setoyama, Michio Sata, Hiroshi Suzuki and Kyuichi Tanikawa., Secretory IgA anti- HAV in saliva of hepatitis A patients. Hepatol Res in press, 1998. 37. Motoaki Kin, Michio Sata, Takato Ueno, Takuji Torimura, Kyuichi Tanikawa, et.al., Basic fibroblast growth factor regulates proliferation and motility of human hepatoma cells by an autocrine mechanism. J Hepatol 1997; 27:677-687. 38. Takuji Torimura, Takato Ueno, Motoaki Kin, Michio Sata, Kyuichi Tanikawa, et.al., Coordinated expression of integrin a 6 ~ 1 and laminin in hepatocellular carcinoma. Hum Pathol 1997; 28:1131-1138. 39. Takuji Torimura, Takato Ueno, Motoaki Kin, Michio Sata, Kyuichi Tanikawa, et al., Increased expression of vascular endothelial growth factor is associated with tumor development in hepatocellular carcinoma. Hum Pathol 1998, in press. 40. Takuji Torimura, Takato Ueno, Motoaki Kin, Michio Sata, Kyuichi Tanikawa, et al., VEGF participates in neovascularization and sinusoidal capillarization in HCC. Liver Diseases and Hepatic Sinusoidal Cells 1998, in press. 41. Tsutomu Nishiyama, Keiichi Mitsuyama, Shotaro Sakisaka, et al., Role of interleukin-10 in experimental colitis. Progress in Medicine. 1998, in press. 42. Hideo Tateishi, Keiichi Mitsuyama, Atsushi Toyonaga, Michiko Tomoyose and Kyuichi Tanikawa., Role of cytokines in experimental colitis: relation to intestinal permeability. Digestion 58: 271-281, 1997. 43. Tomohisa Saiki, Keiichi Mitsuyama, Atsushi Toyonaga, Hiroshi Ishida and Kyuichi Tanikawa. , Detection of pro- and anti-inflammatory cytokines in stools of patients with inflammatory bowel disease. Scand J Gastroenterol, 1998, in press. 44. Shinichi Kuboyama, Keiichi Mitsuyama, et. al., Increased circulating levels of interleukin-1 receptor antagonist in patients with inflammatory bowel disease. Kurume Med J, 1998, in press. 45. Akira Shirachi, Keiichi Mitsuyama, et. al., Therapeutic implications of interleukin-10 in inflammatory bowel disease. Kurume Med J, 1998, in press. 46. Satoe Shigematsu, Keiichi Mitsuyama, et. al., Therapeutic potential of interleukin-1 receptor antagonist in inflammatory boweldisease. Kurume Med J, 1998, in press. 47. Michiko Ide, Keiichi Mitsuyama, et. al., Role of Interleukin 10 in a Murine model of Dextran Sulfate Sodiume-Induced Colitis. Scand J Gastroenterol, 1998, in press. 1997 細胞発生工学 Publications in Division of Cellular and Developmental Biology in 1997-1998 1. S. Tohno, Y. Tohno, T. Minami, Y. Okazaki, M. Utsumi, F. Nishiwaki, Y. Moriwake, M.O.,Yamada, and G. Yamada. Differential accumulation of calcium and phosphorus in aged human arteries Acta. Anat. Nippon,72, 451-454, 1997 2. C. C. Zhul, G.YamadallS. Nakamura, T. Terashi,A. Schweickert andM. Blum. Malformation of trachea, pelvic region and external genitalia in goosecoid mutant mice.Both authors contributed equally to this work;l Dev. Dynamics in press, 1997 3. G. Yamada, S. Nakamura, R. Haraguchi, M. Sakai, K. Suzuki, K. Miyado,H. Hasuwa, Y. Ogino,T. Minami, Y. Tohno, M. Blum and L. D. Shultz. Aberrant regulation of bone trace elements in motheaten and Osteopetrosis mutant mice. Cell. Mol. Biol. in press, 1997 4. G.Yamada. K. Ueno, S. Nakamura, Y. Eizuru, Y. Hanamure, A.Mansouri,K. Yasui, M. Uemura, M.Blum and K. Sugimura. Nasal and pharyngeal abnormalities caused by the mouse Goosecoid gene mutation. BBRC 233, 161-165, 1997 5. M-O.Yamada, T.Minami, G.Yamada, Y.Tohno, S.Tohno, Y. Ikeda, T.Tashiro, Y.Kohno and K. Kawakami. Different element ratios of red cosmetics excavated from ancient burials of Japan. The Science of the Total Environment 199, 293-298, 1997 6. G. Yamada, S. Nakamura, T. Terashi, K. Terai, S. Nomura, Y. Kitamura, T.Minami, M-O Yamada, S. Suzuki, H. Izumi and R. Nagata. Microphthalmia (mi) Mice Display an Aberrant Bone Trace Element Composition. Biol. Trace. Ele. Res. in press, 1997 7. C. Zhu, G. Yamada, and M. Blum. Correlation between loss of middle ear bones and altered goosecoid gene expression in the branchial region following retinoic acid treatment of mouse embryos in vivo BBRC 235, 748-753, 1997 8. K.Fujimori, G.Yamada, M.O.,Yamada, T.Minami, S.Tohnoand Y. Tohno. A periodical change of mercury in the coral reef, Heliofungia species obtained from the Okinawa sea. Cell. Mol. Biol., 43, 809-811, 1997 9. G. Yamada, S. Nakamura, R. Haraguchi, M. Sakai, T. Terashi, S. Sakisaka, T. Toyoda, Y. Ogino, H.Hatanaka and Y. Kaneda. An efficient liposome-mediated gene trasnsfer into the branchial arch, neural tube and the heart of chick embryos; A strategy to elucidate the organogenesis. Cell. Mol. Biol., 43 (8), 1165-1169, 1998 1998 がんワクチン分子 1. Hoshino, T., Ohta, A., Yang, D., Kawamoto, M., Kikuchi, M., Inoue, Y., Kamizono, S., Ota, T., Itoh, K., and Oizumi, K. Elevated serum interleukin 6, interferon-?, and tumor necrosis factor-a levels in patients with adult Still's disease. J. Rheumatol., 25: 396-398, 1998. 2. Suekane, S., Nakao, M., Inoue, M., Noda, S., and Itoh, K. Histocompatibility leukocyte antigen-A2-restricted and tumor-specific cytotoxic T lymphocytes from tumor-infiltrating lymphocytes of patient with testicular embryonal cancer. Jpn. J. Cancer Res., 88: 1181-1189, 1998. 3. Shichijo, S., Nakao, M., Imai, Y., Takasu, H., Kawamoto, M., Niiya, F., Yang, D., Toh, Y., Yamana, H., and Itoh, K. A gene encoding antigenic peptides of human squamous cell carcinoma recognized by cytotoxic T lymphocytes. J. Exp. Med., 187: 277-288, 1998. 4. Eton, O., Kharkevitch, D. D., Gianan, M. A., Ross, M. I., Itoh, K., Pride, M. W., Donawho, C., Buzaid, A. C., Mansfield, P. F., Lee, J. E., Legha, S. S., Plager, C., Papadopoulos, N. E., Bedikian, A. Y., Benjamin, R. S., and Balch, C. M. Active immunotherapy with ultraviolet B-irradiated autologous whole melanoma cells plus DETOXTM in patients with metastatic melanoma. Clin. Cancer Res., 4: 619-627, 1998. 5. Higuchi, T., Seki, N., Kamizono, S., Yamada, A., Kimura, A., Kato, H., and Itoh, K. Polymorphism of the 5'-flanking region of the human tumor necrosis factor (TNF)-a gene in Japanese. Tissue Antigens, 51: 605-612, 1998. 6. Takaki, T., Hiraki, A., Uenaka, A., Gomi, S., Itoh, K., Udono, H., Shibuya, A., Tsuji, T., Sekiguchi, S., and Nakayama, E. Variable expression on lung cancer cell lines of HLA-A2-binding MAGE-3 peptide recognized by cytotoxic T lymphocytes. Int. J. Oncol., 12: 1103-1109, 1998. 7. Gotoh, M., Shichijo, S., Hoshino, T., Imai, Y., Imaizumi, T., Inoue, Y., Takasu, H., Yamaoka, T., and Itoh, K. Sequence analysis of genes encoding rodent homologues of the human tumor-rejection antigen SART-1. Jpn. J. Cancer Res., 89: 849-854, 1998. 8. Matsumoto, H., Shichijo, S., Kawano, K., Nishida, T., Sakamoto, M., and Itoh, K. Expression of the SART-1 antigens in uterine cancers. Jpn. J. Cancer Res., 89: 1292-1295, 1998. 9. Sakaguchi, M., Sugita, S., Sagawa, K., Itoh, K., and Mochizuki, M. Cytokine production by T cells infiltrating in the eye of uveitis patients. Jpn. J. Ophthalmol., 42: 262-268, 1998. 10. Tanaka, K., Yamada, A., Noda, K., Hasegawa, T., Okuda, M., Shoyama, Y., and Nomoto, K. A novel glycoprotein obtained from Chlorella vulgaris strain CK22 shows antimetastatic immunopotentiation. Cancer Immunol. Immunotherapy, 45: 313-320, 1998. 11. A. Yamada, K. Kubo, T. Takeshita, N. Harashima, K. Kawano, T. Mine, K. Sagawa, K. Sugamura, and K. Itoh.　　Molecular cloning of a　glycosylphosphatidylinositol-anchored molecule CDw108.　　J. Immunol. 162:4094-4100, 1999. 12. T. Hasegawa, K. Ito, S. Ueno, S. Kumamoto, Y. Ando, A. Yamada, K. Nomoto, and Y. Yoshikai.　　Oral administration of hot water extracts of Chlorella vulgaris reduces IgE production against milk casein in mice.　　Int. J. Immunopharmcol., in press, 1999. 13. K. Kamizono, A. Yamada, T. Higuchi, H. Kato, and K. Itoh. Analysis of TNF-a production and polymorphisms of TNF- a gene in individuals previously affected with Kawasaki disease.　　Acta Paediatr. Japon, in press, 1999. 14. A. Yamada, K. Kawano, N. Harashima, F. Niiya, K. Nagai, T. Kobayashi, K. Ushijima, T. Nishida, and K. Itoh. 　Study of HLA-class I-restriction and directed antigens of cytotoxic T lymphocytes at the tumor sites of ovarian cancer. Cancer Immunol. Immunotherapy, in press, 1999. 1998 肝癌研究 Publications in 1998 1. Michio Sata, Seiji Noguchi, Tatsuya Ide, Hiroshi Suzuki, Ryukichi Kumashiro, Yumiko Nagao, Masayoshi Kage, Hideki Saitsu, Toshihiko Kurohiji, Kyuichi Tanikawa. Lack of detection of hepatitis C virus replicative intermediate in abdominal lymph nodes. Hepatology Research Vol. 10. p. 66-73, 1998. 2. Michio Sata, Hitoshi Nakano, Hiroshi Suzuki, Semi No uchi, Yohsuke Yamakawa, Eisuke Tanaka, Kunitaka Fukuizumi, Kumi Tanaka, Hiroshi Yoshida, and Kyuichi Tanikawa. Sero-epidemiologic study of hepatitis C virus infection in Fukin Fukuoka, Japan. Journal of Gastroenteorology Vol. 33. p. 218-222, 1998. 3. Michio Sata, Tatsuya Ide, Seiji No~hi, Hiroshi Suzuki, Yumiko Nagao and Kyuichi Tanikawa. Negative- strand HCV RNA was not detected in bone marrow cells of patients with HCV infection. The Kurume Medical Journl Vol. 45. p. 39-43, 1998. 4. Osamu Tsuruta, Atsushi Toyonaga, Hiroshi Kawano, Mitsutake Fujita, Yuichiro Tsuji, Kazuhiro Fujisaki, Hideo Ikeda, Michio Sata. Endoscopic ultrasonography staging of superficial-type colorectal neoplasms for mucosectomy. Endoscopy Vol. 30. p. A92-93, 1998. 5. Yohsuke Yamakawa, Michio Sata, Hiroshi Suzuki, Kumi Tanaka, Eisuke Tanaka, Semi No~uchi, Katsuyuki Ono, Kyuichi Tanikawa. Monitoring of serum levels of HCV RNA in early phase of IFN therapy; as a predictive marker of subsequent response. Hepato-Gastroenterology Vol. 45. p. 133- 136, 1998. 6. Hiroshi Setoyama, Michio Sata, Hiroshi Suzuki and Kyuichi Tanikawa. Secretory IgA anti-HAV in saliva of hepatitis A patients. Hepatology Research Vol. ll. p.12-18, 1998. 7. Akihiko Kimura, Mikako Suzuki, Tsuyoshi Murai, Takao Kurosawa, Masahiko Tohma, Michio Sata, Toshiro moue, Atsuo Hoshiyama, Eisuke Nakashima, Yasuhiro Yamashita, Takuji Fujisawa and Hirohisa Kato. Urinary 7 a -hydroxy-3-oxochol-4 en-24-oic and 3-oxochola-4, 6-then-24-oic acids in infants with cholestasis. Journal of Hepatology Vol. 27. p.270-279, 1998. 8. Fuyuhiko Akiyoshi, Michio Sata, Hiroshi Suzuki, Yasuyo Uchimura, Keiichi Mitsuyama, Katsuhiko Matsuo, and Kyuichi Tanikawa. Serum vascular endothelial growth factor levels in various liver diseases. Digestive Diseases and Sciences. Vol. 43. p. 41-45, 1998. 9. Shigeru Tokeshi, Michio Sata, Hiroshi Suzuki, Kyuichi Tanikawa. Secretory IgA anti-HAV in bile of hepatitis A patients. Hepatology Research Vol. 10. p.167-174, 1998. 10. Miki Shirachi, Michio Sata, Ichiro Miyajima, Masatoshi Tanaka and Kyuichi Tanikawa. Liver- associated natural killer activity in cirrhotic rats. Microbiology and Immunology. Vol. 42. p. 117- 124, 1998. 11. Ichiro Miyajima, Michio Sata, Ryukichi Kumashiro, Yasuyo Uchimura, Tatsuya Ide, Hiroshi Suzuki and Kyuichi Tanikawa. The incidence of hepatocellular carcinoma in patients with chronic hepatitis C after interferon treatment. Oncology Reports Vol. 5. p. 201-204, 1998. 12. Kumi Tanaka, Michio Sata, Yasuyo Uchimura, Hiroshi Suzuki and Kyuichi Tanikawa. Long- term evaluation of interferon therapy in hepatitis C virus-associated cirrhosis: Does IFN prevent development of hepatocellular carcinoma ? Oncology Reports Vol. 5. p. 205-208, 1998. 13. Hideaki Tsuda, Michio Sata, Tsutomu Kumabe, Hiroshi Hara, Naofumi Eriguchi, Yasuo Sugita and Hiroaki Nagamatsu. Quick response of advanced cancer to chemoradiation therapy with antineoplastons. Oncology Reports Vol. 5. p. 597-600, 1998. 14. Tsutomu Kumabe, Hideaki Tsuda, Masafumi Uchida, Yoshio Ogoh, Naofumi Hayabuchi, Michio Sata, Osamu Nakashima, and Hiroshi Hara. Antineoplaston treatment for advanced hepatocellular carcinoma. Oncology Reports Vol. 5. p. 1363-1367, 1998. 15. Yumiko Nagao, Tadamitsu Kameyama, Michio Sata. Hepatitis C virus RNA detection in oral lichen planus tissue. The American Journal of Gastroenterology Vol. 93. p. 850, 1998. 16. Miki Shirachi, Michio Sata, Hiroshi Suzuki, Kunitaka Fukuizumi, Yuji Itoh, Takaaki Mizumoto, Shigenobu Kondoh, Michiko Kasahara, Sachiko Manabe, and Kyuichi Tanikawa. Evaluation of third generation anti-HCV test kit (SynpepTM HCV-EIA II) using sera of inhabitants from HCV hyperendemic area. The Kurume Medical Journal Vol. 45 p. 81-85, 1998. 17. Hiroshi Suzuki, Michio Sata, Masaru Sasaki, Shiro Murashima, Fuyuhiko Akiyoshi, Seiii No uchi, and Kyuichi Tanikawa. Mutations of glucocorticoid responsive element of HBV DNA. The Kurume Medical Journal Vol. 45 p. 171-174, 1998. 18. Masaru Sasaki, Michio Sata, Hiroshi Suzuki and Kyuichi Tanikawa. A case of chronic hepatitis C with sinus bradycardia during IFN therapy. The Kurume Medical Journal Vol. 45 p. 161-163, 1998. 19. Kurumi Sasatomi, Kazunori Noguchi, Shotaro Sakisaka, Michio Sata and Kyuichi Tanikawa. Abnormal accumulation of endotoxin in biliary epithelial cells in primary biliary cirrhosis and primary sclerosing cholangitis. Journal of Hepatology Vol. 29. p. 409-416, 1998. 20. Yuriko Koga, Riko Ogata, Shotaro Sakisaka, Akiko Sakamoto, Ryoko Kuromatsu, Yasuyo Uchimura, Kunihide Ishii, Ryukichi Kumashiro, Michio Sata. A case of erythropoietic protoporphyria (EPP) with liver failure. Porphyrins Vol. 7 p. 279-284, 1998. 21. Kodo Sujaku, Takato Ueno, Takuii Torimura, Michio Sata, Kyuichi Tanikawa. Effects of OK- 432 on matrix metalloproteinase-9 expression and activity in rat cultured Kupffer cells. Hepatology Research Vol. 10. p. 91-100, 1998. 22. Osamu Hashimoto, Takato Ueno, Michio Sata, Yasuyo Uchimura and Kyuichi Tanikawa. Long- tcrm improvement of hepatic fibrosis in chronic hepatitis C treated with interferon- a . Hepatology Rcsearch Vol. 10 p. 200-216, 1998. 