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スタッフ紹介 [追加情報]

氏名：原 好勇（はら こうゆう）[概要]

職名：准教授

全ての業績 [概要]

  1. Hara K, Yaita K, Khamrin P, Kumthip K, Kashiwagi T, Eléouët JF, Rameix-Welti MA, and Watanabe H. A small fragmented P protein of respiratory syncytial virus inhibits virus infection by targeting P protein. J Gen Virol. 2019 Nov 8. doi: 10.1099/jgv.0.001350. [Epub ahead of print] 
  2. Hara K, Kashiwagi T, Hamada N, and Watanabe H. Basic amino acids in the N-terminal half of the PB2 subunit of influenza virus RNA polymerase are involved in both transcription and replication. J. Gen. Virol, 98(5): 900-905, 2017.
  3. Sato R, Hamada N, Kashiwagi T, Imamura Y, Hara K, Naito Y, Koga N, Nishimura M, Kamimura T, Takasaki T, Watanabe H, and Koga T. Dengue hemorrhagic fever in a Japanese traveler who had preexisting Japanese encephalitis virus antibody. Trop Med Health, 43(2): 85-88, 2015.
  4. Uemura Y, Kashiwagi T, Hara K, Nakazono Y, Hamada N, and Watanabe H. The N-terminal fragment of PA subunit of the influenza A virus effectively inhibits ribonucleoprotein (RNP) activity via supression of its RNP expression. J Infect Chemother, 21(9):296-301, 2015.
  5. Kashiwagi T, Hara K, Nakazono Y, Uemura Y, Imamura Y, Hamada N, and Watanabe H. The N-terminal fragment of a PB2 subunit from the influenza A virus (A/Hong Kong/156/1997 H5N1) effectively inhibits RNP activity and viral replication. PLoS ONE, 9(12): e114502, 2014.
  6. Hamada N, Hara K, Matsuo Y, Imamura Y, Kashiwagi T, Nakazono Y, Gotoh K, Ohtsu Y, Ohtaki E, Motohiro T and Watanabe H . Performance of a rapid human metaneumovirus antigen test during an outbreak in a long-term care facility. Epidemiol Infect, 142: 424-427, 2014.
  7. Hara K, Nakazono Y, Kashiwagi T, Hamada N, and Watanabe H. Co-incorporation of the PB2 and PA polymerase subunits from human H3N2 influenza virus is a critical determinant of the replication of reassortant ribonucleoprotein complexes. J Gen Virol, 94: 2406-2416, 2013.
  8. Hamada N, Imamura Y, Hara K, Kashiwagi T, Imamura Y, Nakazono Y, Chijiwa K, and Watanabe H. Intrahost emergent dynamics of oseltamivir-resistant virus of pandemic influenza A (H1N1) 2009 in a fatal immunocompromized patient. J. Infect. Chemother, 18:865-871, 2012.
  9. Nakazono Y, Hara K, Kashiwagi T, Hamada N, and Watanabe H. The RNA polymerase PB2 subunit of influenza A/HongKong/156/1997(H5N1) restricts the replication of reassortant ribonucleoprotein complexes. PLoS ONE 7(2) e32634: 1-9, 2012.
  10. Hara K, Yahara K, Gotoh K, Nakazono Y, Kashiwagi T, Imamura Y, Hamada N, Khositsakulchai W, Sanchai T, Khantawa B, Tharavichitkul P, Maneekarn N, Sirisanthana T, and Watanabe H. Clinical study concerning the relationship between community-acquired pneumonia and viral infection in northern Thailand. Intern Med, 50: 991-998, 2011.
  11. Kashiwagi T, Hara K, Nakazono Y, Hamada N, and Watanabe H. Artificial hybrids of influenza A virus RNA polymerase reveal PA subunit modulates its thermal sensitivity. PLoS ONE 5(12) e15140: 1-11, 2010.
  12. Hamada N, Gotoh K, Hara K, Iwahashi J, Imamura Y, Nakamura S, Taguchi C, Sugita M, Yamakawa R, Etoh Y, Sera N, Ishibashi T, Chijiwa K, and Watanabe H. A nosocomial outbreak of epidemic keratoconjunctivitis accompanying environmental contamination with adenoviruses. J Hosp Infect, 68: 262-268, 2008.
  13. Maier H.J., Kashiwagi T., Hara K. and Brownlee, G.G. Differential role of the influenza A virus polymerase PA subunit for vRNA and cRNA promoter binding. Virology, 370, 2008, 194-204.
  14. Ogata K, Kashiwagi T, Iwahashi J, Hara K, Honda H, Ide T, Kumashiro R, Kohara M, Sata M, Watanabe H, and Hamada N. A mutational shift from domain III to II in the ribosomal entry site of hepatitis C virus with interferon-ribavirin therapy. Archives of Virology, 153: 1575-1579, 2008.
