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----- ２０２３ Kusano S, Ueda S, Oryoji D, Toyoumi A, Hashimoto-Tane A, Kishi H, Hamana H, Muraguchi A, Jin H, Arase H, Miyadera H, Kishikawa R, Yoshikai Y, Yamada H, Yamamoto K, Nishimura Y, Saito T, Sasazuki T, Yokoyama S: Contributions of the N-terminal flanking residues of an antigenic peptide from the Japanese cedar pollen allergen Cry j 1 to the T-cell activation by HLA-DP5. Int Immunol. 2023; 35: 447-458. Hirose M, Harada J, Kashiyama Y, Tamiaki H: Predicted Structure of the BciC Enzyme Catalyzing the Removal of the C132-Methoxycarbonyl Group for Biosynthesis of Chlorosomal Chlorophylls: A Mechanism for Dual Catalytic Functions of Hydrolysis and Decarboxylation inside Its Active Site. Biochemistry, 2023; 62: 1443-1451. Shiozaki M, Mizoguchi T, Harada J, Hirose M, Tamiaki H: Chiral-phase HPLC separation of (divinyl-) protochlorophyllide-a enantiomers as key precursors in chlorophyll biosynthesis from their 132-stereoisomeric prime forms. Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2023; 1864: 148960 Shirahama Y, Yamamoto K: The E2F6 transcription factor is associated with the mammalian SUZ12-containing polycomb complex. Kurume Med J. 2023; 67: 171-183. Joutsuka T, Nanasawa R, Igarashi K, Horie K, Sugishima M, Hagiwara Y, Wada K, Fukuyama K, Yano N, Mori S, Ostermann A, Kusaka K, Unno M: Neutron crystallography and quantum chemical analysis of bilin reductase PcyA mutantsreveal substrate and catalytic residue protonation states. J Biol Chem. 2023; 299: 102763. ----- ２０２２ Toyoda Y, Nakayama A, Nakatochi M, Kawamura Y, Nakaoka H, Yamamoto K, Shimizu S, Ooyama H, Ooyama K, Shimizu T, Nagase M, Hidaka Y, Ichida K, Inoue I, Shinomiya N, Matsuo H; Japan Gout Genomics Consortium (Japan Gout): Genome-widemeta-analysis between renal overload type and renal underexcretion type of clinically defined gout in Japanese populations. Mol Genet Metab. 2022l ;136: 186-189. Hirose M, Tsukatani Y, Harada J, Tamiaki H: Characterization of regioisomeric diterpenoid tails in bacteriochlorophylls produced by geranylgeranyl reductase from Halorhodospira halochloris and Blastochloris viridis. Photosynthesis Research, 2022; 154: 1-12. Yengo L, Vedantam S, Marouli E. et al.: A saturated map of common genetic variants associated with human height. Nature 2022; 610: 704-712. Mahajan A, Spracklen CN, Zhang W. et al.: Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation. Nat Genet. 2022; 54: 560-572. Suzuki H, Iwamoto H, Yamamoto K, Tsukaguchi M, Nakamura T, Masuda A, Sakaue T, Tanaka T, Niizeki T, Okamura S, Shimose S, Shirono T, Noda Y, Kamachi N, Kuromatsu R, Hisaka T, Yano H, Koga H, Torimura T: DNA Methylation in Noncancerous Liver Tissues as Biomarker for Multicentric Occurrence of Hepatitis C Virus–Related Hepatocellular Carcinoma. Gastro Hep Adv. 2022; 1: 555-562. Tsukatani Y, Harada J, Kurosawa K, Tanaka K, Tamiaki H: Incomplete Hydrogenation by Geranylgeranyl Reductase from a Proteobacterial Phototroph Halorhodospira halochloris, Resulting in the Production of Bacteriochlorophyll with a Tetrahydrogeranylgeranyl Tail. J Bacteriol. 2022; 204: e0060521. Jin H, Kishida K, Arase N, Matsuoka S, Nakai W, Kohyama M, Suenaga T, Yamamoto K, Sasazuki T, Arase H: Abrogation of self-tolerance by misfolded self-antigens complexed with MHC class II molecules. Sci Adv. 2022; 8: eabj9867. ----- ２０２１ Hasuzawa N, Moriyama S, Wang L, Nagayama A, Ashida K, Moriyama Y, Nomura M: Quinacrine is not a vital fluorescent probe for vesicular ATP storage. Purinergic Signal. 2021; 17: 725-735. Wang L, Zhang Y, Kiprowska M, Guo Y, Yamamoto K, Li X: Diethyl Succinate Modulates Microglial Polarization and Activation by Reducing Mitochondrial Fission and Cellular ROS. Metabolites 2021; 11: 854. Fujimoto K, Hidaka Y, Koga T, Kaieda S, Yamasaki S, Nakashima M, Hoshino T, Yamamoto K, Nishikomori R, Ida H: MEFV E148Q variant is more associated with familial Mediterranean fever when combined with other non-exon 10 MEFV variants in Japanese patients with recurrent fever. Mod Rheumatol. 