23. Takato Ueno, Osamu Hashimoto, Hiroshi Sugawara, Riko Ogata, Nobuhide Kusaba, Takuji Torimura, Michio Sata and Kyuichi Tanikawa. Serum carboxy-terminal cross-linked telopeptide of type I collagen reflects bone metastasis in hepatocellular carcinoma. International Journal of Oncology Vol. 13 p. 297-303, 1998. 24. Hiroshi Sugawara, Takato Ueno, Takuji Torimura, Sadataka Inuzuka, and Kyuichi Tanikawa. Inhibitory effect of OPC-15161, a component of fungus thielavia minor, on proliferation and extracellular matrix production of rat cultured hepatic stellate cells. Journal of Cellular Physiology Vol. 174. p. 398-406, 1998. 25. Fumihiko Yamashita, Masatoshi Tanaka, Kazuta Fukumori, Eiji Ando, Yoichi Yano, Osamu Kato, Hiroshi Yamamoto, Hitoshi Fukuda, Taku Kusaba, Kyuichi Tanikawa. A crossover study of oral administration of UFT in chronic liver disease: Comparison of continuous and intermittent schedules. Anti-Cancer Drugs Vol. 9. p. 399-404, 1998. 26. Kazuya Sato, Masatoshi Tanaka, Taku Kusaba, Hitoshi Fukuda, and Kyuichi Tanikawa. Immunohistochemical demonstration of a -fetoprotein in small hepatocellular carcinoma. Oncology Reports Vol. 5. p. 355-358, 1998. 27. Keiichi Mitsuyama, Tomohisa Saiki, Osamu Kanauchi, T. Iwanaga, Nobuo Tomiyasu, Tsutomu Nishiyama, Hideo Tateishi, Akira Shirachi, Michiko Ide, Asuka Suzuki, Kazunori Noguchi, Hideo Ikeda, Atsushi Toyonaga & Michio Sata. Treatment of ulcerative colitis with germinated barley foodstuff feeding: a pilot study. Alimentary Pharmacology and Therapeutics Vol. 12. p. 1225-1230, 1998. 28. Keiichi Mitsuyama, Atsushi Toyonaga, Kazuhiro Fujisaki, Kyuichi Tanikawa, Katsuhiko Matsuo. Cancer marker: Vascular endothelial growth factor. Digestive Diseases and Sciences p. 1695-1696, 1998. 29. Osamu Kanauchi, Keiichi Mitsuyama, Tomohisa Saiki, Tohru Fushikia and Toshihiko Iwanaga. Germinated barley foodstuff increases fecal volume and butyrate production in humans. International Journal of Molecular Medicine Vol. 1. p. 937-941, 1998. 30. Osamu Kanauchi, Keiichi Mitsuyama, Tomohisa Saiki, Kazue Agata, Tomohiko Nakamura and Toshihiko Iwanaga. Preventive effects of germinated barley foodstuff on methotrexate-induced enteritis in rats. International Journal of Molecular Medicine Vol. l. p. 961-966, 1998. 31. Osamu Kanauchi, Tomohiko Nakamura, Kazue Agata, Keiichi Mitsu,~, and Toshihiko Iwanaga. Effect of germinated barley foodstuff on dextran sulfate sodium-induced colitis in rats. Journal of Gastroenterology Vol. 33. p. 179-188, 1998. 32. Michiko Tomoyose, Keiichi Mitsuyama, Hiroshi Ishida, Atsushi Toyonaga, Kyuichi Tanikawa. Role of interleukin 10 in a murine model of dextran sulfate sodium-induced colitis. Scandinavian Journal of Gastroenterology Vol. 33. p. 435-440, 1998. 33. Tomohisa Saiki, Keiichi Mitsuyama, Atsushi Toyonaga, Hiroshi Ishida, Kyuichi Tanikawa. Detection of pro-and anti-inflammatory cytokines in stools or patients with inflammatory bowel disease. Scandinavian Journal of Gastroenterology Vol. 33. p. 616-622, 1998. 34. Kazuhiro Fujisaki, Keiichi Mitsuyama; Atsushi Toyonaga, Katsuhiko Matsuo, and Kyuichi Tanikawa. Circulating vascular endothelial growth factor in patients with colorectal cancer. The American Journal of Gastroenterology Vol. 93. p. 249-252, 1998. 35. Taku,~i Torimura, Michio Sata, Takato Ueno, Motoaki Kin, Riko Tsuji, Kodo Sujaku, Osamu Hashimoto, Hiroshi Sugawara, Kyuichi Tanikawa. Increased expression of vascular endothelial growth factor is associated with tumor progression in hepatocellular carcinoma. Human Pathology Vol. 29. p. 986-991, 1998. 36. Tatsunori Nakano, Masashi Mizokami, Kun Cao, Seiji No~uchi, Michio Sata, Young-Min Park, Boo-Sung Kim, Tsendsuren Oyunsuren, Leila Beltrao Pereira, Ruslan Ruzibakiev, Vladimir Gurtsevitch, and Masanori Hayami. Lack of anti-GOR antibody among subjects with GBV C / HGV RNA. Journal of Medical Virology Vol. 55. p. 129-133, 1998. 37. Haruo Muraoka, Shigeru Tokeshi, Hirohiko Abe, Yoichi Miyahara, Yasuyo Uchimura, Seiii No uchi, Michio Sata and Kyuichi Tanikawa. Two cases of adult varicella accompanied by hepatic dysfunction. The Journal of the Japanese Association for Infectious Diseases Vol. 72. p. 418-423, 1998. 38. Masaru Harada, Keiichi Mitsu,~ ama, Hiroshi Yoshida, Shotaro Sakisaka, Eitaro Tani uchi, Takumi Kawaguchi, Mamoru Ariyoshi, Tomohisa Saiki, Masaharu Sakamoto, Kensei Nagata, Michio Sata, Katsuhiko Matsuo and Kyuichi Tanikawa. Vascular endothelial growth factor in patients with rheumatoid arthritis. Scandinavian Journal of Rheumatology Vol. 27. p. 377-380, 1998. 39. Masaru Harada, Hiroshi Yoshida, Keiichi Mitsuyama, Masaharu Sakamoto, Hirovuki Kola, Katsuhiko Matsuo, Yasuo Teshima, Eiko Ikeda, Shotaro Sakisaka, Michio Sata, Kyuichi Tanikawa. Aortitis syndrome (Takayasu's arteritis) with cataract and elevated serum level of vascular endothelial growth factor. Scandinavian Journal of Rheumatology Vol. 27. p. 78-79, 1998. 40. Mina Komuta, Masaru Harada, Takato Ueno, Yasuyo Uchimura, Chizuko Inada, Keiichi Mitsuyama, Shotaro Sakisaka, Michio Sata and Kyuichi Tanikawa. Unusual accumulation of glycogen in liver parenchymal cells in a patient with anorexia nervosa. Internal Medicine Vol. 37. p. 678-682, 1998. 41. Nobuhide Kusaba, Ryukichi Kumashiro, Hideaki Ogata, Michio Sata and Kyuichi Tanikawa. In vitro study of neutrophil apoptosis in liver cirrhosis. Internal Medicine Vol. 37. p. 11-17, 1998. 42. Nobuo Tomiyasu, Keiichi Mitsuyama, Atsushi Toyonaga, Katsuhiko Matsuo, Kyuichi Tanikawa. Vascular permeability factor in ascites from patients with spontaneous bacterial peritonitis. Hepatology Research Vol. 10. p. 185-192, 1998. 43. Osamu Tsuruta, Hiroshi Kawano, Mitsutake Fujita, Yuichiroh Tsuji, Shiroh Miyazaki, Kazahiro Fujisaki, Masahide Watanabe, Keita Nakahara, Hideo Tateishi, Shigeki Ban, Hideo Ikeda, Michio Sata, Atsushi Toyonaga. Usefulness of the high-frequency ultrasound probe in pretherapeutic staging of superficial-type colorectal tumors. Intermational Journal of Oncology Vol. 13. p. 677-684, 1998. 44. Hitoshi Fukuda. Tumor vascularity and lens culinaris agglutinin reactive a -fetoprotein are predictors of long-term prognosis in patients with hepatocellular carcinoma after percutaneous ethanol injection therapy. The Kurume Medical Journal Vol. 45. p. 187-193, 1998. 45. Taku Kusaba. Relationship between lens culinaris agglutinin reactive a -fetoprotein and biological features of hepatocellular carcinoma. The Kurume Medical Journal Vol. 45. p. 113-120, 1998. 1998 細胞発生工学 References (Publications in 1998 are ref. 10-13): 1. Chen, S-H., Cen, X. H. L., Wang, Y., Kosai, K., Finegold, M. J., Rich, S., and Woo, S. L. Combination gene therapy for liver metastases of colon carcinoma in vivo. Proc. Natl. Acad. Sci. USA. (1995) 92, 2477-2581. 2. Caruso. ~1.. Pham-Nguyen, K., Kwong, Y-L., Xu, B., Kosai, K., Finegold, M. J., Woo S. L. and Chen S-H. Adenovirus-mediated gene therapy with interleukin- 12 for metastatic colon carcinoma. Proc. Natl. Acad. Sci. USA. (1996) 93, 11302-11306. 3. Chen, S-H., Kosai, K., Xu, B., Pham-Nguyen, K., Contant, C., Finegold M. J. and Woo, S. L. Combination suicide and cytokine gene therapy for hepatic metastases of colon carcinoma: Sustained antitumor immunity prolongs animal survival. Cancer Res. (1996) 56, 3758-3762. 4. Bonnekoh, B., Greenhalgh, D. A., Bundman, D. S., Kosai, K., Chen, S-H., Finegold, M. J. Krieg, T., Woo, S. L. and Roop D. R. Adenoviral-mediated transfer of HSV Thymidine kinase gene in vivo as treatment for experimental human melanoma. J. Invest. Dermatol. (1996) 106, 1163-1168. 5. Huang, H., Chen, S-H., Kosai, K., Finegold, M. J. and Woo, S. L. Gene therapy for hepatocellular carcinoma; long-term remission of primary and metastatic tumors in mice by interleukin-2 gene therapy in vivo. Gene Ther. (1996) 3, 980-987. 6. Kwong, Y-L., Chen, S-H., Kosai, K., Finegold, M. J. and Woo, S. L. Adenoviral mediated suicide gene therapy for hepatic metastases of breast cancer. Cancer Gene Ther. (1996) 3, 339-344. 7. O'Malley, B. W. Jr., Sewell, D. A., Li, D., Kosai, K., Chen, S-H., Woo, S. L., Duan, L. The role of interleukin-2 in combination adenovirus gene therapy for head and neck cancer. Mol. Endocrinol. (1997) 11, 667-673. 8. Block, A. Chen, S-H., Kosai, K., Finegold M. J. and Woo S. L. Adenoviral- mediated herpes simplex virus thymidine kinase gene transfer: Regression of hepatic metastasis of pancreatic tumors. Pancreas. (1997) 15, 25-34. 9. Kwong Y.L., Chen, S-H., Kosai, K., Finegold, M. J. and Woo S. L. Combination therapy ?kith suicide and cytokine genes for hepatic metastases of lung cancer. Chest. (1997) 112, 1332-1337. 10. Kosai. K.. Huynh, B. B-T., Finegold, M. J., Bowles, N., Woo, S. L., Schwall, R. and Darlington. G. J. Retrovirus-mediated in vivo gene transfer in the replicating liver u~in~~ recombinant hepatocyte growth factor without liver injury or partial hepatectom~-. Hr~man Gene Ther. (1998) 9, 1293-1301. 11.Timchenko, N.A.,. Wilde, M., Kosai, K., Heydari, A., Bilyeu, T. A., Finegold, M. J.. Mohamedali. K., Richardson, A. and Darlington, G. J. Regenerating livers of old rats contain high levels of C/EBP alpha that correlate with altered expression of cell cycle associated proteins. Nucleic Acids Res. (1998) 26, 3293-3299. 12. Kosai. h.. Matsumoto, K., Nagata, S., Tsujimoto, Y., and Nakamura, T. Abrogation of Fas-induced lethal liver apoptosis in mice by hepatocyte growth factor-. Riocltent. Bioph. Res. Com. (1998) 244, 683-690. 13. Kosai. h.. Matsumoto, K., Funakoshi, H. and Nakamura, T.. Hepatocyte growth factor inhibits endotoxin-induced lethal hepatic failure in mice. (1999) Hepatology in press 1999 がんワクチン分子 Selected Publications in 1999-2000 1) Yang, D., Nakao, M., Shichijo, S., Sasatomi, T., Takasu, H., Matsumoto, H., Mori, K., Hayashi, A., Yamana, H., Shirouzu, K., and Itoh, K. A new gene coding for a protein possessing shared tumor epitopes capable of inducing cytotoxic T lymphocytes in cancer patients. Cancer Research, 59: 4056-4063, 1999. 2) Gomi, S., Nakao, M., Niiya, F., Imamura, Y, Kawano, K., Nishizaka, S., Hayashi, A., Sobao, Y, Oizumi, K., and Itoh, K., A cyclophilin B gene encodes antigenic peptides recognized by HLA-A24-restricted and tumor-specific CTLs. J. Immunol., 163: 4994-5004, 1999. 3) Yamada, A., Kubo, K., Takeshita, T., Harashima, N., Kawano, K., Sagawa, K., Sugamura, K., Itoh, K. Molecular cloning of a glycosylphosphatidylinositol- anchored molecule CDw 108. J. Immunology, 1 S2: 4094-4100, 1999. 4) Kawamoto, M., Shichijo, S., Imai, Y, Imaizumi, T., Koga, T. Yanaga, H., Itoh, K. Expression of the SART 1 tumor-rejection antigen in breast cancer. Int. J. Cancer, 80: 64-67, 1999. 5) Kikuchi, M., Nakao, M., moue, Y, Matsunaga, K., Shichijo, S., Yamana, H., Itoh, K., Identification of a SART 1-derived peptide capable of inducing the HLA- A24-restricted and tumor-specific cytotoxic T lymphocytes. Int. J. Cancer, 81: 459- 466, 1999. 6) Yang, D., Hiromatsu, Y, Hoshino, T., moue, Y, Itoh, K., Nonaka, K. Dominant infiltration of Th 1-type CD 4+ T cells at the retroorbital space of patients with thyroid-associated opthalmopathy. THYRIOD 9: 305-310, 1999. 7) Oiso, M., Eura, M., Takiguchi, M., Sobao, Y, Masuyama, K., Nakashima, M., Itoh, K., and Ishikawa, T. A newly identified MAGE-3-derived epitope recognized by HLA-A24 restricted cytotoxic T lymphocytes. Int. J. Cancer. 81: 387-394, 1999. 8) Yamada, A., Kawano, K., Harashima, N., Niiya, F., Nagai, K., Kobayashi, T., Ushijima, K., Nishida, T., and Itoh, K. Study of HLA-class I-restriction and directed antigens of cytotoxic T lymphocytes at the tumor sites of ovarian cancer. Can. Immunol. Immunotherapy, 48:147-152, 1999. 9) Seki, N., Kamizono, S., Yamada, A., Higuchi, T., Matsumoto, H., Niiya, F., Kimura, A., Tsuchiya, K., Suzuki, R., Date, Y, Tomita, T., Itoh, K., and Ochi, T. Polymorphisms in the 5'-flanking region of tumor,necrosis factor-a gene in patients with rheumatiod arthritis. Tissue Antigens, 54: 194-197 1999. 10) Seki, N., Yamaguchi, K., Yamada, A., Kamizono, S., Sugita, S., Taguchi, C., Matsuoka, H., Matsumoto, H., Nishizaka, S., Itoh, K., and Mochizuki, M. Polymorphism in the 5'-flanking region of tumor necrosis factor-a gene and susceptibility to human T cell lymphotropic virus type I (HTLU I) uveitis. J. Infect. Dis., 180:880-883, 1999. 11) Kamizono, S., Yamada, A., Higuchi, T., Kato, H., and Itoh, K. Analysis of tumor- necrosis factor-a production and polymorphisms of the tumor necrosis factor- a gene in individuals with a history of Kawasaki disease. Pediatrics International., 41: 341- 345, 1999. 12) Matsunaga, K., Nakao, M., Masuoka, K., moue, Y , Gouhara, R., Imaizumi, T., Nishizaka, S., and Itoh, K., Cytokines required for induction of histocompatibility I~ukocyte antigen-class I-restricted and tumor-specific cytotoxic T lymphocytes by a .a RT 1-derived peptide. JJCR, 90:1007-1015, 1999. liilaizumi, T., Kuramoto, T., Matsunaga, M., Shichijo, S., Yutani, S., Oizumi, K., ,end Itoh, K., Expression of the tumor-rejection antigen SART1 in brain tumors. Int. i. Cancer, 83: 760-764, 1999. = Date, Y, Seki, N., Kamizono, S., Higuchi, T., Hirata, T., Miyata, K., Ohkuni, Vii.. Tatsuzawa, O., Yokota, S., Joo, K., Ueda, K., Sasazuki, T., Kimura, A., Itch. K., and Kato, H., Identification of a genetic risk factor for systemic juvenile rt~eumatiod arthritis in the 5'-flanking region of the TNF- a gene and HLA genes. ~i-thritis & Rhematism., 42:2577-2582, 1999. ~Ilichijo, S., Nakao M., Imai, Y, Takasu, H., Hayashi, A., Toh, U., Yamana, H., Itoh. K. A gene encoding squamous cell carcinoma antigens recognized by ~-totoxic T lymphocyte. Gann Monograph on Cancer Research, 48:43-5 l , 1999. T. Hasegawa, K. Ito, S. Ueno, S. Kumamoto, Y Ando, A. Yamada, K. Nomoto, and Y Yoshikai. Oral administration of hot water extracts of Chlorella vulgaris reduces IgE production against milk casein in mice. Ii1t. J. Immunopharmacol., 21:311-323, 1999. Nakao, M., Shichijo, S., lmaizumi, T., moue, Y, Matsunaga, K., Yamada, A., Kikuchi, M., Tsuda, N., Takamori, S., Yamana, H., Fujita, H., and Itoh, K., Identification of a gene coding for a new squamous cell carcinoma antigen recognized b~~ cytotoxic T lymphocytes. J. Immunol., 164:2565-2574. 