研究業績

2023年

  1. 生理学の利用法ーこれからの臨床医学の学習に向けてー.
    久留米医学会雑誌 86:83-90

2022年

  1. 脳機能と向精神薬.
    久留米医学会雑誌 85:69-86

2020年

  1. The inhibition of evoked excitatory postsynaptic potentials produced by ammonium chloride in rat hippocampal CA1 neurons
    Heliyon 6: e05830
    doi: 10.1016/j.neulet.2016.11.006. [PubMed]

2017年

  1. Activation of chathepsin L contributes to the irreversible depolarization induced by oxygen and glucose deprivation in rat hippocampal CA1 neurons.
    Neuroscience Letters 636:120-126
    doi: 10.1016/j.neulet.2016.11.006 [PubMed]
  2. 糖脂質代謝および血中グレリン濃度に及ぼす性別、年齢、肥満度、運動習慣の影響についての影響
    久留米医会誌 :80:264-275

2015年

  1. A natural therapeutic approach for the treatment of periodontitis by MK615.
    Med Hypotheses :85(5):618-21
    10.1016/j.mehy.2015.07.028[PubMed]
  2. Voluntary exercise contributed to an amelioration of abnormal feeding behavior, locomotor activity and ghrelin production concomitantly with a weight reduction in high fat diet-induced obese rats.
    Peptides :71:49-55
    doi: 10.1016/j.peptides.2015.06.007[PubMed]
  3. Cleavage of host cytokeratin-6 by lysine-specific gingipain induces gingival inflammation in periodontitis patients.
    PLoS One 17:10(2):e0117775
    doi: 10.1371/journal.pone.0117775[PubMed]
  4. Secondhand smoke exposure-induced nucleocytoplasmic shuttling of HMGB1 in a rat premature skin aging model.
    Biochem Biophys Res Commun. 2:456(1):92-7
    doi: 10.1016/j.bbrc.2014.11.040[PubMed]
  5. Surface vacuolar ATPase in ameloblastoma contributes to tumor invasion of the jaw bone.
    International Journal of Oncology 48(3):1258-70
    doi: 10.3892/ijo.2016.3350[PubMed]
  6. Effects of back massages on stress observed in students preparing for the national license examination.
    Health 7:430-438
  7. Identification of activated protein C as a ghrelin endopeptidase in bovine plasma.
    Journal of Endocrinology 224: 61-73
    doi: 10.1530/JOE-14-0529[PubMed]

2014年

  1. 逆相HPLCとRIAを組み合わせた魚類の胃内グレリンの脂肪酸修飾解析
    久留米大学医学部附属臨床検査専門学校紀要 22: 27-29
  2. Relation between circulating levels of GH, IGF-1, ghrelin and somatic growth in Rett syndrome.
    Brain and Development 36: 794-800[PubMed]
  3. Changes in the nitric oxide-soluble guanylate cyclase system and natriuretic peptide receptor system in placentas of pregnant Dahl salt-sensitive rats.
    The Journal of Obstetrics and Gynaecology Research 41(4): 540-50
    doi: 10.1111/jog.12602[PubMed]
  4. Correction: Potential of the Angiotensin Receptor Blockers (ARBs) Telmisartan, Irbesartan, and Candesartan for Inhibiting the HMGB1/RAGE Axis in Prevention and Acute Treatment of Stroke.
    International Journal of Molecular Sciences15: 5410-5411[PubMed]

2013年

  1. The efficacy of edaravone (redicut), a free radical scavenger, for cardiovascular disease. International Journal of Molecular Sciences14: 13909-13930[PubMed]
  2. Edaravone (Radicut), a free radical scavenger, is a potentially useful addition to thrombolytic therapy in patients with acute ischemic stroke (review)
    Biomedical Reports 1: 7-12[PubMed]
  3. Relation between circulating levels of GH, IGF-1, ghrelin and somatic growth in Rett syndrome.
    Brain and Development doi: 10.1016/j.braindev.2013.11.007[PubMed]
  4. Potential of the Angiotensin Receptor Blockers(ARBs) Telmisartan, Irbesartan, and Candesartan for Inhibiting the HMGB1/RAGE Axis in Prevention and Acute Treatment of Stroke
    International Journal of Molecular Sciences14:18899-18924
  5. Preventive effects of Morus alba L. anthocyanins on diabetes in Zucker diabetic fatty rats
    Experimental and therapeutic medicine 6:689-695
  6. Development of transcranial sonothrombolysis as an alternative stroke therapy: incremental scientific advances toward overcoming substantial barriers.
    Expert Rev Med Devices 10(2):201-213[PubMed]
  7. Changes in subcellular distribution of n-octanoyl or n-decanoyl ghrelin in ghrelin-producing cells.
    Frontiers in Experimental Endocrinology 4:84, doi: 10.3389/fendo.2013.00084[PubMed]