  15. Hara, K., Schmidt, F. I., Crow, M. and Brownlee, G. G. Amino acid residues in the N-terminal region of the PA subunit of influenza A virus RNA polymerase play a critical role in protein stability, endonuclease activity, cap binding, and virion RNA promoter binding. J. Virol. 80, 2006, 7789-7798.
  16. Toyoda, T., Hara, K. and Imamura, Y. Ser624 of the PA subunit of influenza A virus is not essential for viral growth in cells and mice, but required for the maximal viral growth. Arch.Virol., 148, 2003, 1687-1696.
  17. Imanishi, S., Inoue, H., Kawarabata, T., Hara, K., Funakoshi, M., Yasunaga-Aoki, C. and Mitsuda, K. Establishment and characterization of a continuous cell line from pupal ovaries of Japanese oak silkworm Antheraea yamamai Guerin-Meneville. In Vitro Cell Dev Biol Anim. 39, 2003, 1-3.
  18. Hara, K., Shiota, M., Kido, H., Watanabe, K., Nagata, K. and Toyoda, T. Inhibition of the protease activity of influenza virus RNA polymerase PA subunit by viral matrix protein. Microbiol Immunol. 47. 2003, 521-526.
  19. Toyoda T., Hara K., Kashiwagi T., Iwahashi J., Honda H. and Hamada N. Molecular dissection of the transcription and replication machinery of influenza virus. Recent Advances in Influenza Virus Research. 2002, 1-13.
  20. Iwahashi J., Kawasaki I., Kohara Y., Gengyo-Ando K., Mitani S., Ohshima Y., Hamada N.,Hara K., Kashiwagi T. and Toyoda T. Caenorhabditis elegans reticulon interacts with RME-1 during embryogenesis. Biochem Biophys. Res. Commun. 293, 2002, 698-704.
  21. Hamada N., Iwahashi J., Suzuki K., Ogi H., Kashiwagi T., Hara K., Tooda M., Yamada T., and Toyoda T. Molecular cloning and characterization of the mouse reticulon 3 cDNA. Cell. Mol. Biol. 48 (2), 2002, 163-172.
  22. Kashiwagi T., Hara K., Kohara M., Kohara K., Iwahashi J., Hamada N., Yoshino H. and Toyoda T. Kinetic analysis of C-terminally truncated RNA dependent RNA polymerase of hepatitis C virus. Biochem Biophys. Res. Commun. 290, 2002, 1188-1194.
  23. Kashiwagi T., Hara K., Kohara M., Iwahashi J., Hamada N., Honda-Yoshino H. and Toyoda T. Promoter/origin structure of the complementary strand of hepatitis C virus genome. J. Biol. Chem., 277, 2002, 28700-28705.
  24. Iwahashi J, Tsuji K, Ishibashi T, Kajiwara J, Imamura Y, Mori R, Hara K., Kashiwagi T, Ohtsu Y, Hamada N, Maeda H, Toyoda T. Isolation of amantadine-resistant influenza a viruses (H3N2) from patients following administration of amantadine in Japan. J Clin Microbiol. 39(4):1652-1653. 2001.
  25. Hara K., Kashiwagi T., Ohtsu Y., Masunaga K., Akasu Y., Tsumura N., Kato H., Iwahashi J., Hamada N., M. Toyoda and Toyoda T. Molecular evolution of echovirus type 9 isolated from patients with aseptic meningitis in Northern Kyushu during the summer of 1997. Microbiol. Immunol., 45: 717-720, 2001.
  26. Hara K., Shiota M., Kido H., Ohtsu Y. and Toyoda T. Protease activity of influenza virus RNA polymerase PA subunit. In ' The world congress on options for the control of influenza IV. ' ICS 1219 (Albert D.M.E. Osterhaus, et al. eds.), Elsevier, Amsterdam, 1219, 2001, 479-485.
  27. Hara K., Shiota M., Kido H., Ohtsu Y., Kashiwagi T., Iwahashi J., Hamada N., Mizoue K., Tsumura N., Kato H. and Toyoda T. : Influenza virus RNA polymerase PA subunit is a novel serine protease with Ser624 in the active site. Genes to Cells 6: 87-97, 2001.
  28. T. Toyoda, K. Masunaga, Y. Ohtsu, K. Hara, N. Hamada, T. Kashiwagi, and J. Iwahashi.: Antibody-scanning and epitope-tagging methods: Molecular mapping of proteins using antibodies. Curr. Protein Peptide Sci. 1, 303-308, 2000.