2000. ? Harada, K., Yamada, A., Mine, T., Kawagoe, N., Takasu, H., and Itoh, K. Characterization of a gene for a murine homologue of the human tumor-rejection antigen SART3. JJCR, 91:239-247, 2000. -~ ~ Hamaguchi, K., Kimura, A., Seki, N., Higuchi, T., Yasunaga, S., Takahashi, M., Sasazuki, T., Kusuda, Y, Okeda, T., Itoh, K., and Sakata, T., Analysis of tumor necrosis factor- a promoter polymorphism in type 1 diabetes: HLA-B and DRB 1 allele are primarily associated with the disease in Japanese. Tissue Antigen, 55:10- 16, 2000. - ~ ~ Seki, N., Yamada, A., Suefuji, Y, Mine, T., Yoshimura, A., Tanaka, S., Gomi, S., Koufuji, K., and Itoh, K. Establishment and epitope analysis of alto-specific cytotoxic T lymphocytes at a tumor site recognizing a spouse's HLA-A0206 molecule. Am. J. Reprod. Immunol., 43: 167-173, 2000. 1 i Kawagoe, F., Yamada, A., Matsumoto, H., Ito, M., Ushijima, K., Nishida, T., Yakushiji, M., and Itoh, K., Serum MAGE-4 protein in ovarian cancer patients. Gynecologic Oncology, 76:336- 339, 2000. _' ~ ~ Niiya, F., Shichijo, S., Nishizaka, S., Matsunaga, K., Koufuji, K., Mori, M., Katai, H., Yamana, H., and Itoh, K., Expression of SART3 tumor-rejection antigen in gastric cancers. JJCR, 91:337-342, 2000. _' ~ ~ moue, Y, Nakao, M., Matsunaga, K., Kikuchi, M., Gomi, S., Toh, U., Takamori, S., Yamana, Y, and Itoh, K. Induction of HLA-A26-restricted and tumor-specific cytotoxic T lymphocytes by a single peptide of the SARTl antigen in cancer patients with different A26 subtypes. J. Immunotherapy, in press, 2000. -~ ) Murayama, K.,Kobayashi,T., Matsunaga, K., Kuramoto, T., Shigemori, A., Shichijo, S., and Itoh, K. Expression of SART3 tumor-rejection antigen in brain tumors and induction of CTLs by its peptides. J. Immunotherapy, in press, 2000. > > ) Shin-taku, L, Kawagoe, N., Yutani, S., Hoshi, S., Orikasa, S., Yoshizumi, O., and Itoh, K. Expression of SARTl tumor-rejection antigen in renal cell carcinoma. Urol. Res. in press, 2000. 26) Sasatomi, T., Yamana, H.,Shichijo, S., Tanaka, S., Okamura, T., Ogata,Y, Shirouzu, K., and Itoh, K. Expression of SART1 tumor-rejection antigen in colorectal cancers. Colon and Rectum, in press, 2000. 27) Mine, T., T., Harada, K., Matsumoto, T, Yamana, H., Itoh, K., and Yamada, A. Expression of CDw108 antigen during T cell development. Tissue Antigens, in press, 2000. 28) Kamizono, S., Yamada, K., Seki, N., Higuchi, T., Kimura, A., Nonaka, K., and Itoh, K., Susceptible locus for obese Type 2 diabetis mellitus in the 5' flanking region of the tumor necrosis factor-alpha gene, Tissue Antigens, in press, 2000. 29) N. Ikewaki, H. Tamauchi, A. Yamada, N. Mori, Y Fukumoto, R. Shibata, H. Yamao, H. moue, and H. Inoko. A unique monoclonal antibody mNI-11 rapidly enhances spread formation in human umbilical vein endothelial cells (HUVECs). J. Clin. Immunol., in press. 30) Ishida, H., Komiya, S., moue, Y, Yutani, S., moue, A, and Itoh, K. Expression of SART1 tumor -rejection antigen in human osteosarcomas. Int. J. Oncol., in press, 2000. 31) Kawano, K., Gomi, S., Tanaka, K., Tsuda, N., Kamura, T., Itoh, K., and Yamada, A. Identification of a new endoplasmic reticulum-resident protein recognized by the HLA-A24-restricted tumor infiltrating lymphocytes of lung cancer. Cancer Research, in press, 2000. 32) Itoh, M., Shichijo, S., Miyagi, Y, Kobayashi, T., Yamada, A., Saito, N., and Itoh, K. Identification of SART3-derived peptides capable of inducing HLA-A2-restricted and tumor-specific CTLs in cancer patients with different HLA-A2 subtypes. Int. J. cancer, in press, 2000 33) Kawagoe, N., Shin-taku, L, Etoh, H., Shichijo, S., Nada, S., and Itoh, K. Induction of HLA-class I-restricted and tumor-specific CTLs by SART3-derived peptides in patients with renal cell carcinoma. J.Urology, in press, 2000. 34) K. Shimizu, S. Fujii, K. Fujimoto, K. Kawa, A. Yamada, and F. Kawano. Tacrolimus (FK506) treatment of CD34~ hematopoietic progenitor cells promote the development of dendritic cells that drive CD4~ T cells toward Th2 responses. J. Leukocyte Biol., in press, 2000. 1999　肝癌研究 Publications in 1999-2000 １. Haruhiko Yoshida, Yasushi Shiratori, Mitsuhiko Moriyama, Yasuyuki Arakawa, Tatsuya Ide, Michio Sata, Osami moue, Michitami Yano, Motohiko Tanaka, Shigetoshi Fujiyama, Shuhei Nishiguchi, Tetsuo Kuroki, Fumio Imazeki, Osamu Interferon therapy reduces the risk for hepatocellular carcinoma : National surveillance program of cirrhotic and noncirrhotic patients with chronic hepatitis C in Japan Annals of Internal Medicine 131: 174-181, 1999 2. Shiro Iino, Shun-ichi Sato, Hiromitsu Kumada, Gotaro Toda, Hiromasa Ishii, Kazuhiko Miyake, Kumihiko Hino, Takafumi Ichida, Yoshihiro Akahane, Kendo Kiyosawa, Ken-ichi Kobayashi, Norio Hayashi, Tetsuo Kuroki, Takao Tsuji, Involvement of GBV-C / HGV in liver diseases in Japan Hepatology Research 13: 153-159, 1999 3. Jun Nagashima, Koji Okuda, Masatoshi Tanaka, Michio Sata, Shigeaki Aoyagi Prognostic benefit in cytoreductive. surgery for curatively unresectable hepatocellular carcinoma - comparison to transcatheter arterial chemoembolization International Journal of Oncology 15: 1117- 1123, 1999 4. Tadashi Iwao, Kazuhiko Oho, Ryohichi Nakano, Makoto Yamawaki, Teruhiro Sakai, Masahiro Sato, Yasunao Miyamoto, Kenji Sakai, Michio Sata and Atsushi Toyonaga Upright posture blunts postprandial splanchnic hyperemia in patients with cirrhosis and portal hypertension Journal of Gastroenterology 34: 359-365, 1999 5. Ryoichi Nakano, Tadashi Iwao, Kazuhiko Oho, Naofumi Ono, Teruhiro Sakai, Masahiro Sato, Makoto Yamawaki, Yasunao Miyamoto, Kenji Sakai, Teiko Takeda, Osamu Tsuruta, Michio Sata and Atsushi Toyonaga Effect of transcatheter arterial chemoembolization on kidney hemodynamics and function in patients with cirrhosis and hepatocellular carcinoma Journal of Hepatology 31: 340-346, 1999 6. Yasuyo Uchimura, M Uchimura, Ryukichi Kumashiro, A Hattori, Michio Sata Changes in melatonin concentrations during IFN therapy Journal of Hepatology 31: 113 l , 1999 7. Kanae Sasaki, Yoshito Tajiri, Michio Sata, Yasuhiro Fujii, Futoshi Matsubara, Mangen Zhao, Seiichi Shimizu, Atsushi Toyonaga, Kyuichi Tanikawa Helicobacter pylori in the natural environment Scandinavian Journal of Infectious Diseases 31: 275-280, 1999 8. Fuyuhiko Akiyoshi, Michio Sata, Seiii No~uchi, Hiroshi Suzuki, Tatsuya Ide, Yasuyo Uchimura, Masaru Sasaki, Kumi Tanaka, Ichiro Miyajima, Masashi Mizokami, and Kyuichi Tanikawa Intraspousal transmission of GB virus C / hepatitis G virus in an hepatitis C virus hyperendemic area in Japan The American Journal of Gastroenterology 94: 1627-1631, 1999 9. Yasushi Shiratori, Fumio Imazeki, Mitsuhiko Moriyama, Michitami Yano, Yasuyuki Arakawa, Osamu Yokosuka, Tetsuo Kuroki, Shuhei Nishiguchi, Michio Sata, Gotarou Yamada, Shigetoshi Fujiyama, Haruhiko Yoshida, Masao Omata Histologic Improvement of fibrosis in patients with Hepatitis C who have sustained response to interferon therapy Annals of internal medicine 132: 517-524, 2000 10. Satsuki Kobayashi, Kazunori Shimada, Hiroshi Suzuki, Kyuichi Tanikawa, Michio Sata Development of a new method for detecting a mutation in the gene encoding hepatitis B virus reverse transcriptase active site (YMDD motif) Hepatology Research 17: 31-42, 2000 11. Satoshi Toh, Morimasa Wada, Takeshi Uchiumi, Akihiko Inokuchi, Yoshinari Makino, Yutaka Horie, Yukihiko Adachi, Shotaro Sakisaka, and Michihiko Kuwano Genomic structure of the canalicula~- multispecific organic anion - Transporter gene (MRP2 / cMOAT) and mutations in the ATP - Binding - Cassette region in Dubin - Johnson syndrome American Journal of Human Genetics 64: 739-746, 1999 12. Hiroyuki Eguchi, Hisao Ikeda, Toyoaki Murohara, Hideo Yasukawa, Nobuya Haramaki, Shotaro Sakisaka, Tsutomu Imaizumi Endothelial injuries of coronary arteries distal to thrombotic sites -Role of adhesive interaction between endothelial P- selectin and leukocyte sialyl lewisx Circulation Research 84: 525-535, 1999 13. Akiko Ishibashi, Riko Ogata, Shotaro Sakisaka, Ryukichi Kumashiro, Yuriko Koga, Keiichi Mitsuvama, Ryoko Kuromatsu, Yasuyo Uchimura, Hiroyasu Ijyuin, Kumi Tanaka, Tadashi Iwao, Kunihide Ishii, Michio Sata, Yoshiko Erythropoietic protoporphyria with fatal liver failure Journal of Gastroenterology 34: 405-409, 1999 14. Masahito Ohishi, Shotaro Sakisaka, Masaru Harada, Hironori Koga, Eitaro Taniguchi, Takumi Kawa~uchi, Kurumi Sasatomi, Michio Sata, Toshihiko Kurohiji Ai Kyuichi Tanikawa Detection of hepatitis-C virus and Hepatitis-C virus replication in hepatocellular carcinoma by in situ hybridization Scandinavian Journal of Gastroenterology 4: 432-438, 1999 15. Yuji Hiromatsu, Tomoaki Hoshino, Hideo Yagita, Mari Koga, Shotaro Sakisaka, Junnichi Honda, Damu Yang, Nobuhiko Kayagaki, Ko Okumura, and Kyohei Nonaka Functional Fas ligand expression in thyrocytes from patients with Graves' disease The Journal of Clinical Endocrinology & Metabolism 84: 2896-2902, 1999 16. Shotaro Sakisaka, Hironori Koga, Kurumi Sasatomi, Masahito Ohishi, Takumi Kawa~uchi, Masaru Harada, Eitaro Taniguchi, Yasuyo Uchimura, Takato Ueno, Michio Sata, Kyuichi Tanikawa Ursodeoxycholic acid reduces expression of heat shock proteins in primary biliary cirrhosis Liver 20: 78-87, 2000 17. Masaru Harada, Shotaro Sakisaka, Takumi Kawa~uchi, Kurumi Sasatomi, Masahito Ohishi, Hironori Koga, Michio Sata, Kyuichi Tanikawa Intracellular traffic of asialoglycoproteins depends on vacuolar pH in polarized isolated rat hepatocyte couplets Hepatology Research 14: 105-118, 1999 18. Toshiro Ogata, Koji Okuda, Takato Ueno, Naoyuki Saito, Shigeaki Aoyagi Serum hyaluronan as a predictor of hepatic regeneration after hepatectomy in humans European Journal of Clinical Investigation 29: 780-785, 1999 Takato Ueno, Kodo Sujaku, Seishu Tamaki, Riko Ogata, Motoaki Kin, Toru Nakamura, Masaharu Sakamoto, Takuii Torimura, Keiichi Mitsuvama, Shotaro Sakisaka, Michio Sata and Kyuichi Tanikawa OK-432 treatment increases matrix metalloproteinase-9 production and improves dimethylnitrosamine - induced liver cirrhosis in rats International Journal of Molecular Medicine 3: 497-503, 1999 20. Koji Okuda, Masatoshi Tanaka, Naomitsu Kanazawa, Jun Nagashima, Shinji Satomura, Hisafumi Kinoshita, Naofumi Eriguchi, Shigeaki Aoyagi and Masamichi Kojiro Evaluation of curability and prediction of prognosis after surgical treatment for hepatocellular carcinoma by lens culinaris agglutinin-reactive E~-fetoprotein International Journal of Oncology 14: 265-271, 1999 21. Yoshihiro Shimauchi, Masatoshi Tanaka, Ryoko Kuromatsu, Riko Ogata, Yukio Tateishi, Satoshi Itano, Naofumi Ono, Shigeru Yutami, Hiroaki Nagamatsu, Satoshi Matsugaki, Sanki Yamasaki, Kyuichi Tanikawa, Michio Sata A simultaneous monitoring of Lens culinaris agglutinin A -reactive E~-fetoprotein and des -Ei- carboxy prothrombin as an early diagnosis of hepatocellular carcinoma in the follow-up of cirrhotic patients Oncology Reports 7: 249-256, 2000 22. Koji Okuda, Masatoshi Tanaka, Jyunji Shibata, Eiji Ando, Toshiro Ogata, Hisafumi Kinoshita, Naofumi Eriguchi, Shigeaki Aoyagi and Kyuichi Tanikawa Hepatic arterial infusion chemotherapy with continuous low dose administration of cisplatin and 5-fluorouracil for multiple recurrence of hepatocellular carcinoma after surgical treatment Oncology Reports 6: 587-591, 1999 23. Riko Ogata, Takuii Torimura, Motoaki Kin, Takato Ueno, Yukio Tateishi, Ryoko Kuromatsu, Yoshihiro Shimauchi, Masaharu Sakamoto, Seisyu Tamaki, Michio Sata and Kyuichi Tanikawa Increased expression of membrane type 1 matrix metalloproteinase and matrix metalloproteinase - 2 with tumor dedifferentiation in hepatocellular carcinomas Human Pathology 30: 443-450, 1999 24. Takuii Torimura, Takato Ueno, Motoaki Kin, Riko Ogata, Sadataka Inuzuka, Hiroshi Sugawara, Ryoko Kuromatsu, Masahiro Shimada, Hirohisa Yano, Masamichi Kojiro, Kyuichi Tanikawa, Michio Sata Integrin E~6E~,1 plays a significant role in the attachment of hepatoma cells to laminin Journal of Hepatology 31: 734-740, 1999 25. Takuii Torimura, Takato Ueno, Motoaki Kin, Shotaro Sakisaka, Kyuichi Tanikawa, Michio Sata E~ 1- Integrin mediates cell adhesion, haptotaxis, and chemokinesis of hepatoma cells Medical Electron Microscopy 32: 2-10, l 999 26. Osamu Kanauchi, Yoshihide Fujiyama, Keiichi Mitsuvama, Yoshio Araki, Takashi Ishii, Tomohiko Nakamura, Yoshitaka Hitomi, Kazue Agata, Tomohisa Saiki, Akira Andoh, Atsushi Toyonaga, and Tadao Bamba Increased growth of Bifidobacterium and Eubacterium by germinated barley foodstuff, accompanied by enhanced butyrate production in healthy volunteers International Journal of Molecular Medicine 3: 175-179, 1999 27. Osamu Kanauchi, Toshihiko Iwanaga, Keiichi Mitsuvama, Tomohisa Saiki, Osamu Tsuruta, Kazunori Noguchi, Atsushi Toyonaga Butyrate from bacterial fermentation of germinated barley foodstuff preserves intestinal barrier function in experimental colitis in the rat model Journal of Gastroenterology and Hepatology 14: 880-888, 1999 28. Osamu Kanauchi, Akira Andoh, Toshihiko Iwanaga, Yoshihide Fujiyama, Keiichi Mitsuvama, Atsushi Toyonaga and Tadao Bamba Germinated barley foodstuffs attenuate