2003 業績紹介

2003年

1. 成人および高齢者の精神・神経疾患の認知神経科学的研究

－総説－

  1. Maeda H　：　Unification of dopamine and glutamate hypotheses of schizophrenia from the standpoint of emotional circuit.　J Brain Sci　2003;29:5-9.
  2. Morita K　：　The characteristics facial - affect recognitive function in schizophrenic patients using biological markers such as event ? related potentials and exploratory eye. 　J Brain Sci　2003;29:26-31.
  3. Morita K, Shigemori M, Tokutomi T, Shoji Y, Tomita M. Maea H : Characterisics of cognitive function in patients with higher brain dysfunction after brain injury using event-related potentials and exploratory eye movements: comparison with healthy subjects. Proceeding of the 12th Annual Meeting of the Society for Treatment of Coma 2003;12:81-94.
  4. Nose I, Ehira M, Habukawa M, Hashizume Y, Ooyama T, Fukuyama H, Hashimoto T, Okamura H, Uchimura N, Maeda H　：　The change of mental state in medical treatment for sleep apnea syndrome.　 J Brain Sci　2003;29:47.
  5. Ueno T, Morita K, Terasaki M, Abe T, Nishimura H, Maeda H　：　Functional MRI study for case of brain tumor. J Brain Sci　2003;29:57-8.
  6. Tokutomi T , Morimoto K, Miyagi T, Yamaguchi S, IshikawaＫ, Shigemori M：　Optimal temperature for the management of severe traumatic brain injury: Effect of hypothermia on intracranial pressure, systemic and intracranial hemodynamics, and metabolism． Neurosurgery 2003;52:102-12.
  7. Hattori G, Tanaka E, Yokomizo Y, Shigemori M, Higashi H： Electrical and pharmacological properties of the slow depolarization induced by schaffer collateral stimulation in astrocytes of the rat hippocampal CA1 region．Neurosci Lett 2003;343:85-8.
  8. Fujimura N, Abe T, Hirohata M, Morimitsu H, Tokutomi T, Shigemori M： Bilateral anomalous posterior inferior cerebellar artery-anterior inferior cerebellar artery anastomotic arteries associated with a ruptured cerebral aneurysmー　　Case reportー．Neurol Med Chirc　2003;43:396-8.
  9. Hirohata M, Abe T, Morimitsu H, Fujimura N, Shigemori M, A.M. Norbash：　Preoperative seslective internal carotid artery dural branch embolisation for petroclval meningiomas． Interventional Neuroradiology 2003;45:656-60.
  10. Sheila K. Singh, Ian D. Clarke, Terasaki M, Victoria E. Bonn, Cynthia Hawkins, Jeremy Squire, Peter B. Dirks：Identification of a cancer stem cell in human brain tumors．　Cancer Res 2003;63:5821-8.
  11. Sugita Y, Tokunaga O, Terasaki M, Moritatsu M, Shigemori M： Epithelial differentiation in medulloblastoma: Comparison with other embryonal tumors of neuroectodermal origin． Pathol Int 2003；53：858-64.
  12. Terasaki M： Mutant stem cells may seed cancer．　Science 2003;301:1308-10.

－論文－

  1. Yanagimoto K,　Maeda H　：　The nucleus accumbens unit activities related to the emotional significance of complex environmental stimuli in freely moving cats.　Neurosci Res　2003;46;183-9.
  2. Tsuchiya S,　Tsuchiya K,　Tsuchiya K,　Uchimura N　：　Treatment of rapid eye movement sleep behavior disorder complicated by sleep apnea syndrome.　Sleep Biol Rhythms　2003;1:125-6.
  3. Goto S,　Suzuki Y,　Chiyojima N,　Muta A,　Ogino H,　Tanaka Y,　Uchimura N,　Esaki K,　Koga T　：　Two cases of severe obstructive sleep apnea-hypopnea syndrome in which a mandibular advancing positioner was markedly effective. Sleep Biol Rhythms　2003;1:127-9.
  4. Habukawa M,　Uchimura N,　Kotorii N,　Ogi K,　Yamamoto H,　Hiejima H,　Maruoka T,　Maeda M,　Maeda H　：　Evaluation of sleep disturbance in post-traumatic stress disorder.　　Sleep Biol Rhythms　2003；1：241-3.
  5. Nakayama H,　Morita K,　Mori K,　Hirai S,　Maeda H　：　Improvement of exploratory eye movement　in schizophrenic patients during recovery period.　 Psychiat Clin Neurosci　200;57:169-76.
  6. Kolker DE,　Fukuyama H,　Huang DS,　Takahashi JS,　Horton TH,　Turek FW　：　Aging alters circadian and light?induced expression of clock genes in golden hamsters.　　J Biol Rhythms　2003;18:59-69.
  7. Kinoshita T, Imaizumi, T, Miura, Y, Fujimoto H, Ayabe M, Shoji, H, Okamoto Y, Takasima H, Osame M, Nakagawa M：　A case of adult-onset Alexander disease with Arg416 Trp human glial fibrillary acidic protein gene mutation. Neurosci Lett 2003;350:169-72.
  8. Fujimoto H, Asaoka K, Imaizumi T, Ayabe M, Shoji, H, Kaji M: Epstin-Barr virus infections of the central nervous system. Intern Med 2003;42:33-40.
  9. Shoji, H, Kaji M :The influenza vaccination and neurological complications. Intern Med　2003;42:139.