2021; 31: 1208-1214. Wang L, Li X, Hanada Y, Hasuzawa N, Moriyama Y, Nomura M, Yamamoto K: Dynamin-related protein 1 deficiency accelerates lipopolysaccharide-induced acute liver injury and inflammation in mice. Commun Biol. 2021; 4: 894. Oda S, Ashida K, Uchiyama M, Sakamoto S, Hasuzawa N, Nagayama A, Wang L, Nagata H, Sakamoto R, Kishimoto J, Todaka K, Ogawa Y, Nakanishi Y, Nomura M: An open-label phase Ⅰ/Ⅱ a clinical trial of 11β-HSD1 inhibitor for Cushing's syndrome and autonomous cortisol secretion. J Clin Endocrinol Metab. 2021; 106: e3865-e3880. Takeichi Y, Miyazawa T, Sakamoto S, Hanada Y, Wang L, Gotoh K, Uchida K, Katsuhara S, Sakamoto R, Ishihara T, Masuda K, Ishihara N, Nomura M, Ogawa Y: Non-alcoholic fatty liver disease in mice with hepatocyte-specific deletion of mitochondrial fission factor. Diabetologia 2021; 64: 2092-2107. Rogers MA, Hutcheson JD, Okui T, Goettsch C, Singh SA, Halu A, Schlotter F, Higashi H, Wang L, Whelan MC, Mlynarchik AK, Daugherty A, Nomura M, Aikawa M, Aikawa E: Dynamin-related protein 1 inhibition reduces hepatic PCSK9 secretion. Cardiovasc Res. 2021; 117: 2340-2353. Sato H, Sugishima M, Tsukaguchi M, Masuko T, Iijima M, Takano M, Omata Y, Hirabayashi K, Wada K, Hisaeda Y, Yamamoto K: Crystal structures of hydroxymethylbilane synthase complexed with a substrate analog: a single substrate-binding site for four consecutive condensation steps. Biochem J. 2021; 478: 1023-1042. Hirose M, Harada J, Maeda H, Tamiaki H: Physicochemical and biochemical properties of synthetic zinc 131-(un)substituted chlorophyll-a derivatives. Tetrahedron. 2021; 88: 132151. Hirose M, Harada J, Tamiaki H: Detection 132-carbonyl-chlorin produced by the in vitro BciC enzymatic hydrolysis of zinc chlorophyllide. Bioorg Med Chem Lett. 2021; 40: 127931. Hirose M, Harada J, Tamiaki H: In vitro hydrolysis of zinc chlorophyllide a homologues by a BciC enzyme. Biochemistry. 2021; 59: 4622-4626. Harada J, Mizoguchi T, Kinoshita Y, Yamamoto K, Tamiaki H: Over-expression of C82-mehtyltransferase BchQ in the green sulfur bacterium Chlorobaculum limnaeum mutant strains for synthesis of C8-hyper-alkylated chlorosomal pigments. J Photochem Photobiol A: Chem. 2021; 404: 112882. Hasuzawa N, Tatsushima K, Wang L, Kabashima M, Tokubuchi R, Nagayama A, Ashida K, Ogawa Y, Moriyama Y, Nomura M: Clodronate, an inhibitor of the vesicular nucleotide transporter, ameliorates steatohepatitis and acute liver injury. Sci Rep. 2021; 11: 5192. Tatsushima K, Hasuzawa N, Wang L, Hiasa M, Sakamoto S, Ashida K, Sudo N, Moriyama Y, Nomura M: Vesicular ATP release from hepatocytes plays a role in the progression of nonalcoholic steatohepatitis. Biochim Biophys Acta Mol Basis Dis. 2021; 1867: 166013. ----- ２０２０ 英文原著 Konishi KI, Mizuochi T, Takeuchi I, Arai K, Yamamoto K: Congenital chloride diarrhea in a Japanese neonate with a novel SLC26A3 mutation. Pediatr Int. 2020; 62: 1294-1296. Konishi KI, Mizuochi T, Honma H, Etani Y, Morikawa K, Wada K, Yamamoto K: A novel de novo SLC26A3 mutation causing congenital chloride diarrhea in a Japanese neonate. Mol Genet Genomic Med. 2020; 8: e1505. Hanada Y, Ishihara N, Wang L, Otera H, Ishihara T, Koshiba T, Mihara K, Ogawa Y, Nomura M: MAVS is energized by Mff which senses mitochondrial metabolism via AMPK for acute antiviral immunity. Nat Commun. 2020; 11: 5711. Matsushita T, Masaki K, Isobe N, Sato S, Yamamoto K, Nakamura Y, Watanabe M, Suenaga T, Kira JI; Japan Multiple Sclerosis Genetic Consortium: Genetic factors for susceptibility to and manifestations of neuromyelitis optica. Ann Clin Transl Neurol. 