colonic mucosal damage and mucosal nuclear factor kappa B activity in a spontaneous colitis model Journal of Gastroenterology and Hepatology 14: 1173-1 l 79, 1999 29. Masaru Harada, Keiichi Mitsuvama, Hiroshi Yoshida, Shotaro Sakisaka, Yohko Tokunaga, Akiko Sakamoto, Moto Aiga, Kurumi Sasatomi, Masaharu Sakamoto, Hidetoshi Akashi, Michio Sata and Kyuichi Tanikawa Antiphospholipid syndrome modifies the clinical features of systemic lupus erythematosus Japanese Journal of Rheumatology 9: 107-11 1, 1999 30. Yumiko Na~ao, Michio Sata, Hiroshi Suzuki, Tadamitsu Kameyama, Takato Ueno Histological improvement of oral lichen planus in patients with chronic hepatitis C treated with interferon Gastroenterology l l7: 283-284, 1999 31. Yumiko Nagao, Michio Sata, Seiii No~uchi, N Tajiri, Naofumi Ono, T Fukuda, Tadamitsu Kameyama, Takato Ueno Various extrahepatic manifestations caused by hepatitis C virus infection International Journal of Molecular Medicine 4: 621-625, 1999 32. Hironori Koga, Shotaro Sakisaka, Masahito Ohishi, Takumi Kawa~uchi, Eitaro Taniguchi, Kurumi Sasatomi, Masaru Harada, Taku Kusaba, Masatoshi Tanaka, Rina Kimura, Yutaka Nakashima, Osamu Nakashima, Masamichi Kojiro, Expression of cyclooxygenase-2 in human hepatocellular carcinoma: Relevance to tumor dedifferentiation Hepatology 29: 688-696, 1999 33. Takafumi Yoshida, Hironori Ko~a, Fumihiko Saitoh, Masaharu Sakamoto, Masaru Harada, Hiroshi Yoshida, Shotaro Sakisaka and Michio Sata Pulse intravenous cyclophosphamide treatment for steroid-resistant interstitial pneumonitis associated with polymyositis Internal Medicine 38: 733-738, 1999 34. Motoaki Kin, Takuii Torimura, Takato Ueno, Toru Nakamura, Riko Ogata, Masaharu Sakamoto, Seishu Tamaki and Michio Sata Angiogenesis inhibitor TNP-470 suppresses the progression of experimentally-induced hepatocellular carcinoma in rats International Journal of Oncology 16: 375-382, 2000 35. Masaru Harada, Hiroshi Yoshida, Hideo Ikeda, Takafumi Yoshida, Hidetoshi Takedatsu, Hiroaki Nagamatsu, Kenshi Ko~a, Yuko Fujisawa, Masaharu Sakamoto, Kazuhiro Fujisaki, Shotaro Sakisaka, Kiyoshi Yasumoto, Atsushi Toyonaga, Polyarteritis nodosa with mesenteric aneurysms demonstrated by angiography: report of a case and successful treatment of the patient with prednisolone and cyclophosphamide Journal of Gastroenteorology 34: 702-705, l 999 36. Shiro Murashima, Tatsuya Ide, Ichiro Miyajima, Ryukichi Kumashiro, Takato Ueno, Shotaro Sakisaka and Michio Sata Mutations in the NSSA gene predict response to interferon therapy in Japanese patients with chronic hepatitis C and cirrhosis Scandinavian Journal of Infectious Diseases 31: 27-32, 1999 37. Shiro Murashima, Ryukichi Kumashiro, Tatusya Ide, Michio Sata HCV NSSA 2209-2248 amino acid substitutions affect serum 2,SAS activities Journal of Hepatology 31: 382, 1999 38. Takumi KawaQuchi, Shotaro Sakisaka, Michio Sata, Michio Mori, and Kyuichi Tanikawa Different lobular distributions of altered hepatocyte tight junctions in rat models of intrahepatic and extrahepatic cholestasis Hepatology 29: 205-216, 1999 39. Takumi Kawaguchi, Michio Sata, Naofumi Ono, Shotaro Sakisaka, Hironori Ko~a, Hiroyasu Ijuin, Keiichi Mitsuyama, Takato Ueno, Masayoshi Kage, Kyuichi Tanikawa Budd-Chiari syndrome complicated by hepatocellular carcinoma with no evidence of infection with hepatitis virus : a case report Hepato-Gastroenterology 46: 3237-3240, 1999 1999 細胞発生工学 Publications by our department during April 1999 - March 2000 l. Development 2000, in press Molecular analysis of external genitalia formation: The role of Fgf genes during genital tubercle formation. Haraguchi R, Suzuki K, Murakami R, Sakai M, Kamikawa M, Kengaku M, Sekine K, Kawano H, Kato S, Ueno N, Yamada G 2. Science 2000, 287(5451):321-324 Requirement of CD9 on the egg plasma membrane for fertilization. Miyado K, Yamada G, Yamada S, Hasuwa H, Nakamura Y, Ryu F, Suzuki K, Kosai K, moue K, Ogura A, Okabe M, Mekada E 3. Cell Mol Biol 1999, 45(5):589-599 Middle ear defects associated with the double knock out mutation of murine goosecoid and Msxl genes. Kuratani S, Satokata I, Blum M, Komatsu Y, Haraguchi R, Nakamura S, Suzuki K, Kosai K, Maas R, Yamada G 4. Cell Mol Biol 1999, 45(5):479-750 Cellular and molecular mechanisms of organogenesis and early development. Yamada G(editor) 5. Cell Mol Biol 1999, 45(5):617-629 Retinoic acid teratogenicity: the role of goosecoid and BMP-4. Zhu CC, Yamada G, Blum M 6. Dev Biol 1999, 208(1):123-133 A BMP-inducible gene, d1x5, regulates osteoblast differentiation and mesoderm induction. Miyama K, Yamada G, Yamamoto TS, Takagi C, Miyado K, Sakai M, Ueno N, Shibuya H 2000 がんワクチン分子 Selected Publications in 2000-2001 1. Nakao, M., Shichijo, S., Imaizumi, T., moue, Y, Matsunaga, K., Yamada, A., Kikuchi, M., Tsuda, N., Ohta, K., Takamori, S., Yamana, H., Fujita, H., and Itoh, K., Identification of a gene coding for a new squamous cell carcinoma antigen recognized by the CTL. J. Immunol. 164: 2565- 2574, 2000. 2. Harada, K., Yamada, A., Mine, T., Kawagoe, N., Takasu, H., and Itoh, K., Mouse homologue of the human SART3 gene encoding tumor-rejection antigen. Jpn. J. Cancer Res. 91: 239-247, 2000. 3. Hamaguchi, K., Kimura, A., Seki, N., Higuchi, T., Yasunaga, S., Takahashi, M., Sasazuki, T., Kusuda, Y, Okeda, T., Itoh, K., and Sakata, T., Analysis of tumor necrosis factor-a promoter polymorphism in type 1 diabetes: HLA-B and -DRB 1 alleles are primarily associated with the disease in Japanese. Tissue Antigens 55: 10-16, 2000. 4. Seki, N., Yamada, A., Suefuji, Y, Mine, T., Tanaka, S., Gomi, SY, Kawagoe, N., Koufuji, K., and Itoh, K., Establishment and epitope analysis of allo-specific cytotoxic T lymphocytes at a tumor site recognizing a spouse's HLA-A0206 molecule. Am. J. Reprod Immunol. 43: 167-173, 2000. 5. moue, Y, Nakao, M., Matsunaga, K., Kikuchi, M., Gomi, S., Toh, U., Takamori, S., Yamana, H., and Itoh, K., Induction of human leukocyte antigen-A26-restricted and tumor-specific cytotoxic T lymphocytes by a single peptide of the SARTl antigen in patients with cancer with different A26 subtypes. J. Immunother 23: 296-303, 2000. 6. Kawagoe, H., Yamada, A., Matsumoto, H., Ito, M., Ushijima, K., Nishida, T., Yakushiji, M., and Itoh, K., Serum MAGE-4 protein in ovarian cancer patients. Gynecol Oncol. 76: 336-339, 2000. 7. Niiya, F., Nishizaka, S., Matsunaga, K., Koufuji, K., Mori, M., Katai, H., Yamana, H., and Itoh, K., Expression of SART3 tumor-rejection antigen in gastric cancers. Jpn. J. Cancer Res. 91: 337- 342, 2000. 8. Murayama, K., Kobayashi, T., Imaizumi, T., Matsunaga, K., Kuramoto, T., Shigemori, M., Shichijo, S., and Itoh, K., Expression of the SART3 tumor-rejection antigen in brain tumors and induction of cytotoxic T lymphocytes by its peptides. J. Immunother. 23: 511-518, 2000. 9. Shintaku, I., Kawagoe, N., Yutani, S., Hoshi, S., Orikasa, S., Yoshizumi, O., and Itoh, K., Expression of the SARTl tumor rejection antigen in renal cell carcinoma. Urol Res. 28: 178-184, 2000. 10. Sasatomi, T., Yamana, H., Shichijo, S., Tanaka, S., Okamura, T., Ogata, Y, Itoh, K., and Shirouzu, K., Expression of the SART1 tumor-rejection antigens in colorectal cancers. Dis. Colon Rectum. 43: 1754-1758, 2000. 11. Mine, T., Harada, K., Matsumoto, T., Yamana, H., Shirouzu, K., Itoh, K., and Yamada, A., CDw108 expression during T cell development. Tissue Antigens 55: 429-436, 2000. 12. Kamizono, S., Yamada, K., Seki, N., Higuchi, T., Kimura, A., Nonaka, K., and Itoh, K., Susceptible locus for obese type 2 diabetes mellitus in the 5'-flanking region of the tumor necrosis factor-alpha gene. Tissue Antigens 55: 449-452, 2000. 13. Ishida, H., Komiya, S., moue, Y, Yutani, S., moue, A., and Itoh, K., Expression of the SART1 tumor-rejection antigen in human osteosarcomas. Int. J. Oncol. 17: 29-32, 2000. 14. Kawano, K., Gomi, S., Tanaka, K., Tsuda, N., Kamura, T., Itoh, K., Yamada, A., Identification of a new endoplasmic reticulum-resident protein recognized by HLA-A24-restricted tumor-infiltrating lymphocytes of lung cancer. Cancer Res. 60: 3550-3558, 2000. 15. Ito, M., Shichijo, S., Miyagi, Y, Kobayashi, T., Tsuda, N., Yamada, A., Saito, N., and Itoh, K., Identification of SART3-derived peptides capable of inducing HLA-A2-restricted and tumor- specific CTLs in cancer patients with different HLA-A2 subtypes. Int. J. Cancer 88: 633-639, 2000. 16. Kawagoe, N., Shintaku, I., Yutani, S., Etoh, H., Matuoka, K., Noda, S., and Itoh, K., Expression of the sart3 tumor rejection antigen in renal cell carcinoma. J. Urol. 164: 2090-2095, 2000. 17. Nishizaka, S., Gomi, S., Harada, K., Oizumi, K., Itoh, K., and Shichijo, S., A new tumor- rejection antigen recognized by cytotoxic T lymphocytes infiltrating into a lung adenocarcinoma. Cancer Res. 60: 4830-4837, 2000. 18. Toh, U., Yamana, H., Sueyoshi, S., Tanaka, T., Niiya, F., Katagiri, K., Fujita, H., Shirozou, K., and Itoh, K., Locoregional cellular immunotherapy for patients with advanced esophageal cancer. Clin. Cancer Res. 6:4663-4673, 2000. 19. Kamizono, S., Hiromatsu, Y, Seki, N., Bednarczuk, T., Matsumoto, H., Kimura, A., and Itoh, K., A polymorphism of the 5' flanking region of tumour necrosis factor alpha gene is associated with thyroid-associated ophthalmopathy in Japanese. Clin. Endocrinol (Oxf). 52: 759-764, 2000. 20. Tanaka, S., Tsuda, N., Kawano, K., Sakamoto, M., Nishida, T., Hashimoto, T., Shichijo, S., Kamura, T., and Itoh, K., Expression of Tumor-rejection Antigens in Gynecologic Cancers. Jpn. J. Cancer Res. 91: 1177-1184, 2000. 21. Sugita, S., Taguchi, C., Takase, H., Sagawa, K., Sueda, J., Fukushi, K., Hikita, N., Watanabe, T., Itoh, K., and Mochizuki, M., Soluble fas ligand and soluble fas in ocular fluid of patients with uveitis. Br. J. Ophthalmol. 84: 1130-1134, 2000. 22. N. Ikewaki, H. Tamauchi, A. Yamada, N. Mori, Y Fukumoto, R. Shibata, H. Yamao, H. moue, and H. Inoko. A unique monoclonal antibody mNI-11 rapidly enhances spread formation in human umbilical vein endothelial cells (HUVECs). J. Clin. Immunol., 20: 317-324, 2000. 23. K. Shimizu, S. Fujii, K. Fujimoto, K. Kawa, A. Yamada, and F. Kawano. Tacrolimus (FK506) treatment of CD34~ hematopoietic progenitor cells promote the development of dendritic cells that drive CD4~ T cells toward Th2 responses. J. Leukocyte Biol. 68:633-640, 2000. 24. Tsuda, N., Murayama, K., Ishida, H., Matsunaga, K., Komiya, S., Itoh, K, and Yamada, A., Expression of a newly defined tumor-rejection antigen SART3 antigen in musculoskeletal tumors and induction of HLA-class I-restricted CTLs by SART3-derived peptides. J. Orthopedic Research 2001, in press. 25. Harashima, N,. Tanaka, K., Sasadomi, T., Locoregional, Y, Miyagi, Y , Yamada, A., Tamura, M., Yamana, Y, Itoh., K., and Shichijo, S., Recognition of the Lck tyrosine kinase as a tumor antigen by T cells of metastatic cancer patients. Eur. J. Immunology 2001, in press 26. Suefuji, Y, Sasatomi, T., Shichijo, S., Nakagawa, S., Deguchi, H., Koga, T., Kameyama, T., and Itoh, K., Expression of SART3 antigen and induction of CTLs by SART3-derived peptides in breast cancer patients. British J. Cancer 2001, in press. 27. Ito, M., Sichichijo, S., Tsuda, N., Ochi, M., Harashima, N., Saito, N., and Itoh, K., Molecular basis of T cell-mediated recognition of pancreatic cancer cells. Cancer Research 2001, in press. 28. Yutani, S., Shichijo, S., moue, Y, Kawagoe, N., Okuda, K., Kurohiji, T., Tanaka, M., Sata, M., and Itoh, K., Expression of the SARTl tumor-rejection antigen in hepatocellular carcinomas. Oncol Rep., 8:369-372, 2001. 29. N. Ikewaki, H. Tamauchi, A. Yamada, M. Aoki , R. Yamamoto , A. Sawada and H. Inoko A tnicrofilament formation inhibitor, cytochalasin, strongly enhances the low affinity Fc-~ receptor II (CD23) expression on the human monocyte-like cell line, U937. J. Clin. Immunol., in press. 30. T. Nishida, K. Nagata, T. Ueno, M. Tsuru, A. Jimi, K. Irie, A. Yamada, M. Sata, and A. moue. Electron microscopic observation of cultured chondrocytes derived from human intervertebral disc ~lernia and role of macrophages on spontaneous regression of degenerated tissues. Spine, in press. 31. K. Tanaka, Y. Shoyama, A. Yamada, K. Noda, F. Konishi, and K. Nomoto. Immunopotentiating effects of a glycoprotein from Chlorella vulgaris strain CK and its characteristics. In "Bioactive Natural Products" (Atta-Ur-Rahman, Ed). Elsevier Science Publishers, Amsterdam, in press. 