2012年

  1. Ghrelin acylation by ingestion of medium-chain fatty acids.
    Methods in Enzymology 514:303-315[PubMed]
  2. Periodontal disease and type 2 diabetes mellitus: Is the HMGB1-RAGE axis the missing link?
    Medical Hypotheses 79(4):452-455[PubMed]
  3. Activation of protein kinase A and C prevents recovery from persistent depolarization produced by oxygen and glucose deprivation in rat hippocampal neurons.
    Journal of Neurophysiology 107:2517-2525[PubMed]
  4. Methylseleninic acid is a novel suppressor of aromatase expression.
    Journal of Endocrinology 212:199-205[PubMed]
  5. A-type natriuretic peptide level in angiotensin II type 1a receptor knockout mice.
    Experimental Animals 61(2):131-138[PubMed]
  6. Increased production of active ghrelin is relevant to hyperphagia in non-obese spontaneously diabetic Torii rat.
    Metabolism 61:491-495[PubMed]
  7. Secondary prevention of stroke: Pleiotropic effects of optimal oral pharmacotherapy.
    Experimental and therapeutic medicine 4:3-7
  8. Different A-type natriuretic peptide level in five strains of mice.
    The Journal of Veterinary Medical Science 74：499-502[PubMed]
  9. Disrupted regulation of ghrelin production under antihypertensive treatment in spontaneously hypertensive rats.
    Circulation Journal 76：1423-1429[PubMed]

2011年

  1. Ghrelin levels are reduced in Rett syndrome patients with eating difficulties.
    Int J Devl Neurosci 29(8):899-902[PubMed]
  2. Structures and molecular forms of the ghrelin-family peptides.
    Peptides 32(11):2175-2182[PubMed]
  3. Plasma levels of n-decanoyl ghrelin, another acyl- and active-form of ghrelin, in human subjects and the effect of glucose- or meal-ingestion on its dynamics.
    Regulatory Peptides 167(1):140-148[PubMed]

2010年

  1. Connexon-mediated cell adhesion drives microtissue self-assembly
    The FADEB Journal 25(1): 255-264[PubMed]
  2. Identification and characterization of acyl-protein thioesterase 1/lysophospholipase I as a ghrelin deacylation/lysophospholipid hydrolyzing enzyme in fetal bovine serum and conditioned medium.
    Endocrinology 151(10)：4765-4775[PubMed]
  3. Homeobox A7 increases cell proliferation by upregulation of epidermal growth factor receptor expression in human granulosa cells.
    Peproductive biology and endocrinology 8:61 [PubMed]
  4. Dihydrotestosterone suppresses foam cells formation and attenuates atherosclerosis development.
    Endocrinology 151(7):3307-3316[PubMed]
  5. Dynamics of placental ghrelin production and its receptor expression in a Dahl salt-sensitive rat model of intrauterine growth restriction.
    Placenta 31(5):358-364[PubMed]
  6. 生殖機能調節の新しい視点 6. グレリンと生殖機能の関連.
    産科と婦人科 77(3):283-287
  7. Peroxisome proliferator-activated receptor gamma mediates the endocrine disrupter bisphenol a inhibition of FSH-stimulated IGF-I, aromatase and Estradiol in human granulosa cells.
    Environ Health Perspect 118:400-406[PubMed]

2009年

  1. Regional distribution and the dynamics of n-decanoyl ghrelin, another acyl-form of ghrelin, upon fasting in rodents.
    Regulatory Peptides 156:47-56[PubMed]
  2. Peripherally administered ghrelin induces bimodal effects on mesolimbic dopamine system depending on food-consumptive states.
    Neuroscience 161:855-864[PubMed]
  3. TRAIL pathway components and their putative role in granulosa cell apoptosis in the human ovary.
    Differentiation 77:369-376[PubMed]