2020; 7: 2082-2093. Takaichi S, Okoshi A, Otomo S, Misumi M, Sonoike K, Harada J: Direct injection of pigment-protein complexes and membrane fragments suspended in water from phototrophs to C18HPLC. Photosynth Res. 2020; 144: 101-107. Hirose M, Teramura M, Harada J, Ogasawara S, Tamiaki H: In vitro C132-dealkoxycarbonylations of zinc chlorophyll a derivatives including C132-substitutes by a BciC enzyme. Bioorg Chem. 2020; 102: 104111. Meguro A, Ishihara M, Petrek M, Yamamoto K, Takeuchi M, Mrazek F, Kolek V, Benicka A, Yamane T, Shibuya E, Yoshino A, Isomoto A, Ota M, Yatsu K, Shijubo N, Nagai S, Yamaguchi E, Yamaguchi T, Namba K, Kaburaki T, Takase H, Morimoto SI, Hori J, Kono K, Goto H, Suda T, Ikushima S, Ando Y, Takenaka S, Takeuchi M, Yuasa T, Sugisaki K, Ohguro N, Hiraoka M, Kitaichi N, Sugiyama Y, Horita N, Asukata Y, Kawagoe T, Kimura I, Ishido M, Inoko H, Mochizuki M, Ohno S, Bahram S, Remmers EF, Kastner DL, Mizuki N: Genetic control of CCL24, POR, and IL23R contributes to the pathogenesis of sarcoidosis. Commun Biol. 2020; 3: 465. Sugishima M, Taira J, Sagara T, Nakao R, Sato H, Noguchi M, Fukuyama K, Yamamoto K, Yasunaga T, Sakamoto H: Conformational Equilibrium of NADPH–cytochrome P450 Oxidoreductase is Essential for Heme Oxygenase Reaction. Antioxidants. 2020; 9: 671. Hirose M, Teramura M, Harada J, Tamiaki H: BciC-catalyzed C132-Demethoxycarbonylation of metal pheophorbide a alkyl esters. ChemBioChem. 2020; 21: 1473-1480. Azai C, Harada J, Fujimoto S, Masuda S, Kosumi D: Anaerobic energy dissipation by glycosylated carotenoids in the green sulfur bacterium Chlorobaculum tepidum. J Photochem Photobiol A: Chem. 2020; 403: 112828. Miyake K, Fushimi K, Kashimoto T, Maeda K, Win N, Kimura H, Sugishima M, Ikeuchi M, Narikawa R: Functional diversification of two bilin reductases for light perception and harvesting in unique cyanobacterium Acaryochloris marina MBIC 11017. FEBS J. 2020; 287: 3873-4098. Cha PC, Satake W, Ando-Kanagawa Y, Yamamoto K, Murata M, Toda T: Genome-wide association study identifies zonisamide responsive gene in Parkinson's disease patients. J Hum Genet. 2020; 65: 693-704. Miura S, Kosaka K, Shimojo T, Matsuura E, Noda K, Fujioka R, Mori SI, Umehara F, Iwaki T, Yamamoto K, Saitsu H, Shibata H: Intronic variant in IQGAP3 associated with hereditary neuropathy with proximal lower dominancy, urinary disturbance, and paroxysmal dry cough. J Hum Genet. 2020; 65: 717-725. Spracklen CN, Horikoshi M, Kim YJ, Lin K, Bragg F, Moon S, Suzuki K, Tam CHT, Tabara Y, Kwak SH, Takeuchi F, Long J, Lim VJY, Chai JF, Chen CH, Nakatochi M, Yao J, Choi HS, Iyengar AK, Perrin HJ, Brotman SM, van de Bunt M, Gloyn AL, Below JE, Boehnke M, Bowden DW, Chambers JC, Mahajan A, McCarthy MI, Ng MCY, Petty LE, Zhang W, Morris AP, Adair LS, Akiyama M, Bian Z, Chan JCN, Chang LC, Chee ML, Chen YI, Chen YT, Chen Z, Chuang LM, Du S, Gordon-Larsen P, Gross M, Guo X, Guo Y, Han S, Howard AG, Huang W, Hung YJ, Hwang MY, Hwu CM, Ichihara S, Isono M, Jang HM, Jiang G, Jonas JB, Kamatani Y, Katsuya T, Kawaguchi T, Khor CC, Kohara K, Lee MS, Lee NR, Li L, Liu J, Luk AO, Lv J, Okada Y, Pereira MA, Sabanayagam C, Shi J, Shin DM, So WY, Takahashi A, Tomlinson B, Tsai FJ, van Dam RM, Xiang YB, Yamamoto K, Yamauchi T, Yoon K, Yu C, Yuan JM, Zhang L, Zheng W, Igase M, Cho YS, Rotter JI, Wang YX, Sheu WHH, Yokota M, Wu JY, Cheng CY, Wong TY, Shu XO, Kato N, Park KS, Tai ES, Matsuda F, Koh WP, Ma RCW, Maeda S, Millwood IY, Lee J, Kadowaki T, Walters RG, Kim BJ, Mohlke KL, Sim X: Identification of type 2 diabetes loci in 433,540 East Asian individuals. Nature 2020; 582: 240-245. Sugishima M, Wada K, Fukuyama K, Yamamoto K: Crystal structure of phytochromobilin synthase in complex with biliverdin IXα, a key enzyme in the biosynthesis of phytochrome. J Biol Chem. 2020; 295: 771-782. Sugiyama K, Takahashi K, Nakazawa K, Yamada M, Kato S, Shinomura T, Nagashima Y, Suzuki H, Ara T, Harada J, Takaichi S: Oxygenic phototrophs need ζ-carotene isomerase (Z-ISO) for carotene synthesis: its functional analysis of Arthrospira and Euglena. Plant & Cell Physiol. 