2000 肝癌研究 Publications in 2000-2001 1 Masatoshi Tanaka, Eiji Ando, Shigeru Yutani, Kazuta Fukumori, Ryoko Kuromatsu, Yoshihiro Shimauchi, Hiroaki Na~amatsu, Satoshi Matsu~aki, Satoshi Itano, Naofumi Ono, Shotaro Sakisaka, Phase II trial hepatic arterial infusion chemotherapy using cisplatin and 5-fluorouracil in patients with advancedhepatocellularcarcinoma Frontier in Hepatology Progress in Hepatocellular Carcinoma p. 49-55, 2000 2 Masatoshi Tanaka, Ryoko Kuromatsu, Yoshihiro Shimauchi, Michio Sata Determination of PIV KA-II and cr -fetoprotein in serum for diagnosing hepatocellular carcinoma ImmunoassaysforPIVKA-II p. 37-40, 2000 3 Yoshihiro Shimauchi, Masatoshi Tanaka, Kenshi Koga, Satoshi Itano, Kunihide Ishii, Ryukichi Kumashiro, Shotaro Sakisaka, Michio Sata Clinical characteristics of patients in their 40s with HCV antibody-positive hepatocellular carcinoma Alcoholism: Clinical and Experimental Research 24: 64s-67s, 2000 4 Yasushi Shiratori, Fumio Imazeki, Mitsuhiko Moriyama, Michitami Yano, Yasuyuki Arakawa, Osamu Yokosuka, Tetsuo Kuroki, Shuhei Nishi~uchi, Michio Sata, Gotarou Yamada, Shi~etoshi Fujiyama, Histologic improvement of fibrosis in patients with hepatitis C who have sustained response to interferontherapy Annals of Internal Medicine 132: 517-524, 2000 5 Rina Kimura, Hironori Yoshii, Masatoshi Nomura, Naoe Kotomura, Tokuo Mukai, Satoru Ishihara, Koichi Ohba, Toshihiko Yanase, Osamu Gotoh, Hajime Nawata, Ken-ichiro Morohashi Identification of novel first exons in Ad4BP/SF-1(NR5A1) gene and their tissue-and species-specific usage BiochemicalandBiophysicalResearchCommunications 273: 63-71, 2000 6 Masaru Harada, Shotaro Sakisaka, Takumi Kawaguchi, Rina Kimura, EitaroTaniguchi, Hironori Koga, Shinichiro Hanada, Shinji Baba, Koh Furuta, Ryukichi Kumashiro, Toshihiro Su~iyama, Michio Sata Copper does not alter the intracellular distribution of ATP7B, a copper-transporting ATPase Biochemicaland Biophysical Research Communications 275: 871-876, 2000 7 Kiyomi Yasuda, Yasuo Ohashi, Takashi Matsushima, Hiromitsu Kumada, Kumihiko Hino, Madoka Ito, Toshihiko Takeuchi, Shinichi Kakumu, Tetsuo Kuroki, Norio Hayashi, Michio Sata, Shiro Iino Low-dose oral interferon- a in the treatment of chronic viral hepatitis type B: a double-blind, randomized, placebo-controlled, clinical trial CurrentTherapeutic Research Clinicaland Experimental 61: 245-254, 2000 8 Osamu Tsuruta, YuichiroTsuji, Hiroshi Ka~wano, Shiro Miyazaki, Masahide Watanabe, Keita, Nakahara, HideoTateishi Mitsutake Fujita, Shi~eki Ban, Michio Sata, Atsushi Toyona~a, Minoru Morimatsu Indication for endoscopic resection of submucosal colorectal carcinoma: special reference to lymph node metastasis DiagnosticandTherapeuticEndoscopy 6: 101-109, 2000 g Keiichi Mitsuyama, Atsushi Toyonaga, Michio Sata Cytokine-targeted therapeutic approaches for inflammatory bowel disease Drugs of Today 36: 281-293, 2000 10 Yumiko Nagao, Michio Sata, Masayoshi Kage, Tadamitsu Kameyama, Takato Ueno Histopathological and immunohistochemical study of oral lichen planus-associated HCV infection EuropeanJournal of Internal Medicine 11: 277-282, 2000 11 Masaru Harada, Shotaro Sakisaka, KunihikoTerada, Rina Kimura, Takumi Kawaguchi, Hironori Koga, Eitaro Tani~uchi, Kurumi Sasatomi, Naoyuki Miura, Tatsuo Suganuma, Hideaki Fujita, Koh Furuta, Role of ATP7B in biliary copper excretion in a human hepatoma cell line and normal rat hepatocytes Gastroenterology 118: 921-928, 2000 12 Yumiko Nagao, Michio Sata, Kunitaka Fukuizumi, Fuminori Ryu, Takato Ueno High incidence of oral lichen planus in an HCV hyperendemic area Gastroenterology 119: 882-883, 2000 13 Takumi Kawaguchi, Shotaro Sakisaka, Keiichi Mitsuyama, Masaru Harada, Hironori Koga, Eitaro Tani~uchi, Kurumi Sasatomi, 1Zina Kimura, Takato Ueno, Norimasa Sawada, Michio Mori, Michio Sata Cholestasis with altered structure and function of hepatocyte tight junction and decreased expression of canalicttlar multispecific organic anion transporter in a rat model of colitis Hepatology 31: 1285-1295, 2000 14 Toru Nakamura, Ryuichiro Sakata, Takato Ueno, Michio Sata, Hikaru Ueno Inhibition of transforming growth factor (3 prevents progression of liver fibrosis and enhances hepatocyteregenerationindimethylnitrosamine-treatedrats Hepatology 32: 247-255, 2000 15 Satsuki Kobayashi, Kazunori Shimada, Hiroshi Suzuki, Kyuichi Tanikawa, Michio Sata Development of a new method for detecting a mutation in the gene encoding hepatitis B virus reverse transcriptase active site (YMDD motif) HepatologyResearch 17: 31-42, 2000 16 Tatsuya Ide, Ryukichi Kumashiro, Hiroshi Suzuki, Kyuichi Tanika?~a, Michio Sata Two-year follow-up study after treatment with lamivudine for chronic hepatitis B: seven cases reported HepatologyResearch 17: 197-204, 2000 17 Tatsuya Ide, Ryukichi Kumashiro, NaokoToyoda, Kazuhiro Matsuyama, Toshiaki Miura, Michio Sata Second generation amplicor-HCV monitor assay : clinical features and predictors of the response to interferon HepatologyResearch 18: 230-238, 2000 18 Hikaru Ueno, Taiji Sakamoto, Toru Nakamura, Zhe Qi, Nobuhiko Astuchi, Akira Takeshita, Kiyoshi Shimizu, HideyaOhashi A soluble transforming growth factor /3 receptor expressed in muscle prevents liver fibrogenesis and dysfunction in rats HumanGeneTherapy 1: 33-42, 2000 19 Motoaki Kin, Takuji Torimura, Takato Ueno, Toru Nakamura, Riko Ogata, Masaharu Sakamoto, Seishu Tamaki and Michio Sata Angiogenesis inhibitorTNP-470 suppresses the progression of experimentally-induced hepatocellular carcinoma in rats International Journal of Oncology 16: 375-382, 2000 20 Yoichi Yano, FumihikoYamashita, Kazuta Fukumori, Masahiro Kiyama, Shuji Sumie, Kentaro Iwanaga, Shi~etaka Kuroki, Osamu Kato, Kazumitsu Kiyomatsu, Naoki Hirose, Hiroshi Yamamoto, Masatoshi Anti-HBc in hepatocellular carcinoma without HBsAg, HBV DNA, anti-HCV ,and HCV RNA Journal of Clinical Gastroenterology 30: 213, 2000 21 Osamu Kanauchi, Yoshio Araki, Akira Andoh, Toshihiko Iwanaga, Norio Maeda, Keiichi Mitsuyama, Tadao Bamba, Toshifumi Hibi Effect of germinated barley foodstuff administration on mineral utilization in rodents Journal of Gastroenterology 35: 188-194, 2000 22 Masaru Harada, Yuko Fujisawa, Shotaro Sakisaka, Takumi Kawaguchi, EitaroTaniguchi, Masaharu Sakamoto, Shuji Sumie, Kurumi Sasatomi, Hironori Koga, Takuji Torimura, Takato Ueno, Kazuhisa High prevalence of anticardiolipin antibodies in hepatitis C virus infection: lack of effects on thrombocytopenia and thrombotic complications Journal of Gastroenterology 35: 272-277, 2000 23 Tadashi Iwao, Kazuhiko Oho, Ryoichi Nakano, Teruhiro Sakai, Masahiro Sato, Yasunao Miyamoto, Masafumi Kumamoto, Kenji Sakai, Michio Sata, Atsushi Toyona~a High plasma cardiac natriuretic peptides associated with enhanced cyclic guanosine monophosphate production in preascitic cirrhosis Journal of Hepatology 32: 426-433, 2000 24 Shiro Murashima, Ryukichi Kumashiro, Tatsuya Ide, Ichiro Miyajima, Teruko Hino, Yuriko Koga, Kunihide Ishii, Takato Ueno, Shotaro Sakisaka, Michio Sata Effect of interferon treatment on serum 2', 5'- oligoadenylate synthetase levels in hepatitis C-infected patients Journal of Medical Virology 62: 185-190, 2000 25 Tian-Cheng Li, Jing Zhang, Haruhide Shinzawa, Masamichi Ishibashi, Michio Sata, Eric E Mast, Kisoon Kim, Tatsuo Miyamura, Naokazu Takeda Empty virus-like particle-based enzyme-linked immunosorbent assay for antibodies to hepatitis E virus Journal of Medical Virology 62: 327-333, 2000 26 Yumiko Nagao, Michio Sata, Seiji Noguchi, Tamiko Seno'o, Moritoshi Kinoshita, Tadamitsu Kameyama, Takato Ueno Detection of hepatitis C virus RNA in oral lichen planus and oral cancer tissues Journal of Oral Pathology and Medicine 29: 259-266, 2000 27 Shotaro Sakisaka, Hironori Koga, Kurumi Sasatomi, Masahito Ohishi, Takumi Kawaguchi, Masaru Harada, Eitaro Tani~uchi, Yasuyo Uchimura, Takato Ueno, Michio Sata, Kyuichi Tanikawa Ursodeoxycholic acid reduces expression of heat shock proteins in primary biliary cirrhosis Liver 20: 78-87, 2000 28 Eiji Nishiwaki, Saralinda LTurner, Susanna Harju, Shiro Miyazaki, Masahide Kashiwagi, James Koh, HiroakiSerizawa Regulation of CDK7-carboxyl-terminal domain kinase activity by the tumor suppressor p 16"`'``'~~ contributes to cell cycle regulation Molecular and Cellular Biology 20: 7726-7734, 2000 29 Yoshihiro Shimauchi, Masatoshi Tanaka, Ryoko Kuromatsu, lZiko Ogata, Yukio Tateishi, Satoshi Itano, Naofumi Ono, Shi~eru Yutami, Hiroaki Nagamatsu, Satoshi Matsu~aki, Sanki Yamasaki, Kyuichi A simultaneous monitoring of Lens culinaris agglutinin A -reactive a -fetoprotein and des - r - carboxy prothrombin as an early diagnosis of hepatocellular carcinoma in the follow-up of cirrhotic patients Oncology Reports 7: 249-256, 2000 30 1Ziko Ogata, Yasuo Majima, YukioTateishi, Ryoko Kuromatsu, Yoshihiro Shimauchi, Takuji Torimura, Masatoshi Tanaka, Ryukichi Kumashiro, Masamichi Koiiro, Michio Sata Bright loop appearance; a characteristic ultrasonography sign of early hepatocellular carcinoma Oncology Reports 7: 1293-1298, 2000 31 Yumiko Nagao, Naoko Seki, Shigeru Tamatsukuri, Michio Sata Detection of hepatitis C virus in saliva before and after scaling of dental calculus The Journal of The Japanese Association for Infectious Diseases 74: 961-965, 2000 32 Atsushi Toyonaga, Hiroshi Okamatsu, Kanae Sasaki, Hiroyuki Kimura, Takao Saito, Seiichi Shimizu, Kunitaka Fukuizumi, OsamuTsuruta, KyuichiTanikawa, MichioSata Epidemiological study on food intake and helicobacter pylori infection The Kurume MedicalJournal 47: 25-30, 2000 33 Ryo Noguchi, Shinichiro Ohishi, Chihiro Koga, Yumiko Nagao, Shigeaki Okinaga, Jingo Kusukawa and TadamitsuKameyama Comparison of the inpatients admitted during the recent 5 years (January 1994-December 1998 ) with those admitted during the previous 5 years (January 1989-December 1993 ) : a clinico-statistical study The Kurume MedicalJournal 47: 291-297, 2000 34 N L7chida, H Gondo, D Himeji, Y Kaji, Micio Sata, Y Niho Lamivudine therapy for a hepatitis B surface antigen (HBsAg)-positive leukemia patient receiving myeloablative chemotherapy and autologous stem cell transplantation Bone MarrowTransplantation 26: 1243-1245, 2000 35 K Kohno, T Katayama, K Majima, M Fujisawa, S lida, K Fukami, S L1eda, H Nishida, Michio Sata, S Kato, M Morimatsu and S Okuda Acase of normotensive scleroderma renal crisis after high-dose methylprednisolone treatment Clinical Nephrology 53: 479-482, 2000 36 Eiji Ando, Masatoshi Tanaka, Fumihiko Yamashita, Kazuta Fukumori, Shuji Sumie, Yoichi Yano, Michio Sata Chemotherapy for hepatocellular carcinoma with portal hypertension due to tumor thrombus Journal of Clinical Gastroenterology 31: 247-249, 2000 37 Takato Ueno, Toru Nakamura, Hikaru Ueno, Kyuichi Tanikawa, Michio Sata Present status and future of gene therapy for hepatic fibrosis Frontier in Hepatology - Liver Cirrhosis p. 36-43, 2001 3g Osamu Kanauchi, Toshihiko Iwanaga, Keiichi Mitsuyama Germinated barley foodstuff feeding -Anovel neutraceutical therapeutic strategy for ulcerative colitis Digestion 63: 60-67, 2001 3g Keiichi Mitsuyama, Asuka Suzuki, Nobuo Tomiyasu, Kosuke Takaki, Atsushi Toyonaga, Michio Sata Transcription factor-targeted therapies in inflammatory bowel disease Digestion 63: 68-72, 2001 40 Masaru Harada, Shotaro Sakisaka, Kunihiko Terada, IZina Kimura, Takumi Kawaguchi, Hironori Koga, Motoaki Kin, EitaroTaniguchi, SMnichiro Hanada, Tatsuo Suganuma, Koh Furuta, Toshihiro Sugiyama, A Mutation of Wilson's disease protein, ATP7I3, Is Degraded in the Proteasomes and Forms Protein Aggregates Gastroenterology in press 41 Takato Ueno, Tatsuya Ide, Osamu Hashimoto, Yasuyo Llchimura, Takuji Torimura, Ryukichi Kumashiro, Michio Sata Long-term course of interferon-treated chronic hepatitis C and serum hepatic fibrosis markers Hepato-Gastroenterology in press 42 Takumi Kawaguchi, Shotaro Sakisaka, Masaru Harada, Shinichiro Hanada, EitaroTaniguchi, Hironori Koga, Kyuichi Tanikawa, Michio Sata Endotoxin Increases Paracellular Permeability of Isolated Rat Hepatocyte Couplets HepatologyResearch in press 43 Takato L?eno, Osamu Hashimoto, Rina Kimura, Takuji Torimura, Takumi Kawaguchi, Toru Nakamura, Ryuichiro Sakata, Hironori Koga, and Michio Sata Relation of type II transforming growth factor- (3 receptor to hepatic fibrosis and hepatocellular carcinoma IntermationalJournalofOncology 18: 49-55, 2001 44 Osamu Kanauchi, Isao Seri2awa, Tetsuya Matsumura, Yoshihiro Fukuda, Masamichi Satomi Evaluation of antigenicity of germinated barley foodstuff for the treatment of ulcerative colitis in a chronic murine colitis model InternationalJournalofMolecularMedicine 7: 143-147, 2001 45 Shigeru Yutani, Shigeki Shichijo, Yoshiko moue, Nobutoshi Kawagoe, Kouji Okuda, Toshihiko Kurohiji, Masatoshi Tanaka, Michio Sata, Kyogo Itoh Expression of the SART1 tumor-rejection antigen in hepatocellular carcinomas Oncology Reports 8: 369-372, 2001 46 Asuka Suzuki, Toshikatsu Hanada, Keiichi Mitsuyama, Takafumi Yoshida, Shintaro Kamizono, Tomoaki Hoshino, Masato Kubo, ~tstzko Yamashita, Masaru Okabe, Kiyoshi Takeda, Shizuo Akira, Satoshi CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation The Journal of Experimental Medicine 193: 471-481, 2001 47 Eitaro Taniguchi, Shotaro Sakisaka, Katsuhiko Matsuo, Kyuichi Tanikawa, and Michio Sata Expression and Role of Vascular Endothelial Growth Factor in Liver Regeneration After Partial Hepatectomy in Rats The Journal of Histochemistry and Cytochemistry 49: 121-129, 2001 4g Michio Sata, Yumiko Nagao Hepatitis virus and extrahepatic manifestations - skin, Mucosa, Muscle, and hematopoietic organs - InternalMedicine 40: 185-189, 2001 4g Takumi Kawaguchi, Michio Sata, Naofwni Ono, Shotaro Sakisaka, Hironori Koga, Hiroyasu Ijuin, Keiichi Mitsuyama, Takato Ueno, Masayoshi Kage and Kyuichi Tanikawa Budd-Chiari syndrome complicated by hepatocellular carcinoma with no evidence of infection with hepatitis virus Hepatitis Review in press 50 Takumi Kawaguchi, Masatoshi Tanaka, Satoshi Itano, Naofumi Ono, Yoshihiro Shimauchi, Hiroaki Nagamatsu, Shotaro Sakisaka, Michael ll. llake, Kyuichi Tanikawa, Michio Sata Successful treatment for bronchial bleeding for invasive pulmonary metastasis of hepatocellular carcinoma He~ato-Gastroenterology in press 51 Masaru Harada, Reiichiro Kuwahara, Hiroshi Yoshida, Osamu Hashimoto, Masaharu Sakamoto, Yuriko Koga, Tatsuhiko Kano, Michio Sata Dextromethorphan for neuropathic pain with Churg Strauss syndrome ModernRheumatology in press 2000 細胞発生工学 Publications by our department during Apri12000 - March 2001 1. Development 2000 127, 2471-2479 Molecular analysis of external genitalia formation: The role of Fgf genes during genital tubercle formation. Haraguchi, R., Suzuki, K., Murakami, R., Sakai, M., Kamikawa, M., Kengaku, M., Sekine, K., Kawano, H., Kato, S., Ueno, N. and Yamada, G. 2. FEBS Letters 481 (2000) 53-56 Defective terminal differentiation and hypoplasia of the epidermis in mice lacking the Fgf 10 gene Kentaro Suzuki, Kiyofumi Yamanishi, Osamu Mori, Mami Kamikawa, Bogi Andersend, Shigeaki Kato, Tetsuya Toyoda and Gen Yamada 3. NY Acad Sci 2001, in press External Genitalia Formation: Role of Fibroblast Growth Factor, Retinoic Acid Signaling and Distal Urethral Epithelium (DUE) Yukiko Ogino, Kentaro Suzukia, Ryuma Haraguchi, Yoshihiko Satoh, Pasacal Dolle and Gen Yamada 2001 がんワクチン分子 Selected Publications in 2001-2002 1. Tsuda, N., Murayama, K., Ishida, H., Matsunaga, K., Komiya, S., Itoh, K, and Yamada, A., Expression of a newly defined tumor-rejection antigen SART3 antigen in musculoskeletal tumors and induction of HLA-class I-restricted CTLs by SART3- derived peptides. J. Orthopedic Research, 19:346-351, 2001. ?. Harashima, N,. Tanaka, K., Sasadomi, T., Miyagi, Y , Yamada, A., Tamura, M., Yamana, Y, Itoh., K., and Shichijo, S., Recognition of the Lck tyrosine kinase as a tumor antigen by T cells of metastatic cancer patients. Eur. J. Immunolo., 31:323-332, 2001. 