2008年

  1. Regulation of LH receptor and PGF2α receptor signaling by the regulator of G protein signaling 2 (RGS2) in human and mouse granulosa cells.
    Chinese Journal of Physiology 51: 282-291[PubMed]
  2. Functional potentiation of leptin-Stat3 signaling by the androgen receptor.
    Endocrinology 149: 6028-6036[PubMed]
  3. Characterization of recombinant human growth differentiation factor-9 signaling in ovarian granulosa cells.
    Molecular and Cellular Endocrinology 283: 58-67[PubMed]
  4. Inhibition of proteasome activity sensitizes human granulosa tumor cells to TRAIL-induced cell death.
    Cancer Letters 260: 20-27[PubMed]
  5. ラット海馬CA1錐体細胞における興奮性シナプス伝達のリドカインによる増強の機序.
    久留米医学会雑誌 71:327-340
  6. Glutathione S-transferase theta 1 expressed in granulosa cells as a biomarker for oocyte quality in agerelated infertility.
    Fertillity and Sterility 90: 1026-1035[PubMed]

2007年

  1. ロゴスとパトスの脳 −意識とは何か─.
    久留米医学会雑誌 70:47-53
  2. 褥婦の下肢浮腫軽減のための下肢マッサージの検討.
    ペリネイタルケア 26:89-93

2006年

  1. A new cytochemical method for in situ detection of cholinergic synaptic transmission by staining of Cu2+ incorporated in frog neuromuscular junction during nerve stimulation.
    Biomedical Research 27:125-130[PubMed]
  2. Two opposing roles of 4-AP-sensitive K+ current in initiation and invasion of spikes in rat mesencephalic trigeminal neurons.
    Journal of Neurophysiology 96:1887-1901[PubMed]
  3. Immunohistochemical localization of ghrelin in rodent kidneys.
    Histochemistry and Cell Biology 126:231-238[PubMed]
  4. Ghrelin and leptin: A link between obesity and allergy?
    Journal of Allergy and Clinical Immunology 117: 705-706[PubMed]
  5. Role of adenosine A1 receptors in the modulation of dopamine D1 and adenosine A2A receptor signaling in the neostriatum.
    Neuroscience 141: 19-25[PubMed]
  6. グリシン作動性神経終末部からの自発性グリシン放出への2価陽イオンの効果.
    久留米医学会雑誌 69:326-335
  7. 虚血性神経細胞死とアラキドン酸カスケード.
    久留米医学会雑誌 69:343-350
  8. ヒトレニン・アンギオテンシノーゲン遺伝子導入マウスを用いた妊娠高血圧症候群モデル動物の病態について.
    九州動物実験雑誌 22:35-39

2005年

  1. Excitatory GABAergic synaptic potentials in the mesencephalic trigeminal nucleus of adult rat in vitro.
    Neurosci. Res. 51:463-474[PubMed]
  2. Neuroprotective mechanisms of lidocaine against in vitro ischemic insult of the rat hippocampal CA1 pyramidal neurons.
    Neurosci. Res. 53:271-278[PubMed]
  3. Nicotine regulates DARPP-32 (Dopamine- and cAMP- regulated phosphoprotein of 32 kDa) phosphorylation at multiple sites in neostriatal neurons.
    JPET 315:872-878[PubMed]
  4. Regulation of spinophilin Ser94 phosphorylation in neostriatal neurons involves both DARPP-32-dependent and independent pathways.
    J Neurochem 95:1642-1652[PubMed]
  5. Ingested medium-chain fatty acids are directly utilized for the acyl modification of ghrelin.
    Endocrinology 146:2255-2264[PubMed]
  6. Developmental changes in the pattern of ghrelin's acyl modification and the levels of acyl-modified ghrerins in murine stomach.
    Endocrinology 146:2709-2715[PubMed]