2020; 61: 276-282. Higashino T, Morimoto K, Nakaoka H, Toyoda Y, Kawamura Y, Shimizu S, Nakamura T, Hosomichi K, Nakayama A, Ooyama K, Ooyama H, Shimizu T, Ueno M, Ito T, Tamura T, Naito M, Nakashima H, Kawaguchi M, Takao M, Kawai Y, Osada N, Ichida K, Yamamoto K, Suzuki H, Shinomiya N, Inoue I, Takada T, Matsuo H: Dysfunctional missense variant of OAT10/SLC22A13 decreases gout risk and serum uric acid levels. Ann Rheum Dis. 2020; 79: 164-166. Nakayama A, Nakatochi M, Kawamura Y, Yamamoto K, Nakaoka H, Shimizu S, Higashino T, Koyama T, Hishida A, Kuriki K, Watanabe M, Shimizu T, Ooyama K, Ooyama H, Nagase M, Hidaka Y, Matsui D, Tamura T, Nishiyama T, Shimanoe C, Katsuura-Kamano S, Takashima N, Shirai Y, Kawaguchi M, Takao M, Sugiyama R, Takada Y, Nakamura T, Nakashima H, Tsunoda M, Danjoh I, Hozawa A, Hosomichi K, Toyoda Y, Kubota Y, Takada T, Suzuki H, Stiburkova B, Major TJ, Merriman TR, Kuriyama N, Mikami H, Takezaki T, Matsuo K, Suzuki S, Hosoya T, Kamatani Y, Kubo M, Ichida K, Wakai K, Inoue I, Okada Y, Shinomiya N, Matsuo H; Japan Gout Genomics Consortium (Japan Gout): Subtype-specific gout susceptibility loci and enrichment of selection pressure on ABCG2 and ALDH2 identified by subtype genome-wide meta-analyses of clinically defined gout patients. Ann Rheum Dis. 2020; 79: 657-665. Umezu R, Koga JI, Matoba T, Katsuki S, Wang L, Hasuzawa N, Nomura M, Tsutsui H, Egashira K: Macrophage (Drp1) Dynamin-Related Protein 1 Accelerates Intimal Thickening After Vascular Injury. Arterioscler Thromb Vasc Biol. 2020; 40: e214-e226. 総説 Sugishima M, Wada K, Fukuyama K: Recent Advances in the Understanding of the Reaction Chemistries of the Heme Catabolizing Enzymes HO and BVR Based on High Resolution Protein Structure. Curr Med Chem. 2020; 27: 3499-3518. Oh-oka H, Harada J, Azai C: Green Bacteria: Energy Transfer and Electron Transport. In Reference Module in Life Sciences. 2020; DOI: 10.1016/B978-0-12-819460-7.00031-1. 著書 浅井智広, 井上和仁, 大友征宇, 嶋田敬三, 高市真一, 塚谷祐介, 永島賢治, 原田二朗, 平石 明: 光合成細菌 -酸素を出さない光合成-. 嶋田敬三, 高市真一 編集. 裳華房. 2020年10月発行. ----- ２０１９ 英文原著 Tsukatani Y, Hirose Y, Harada J, Yonekawa C, Tamiaki H: Unusual features in the photosynthetic machinery of Halorhodospira halochloris DSM 1059 revealed by complete genome sequencing. Photosynth Res. 2019; 140: 311-319. Kinoshita Y, Harada J, Mizoguchi T, Tamiaki H: Isolation and optical properties of epimerically pure bacteriochlorophyll-f homologs. Dyes and pigments. 2019; 164: 267-271. Nakatochi M, Kanai M, Nakayama A, Hishida A, Kawamura Y, Ichihara S, Akiyama M, Ikezaki H, Furusyo N, Shimizu S, Yamamoto K, Hirata M, Okada R, Kawai S, Kawaguchi M, Nishida Y, Shimanoe C, Ibusuki R, Takezaki T, Nakajima M, Takao M, Ozaki E, Matsui D, Nishiyama T, Suzuki S, Takashima N, Kita Y, Endoh K, Kuriki K, Uemura H, Arisawa K, Oze I, Matsuo K, Nakamura Y, Mikami H, Tamura T, Nakashima H, Nakamura T, Kato N, Matsuda K, Murakami Y, Matsubara T, Naito M, Kubo M, Kamatani Y, Shinomiya N, Yokota M, Wakai K, Okada Y, Matsuo H: Genome-wide meta-analysis identifies multiple novel loci associated with serum uric acid levels in Japanese individuals. Commun Biol. 2019; 2: 115. Teramura M, Tsukatani Y, Harada J, Hirose M, Tamiaki H: Stereoselective C3-substituent modification and substrate channeling by oxidoreductase BchC in bacteriochlorophyll a biosynthesis. FEBS Lett. 2019; 593: 799-809. Sugishima M, Sato H, Wada K, Yamamoto K: Crystal structure of a NADPH-cytochrome P450 oxidoreductase (CYPOR) and heme oxygenase 1 fusion protein implies a conformational change in CYPOR upon NADPH/NADP+ binding. FEBS Lett. 2019; 593: 868-875. Teramura M, Harada J, Tamiaki H: In vitro demethoxycarbonylation of various chlorophyll analogs by a BciC enzyme. Photosynth Res. 2019; 139: 163-171. Iijima M, Ohnuki J, Sato T, Sugishima M, Takano M: Coupling of redox and structural states in cytochrome P450 reductase studied by molecular dynamics simulation. Sci Rep. 2019; 9341. Otsuka I, Akiyama M, Shirakawa O, Okazaki S, Momozawa Y, Kamatani Y, Izumi T, Numata S, Takahashi M, Boku S, Sora I, Yamamoto K, Ueno Y, Toda T, Kubo M, Hishimoto A: Genome-wide association studies identify polygenic effects for completed suicide in the Japanese population. Neuropsychopharmacology 2019; 44: 2119-2124. Konishi KI, Mizuochi T, Yanagi T, Watanabe Y, Ohkubo K, Ohga S, Maruyama H, Takeuchi I, Sekine Y, Masuda K, Kikuchi N, Yotsumoto Y, Ohtsuka Y, Tanaka H, Kudo T, Noguchi A, Fuwa K, Mushiake S, Ida S, Fujishiro J, Yamashita Y, Taguchi T, Yamamoto K: Clinical Features, Molecular Genetics, and Long-Term Outcome in Congenital Chloride Diarrhea: A Nationwide Study in Japan. J Pediatr. 