3. Suefuji, Y., Sasatomi, T., Shichijo, S., Nakagawa, S., Deguchi, H., Koga, T., Kameyama, T., and Itoh, K., Expression of SART3 antigen and induction of CTLs by SART3-derived peptides in breast cancer patients. British J. Cancer, 84:915-919, 2001. 4. Ito, M., Shichijo, S., Tsuda, N., Ochi, M., Harasima, N., Saito, N., and Itoh, K., Molecular basis of T cell-mediated recognition of pancreatic cancer cells. Cancer Res., 61:2038-2046, 2001. ~. Yutani, S., Shichijo, S., moue, Y, Kawagoe, N., Okuda, K., Kurohiji, T., Tanaka, M., Sata, M., and Itoh, K., Expression of the SART1 tumor-rejection antigen in hepatocellular carcinomas. Oncol Rep., 8:369-372, 2001. 6. Koga, C., Itoh, K., Aoki, M., Suefuji, Y, Yoshida, M., Asosina, S., and Tadamitsu, K., Anxiety and pain suppresses the natural killer cell activity in oral surgery outpatients. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodonitics, 91:654-658, 2001. 7. Harada, K., Yamada, A., Yang, D., Itoh, K., and Shichijo, S., Binding of a SART3 tumor-rejection antigen to a pre-mRNA splicing activation factor RNPS 1: a possible regulation of splicing by a complex formation. Int. J. Cancer, 93:623-629, 2001. ~. Tamura, M., Nishizaka, S., Maeda, Y, Ito, M., Harashima, N., Harada, M., Shichijo, S., and Itoh, K., Identification of cyclophilin B-derived peptides capable of inducing histocompatibility leukocyte antigen-A2-restricted and tumor-specific cytotoxic T lymphocytes. Jpn. J. Cancer Res., 92:762-767, 2001. 9 . moue, Y , Takaue, Y , Takei, M., Kato, K., Kanai, S ., Harada, Y , Tobisu, K., Noguchi, M., Kakizoe, T., Itoh, K., and Wakasugi, H., Induction of tumor specific cytotoxic T lymphocytes in prostate cancer using prostatic acid phosphatase derived HLA-A2402 binding pepride. J. Urol., 166:1508-1513, 2001. 10. Imai, N., Harashima, N., Ito, M., Miyagi, Y, Harada, M., Yamada, A., and Itoh, K., Identification of Lck-derived peptides capable of inducing HLA-A2-restricted and tumor-specific CTLs in cancer patients with distant metastases. Int. J. Cancer, 94:237- 242, 2001. 11. Yamada, A., Kawano, K., Koga, M., Matsumoto, T., and Itoh, K., Multidrug resistance-associated protein 3 is a tumor rejection antigen recognized by HLA- A2402-restricted cytotoxic T lymphocytes. Cancer Res., 61:6459-6466, 2001. 12. Suzuki, N., Tanaka, S., Maeda, Y, Hida, N., Mine, T., Yamamoto, K., Oka, M., and Itoh, K., Detection of peptide-specific Cytotoxic T lymphocyte precursors used for specific immunotherapy of pancreatic cancer. Int. J. Cancer, in press, 2001. 13. Miyagi, Y, Imai, N., Sasatomi, T., Yamada, A., Mine, T., Katagiri, K., Nakagawa, M., Muto, A., Okouchi, S., Isomoto, H., Shirouzu, K., Yamana, H., and Itoh, K., Induction of cellular immune responses to tumor cells and peptides in colorectal cancer patients by vaccination of SART3 peptides. Clin. Can. Res., 7:3950-3962, 2001. 14. Masuoka, M., Yoshimuta, T., Hamada, M., Okamoto, M., Fumimori, T., Honda, J., Oizumi, K., and Itoh, K. Identification of the HLA-A24 peptide epitope within cytomegalovirus pp65 recognized by CMV-specific cytotoxic T lymphocytes. Viral Immunology, in press, 2002. 15. Sasatomi, T., Suefuji, Y, Miyagi, Y, Ogata, H., Akagi, T., Shirouzu, K., and Itoh, K., Expression of tumor-rejection antigens in colorectal cancers. Cancer, in press, 2002. 16. Tanaka, K., Harashima, N., Niiya, F., Miyagi, Y, Hida, N., Ochi, M., Imai, N., Harada, M., Itoh, K., and Shichijo, S. Serine proteinase inhibitor 9 can be recognized by cytotoxic T lymphocytes of epithelial cancer patients. Jpn. J. Cancer Res., in press, 2002. 17. Yutani, S., Tanaka, M., Mastumoto, H., Imai, N., Sata, M., Shichijo, S., and Itoh, K. Elevation of serum MAGE-4 protein levels and prediction of hepatocellular carcinogenesis in patients with liver cirrhosis. Jpn. J. Cancer Res., in press, 2002. 18. Nakatsura, R., Senji, S., Ito, M, Nishimura, Y, and Itoh, K. Cellular and humoral immune responses to a human pancreatic cancer antigen, CLP, originally defined by the SEREX method. Eur. J. Immunology, in press, 2002. 19. Hida, N., Maeda, Y , Katagiri, K., Takasu, H., Harada, M., and Itoh, K. A simple culture protocol to detect peptide-specific cytotoxic T lymphocyte precursors in the circulation. Can. Immunol. Immunother, in press, 2002. 20. Komatsu, N., Shichijo, S., Maeda, Y, and Itoh, K. Measurement of interferon- y by high-throughput fluorometric microvolume assay technology (FMAT) system. J Immunological method, in press, 2002. 21. Ohkouchi, S., Yamada, A., Imai, N., Mine, T., Harada, T., Shichijo, S., Maeda, Y, Saij o, Y , Nukiwa, T., Itoh, K. Non-mutated tumor-rej ection antigen peptides elicit type-I allergy in the majority of healthy individuals. Tissue Antigens, in press, 2002. 22. M. Tsuru, K. Nagata, T. Ueno, A. Jimi, K. Irie, A. Yamada, T. Nishida, and M. Sata. Electron microscopic observation of established chondrocytes derived from human intervertebral disc hernia (KTN-1) and role of macrophages in spontaneous regression of degenerated tissues. Spine J., 1:422-431, 2001. 23. K. Noda, K.Tanaka, A. Yamada, J. Ogata, H. Tanaka, and Y Shoyama. Simple assay for antitumor immuno-active glycoprotein derived from Chlo~ella vulgar~is strain CK22 using ELISA. Phytother. Res., in press. 24. K. Tanaka, Y. Shoyama, A. Yamada, K. Noda, F. Konishi, and K. Nomoto. Immunopotentiating effects of a glycoprotein from Chlorella vulgar~is strain CK and its characteristics. In "Studies in Natural Products Chemistry (Atta-ur-Rahman, eds), Vol 25 Bioactive Natural Products (Part F). Elsevier Science, Oxford. pp. 429-458, 2001. 2001 肝癌研究 Publications in 2001-2002 1 Kohji Yoshimoto, Kazuaki Yakushiji, Hiroyasu Ijuin, Naofumi Ono, Michitoshi Hashiguchi, Rie Imamura, Hideaki O~ata, Takashi Okamura, Michio Sata, Hiroshi Hashimoto Colour Doppler ultrasonography of a segmental branch of the portal vein is useful for early diagnosis and monitoring of the therapeutic course of veno-occlusive disease after allogenic haematopoietic stem British Journal of Haematology 115: 945-948, 2001 2 Ryuichiro Sakata, Takato Ueno, Toru Nakamura, Takuji Torimura, Hikaru Ueno, Kyuichi Tanikawa, Michio Sata Stretch in hepatic stellate cells induces TGF- a synthesis via Rho family small GTP-binding proteins Cells of the Hepatic Sinusoid Vol. 8 p. 256-258, 2001 3 Toru Nakamura, Takato Ueno, Ryuichiro Sakata, Takuji Torimura, Kyuichi Tanikawa, Hikaru Ueno, Michio Sata Blockade of transforming growth factor- a prevents progression of liver fibrosis and enhances liver regeneration in dimethylnitrosamine-treated rats Cells of the Hepatic Sinusoid Vol. 8 p. 283-286, 2001 4 Osamu Kanauchi, Toshihiku Iwanaga, Keiichi Mitsuyama Germinated barley foodstuff feeding-A~ novel neutraceutical therapeutic strategy for ulcerative colitis- Digestion 63: 60-67, 2001 5 Keiichi Mitsuyama, Asuka Suzuki, Nobuo Tomiyasu, Kosuke Takaki, Atsushi Toyonaga, Michio Sata Transcription factor-targeted therapies in inflammatory bowel disease Digestion 63: 68-72, 2001 6 Takato Ueno. Toro Nakamura, Hikaru Ueno, Kyuichi Tanikawa, Michio Sata Present status and future of gene therapy for hepatic fibrosis Frontier itl Hepatology - Liver Cirrhosis p. 36-43, 2001 7 Masaru Harada, Shotaro Sakisaka, Kunihiko Terada, Rina Kimura, Takumi Kawaguchi, Hironori Koga, Motoaki Kin, Eitaro Tanitzuchi, Shinichiro Hanada, Tatsuo Su~anuma, Koh Furuta, Toshihiro Su~iyama, A mutation of Wilson disease protein, ATP7B, is degraded in the proteasomes and forms protein aggregates Gastroenterology 120: 967-974, 2001 8 Takato tleno, Tatsuya Ide, Osamu Hashimoto, Yasuyo Uchimura, Takuji Torimura, Ryukichi Kumashiru, Sadataka Inuzuka, Mlchio Sata Long-term follow up of interferon-treated chronic hepatitis C and serum hepatic fibrosis markers Hepato-Gastroenterology 48: 1124-1128, 2001 9 Hironori Koga, Shotaro Sakisaka, Masaru Hanada, Toshiyuki Takagi, Shinichiro Hanada, Eitaro Tanit~uchi. Takumi Kawa~uchi, Kurumi Sasatomi, Ring Kimura, Osamu Hashimoto, Takato Ueno, Involvement of p21WAFl/Cipl, p27Kipl, and p18INK4c in troglitazone- induced cell-cycle arrest in human hepatoma cell lines Hepatology 33: 1087-1097, 2001 10 Shotaro Sakisaka, Takumi Kawaguchi, Eitaro Taniguchi, Shinichiro Hanada, Kurumi Sasatomi, Hironori Koga, Masaru Harada, Rina Kimura, Michio Sata, Norimasa Sawada, Michio Mori, Satoru Todo, Alterations in tight junctions differ between primary biliary cirrhosis and primary sclerosing cholangitis Hepatology 33: 1460-1468, 2001 11 Etsuro Orito, Takafumi Ichida, Hiroshi Sakugawa, Michio Sata, Norio Horiike, Keisuke Hino, Kiwamu Okita, Takeshi Okanoue, Shiro Iino, Eiii Tanaka, Kazuyuki Suzuki, Hisayoshi Watanabe, Shuhei Hire, Geographic distrubution of hepatitis B virus ( HBV ) genotype in patients with chronic HBV infection in Japan Hepatology 34: 590-594, 2001 12 Takuji Torimura, Takato Ueno, Motoaki Kin, Riko Harada, Toru Nakamura, Takumi Kawaguchi, Masaru Harada, Ryukichi Kumashiro, Hideomi Watanabe, Raz Avraham, Michio Sata Autocrine motility factor enhances hepatoma cell invasion across the basement membrane through activation of (31 integrins Hepatology 34: 62-71, 2001 13 Takumi Kawaguchi, Shotaro Sakisaka, Masaru Harada, Shinichiro Hanada, Eitaro Taniguchi, Hironori Koga, Kurumi Sasatomi, Kyuichi Tanikawa, Michio Sata Endotoxin increases paracellular permeability of isolated rat hepatocyte couplets Hepatology Research 20: 144-154, 2001 14 Tatsuya Ide, Ryukichi Kumashiro, Teruko Hino, Shiro Murashima, Kei Ogata, Yuriko Koga, Michio Sata Transcription-mediated amplification is more useful in the follow-up of patients with chronic hepatitis B treated with lamivudine Hepatology Research 21: 76-84, 2001 15 Usamu Kanauchi, Isao Serizawa, Tetsuya Matsumura, Yoshihiro Fukuda, Masamichi Satomi Evaluation of antigenicity of germinated barley foodstuff for the treatment of ulcerative colitis in a chronic murine colitis model International Journal of Molecular Medicine 7: 143-147, 2001 16 Takato Ueno, Osamu Hashimoto, Rina Kimura, Takuji Torimura, Takumi Kawaguchi, Toru Nakamura, Ryuichiro Sakata, Hironori Ko~a, and Michio Sata Relation of type II transforming growth factor- a receptor to hepatic fibrosis and hepatocellular carcinoma International Journal of Oncology 18: 49-55, 2001 17 Osamu Kanauchi, Keiichi Mltsuyama and Yoshio Araki Development of a functional germinated barley foodstuff from brewer's spent grain for the treatment of ulcerative colitis Journal of American Society Brewing Chemists 59: 59-62, 2001 18 Takumi Kawaguchi, Richard L. Veech, Kosaku Uyeda Regulation of energy metabolism in macrophages during hypoxia: Roles of fructose 2, 6-bisphosphate and ribose 1, 5-bisphosphate Journal of Biological Chemistry 276: 28554-28561, 2001 19 Takamasa Oono, Yoshinori Fukui, Sadahiko Masuko, Osamu Hashimoto, Takato Ueno, Terukazu Sanui, Ayumi Inayoshi, Masuko Noda, Michio Sata, Takehiko Sasaauki Organ-specific autoimmunity in mice whose T cell repertoire is shaped by a single antigenic peptide Journal of Clinical Investigation 108; 1589-1596, 2001 20 Satsuki Kobayashi, Tatusya Ide, Michio Sata Detection of YMDD motif mutations in some lamivudine-untreated asymptomatic hepatitis B virus carriers Journal of Hepatology 34: 584-586, 2001 21 Masaharu Sakamoto, Takato Ueno, Toru Nakamura, Osamu Hashimoto, Ryuichiro Sakata, Motoaki Kin, Riko O~ata, Takumi Kawa~uchi, Takuii Torimura, Michio Sata Estrogen upregulates nitric oxide synthase expression in cultured rat hepatic sinusoidal endothelial cells Jc>urrlal of Hepatology 34: 858-864, 2001 22 Takuji Torimura, Takato Ueno, Motoaki Kin, Riko Harada, Toru Nakamura, Masaharu Sakamoto, Ryukichi Kumashiro, Hirohisa Yano, Masamichi Kojiro, Michio Sata Laminin deposition to type IV collagen enhances haptotaxis, chemokinesis, and adhesion of hepatoma cells through a 1-integrins Journal of Hepatology 35: 245-253, 2001 23 Yoshinori Fukui. Osamu Hashimoto, Terukazu Sanui, Takamasa Oono, Hironori Koga, Masaaki Abe, Ayumi Inayoshi. Mayuko Noda, Masahiro Oike, Toshikazu Shirai, Takehiko Sasazuki Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration Nature 412: 826-831, 2001 24 Shigeru Yutani, Shigeki Shichijo, Yoshiko moue, Nobutoshi Kawagoe, Kouji Okuda, Toshihiko Kurohiji, Masatoshi Tanaka, Michio Sata, Kyoto Itoh Expression of the SART1 tumor-rejection antigen in hepatocellular carcinomas Oncolc>gy Reports 8: 369-372, 2001 25 Takumi Kawaguchi, Makoto Takenoshita, Tsutomu Kabasluma, Kosaku Uyeda Glucose and cAMP regulate the L-type pyruvate kinase gene by phosphorylation / dephosphorylation of the carbohydrate response element binding protein Proceedings of The National Academy of Sciences of The United 98: 13710-13715, 2001 26 Asuka Suzuki, Toshikatsu