  29. Toyoda T., Imamura Y., Takaku H., Kashiwagi T., Hara K., Iwahashi J., Ohtsu Y., Tsumura N., Kato H., and Hamada N. Inhibition of influenza virus replication in cultured cells by RNA-cleaving DNA enzyme. FEBS Lett., 481: 113-116, 2000.
  30. Kashiwagi T., Hamada N., Iwahashi J., Hara K., Ueda T.,Noguchi H., and Toyoda T. : Emergence of new influenza A viruses which carry an escape mutation of the HLA-B27-restricted CTL epitope of NP in Japan. Microbiol. Immunol., 44: 867-870, 2000.
  31. Toyoda T., Ohtsu Y., Hara K., Masunaga K., Hamada N., Koga M., Kashiwagi T. and Iwahashi J. Molecular dissection of influenza virus RNA polymerase.   Rec. Res. Dev. Virol. 1: 839-847, 1999.
  32. Kondo M., Funakoshi M., Hara K., and Kawarabata T. : Replication of Mamestra brassicae nuclear polyhedrosis virus in a newly established Mamestra brassicae cell line.   Acta Virol. 39: 136-141, 1995.
  33. Hara K., Funakoshi M., and Kawarabata T. : In vivo and in vitro characterization of several isolates of Spodoptera exigua nuclear polyhedrosis virus.   Acta Virol. 39: 215-222, 1995.
  34. Hara K., Funakoshi M., and Kawarabata T. : A cloned cell line of Spodoptera exigua has a highly increased susceptibility to the Spodoptera exigua nuclear polyhedrosis virus.   Can. J. Microbiol. 41: 1111-1116, 1995
  35. Hara K., Funakoshi M., Tsuda K., and Kawarabata T. :  Plaque assay for Spodoptera exigua and Autographa californica nuclear polyhedrosis viruses in a newly established cell line of the beet armyworm, Spodoptera exigua.   Acta Virol. 38: 293-296, 1994
  36. Hara K., Funakoshi M., Tsuda K., and Kawarabata T. :   Susceptibility of lepidopteran cell lines to Spodoptera exigua (Lepidoptera: Noctuidae) nuclear polyhedrosis virus.   Appl. Entomol. Zool. 29: 395-402, 1994
  37. Hara K., Funakoshi M., Tsuda K., and Kawarabata T. :  New Spodoptera exigua cell lines susceptible to Spodoptera exigua nuclear polyhedrosis virus.   In Vitro Cell. Dev. Biol. 29A:  904-907, 1993.
  38. 原 好勇、渡邊 浩 「黄熱」 ウイルス検査法（日本臨床ウイルス学会編集、春恒社出版）, p336-341, 2018.
  39. 八板謙一郎、倉重智之、加藤正樹、高濱宗一郎、原 好勇 「渡航後のデング熱疑いとして紹介された、A型肝炎国内感染の1症例」 日本渡航医学会誌Vol.12/No. 2, 77-80, 2018.
  40. 原 好勇. マイクロRNAをかわすウイルスたち. 久留米医学会雑誌 79 (1/2), 1-7, 2016.
  41. 今村宜寛、濱田信之、原　好勇、柏木孝仁、渡邊　浩 「インフルエンザ（H1N1）2009発生時に地域に密着して実施した実験室内診断症例の検討」 感染症学雑誌 第87巻 第3号 368-374. 2013.
  42. 今村宜寛、濱田信之、大津 寧、原 好勇、渡邊 浩 ｢九州北部でのヒト・メタニューモウイルスに対する中和抗体保有調査」 医学検査 59: 767-772, 2010
  43. 原 好勇、渡邊 浩 「インフルエンザの最新知識 Q & A 2010 パンデミック H1N1 2009 第一波を振り返って－ 一般的な予防法とその効能は？－」、医薬ジャーナル社、82-84、2010．
  44. 原　好勇、渡邊　浩：インフルエンザの最新知識Q & A 2009．医薬ジャーナル社, 2009.
  45. 原　好勇、渡邊　浩：ヒト・メタニューモウイルス感染症．臨床検査 53: 92-96, 2009.
  46. 今村宜寛、濱田信之、大津 寧、原 好勇、渡邊 浩 「入院を必要とした乳幼児の下気道感染症に関与するウイルスの検討」 医学検査 58: 287-293, 2009.
  47. 原 好勇、渡邊 浩：インフルエンザの臨床像と診断．Progress in Medicine、27: 2271-2275, 2007.
  48. 豊田哲也、原 好勇：インフルエンザウイルスの分子生物学４・感染分子機構からみた治療薬開発の方向性．治療学 34:44－49, 2000
  49. 原 好勇、豊田哲也：抗インフルエンザウイルス薬．治療学 34:981-986, 2000