2019; 214: 151-157. Kawamura Y, Nakaoka H, Nakayama A, Okada Y, Yamamoto K, Higashino T, Sakiyama M, Shimizu T, Ooyama H, Ooyama K, Nagase M, Hidaka Y, Shirahama Y, Hosomichi K, Nishida Y, Shimoshikiryo I, Hishida A, Katsuura-Kamano S, Shimizu S, Kawaguchi M, Uemura H, Ibusuki R, Hara M, Naito M, Takao M, Nakajima M, Iwasawa S, Nakashima H, Ohnaka K, Nakamura T, Stiburkova B, Merriman TR, Nakatochi M, Ichihara S, Yokota M, Takada T, Saitoh T, Kamatani Y, Takahashi A, Arisawa K, Takezaki T, Tanaka K, Wakai K, Kubo M, Hosoya T, Ichida K, Inoue I, Shinomiya N, Matsuo H: Genome-wide association study revealed novel loci which aggravate asymptomatic hyperuricaemia into gout. Ann Rheum Dis. 2019; 78: 1430-1437. 総説 Sugishima M, Wada K, Unno M, Fukuyama K: Bilin-metabolizing enzymes: site-specific reductions catalyzed by two different type of enzymes. Curr Opin Struct Biol. 2019; 59: 73-80. ----- ２０１８ 英文原著 Takeuchi F, Akiyama M, Matoba N, Katsuya T, Nakatochi M, Tabara Y, Narita A, Saw WY, Moon S, Spracklen CN, Chai JF, Kim YJ, Zhang L, Wang C, Li H, Li H, Wu JY, Dorajoo R, Nierenberg JL, Wang YX, He J, Bennett DA, Takahashi A, Momozawa Y, Hirata M, Matsuda K, Rakugi H, Nakashima E, Isono M, Shirota M, Hozawa A, Ichihara S, Matsubara T, Yamamoto K, Kohara K, Igase M, Han S, Gordon-Larsen P, Huang W, Lee NR, Adair LS, Hwang MY, Lee J, Chee ML, Sabanayagam C, Zhao W, Liu J, Reilly DF, Sun L, Huo S, Edwards TL, Long J, Chang LC, Chen CH, Yuan JM, Koh WP, Friedlander Y, Kelly TN, Bin Wei W, Xu L, Cai H, Xiang YB, Lin K, Clarke R, Walters RG, Millwood IY, Li L, Chambers JC, Kooner JS, Elliott P, van der Harst P; International Genomics of Blood Pressure (iGEN-BP) Consortium, Chen Z, Sasaki M, Shu XO, Jonas JB, He J, Heng CK, Chen YT, Zheng W, Lin X, Teo YY, Tai ES, Cheng CY, Wong TY, Sim X, Mohlke KL, Yamamoto M, Kim BJ, Miki T, Nabika T, Yokota M, Kamatani Y, Kubo M, Kato N: Interethnic analyses of blood pressure loci in populations of East Asian and European descent. Nat Commun. 2018; 9: 5052. Miki A, Sakurada Y, Tanaka K, Semba K, Mitamura Y, Yuzawa M, Tajima A, Nakatochi M, Yamamoto K, Matsuo K, Imoto I, Honda S: Genome-Wide Association Study to Identify a New Susceptibility Locus for Central Serous Chorioretinopathy in the Japanese Population. Invest Ophthalmol Vis Sci. 2018; 59: 5542-5547. Igarashi K, Hagiwara Y, Sugishima M, Wada K, Fukuyama K, Ikeda A, Yano N, Kusaka K, Ostermann A, Unno M: Crystal Growth of a Bilin Reductase PcyA I86D Mutant-Substrate Complex for Neutron Crystallography. Crystal Growth & Design 2018; 18: 5174-5181. Sakiyama M, Matsuo H, Nakaoka H, Kawamura Y, Kawaguchi M, Higashino T, Nakayama A, Akashi A, Ueyama J, Kondo T, Wakai K, Sakurai Y, Yamamoto K, Ooyama H, Shinomiya N: Common variant of BCAS3 is associated with gout risk in Japanese population : the first replication study after gout GWAS in Han Chinese. BMC Med Genet. 2018 Jun 7; 19 (1): 96. doi: 10.1186/s12881-018-0583-z. Mizoguchi T, Kinoshita Y, Harada J, Ogasawara S, Tamiaki H: Light-dependent accumulation of new bacteriochlorophyll-e bearing a vinyl group at the 8-position in the green sulfur bacterium Chlorobaculum limnaeum. J Photochem Photobiol A Chem. 2018 May 1; 358: 356-361. doi.org/10.1016/j.jphotochem.2017.08.071. Iwaya C, Kitajima H, Yamamoto K, Maeda Y, Sonoda N, Shibata H, Inoguchi T: DNA methylation of the Klf14 gene region in whole blood cells provides prediction for the chronic inflammation in the adipose tissue. Biochem Biophys Res Commun. 