Hanada, Keiichi Mitsuyama, Takafumi Yoshida, Shintaro Kamizono, Tomoaki Hoshino, Masato Kubo, Atsuko Yamashita, Masaru Okabe, Kiyoshi Takeda, Shizuo Akira, Satoshi CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation The Journal of Experimental Medicine 193: 471-481, 2001 27 Eitaro Taniguchi, Shotaro Sakisaka, Katsuhiko Matsuo, Kyuichi Tanikawa, and Michio Sata Expression and role of vascular endothelial growth factor in liver regeneration after partial hepatectomy in rats The Journal c>f Histochemistry and Cytochemistry 49: 121-129, 2001 28 Michiyo Tsuru, Kensei Nagata, Takato Ueno, Atsuo Jimi, Kouji Irie, Akira Yamada, Toshiharu Nishida, Michio Sata Electrc>r~ microscopic observation of established chondrocytes derived from human intervertebral disc hernia (KTN-1) and role of macrophages in spontaneous regression of degenerated tissues The Spine Journal l: 422-431, 2001 2g Mutsuko Nakahara, Hiroko Iida, Michiyo Urata, Masako Fujise, Machiko Wakiyama, Sachiko Kinoshita, Hiroko Tsuda, Takashi Okamura, Kenshi Yao, Tsuneyoshi Yao, Naotaka Hamasaki A novel splice acceptor site mutaion of Protein S gene in affected individuals with type I Protein S deficiency: Allelic exclusion of the mutant gene ThromUosis Research 101: 387-393, 2001 30 Yoichi Yano, Fumihiko Yamashita, Shoji Sumie, Eiji Ando, Kazuta Fukumori, Masahiro Kiyama, Takashi Oyama, Shi~etaka Kuroki, Osamu Kato, Hiroshi Yamamoto, Masatoshi Tanaka, Michio Sata Clinical features of hepatocellular carcinoma seronegative for both HBsAg and anti-HCV antibody but positive for anti-HBc antibody in Japan American Journal of Gastroenterology 97: 156-161, 2002 31 Ryukichi Kumashiro, Tatsuya Ide, Masaru Sasaki, Shiro Murashima, Hiroshi Suzuki, Teruko Hino, Yasuyo Morita, Ichiro Miya~ima, Kei O~ata, Eisuke Tanaka, Hiroshi Yoshida, Kyuichi Tanikawa, Michio Interferon- r brings additive anti-viral environment when combined with interferon- a in patients with chronic hepatitis C Hepatology Research 22: 20-26, 2002 32 Yumiko Nagao, Jurlko Tanaka, Toshio Nakanishi, Takashi Moriya, Keiko Katayama, Junko Kumagai, Yutaka Komiya. Yuii Itoh, Yoshinari Myoken, Met~umu Fujihara, Michio Sata, Hiroshi Yoshizawa High incidence of extrahepatic manifestations in an HCV hyperendemic area Hepatology Research 22: 27-36, 2002 33 Tatsuya Ide, Rvukichi Kumashiro, Teruko Hino, Shiro Murashima, Kei Ogata, Yuriko Koga, Michio Sata Short term and two-step interferon therapy for chronic hepatitis C patients with low HCV RNA levels Hepatology Research 22: 145-151, 2002 34 Masanobu Fukuda, Osamu Kanauchi, Yoshio Araki, Akira Andoh, Keiichi Mitsuyama, Kosuke Takaki, Atsushi Toyona~a, Michio Sata, Yoshihide Fu~iyama, Masamichi Fukuoka, Yoshiaki Matsumoto, Tadao Prebiotic .treatment of experimental colitis with germinated barley foodstuff: A comparison with probiotic or antibiotic treatment International Journal of Molecular Medicine 9: 65-70, 2002 35 Yumiko Nagao, K Tsubone, Rina Kimura, Shinichiro Hanada, Ryukichi Kumashiro, Takato Ueno, Michio Sata High prevalence of anticardiolipin antiUodies in patients with HCV-associated oral lichen planus International Journal of Molecular Medicine 9: 293-297, 2002 36 Takumi Kawaguchi, Kiyoshi Osatomi, Hiroshi Yamashita, Tsutomu Kabashima, Kosaku Uyeda Mechanism for fatty acid "sparing" effect on glucose-induced transcription: Regulation of carbohydrate-responsive element-binding protein by AMP-activated protein kinase 37 Hideaki Tsuda, Michio Sata, Hiroyasu Ijuin, T Kumabe, M Uchida, Yoshio Ogou, Y Akagi, Kaauo Shirouzu, H Hara, Yutaka Nakashima A novel strategy for remission induction and maintenance in cancer therapy Oncology Report 9: 65-68, 2002 2001 分子外科 Publications in 2001-2002 1- Sugiyama T,Hasuo Y,Nishida K, Kamura T.Impact on survival follwing succsessful neoadjuvant chemotherapy and radical surgery for stage II b bulkly and stage III b cervical cancer.GynecolOncol 81:330-331,2001 2- Inazu T,Nozaki M,Egami R,Koera K, Kamura T,Nakano H.Laparoscopically Assisted Colpopoiesis Using the Inverted Sigmoid Colon Graft in Patient with Mayer- Rokitansky-Kuster-Hauser Syndrome.J Gynecol Surg.17:97-101,2001 3- Ota S,Sugiyama S,Komai K,Hirai N,Kumagai S,Ushijima K,Nishida T, Kamura T.Weekly 1Hour Paclitaxel Infusion in Patients with Recurrent Gynecological Tumors:a Pilot Study.Jpn J Clin Onco131:395-398,2001 4- Okugawa K,Hirakawa T,Fukushima K, Kamura T, Amada S,Nakano H, Relationship between age,histological type,and size of ovarian tumors. Int J Gynecol Obstet .74:45- 50,2001 5- Akahira J,Yoshikawa H,Shimizu Y,Tsunematsu R,Hirakawa T,Kuramoto H,Shiromizu K,Kuzuya K, Kamura T,Kikuchi Y,Kodama S,Ymamoto K,Sato S.Prognastic Factors of Stage IV Epithelial Ovarian Cancer:A Multicenter Retrospective Study .Gynecol Oncol .81:398-403,2001 6- Ota S,Sugiyama T,Ushijima K,Fujiyoshi K,Komai K,Hirai N,Nishida T, Kamura T.Remission of metastatic cervical adenocarcinoma with weekly paclitaxel.Int J Gynecol Cancer .11:167-168,2001 7- Kaku T,Yoshikawa H,Tsuda H,Sakamoto A,Fukunaga M,Kuwabara Y,Hataeg M,Komada S,Kuzuya K,Sato S,Nishimura T,Hiura M,Nakano H,Iwasaka T,Miyazaki Kamura T,Conservative therapy for adenocarcinoma and atypical endometrial hyperplasia of the endometrium in young women:central pathologic review and treatment outcome.Cancer Letters.167:39-48,2001 2002 ワクチン tielected Publications in 2002-2003. 1.Sasatomi, T., Suefuji, Y, Matsunaga, K., Yamana, H., Miyagi, Y, Araki, Y, Ogata, Y, Itoh, K., and Shirouzu, K. Expression of Tumor Rejection Antigens in Colorectal Carcinomas. Cancer, 94:1636-1641, 2002. 2.Suzuki, N., Tanaka, S., Maeda, Y, Hida, N., Mine, T., Yamamoto, K., Oka, M., and Itoh, K., Detection of peptide-specific Cytotoxic T lymphocyte precursors used for specific immunotherapy of pancreatic cancer. Int. J. Cancer. 98:45-50, 2002. 3.Tanaka, K., Harashima, N., Niiya, F., Miyagi, Y, Hida, N., Ochi, M., Imai, N., Harada, M., Itoh, K., and Shichijo, S. Serine proteinase inhibitor 9 can be recognized by cytotoxic T lymphocytes of epithelial cancer patients. Jpn. J. Cancer Res., 98:198-208, 2002. 4. Yutani, S., Tanaka, M., Mastumoto, H., Imai, N., Sata, M., Shichijo, S., and Itoh, K. Elevation of serum MAGE-4 protein levels and prediction of hepatocellular carcinogenesis in patients with liver cirrhosis. Jpn. J. Cancer Res., 93:453-458, 2002. 5. Nakatsura, R., Senji, S., Ito, M, Nishimura, Y, and Itoh, K. Cellular and humoral immune responses to a human pancreatic cancer antigen, CLP, originally defined by the SEREX method. Eur. J. Immunology, 32:826-836, 2002. 6. Hida, N., Maeda, Y , Katagiri, K., Takasu, H., Harada, M., and Itoh, K. A simple culture protocol to detect peptide-specific cytotoxic T lymphocyte precursors in the circulation. Cancer Immunol. Immunother., 51:219-228, 2002. 7. Komatsu, N., Shichijo, S., Maeda, Y, and Itoh, K. Measurement of interferon-y by high- throughput fluorometric microvolume assay technology (FMAT) system. J Immunological method, 263 :169-176, 2002. 8. Ohkouchi, S., Yamada, A., Imai, N., Mine, T., Harada, T., Shichijo, S., Maeda, Y, Saijo, Y, Nukiwa, T., and Itoh, K. Non-mutated tumor-rejection antigen peptides elicit type-I allergy in the majority of healthy individuals. Tissue Antigens, 59:259-272, 2002. 9. Maeda, Y, Ito, M, Harashima, N., Nakatsura, T., Hida, N., Imai, N., Sato, Y, Shichijo, S., Todo, S., and Itoh, K. Cleavage and polyadenylation specificity factor (CPSF)-derived peptides can induce HLA-A2-restricted and tumor-specific CTLs in the majority of gastrointestinal cancer patients. Int. J. Cancer, 99:409-417, 2002. 10. Gohara, R., Imai, N., Rikimaru, T., Yamada, A., Hida, N., Ichiki, M., Kawamoto, M., Matsunaga, K., Ashihara, J., Yano, S., Tamura, M., Ohkouchi, S., Yamana, H., Oizumi, K., and Itoh, K. Phase I Clinical Study of CyclophilinB Peptide Vaccine for Lung Cancer Patients. J. Immunother., 25:439-444, 2002. 11. Maeda, Y , Hida, N., Niiya, F., Katagiri, K., Harada, M., Yamana, H., Kamura, T., Takahashi, M., Sato, Y, Todo, S and Itoh, K. Detection of peptide-specific CTL-precursors in peripheral blood lymphocytes of cancer patients. Br. J. Cancer, 87:796-804, 2002. 12. Nonaka, Y, Tsuda, N., Shichijo, S., Ito, M., Maeda, Y, Harada, M., Kamura, T., Shigemori, M., and Itoh, K. Recognition of ADP-ribosylation factor 4-like by HLA-A2-restricted and tumor-reactive cytotoxic T lymphocytes from patients with brain tumor. Tissue Antigens, 60:319-327, 2002. 13. Tsuda, N., Nonaka, Y, Shichijo, S., Yamada, A., Ito, M., Maeda, Y, Harada, M., Kamura, T., and Itoh, K. UDP-Gal: beta G1cNAc betal, 3-galactosyltransferase, polypeptide 3 (GALT3) is a tumor antigen recognized by HLA-A2-restricted cytotoxic T lymphocytes from patients with brain tumor. Br. J. Cancer, 87:1006-1012, 2002. 14. Noda, K., Tanaka, K., Yamada, A., Ogata, J., Tanaka, H., and Shoyama, Y Simple assay for antitumour immunoactive glycoprotein derived from Chlorella vulgaris strain CK22 using ELISA. Phytother Res., 16:581-585, 2002. 15. Tsuru, M., Nagata, K., Jimi, A., Irie, K., Yamada, A., Nagai, R., Horiuchi, S., and Sata, M. Effect of AGEs on human disc herniation: intervertebral disc hernia is also affected by AGEs. Kurume Med. J., 49:7-13, 2002. 16. Yamada, A., Yamana, H., and Itoh, K. Development of peptide-based vaccines for epithelial cancer. In "Research Progress in Cancer 2", R. M. Mohan (Ed), Global Research Network, India. pp. 241-247, 2002. 17. Koga, M., Shichijo, S., Yamada, A., Ashihara, J., Sawamizu, H., Kosukawa, J., and Itoh K. Identification of ribosomal proteins S2 and LlOa as tumor antigens recognized by HLA-A26- restricted CTL. Tissue Antigens, 61:136-145, 2003. 18. Azuma, K., Shichijo, S., Maeda, Y, Nonaka, Y, Fujii, T., Kenta, K., and Itoh, K. Mutated p53 gene encodes a non-mutated epitope recognized by HLA-B4601-restrited and tumor-reactive CTLs at tumor site. Cancer Res 63: 854-858, 2003. 19. Yamada, A., Kawano, K., Koga, M., Takamori. S., Nakagawa, M., and Itoh, K. Gene and peptide analyses of newly defined lung cancer rejection antigens recognized by HLA-A2402- restricted tumor-specific cytotoxic Tlymphocytes. Cancer Res., in press, 2003. 20. Noguchi, M., Kobayashi, K., Suetsugu, N., Tomiyasu, K., Suekane, S., Yamada, A., Itoh, K. and Noda, S. Induction Of Cellular And Humoral Immune Responses To Tumor Cells And Peptides In HLA-A24 Positive Hormone-Refractory Prostate Cancer Patients By Peptide Vaccination. The Prostate, in press, 2003. 21. Harada, M., Kobayashi, K., Matsueda, S., Nakagawa, M., Noguchi, M., and Itoh, K. Prostate- specific antigen-derived epitopes capable of inducing cellular and humoral responses in HLA- A24+ prostate cancer patients. The Prostate, accepted. 22. Kawamoto, N., Yamada, A., Ohkouchi, S., Maeda, T., Tanaka, S., Hashimoto, T., Saijo, Y, Saijo, S., Nukiwa, T., Shichijo, S., Aizawa, H., and Itoh, K. IgG reactive to CTL-directed epitopes of self-antigens is either lacking or unbalanced in atopic dermatitis patients. Tissue Antigen, 61:1-10, 2003. 23. Tanaka, S., Harada, M., Mine, T., Noguchi, M., Gohara, R., Azuma, K., Tamura, M., Yamada, A., Morinaga, A., Nishikori, M., Katagiri, K., Itoh, K., Yamana, H., and Hashimoto, T. Peptide vaccination for patients with melanoma and other types of cancer based on pre-existing peptide-specific cytotoxic T lymphocyte precursors in the periphery. J. Immunother., in press, 2003. 24. Mine, T., Gouhara, R., Hida, N., Imai,N., Azuma, K., Rikimaru, T., Katagiri, K., Nishikori, M., Sukehiro, A., Nakagawa, M., Yamada, A., Aizawa, H., Shirouzu, K., Itoh, K., and Yamana, H. Immunological evaluation of CTL precursor-oriented vaccines for advanced lung cancer patients. Cancer Science, in press, 2003. 25. Yamada, A., Yamana, H., and Itoh, K. Peptide-based vaccines for cancer immunotherapy. In "Current Topics in Peptide & Protein Research", Research Trend. 2002 肝癌研究 Selected Publications in 2002-2003. 