2004年

  1. A new cytochemical method for ultrastructural localization of Co2+ in rat hippocampal CA1 pyramidal neurons in vitro.
    J Neurosci Methods 135: 1-8[PubMed]
  2. Differential regulation of dopamine D1 and D2 signaling by nicotine in neostriatal neurons.
    J Neurochem 90: 1094-1103[PubMed]
  3. Protective actions of various local anesthetics against the membrane dysfunction produced by in vitro ischemia in rat hippocampal CA1 neurons.
    Neurosci Res 50: 291-298[PubMed]
  4. Glutamate regulation of DARPP-32 phosphorylation in neostriatal neurons involves activation of multiple signaling cascades.
    Proc Natl Acad Sci USA 102(4): 1199-1204[PubMed]
  5. DARPP-32: An integrator of neurotransmission.
    Annu Rev Pharmacol Toxicol 44: 269-296[PubMed]
  6. Mechanical unloading improves intracellular Ca2+ regulation in rats with doxorubicin-induced cardiomyopathy.
    J Am Coll Cardiol 44(11): 2239-2246[PubMed]
  7. Distinct profiles of refilling of inhibitory neurotransmitters into presynaptic terminals projecting to spinal neurones in immature rats.
    J Physiol 560(2): 469-478[PubMed]

2003年

  1. Electrical and pharmacological properties of the slow depolarization induced by Schaffer collateral stimulation in astrocytes of the rat hippocampal CA1 region.
    Neurosci Lett 343: 85-88[PubMed]
  2. Arachidonic acid metabolites contribute to the irreversible depolarization induced by in vitro ischemia.
    J Neurophysiol 90:3213-3223[PubMed]
  3. Effect of methylphenidate on dopamine/DARPP signalling in adult, but not young, mice.
    J Neurochem 87:1391-1401[PubMed]
  4. Metabotropic mGlu5 receptors regulate adenosine A2A receptor signaling.
    Proc Natl Acad Sci USA 100:1322-1327[PubMed]
  5. Regulation of DARPP-32 Thr75 phosphorylation by neurotensin in neostriatal neurons: involvement of glutamate signalling.
    Eur J Neurosci 18:1247-1253[PubMed]
  6. ドパミンによる運動精神機能調節：新たな研究への展開.
    日本薬理学雑誌 122 (3):215-225
  7. 快と不快とドーパミン.
    脳の科学 25:257-264

2002年

  1. Bupivacaine, but not tetracaine, protects against the in vitro ischemic insult of rat hippocampal CA1 neurons.
    Neurosci Res. 42:231-241[PubMed]
  2. Direct and indirect actions of dopamine on the membrane potential in medium spiny neurons of the mouse neostriatum.
    Neurophysiol. 87:1234-1243[PubMed]
  3. Extrusion of intracellular calcium ion after in vitro ischemia in the rat hippocampal CA1 region.
    J Neurophysiol. 88:879-887[PubMed]
  4. Neurotensin regulates DARPP-32 Thr34 phosphorylation in neostriatal neurons by activation of dopamine D1-type receptors.
    J Neurochem. 81:325-334[PubMed]
  5. Regulation of DARPP-32 dephosphorylation at PKA-and Cdk5-sites by NMDA and AMPA receptors: distinct roles of calcineurin and protein phosphatase-2A.
    J Neurochem. 81:832-841[PubMed]
  6. The presynaptic modulation of glutamate release and the membrane dysfunction induced by in vitro ischemia in rat hippocampal CA1 neurons.
    Life Sci. 72: 363-374[PubMed]
  7. Postnatal changes in the overall postsynaptic currents evoked in CA1 pyramidal neurons of the rat hippocampus.
    Life Sci. 72: 341-353[PubMed]

2001年

  1. Phosphorylation of protein phosphatase inhibitor-1 by Cdk5.
    J. Biol. Chem. 276:14490-11497[PubMed]
  2. Mechanisms underlying the depression of evoked fast EPSCs following in vitro ischemia in rat hippocampal CA1 neurons.
    J. Neurophysiol. 86:1095-1103[PubMed]
  3. Correlation between electrophysiology and morphology of three groups of neuron in the dorsal commissural nucleus of lumbosacral spinal cord of mature rats studied in vitro.
    J. Comp. Neurol. 437:156-169[PubMed]
  4. Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5.
    Nature 410:376-380[PubMed]
  5. Regulation of cyclin-dependent kinase 5 and casein kinase 1 by metabotropic glutamate receptors.
    Proc. Natl. Acad. Sci. USA 98:11062-11068[PubMed]
  6. Functional reorganization of sensory pathways in the rat spinal dorsal horn following peripheral nerve injury.
    J. Physiol. 532(1):241-250[PubMed]