2018 Mar 11; 497 (3): 908-915. doi: 10.1016/j.bbrc.2017.12.104. Harada J, Shibata Y, Teramura M, Mizoguchi T, Kinoshita Y, Yamamoto K, Tamiaki H: In vivo Excited Energy Transfer of Bacteriochlorophyll c, d, e, or f to Bacteriochlorophyll a in the Wild-Type and Mutant Cells of the Green Sulfur Bacterium Chlorobaculum limnaeum ChemPhotoChem. 2018 Mar; 2 (3): 190-195. doi.org/10.1002/cptc.201700164. Teramura M, Harada J, Tamiaki H: In vitro enzymatic assays of photosynthetic bacterial 3-vinyl hydratases for bacteriochlorophyll biosyntheses. Photosynth Res. 2018 Mar; 135 (1-3): 319-328. doi: 10.1007/s11120-017-0415-6. 総説・著書 Sugishima M, Wada K, Fukuyama K: Recent Advances in the Understanding of the Reaction Chemistries of the Heme Catabolizing Enzymes HO and BVR Based on High Resolution Protein Structures. Curr Med Chem. 2018 Dec 17. 山本 健： 疾患感受性遺伝子同定の方法論 ー連鎖解析からＧＷＡSへー 消化器病サイエンス 2018; 2 (2): 22-24. ----- ２０１７ 英文原著 Takahashi Y, Sugimachi K, Yamamoto K, Niida A, Shimamura T, Sato T, Watanabe M, Tanaka J, Kudo S, Sugihara K, Hase K, Kusunoki M, Yamada K, Shimada Y, Moriya Y, Suzuki Y, Miyano S, Mori M, Mimori K: Japanese genome-wide association study identifies a significant colorectal cancer susceptibility locus at chromosome 10p14. Cancer Sci. 2017 Nov; 108 (11): 2239-2247. doi: 10.1111/cas.13391. Takeuchi F, Katsuya T, Kimura R, Nabika T, Isomura M, Ohkubo T, Tabara Y, Yamamoto K, Yokota M, Liu X, Saw WY, Mamatyusupu D, Yang W, Xu S; Japanese Genome Variation Consortium, Teo YY, Kato N: The fine-scale genetic structure and evolution of the Japanese population. PLoS One 2017 Nov 1; 12 (11): e0185487. doi: 10.1371/journal.pone.0185487. Inoue C, Zhao C, Tsuduki Y, Udono M, Wang L, Nomura M, Katakura Y: SMARCD1 regulates senescence-associated lipid accumulation in hepatocytes. NPJ Aging Mech Dis. 2017 Aug 30; 3: 11. doi: 10.1038/s41514-017-0011-1. Higashino T, Takada T, Nakaoka H, Toyoda Y, Stiburkova B, Miyata H, Ikebuchi Y, Nakashima H, Shimizu S, Kawaguchi M, Sakiyama M, Nakayama A, Akashi A, Tanahashi Y, Kawamura Y, Nakamura T, Wakai K, Okada R, Yamamoto K, Hosomichi K, Hosoya T, Ichida K, Ooyama H, Suzuki H, Inoue I, Merriman TR, Shinomiya N, Matsuo H: Multiple common and rare variants of ABCG2 cause gout. RMD Open 2017 Aug 29; 3 (2): e000464. doi: 10.1136/rmdopen-2017-000464. Mizoguchi T, Isaji M, Yamano N, Harada J, Fujii R, Tamiaki H: Molecular Structures and Functions of Chlorophylls-a Esterified with Geranylgeranyl, Dihydrogeranylgeranyl, and Tetrahydrogeranylgeranyl Groups at the 17-Propionate Residue in a Diatom, Chaetoceros calcitrans. Biochemistry. 2017 Jul 18; 56 (28): 3682-3688. doi: 10.1021/acs.biochem.7b00381. Nomura A, Won HH, Khera AV, Takeuchi F, Ito K, McCarthy S, Emdin CA, Klarin D, Natarajan P, Zekavat SM, Gupta N, Peloso GM, Borecki IB, Teslovich TM, Asselta R, Duga S, Merlini PA, Correa A, Kessler T, Wilson JG, Bown MJ, Hall AS, Braund PS, Carey DJ, Murray MF, Kirchner HL, Leader JB, Lavage DR, Manus JN, Hartze DN, Samani NJ, Schunkert H, Marrugat J, Elosua R, McPherson R, Farrall M, Watkins H, Juang JJ, Hsiung CA, Lin SY, Wang JS, Tada H, Kawashiri MA, Inazu A, Yamagishi M, Katsuya T, Nakashima E, Nakatochi M, Yamamoto K, Yokota M, Momozawa Y, Rotter JI, Lander ES, Rader DJ, Danesh J, Ardissino D, Gabriel S, Willer CJ, Abecasis GR, Saleheen D, Kubo M, Kato N, Ida Chen YD, Dewey FE, Kathiresan S: Protein-Truncating Variants at the Cholesteryl Ester Transfer Protein Gene and Risk for Coronary Heart Disease. Circ Res. 2017 Jun 23; 121 (1): 81-88. doi: 10.1161/CIRCRESAHA.117.311145. Nakatochi M, Ichihara S, Yamamoto K, Naruse K, Yokota S, Asano H, Matsubara T, Yokota M: Epigenome-wide association of myocardial infarction with DNA methylation sites at loci related to cardiovascular disease. Clin Epigenetics 2017 May 15; 9: 54. doi: 10.1186/s13148-017-0353-3. Taniguchi I, Iwaya C, Ohnaka K, Shibata H, Yamamoto K: Genome-wide DNA methylation analysis reveals hypomethylation in the low-CpG promoter regions in lymphoblastoid cell lines. Hum Genomics 2017 May 12; 11 (1): 8. doi: 10.1186/s40246-017-0106-6. Nakayama A, Nakaoka H, Yamamoto K, Sakiyama M, Shaukat A, Toyoda