2. 成人および高齢者の精神・神経疾患の分子生物学的研究

－総説－

  1. Okamura H, Tsuda A, Yajima J, Maeda H　：　Are saliva level of free-MHPG and s-IgA useful as an indicator of panic disorder with SSRI treatment.　J Brain Sci　2003;29:44-5.
  2. Suzuki A, Nakamura K, Sekine Y, Osada N, Minabe Y, Takei N, Suzuki K, Iwata Y, Kawai M, Iyo M, Ozaki N, Inada T, Harano M, Komiyama T, Mitsushio H, Maeda T, Iwashita S, Yamada M, Sora I, Ujike H, Mori N, JGIDA　：　An association study of MAOA gene polymorphism in methamphetamine psychosis. 　J Brain Sci　2003;29:53-4.
  3. Hattori G, Tanaka E, Yokomizo Y, Shigemori M, Higashi H ：　Electrical andpharmacological properties of the slow depolarization induced by Schaffer collateral stimulation in astrocytes of the rat hippocampal CA1 region. 　Neurosci Lett 　 2003;343:85-8.
  4. Tanaka E, Niiyama S, Sato S, Yamada A, Higashi H ：　Arachidonic acid metabolites contribute to the irreversible depolarization induced by in vitro ischemia. 　 J Neurophysiol　 2003;90:3213-23.
  5. Gu J-W, Hasuo H, Akasu T： Effects of emodin on synaptic transmission in rat hippocampal CA1 area in vitro. 2003' Xian International Neurosurgical Academic Forum　　 2003；151-9.

－論文－

  1. Harano M, Etoh Y, Habukawa M, Uchimura N　：　Association study between REM sleep behavior disorder and melatonin receptor gene polymorphism.　　Am J Med Genet　2003:122B:70.
  2. Ujike H, Harano M, Inada T, Yamada M, Komiyama T, Sekine Y, Sora I, Iyo M, Katsu T, Nomura A, Nakata K,　Ozaki N ： Nine- or fewer repeat alleles in VNTR polymorphism of the dopamine transporter gene is a　strong risk factor for prolonged methamphetamine psychosis.　Pharmacogenomics J　　2003;3:242-7.
  3. Matsuyama S, Fukui R, Higashi H, Nishi A : Regulation of DARPP-32 Thr75 phosphorylation by neurotensin in neostriatal neurons: involvement of glutamate signaling. Eur J Neuroscience 　2003;18:1-7.
  4. Fukui R, Svenningsson P, Matsuishi T, Higashi H, Angus C. N, Greengard P, Nishi A. : Effect of methylphenidate on dopamine / DARPP signalling in adult, but not young, mice.　 J Neurochem 2003;87:1391-401.
  5. Takeya M, Hasuo H, Akasu T ：　　 L-Arginine enhances heat-induced depression of neuronal activity in the rat hippocampal CA1 area. Kurume Med J 2003;5:27-34.
  6. Takeya M, Hasuo H, Akasu T. ：　Contribution of nitric oxide to the depression of neuronal activity induced by temperature increase in the rat hippocampal CA1 area. Neurosci Lett 2003;344:153-6.
  7. Iida S, Ishimatsu M, Chikama S, Inoue M, Matsuoka K, Akasu T, Noda S, Khan SR： Protective role of heparin/heparan sulfate on oxalate-induced changes in cell morphology and intracellular Ca2+. Urol Res 2003;31:198-206.
  8. Hasuo H, Akasu T ：　Monocarboxylate transporters contribute to the adaptation of neuronal activity to repeated glucose deprivation in the rat lateral septal nucleus. 　Synapse 　2003;49:97-105.
  9. Hasuo H, Asaumi Y, Matsuoka T, Akasu T ：　Effects of serotonin and dopamine in neurons of the dorsolateral septal nucleus. J Brain Sci 2003;29:21-5.