1. Yoichi Yano, Fumihiko Yamashita, Shuji Sumie, Eiji Ando, Kazuta Fukumori, Masahiro Kiyama, Takashi Oyama, Shigetaka Kuroki, Osamu Kato, Hiroshi Yamamoto, Masatoshi Tanaka, Michio Sata Clinical features of hepatocellular carcinoma seronegative for both HBsAg and anti-HCV antibody but positive for anti-HBc antibody in Japan American Journal of Gastroenterology 97: 156-161, 2002 2. Ryoko Kuromatsu, Masatoshi Tanaka, Eiji Ando, Riko Harada, Ryukichi Kumashiro and Michio Sata Long-term results after PEIT for HCV-related small HCC and its prognostic factors Asian Pacific Association for the Study of the Liver Meeting 2002 149-151, 2002 3. Eiji Ando, Masatoshi Tanaka, Fumihiko Yamashita, Ryoko Kuromatsu, Shigeru Yutani, Kazuta Fukumori, Shuji Sumie, Yoichi Yano, Koji Okuda, Michio Sata Hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma with portal vein tumor thrombosis: Analysis of 48 cases Cancer 95: 588-595, 2002 4. Yutaka Matsui, Keiichi Mitsuyama, Nobuo Tomiyasu, Atsushi Toyonaga, Michio Sata Efficacy of vascular endothelial growth factor in the treatment of experimental gastric injury Digestion 66:99-105, 2002 5. Haruhiko Yoshida, Yasuyuki Arakawa, Michio Sata, Shuhei Nishiguchi, Michitami Yano, Shigetoshi Fujiyama, Gotarou Yamada, Osamu Yokosuka, Yasushi Shiratori, and Masao Omata Interferon therapy prolonged life expectancy among chronic hepatitis C patients Gastroenterology 123: 483-491, 2002 6. Hironori Koga and Michio Sata Involvement of p21WAFl/Cipl and p27Kipl in troglitazone-induced cell cycle arrest in human hepatome cell lines Growth, Proliferation, and Apoptosis in Hepatocytes p. 61-72, 2002 7. Ryukichi Kumashiro, Tatsuya Ide, Masaru Sasaki, Shiro Murashima, Hiroshi Suzuki, Teruko Hino, Yasuyo Morita, Ichiro Miyajima, Kei OQata, Eisuke Tanaka, Hiroshi Yoshida, Kyuichi Tanikawa, Michio Sata Interferon-y brings additive anti-viral environment when combined with interferon-a in patients with chronic hepatitis C Hepatology Research 22: 20-26, 2002 8. Yumiko Nagao, Junko Tanaka, Toshio Nakanishi, Takashi Moriya, Keiko Katayama, Junko Kumagai, Yutaka Komiya, Yuji Itoh, Yoshinari Myoken, Megumu Fujihara, Michio Sata, Hiroshi Yoshizawa High incidence of extrahepatic manifestations in an HCV hyperendemic area Hepatology Research 22: 27-36, 2002 9. Tatsuya Ide, Ryukichi Kumashiro, Teruko Hino, Shiro Murashima, Kei Ogata, Yuriko Koga, Michio Sata Short term and two-step interferon therapy for chronic hepatitis C patients with low HCV RNA levels Hepatology Research 22: 145-151, 2002 10. Shinichi Kakumu, Takashi Matsushima, Shunichi Sato Kenichi Kobayashi, Kendo Kiyosawa, Norio Hayashi, Takao Tsuji, Michio Sata, Hideki Origasa, Shiro Iino, RAM Study Grouop Serum HCV RNA levels during early phase of recombinant interferon alfa-2a (Roferon A) therapy for chronic hepatitis C and efficacy of short-term therapy with earlier loss of viremia Hepatology Research 22: 152-160, 2002 11. Takato Ueno, Osamu Hashimoto, Seishu Tamaki, Toshiro Ogata, Toru Nakamura, Ryuichiro Sakata, Kyuichi Tanikawa, and Michio Sata Clinical appliciation of serum hyaluronan for liver diseases and its significance HYALURONAN Volume 2 biomedical, Medical and Clinical Aspests p. 445-452, 2002 12. Masanobu Fukuda, Osamu Kanauchi, Yoshio Araki, Akira Andoh, Keiichi Mitsuyama, Kosuke Takaki, Atsushi Toyonaga, Michio Sata, Yoshihide Fujiyama, Masamichi Fukuoka, Yoshiaki Matsumoto, Tadao Pamba Prebiotic treatment of experimental colitis with germinated barley foodstuff: A comparison with probiotic or antibiotic treatment International Journal of Molecular Medicine 9: 65-70, 2002 13. Yumiko Nagao, Kumiko Tsubone, Rina Kimura, Shinichiro Hanada, Ryukichi Kumashiro, Takato Ueno, Michio Sata High prevalence of anticardiolipin antibodies in patients with HCV associated oral lichen planus International Journal of Molecular Medicine 9: 293-297, 2002 14. Hironori Koga, Shotaro Sakisaka, Masao Yoshitake, Masaru Harada, Hiroto Kumemura, Shinichiro Hanada, Eitaro Taniguchi, Takumi Kawaguchi, Ryukichi Kumashiro and Michio Sata Abnormal accumulation in lipopolysaccharide in biliary epithelial cells of rats with self-filling blind loop International Journal of Molecular Medicine 9: 621-626, 2002 15. Yumiko Nagao, Renpei Tomonari, Masayoshi Kage, Kan Komai, Kumiko Tsubone, Toshiharu Kamura and Michio Sata The possible intraspousal transmission of HCV in terms of lichen planus International Journal of Molecular Medicine 10: 569-573, 2002 16. Takumi Kawaguchi, Kiyoshi Osatomi, Hiroshi Yamashita, Tsutomu Kabashima, Kosaku Uyeda Mechanism for fatty acid "sparing" effect on glucose-induced transcription: Regulation of carbohydrate-responsive element-binding protein by AMP-activated protein kinase Journal of Biological Chemistry 277: 3829-3835, 2002 17. Takafumi Yoshida, Toshikatsu Hanada, Takeshi Tokuhisa, Ken-ichiro Kosai, Michio Sata, Michinori Kohara, and Akihiko Yoshimura Activation of STAT3 by the hepatitis C virus core protein leads to cellular transformation Journal of Experimental Medicine 196: 641-653, 2002 18. Kenji Sakai, Tadashi Iwao, Kazuhiko Oho, Atsushi Toyonaga, and Michio Sata Propranolol ameliorates thrombocytopenia in patients with cirrhosis Journal of Gastroenterology 37: 112-118, 2002 19. Eitaro Taniguchi, Masaru Harada, Takumi Kawaguchi, Hironori Koga, Hiroto Kumemura, Shinichiro Hanada, Shochiro Shishido, Shinji Baba, Ryukichi Kumashiro, Takato Ueno, Shotaro Sakisaka, Michio Sata Expression of uncoupling protein-2 in biliary epithelial cells in primary biliary cirrhosis Liver 22: 451-458, 2002 20. Hideaki Tsuda, Michio Sata, Hiroyasu Ijuin, T Kumabe, M Uchida, Yoshio Ogou, Y Akagi, Kazuo Shirouzu, H Hara, Yutaka Nakashima A novel strategy for remission induction and maintenance in cancer therapy Oncology Report 9: 65-68, 2002 21. Osamu Kanauchi, Keiichi Mitsuyama, Yoshio Araki, Akira Andoh Modification of intestinal flora in the treatment of inflammatory bowel disease Current Pharmaceutical Design 9: 333-346, 2003 22. Takato Ueno, Micho Sata and Kyuichi Tanikawa Cells responsible for extracellular matrix production in the liver Extracellular Matrix and the Liver p. 89-103, 2003 23. Shoichiro Shishido, Hironori Koga, Masaru Harada, Hiroto Kumemura, Shinichiro Hanada, Eitaro Taniguchi, Ryukichi Kumashiro, Hiromasa Ohira, Yukio Sato, Masayoshi Namba, Takato Ueno, and Michio Sata Hydrogen peroxide overproduction in megamitochondria of troglitazone-treated human hepatocytes Hepatology 37: 136-147, 2003 24. Ryoko Kuromatsu, Masatoshi Tanaka, Yoshihiro Shimauchi, Riko Harada, Eiji Ando, Satoshi Itano, Ryukichi Kumashiro, Shuichi Fukuda, Koji Okuda and Michio Sata Light and electron microscopic analyses of immediate and late tissue damage caused by radiofrequency ablation in porcine liver International Journal of Molecular Medicine 11: 199-204, 2003 25. Masaru Harada, Hiroto Kumemura, Shotaro Sakisaka, Shoichiro Shishido, Eitaro Taniguchi, Takumi Kawaguchi, Shinichiro Hanada, Hironori Koga, Ryukichi Kumashiro, Takato Ueno, Tatsuo Suganuma, Koh Furuta, Masayoshi Namba, Toshihiro Sugiyama and Michio Sata Wilson disease protein ATP7B is localized in the late endosomes in a polarized human hepatocyte cell line International Journal of Molecular Medicine 11: 293-298, 2003 26. Teruko Hino, Ryukichi Kumashiro. Tatsuya Ide. Yuriko Koga, Kunihide Ishii, Eisuke Tanaka, Yasuyo Morita, Akiko Hisamochi. Shiro Murashima, Kazuo Tanaka, Kei Ogata, Reiichiro Kuwahara, Michio Sata. and The Autoimmune Hepatitis Study Group Predictive factors for remission and death in 73 patients with autoimmune hepatitis in Japan International Journal of Molecular Medicine 11: 749-755, 2003 27. Osamu Kanauchi, Isao Serizawa, Yoshio Araki, Asuka Suzuki, Akira Andoh, Yoshihide Fujiyama, Keiichi Mitsuyama, Kosuke Takaki, Atsushi Toyonaga, Michio S ata, and Tadao B amba Germinated barley foodstuff, a prebiotic product, ameliorates inflammation of colitis through modulation of the enteric environment Journal of Gastroenterology 38: 134-141, 2003 28. Yumiko Nagao, Shinichiro Hanada, Shoichiro Shishido, Tatsuya Ide, Ryukichi Kumashiro, Takato Ueno, and Michio Sata Incidence of Sjgren's syndrome in Japanese patients with hepatitis C virus infection Journal of Gastroenterology and Hepatology 18: 258-266, 2003 29. Kohji Yoshimoto, Naofumi Ono, Takashi Okamura and Michio Sata Recent progress in the diagnosis and therapy for veno-occlusive disease of the liver Leukemia & Lymphoma 44: 229-234, 2003 30. Shinichiro Hanada, Masaru Harada, Hironori Koga, Takumi Kawaguchi, Eitaro Taniguchi, Ryukichi Kumashiro, Takato Ueno, Yoshiyuki Ueno, Motoyasu Ishii, Shotaro Sakisaka, and Michio Sata Tumor necrosis factor-a and interferon-y directly impair epithelial barrier function in cultured mouse cholangiocytes Liver International 23: 3-11, 2003 31. Hideaki Tsuda, Michio Sata, Tutomu Kumabe, Masafumi Uchida and Hiroshi Hara The preventive effect of antineoplaston AS2-1 on HCC recurrence Oncology Reports 10: 391-397, 2003 32. Tsutomu Kabashima, Takumi Kawaguchi, Brian E. Wadzinski, and Kosaku Uyeda Xylulose5-phosphate mediates glucose-induced lipogenesis by xylulose 5- phosphate-activated protein phosphatase in rat liver Proceedings of The National Academy of Sciences of The United States of America 100: 5107-5112, 2003 2002 分子外科 1) H Shiozaki, Y Doki, H Yamana, K Isono: A multi-institutional study of immunohistochemical investigation for the roles of cyclin D 1 and E-cadherin in superficial squamous cell carcinoma of the esophagus: J Surg Oncol. 2002;79(3):166-73 2) T Sasatomi, Y Suefuji, K Matsunaga, H Yamana, Y Miyagi, Y Araki, Y Ogata, K Itoh, K Shirouzu: Expression of tumor rejection antigens in colorectal carcinomas: Cancer. 2002;94(6):1636-41 3) M Kubota, H Yamana, S Sueyoshi, H Fujita, K Shirouzu: The significance of telomerase activity in cancer lesions and the noncancerous epithelium of yhe esophagus: Int J Clin Oncol. 2002;7(1):32-7 4) H Yamana: Immunotherapy for esophageal carcinoma: Nippon Geka Gakkai Zasshi. 2002:103(4):376-80 5) H Nojiri. H Yamana, G Shirouzu, T Suzuki, H Isono, Glycotherapy for cancer:remodeling of ganglioside pattern as an effective approach for cancer therapy: Cancer Detect Prev. 2002:26( 2 >:114-20 6) R Gohara. N Imai, T Rikimaru, A Yamada, N Hida, M Ichiki M Kawamoto K Matsunaga, J Ashihara. S Yano, M Tamura, S Oukouchi, H YamanaK Oizumi, K Itoh: Phase 1 clinical study of evclophilin B peptide vaccine for patients with lung cancer: J. Immunotherapy. 2002 : 2 ~ ( ~ ) : 4 ~ 9-44 7) Y Maeda. :~ Hida. F '~iiya. K Katagiri. ~1 Harada, H Yamana, T Kamura, M Takahashi, Y Sato, S Todo. K Itoh: Detection of peptide-specific CTL-precursors in peripheral blood lymphocytes of cancer patient: British J of Cancer. 2002;87(7):796-804 8) . U Toh, T Sudo. K Kido. S ~Iatono. H Sasahara, T Mine, T anaka, S Sueyoshi, H Fujita, K Shirouzu, H Yamana: Locore`Tional adoptive Immunotherapy resulted in regressioin in distant metastases of a recurrent e~opha~Teal cancer: Int J Clin Oncol. 2002;7(6):372-5 9) Yuko Aoyama: Experimental Studies on the Effects of the Combined Use of N-(4-hydrox- yphenyl) retinamide (4-HPR ~ and Tarlloxifen (TAM) for Estrogen Receptor (ER)-Negative Breast Cancer: Kurume medical journal. 2002;49:27-33 10) T Fujii, S Nakagawa, M Hanzawa. S Susumu, H Fujita, K Shirouzu, H Yamana: Immunohistological study of cell cycle-related factors, oncogene expression, and cell proliferation in adenocarcinoma developed in barrett's esophagus: Oncology Reports. 2002;10:427-431 11)H Deguchi, T Fujii, S Nakagawa, T Koga, K Shirouzu: Analysis of cell growth inhibitory effects of catechin through MAPK in human breast cancer cell line T47D: Int J Oncol. 2002;21:1301-1305 12) T Fujii, T Sudo, S, Sueyoshi, T Tanaka, H Fujita, K Shirouzu, S Ban, A Toyonaga, S Kato, H YamaClinicopathologic study of neovascularization and VEGF expression in superficial esophageal carcinoma: Int J Oncol. 2002;21:1181-1187 13) K Azuma, S Shichijo, Y Maeda, T Nakatsura, Y Nonaka, T Fujii, K Koike, K Itoh: Mutated p53 Gene Encodes a Nonmutated Epitopr recognized by HLA-B4601-restricted and Tumor Cell-reactive CTLs at Tumor Site: Cancer Res. 2002;63:854-858 14) H Yanaga, T Fujii, T Koga, R Araki, K Shirouzu: Prevention of carcinogenesis of mouse mammary epithelial cells RIII/MG by epigallocatechin gallate: Int J mol med. 2002;10:311-315 15) M Laura, G Bermejo, F C Leskow, T Fujii, Q Wang, P M Blumberg, M Ohba, T Kuroki, K-C Han, J Lee, V E Marquez, M G Kazanietz: Diacylglycerol (DAG)-lactones, a New Class of Protein Kinasa C (PKC) Agonists, Induce Apoptosis in LNCaP Prostate Cancer Cells by Selective Activation of PKCa: J. biol. Chem. 2002;277:645-655 16) Y Kanamori, J Kigawa, H Itamochi, H Sultan, M Suzuki, M Ohwad, T Kamura, T Sugiyama, Y Kikuchi, T Kita, K Fujiwara, N Terakawa: PTEN expression is associated with prognosis for patienz with advanced endometarial carcinoma undergoing postoperative chemotherapy: Int. J. Cancer. 2002;100:686-689 17) Y Nagao, R Tomonari, M Kage, K Komai, K Tsubone, T Kamura, M Sata: The possible intraspousal transmission of HCV in terms of lichen planus: Int J Mol Med. 2002;10:569-573 18) Y Nonaka, N Tsuda, S Shichijo, M Ito, Y Maeda, M Harada, T Kamura, M Shigemori, K Itoh: Recongnition of ADP-ribosylation factor 4-like by HLA-A2-restricted and tumor-reactive cytotoxic T lymphocytes from patients with brain tumors: Tissue Antigens. 2002;60:319-327 19) N Tsuda, Y Nonaka, S Shichijo, A Yamada M Ito, M Harada, T Kamura, K Itoh : UDP-Ga1:B G1cNAc Bl, 3-galactosyltransferase, polypeptide 3(GALT3)is a tumor antigen recognized by HLA-A2-restricted cytoxic T lymphocytes from patients with brain tumor: Br J Cancer. 2002;87:1006-1012 20) H Yahata, H Kobayashi, T Kamura, S Yamada S, T Hirakawa, K Kohno, M Kuwano, H Nakano: Increased nuclear localization of transcription factor YB-1 in acquired cisplatin- resistant ovarian cancers: J Cancer Res clin Oncol. 2002;128:621-626 21) Michiyo Tsuru, Kensei Nagata, Takato Ueno, Atsuo Jimi, Kouji Irie Akira Yamada , Toshiharu SNishida and Michio Sata. Electron Microscopic Observation of Established Chondrocytes Derived from Human Intervertebral Disc Hernia (KTN-1) and Role of Macrophages in Spontaneous Regression of Degenerated Tissues. The Spine Journal. Vol. 1 No. 6 422-431 2001. 22) Michiyo Tsuru, Kensei Nagata, Atsuo Jimi, Kouji Irie, Akira Yamada, Ryoji Nagai, Seikoh Horiuchi and Michio Sata. Effect of AGEs on Human Disc Herniation: Intervertebral Disc Hernia is Also Effected by AGEs. The Kurume Medical Journal, Vol. 49. No. 1 7-13 2002. 23)Michiyo Tsuru, Kensei Nagata, Takato Ueno, Atsuo Jimi, Shinshi Noda, Shizuka Iida and Michiyo Sata. Confocal laser microscopy of chondrocytes that received gene transfer using in vitro electroporation . The Kurume Medical Journal, Vol. 49. No. 1 1-5 2002. 24) Kensei Nagata, Michiyo Tsuru. Spontaneous Remission of Intervertebral Disk Hernia and Responses of Surrounding Macrophages. Advances in Spinal Fusion-Molecular Science, Biomechanics and Clinical Management. Cambridge Scientific, Inc. c/o M&N Toscano. 2003. 25) Kamura T, Kim-Y T : Pitfall in chemotherapy for ovarian cancer: Yonsei M J. 2002;43:779- 782 26) Kamura T, Jeon-J-D: L~ mph node metastasis in a gynecologic malignancy: Yonsei M J. 2002;43:783-791 27) Kensei Nagata. ~-lichiyo T~uru. Jun-ichi Miyazaki, You-ichi Nabeshima. The Second European Conference on Bone ~~lorphoQenetic Proteins. "Gene therapy using in vivo electroporation of the human BLIP-? gene in Klotho mice."