Y, Okada Y, Kamatani Y, Nakamura T, Takada T, Inoue K, Yasujima T, Yuasa H, Shirahama Y, Nakashima H, Shimizu S, Higashino T, Kawamura Y, Ogata H, Kawaguchi M, Ohkawa Y, Danjoh I, Tokumasu A, Ooyama K, Ito T, Kondo T, Wakai K, Stiburkova B, Pavelka K, Stamp LK, Dalbeth N; Eurogout Consortium., Sakurai Y, Suzuki H, Hosoyamada M, Fujimori S, Yokoo T, Hosoya T, Inoue I, Takahashi A, Kubo M, Ooyama H, Shimizu T, Ichida K, Shinomiya N, Merriman TR, Matsuo H; Eurogout Consortium: GWAS of clinically defined gout and subtypes identifies multiple susceptibility loci that include urate transporter genes. Ann Rheum Dis. 2017 May; 76 (5): 869-877. doi: 10.1136/annrheumdis-2016-209632. Mizoguchi T, Kinoshita Y, Harada J, Tamiaki H: Supramolecular organogelation of bacteriochlorophyll-c possessing an isobutyl substituent at the 8-position in carbon tetrachloride. ChemPlusChem. 2017 Apr; 82 (4): 595-597. doi: 10.1002/cplu.201600494. Liu X, Lu D, Saw WY, Shaw PJ, Wangkumhang P, Ngamphiw C, Fucharoen S, Lert-Itthiporn W, Chin-Inmanu K, Chau TN, Anders K, Kasturiratne A, de Silva HJ, Katsuya T, Kimura R, Nabika T, Ohkubo T, Tabara Y, Takeuchi F, Yamamoto K, Yokota M, Mamatyusupu D, Yang W, Chung YJ, Jin L, Hoh BP, Wickremasinghe AR, Ong RH, Khor CC, Dunstan SJ, Simmons C, Tongsima S, Suriyaphol P, Kato N, Xu S, Teo YY: Characterising private and shared signatures of positive selection in 37 Asian populations. Eur J Hum Genet. 2017 Apr; 25 (4): 499-508. doi: 10.1038/ejhg.2016.181. Morimoto T, Mineharu Y, Ono K, Nakatochi M, Ichihara S, Kabata R, Takagi Y, Cao Y, Zhao L, Kobayashi H, Harada KH, Takenaka K, Funaki T, Yokota M, Matsubara T, Yamamoto K, Izawa H, Kimura T, Miyamoto S, Koizumi A: Significant association of RNF213 p.R4810K, a moyamoya susceptibility variant, with coronary artery disease. PLoS One. 2017 Apr 17; 12 (4): e0175649. doi: 10.1371/journal.pone.0175649. Takao H, Hirabayashi K, Nishigaya Y, Kouriki H, Nakaniwa T, Hagiwara Y, Harada J, Sato H, Yamazaki T, Sakakibara Y, Suiko M, Asada Y, Takahashi Y, Yamamoto K, Fukuyama K, Sugishima M, Wada K: A substrate-bound structure of cyanobacterial biliverdin reductase identifies stacked substrates as critical for activity. Nat Commun. 2017 Feb 7; 8: 14397. doi: 10.1038/ncomms14397. Oki R, Yamada K, Nakano S, Kimoto K, Yamamoto K, Kondo H, Kubota T: A Japanese Family With Autosomal Dominant Oculocutaneous Albinism Type 4. Invest Ophthalmol Vis Sci. 2017 Feb 1; 58 (2): 1008-1016. doi: 10.1167/iovs.16-20612. ----- ２０１６ 英文原著 Maeki M, Yamazaki S, Pawate SA, Ishida A, Tani H, Yamashita K, Sugishima M, Watanabe K, Tokeshi M, Kenis PJA, Miyazaki M： A microfluidic-based protein crystallization method in 10 micrometer-sized crystallization space. Cryst. Eng. Comm. 2016; 18: 7722-7727. doi: 10.1039/C6CE01671E Teramura M, Harada J, Tamiaki H: In vitro stereospecific hydration activities of the 3-vinyl group of chlorophyll derivatives by BchF and BchV enzymes involved in bacteriochlorophyll c biosynthesis of green sulfur bacteria. Photosynth Res. 2016 Dec;130(1-3):33-45. doi:10.1007/s11120-016-0220-7. Hagiwara Y, Wada K, Irikawa T, Sato H, Unno M, Yamamoto K, Fukuyama K, Sugishima M: Atomic-resolution structure of the phycocyanobilin:ferredoxin oxidoreductase I86D mutant in complex with fully protonated biliverdin. FEBS Lett. 2016 Oct;590(19):3425-3434. doi: 10.1002/1873-3468.12387. Sakiyama M, Matsuo H, Nakaoka H, Yamamoto K, Nakayama A, Nakamura T, Kawai S, Okada R, Ooyama H, Shimizu T, Shinomiya N: Identification of rs671, a common variant of ALDH2, as a gout susceptibility locus. Sci Rep. 2016 May 16; 6: 25360. doi: 10.1038/srep25360. Sawada G, Niida A, Uchi R, Hirata H, Shimamura T, Suzuki Y, Shiraishi Y, Chiba K, Imoto S, Takahashi Y, Iwaya T, Sudo T, Hayashi T, Takai H, Kawasaki Y, Matsukawa T, Eguchi H, Sugimachi K, Tanaka F, Suzuki H, Yamamoto K, Ishii H, Shimizu M, Yamazaki H, Yamazaki M, Tachimori Y, Kajiyama Y, Natsugoe S, Fujita H, Mafune K, Tanaka Y, Kelsell DP, Scott CA, Tsuji S, Yachida S, Shibata T, Sugano S, Doki Y, Akiyama T, Aburatani H, Ogawa S, Miyano S, Mori M, Mimori K: Genomic Landscape of Esophageal Squamous Cell Carcinoma in a Japanese Population. Gastroenterology 2016 May; 150 (5): 1171-82. doi: 10.1053/j.gastro.2016.01.035. Teramura M, Harada J, Mizoguchi T, Yamamoto K, Tamiak H: In Vitro Assays of BciC Showing C132 -Demethoxycarbonylase Activity Requisite for 5 Biosynthesis of Chlorosomal Chlorophyll Pigments. Plant Cell Physiol. 