3. 小児の精神・神経疾患の分子基盤解明と遺伝子治療に関する研究

－論文－

  1. Leonard H, Colvin L, Christodoulou J, Schiavello T, Raffaele L, Williamson S, Davis M, Ravine D, Fyfe S, N de Klerk, Matsuishi T, Kondo I, Clarke A, Yamashita Y : Patients with R133C MECP2 mutations:is their phenotype different from what we expect in Rett syndrome. J Med Genet 2003;40(5):E52.
  2. Egami K, Murohara T, Shimada T, Sasaki K, Shintani S, Sugaya T, Ishii M, Akagi T, Ikeda H, Matsuishi T, Imaizumi T : Role of angiotensin Ⅱ type 1 receptor in tumor angiogenesis and growth. J Clin Invest 2003;112:67-75.
  3. Muta H, Akagi T, Egami K, Furui J, Sugahara Y, Ishii M, Mastuishi T : Incidence and clinical features of asymptomatic atrial septal defect in school children diagnosed by heart disease screening. Circulation J 2003;67:112-5.
  4. Himeno W, Akagi T, Murohara T, Kosai K, Maeno Y, Ishii M, Kato H : Increased angiogenic growth factor levels in cyanotic congenital heart disease. Pediatr Cardiol 　2003;24:127-32.
  5. Himeno W, Maeno Y, Kamura T, Matsuishi T : Enlarged bronchial arteries in a fetus with transposition of the great arteries and intact ventricular septum. 　Pediatr Cardiol 　2003;24:172-4.
  6. Nakamura S, Maeno Y, Matsuishi T : Complete atrioventriculkar block associated with atrial flutter in fetus with positive maternal anti-SSA antibody. Pediatr Cardiol　 2003;24:182-3.
  7. Sugahara Y, Ishii M, Muta H, Egami K, Akagi T, Matsuishi T : Efficacy and Safety of thermal vasodilation therapy by sauna in infants with severe congestive heart failure secondary to ventricular septal defect. Am J Cardiol 2003;92:109-13.
  8. Hidaka Y, Akagi T, Himeno W, Ishii M, Matsuishi T : Left ventricular performance during pregnancy in patients with repaired tetralogy of Fallot - Prospective evaluation using the tie index - . Circulation J 2003;67:682-6.
  9. Uehara R, Yashiro M, Hayamura S, Oki I, Nakamura Y, Muta H, Ishii M, Matsuishi T, Sonobe T, Yanagawa H : Serum alanine aminotransferase concentrations in patients with kawasaki disease. Pediatr Infect Dis J 　2003;22:839-42.
  10. Terazaki Y, Yano S, Yuge K, Nagano S, Fukunaga M, Guo Z S, Komiya S, Shirouzu K, Kosai K : An optimal therapeutic expression level is crucial for suicide gene therapy for hepatic metastatic cancer in mice. Hepatology 　2003;37:155-63.
  11. Li Y, Takemura G, Kosai K, Yuge K, Nagano S, Esaki M, Goto K, Takahashi T, Hayakawa K, Koda M, Kawase Y, Maruyama R, Okada H, Minatoguchi S, Mizuguchi H, Fujiwara T, Fujiwara H : Post-infarct treatment with an adenoviral vector expressing hepatocyte growth factor relieves chronic left ventricular remodeling and dysfunction in mice. 　Circulation　　 2003;107:2499-506.
  12. Tsuneoka M, Umata T, Kimura H, Koda Y, Nakajima M, Kosai K, Takahashi T, Takahashi Y, Yamamoto A: c-myc induces autophagy in rat 3Y1 fibroblast cells. 　　Cell Struct Funct 2003;28(3):195-204.
  13. Matsunaga S, Nagano S, Onishi T, Morimoto N, Suzuki S, Komiya S: Age-related changes in expression of transforming growth factor-beta and receptors in cells of intervertebral discs.　 J Neurosurg 　2003;Jan98(1 Suppl):63-7.
  14. Kamizono J, Matsunaga S, Hayashi K, Shinkura R, Koriyama C, Sakoou T, Komiya S : Occupational recovery after open-door type laminoplasty for patients with ossification of the posterior longitudinal ligament. 　Spine 　2003;28(16):1889-92.
  15. Nakashima E,Fujisawa T, Kimura A, Kage M, Yamato Y, Maeda K, Kumagai M, Ushijima K,Yamato Y, Matsuishi T : Efficacy of interferon-α treatment in Japanese children with chronic hepatitis C.　 J Gastroenterol Hepatol 　　2003;18:411-4.
  16. Maeda K, Kimura A, Yamato Y, Matsuishi T : Perinatal bile acid metabolism: analysis of urinary unsaturated ketonic bile acids in preterm and full-term infants. Acta Paediatr 2003;92:216-20.
  17. Yamashita Y, Fujimoto C, Nakashima E, Isagai T , Matsuishi T : Possible association Between　Congenital Cytomegalovirus Infection and AutisticDisorder. J Autism Dev Disord 2003;33(4):455-9.
  18. Yoshino M, Tokunaga Y, Watanabe Y, Yoshida I, Sakaguchi M, Hata I, Shigematsu Y, Kimura M, Yamaguchi S : Effects of supplementation with L-carnitine at a small dose on acylcarmitine profilrs in serum and urine and the renal handling of acylcarnitine in a patient with multiple acyl-coenzyme a dehydrogenation detect. J Chromatogr B　 2003;792: 73-82.
  19. Hirayama A, Oka A, Itoh M, Tanaka F, Okoshi Y, Takashima S: Myelin transcription factor 1 (MyT1) immunoreactivity in infants with perivetricular leukomalacia. Dev Brain Res 2003;140:85-92.
  20. Nakai Y, Itoh M, Mizuguchi M, Ozaki E, Kobayashi Y, Takahashi M, Ohtani K, Ogawa A, Narita M, Togashi T, Takashima S: Apotosis and microglial activation in influenza encephalopathy. 　Acta Neuropathol 　2003;105:233-9.
  21. Hirayama A, Horikoshi Y, Maeda M, Itoh M, Takashima S: Characterisitic development of amyloid β40, 42 and 43 in patients with Down syndrome. 　Brain Dev 　2003;25:180-5.
  22. Shiraishi K, Itoh M, Sano K, Takashima S, Kubota T: Myelination of a fetus with Pelizaeus-Merzbacher disease; Immunopathological study. 　Ann Neurol 　2003;54:259-62.
  23. Iwata O, Iwata S, Tamura M, Nakamura T, Sugiura M, Ogiso Y, Takashima S: Early head cooling in newborn piglets is neuroprotective even in the absence of profound systemic hypothermia. 　Pediatr Int 　2003;45:522-9.
  24. Shimizu A, Asakawa S, Sasaki T, Yamazaki S, Yamagata H, Kudoh J,Minoshima S, Kondo I, Shimizu N: A novel giant gene CSMD3 encodiing a protein with CUB and sushi multiple domains: a candidate gene for benign adult familial myclonus epilepsy on human chromosome 8q23.3-q24.1. Biochem Biophys Res Commun 2003;09:143-54.
  25. Tabara Y, Kohara K, Yamamoto Y, Igase M, Nakura J, Kondo I, Miki t:　　Poly,morphism of MCP-1 gene is associated with plasma level of MCP-1 but Not with carotid intima-media thickness. Hypertns Res　 2003;26:677-83.
  26. Leonard H, Colvin L, Christodoulo J, Schiavello T, Willoamson S, Davis M,Ravine D, Fyfe S, de Klerk N, Matsuishi T, Kondo I, Clarke A, Hackwell S, Yamashita Y. Patients with the R133C mutation: istheir phenotypedifferent from patients with Rett syndrome with other mutations ?　 J Med Genet 　2003;40:e52.
  27. Fujimoto C, Yamashita Y, Kanda H, Harada E, Maeno Y, Matsuishi T　：　 In vivo quantitative ultrasonic evaluation of neonatal brain with a real time integrated backscatter imaging system. Brain Dev　2003;25(6):411-5.
  28. Koga A, Koga Y, Akita Y, Fukiyama R,Ueki I, Yatsuga S, Matsuishi T : Increased mitochondrial processing intermediates associated with three tRNALeu(UUR) gene mutations. Neuromuscular Dis 2003;13:259-62.