2016 May; 57 (5): 1048-57. doi: 10.1093/pcp/pcw045. Nishida N, Ohashi J, Khor SS, Sugiyama M, Tsuchiura T, Sawai H, Hino K, Honda M, Kaneko S, Yatsuhashi H, Yokosuka O, Koike K, Kurosaki M, Izumi N, Korenaga M, Kang JH, Tanaka E, Taketomi A, Eguchi Y, Sakamoto N, Yamamoto K, Tamori A, Sakaida I, Hige S, Itoh Y, Mochida S, Mita E, Takikawa Y, Ide T, Hiasa Y, Kojima H, Yamamoto K, Nakamura M, Saji H, Sasazuki T, Kanto T, Tokunaga K, Mizokami M: Understanding of HLA-conferred susceptibility to chronic hepatitis B infection requires HLA genotyping-based association analysis. Sci Rep. 2016 Apr 19; 6: 24767. doi: 10.1038/srep24767. Matsuo H, Yamamoto K, Nakaoka H, Nakayama A, Sakiyama M, Chiba T, Takahashi A, Nakamura T, Nakashima H, Takada Y, Danjoh I, Shimizu S, Abe J, Kawamura Y, Terashige S, Ogata H, Tatsukawa S, Yin G, Okada R, Morita E, Naito M, Tokumasu A, Onoue H, Iwaya K, Ito T, Takada T, Inoue K, Kato Y, Nakamura Y, Sakurai Y, Suzuki H, Kanai Y, Hosoya T, Hamajima N, Inoue I, Kubo M, Ichida K, Ooyama H, Shimizu T, Shinomiya N: Genome-wide association study of clinically defined gout identifies multiple risk loci and its association with clinical subtypes. Ann Rheum Dis. 2016 Apr; 75 (4): 652-9. doi: 10.1136/annrheumdis-2014-206191. Uchi R, Takahashi Y, Niida A, Shimamura T, Hirata H, Sugimachi K, Sawada G, Iwaya T, Kurashige J, Shinden Y, Iguchi T, Eguchi H, Chiba K, Shiraishi Y, Nagae G, Yoshida K, Nagata Y, Haeno H, Yamamoto H, Ishii H, Doki Y, Iinuma H, Sasaki S, Nagayama S, Yamada K, Yachida S, Kato M, Shibata T, Oki E, Saeki H, Shirabe K, Oda Y, Maehara Y, Komune S, Mori M, Suzuki Y, Yamamoto K, Aburatani H, Ogawa S, Miyano S, Mimori K: Integrated Multiregional Analysis Proposing a New Model of Colorectal Cancer Evolution. PLoS Genet. 2016 Feb 18; 12 (2): e1005778. doi:10.1371/journal.pgen.1005778. Yanagi T, Mizuochi T, Takaki Y, Eda K, Mitsuyama K, Ishimura M, Takada H, Shouval DS, Griffith AE, Snapper SB, Yamashita Y, Yamamoto K: Novel exonic mutation inducing aberrant splicing in the IL10RA gene and resulting in infantile-onset inflammatory bowel disease: a case report. BMC Gastroenterol. 2016 Jan 28; 16 (1): 10. doi: 10.1186/s12876-016-0424-5. Wen W, Kato N, Hwang JY, Guo X, Tabara Y, Li H, Dorajoo R, Yang X, Tsai FJ, Li S, Wu Y, Wu T, Kim S, Guo X, Liang J, Shungin D, Adair LS, Akiyama K, Allison M, Cai Q, Chang LC, Chen CH, Chen YT, Cho YS, Choi BY, Gao Y, Go MJ, Gu D, Han BG, He M, Hixson JE, Hu Y, Huang T, Isono M, Jung KJ, Kang D, Kim YJ, Kita Y, Lee J, Lee NR, Lee J, Wang Y, Liu JJ, Long J, Moon S, Nakamura Y, Nakatochi M, Ohnaka K, Rao D, Shi J, Sull JW, Tan A, Ueshima H, Wu C, Xiang YB, Yamamoto K, Yao J, Ye X, Yokota M, Zhang X, Zheng Y, Qi L, Rotter JI, Jee SH, Lin D, Mohlke KL, He J, Mo Z, Wu JY, Tai ES, Lin X, Miki T, Kim BJ, Takeuchi F, Zheng W, Shu XO: Genome-wide association studies in East Asians identify new loci for waist-hip ratio and waist circumference. Sci Rep. 2016 Jan 20; 6: 17958. doi: 10.1038/srep17958. 総説・著書 海野昌喜、日下勝弘、玉田太郎、杉島正一、和田啓、萩原義徳、福山恵一: ビリン還元酵素PcyAと基質ビリベルジン複合体の中性構造解析から見えてきたもの 日本中性子科学会誌「波紋」 2016; 26: 130-134. Unno M, Ishikawa-Suto K, Kusaka K, Tamada T, Hagiwara Y, Sugishima M, Wada K, Ishikawa M, Fukuyama K： Neutron Crystallography Reveals Two Protonation States of PcyA, a Bilin Reductase. MLF Annual Reports 2014, 2016: 15-17. 杉島正一： X線小角散乱によるNADPH-シトクロムP450還元酵素とヘムオキシゲナーゼの複合体の構造解析 九州シンクロトロン光研究センター年報2014、2016: 14-16. 杉島正一： ヘム代謝系関連酵素の構造生物学的研究 生化学 2016 Apr; 88 (2): 171-81. doi: 10.14952/SEIKAGAKU.2016.880171. ----- ２０１５ Sato-Otsubo A, Nannya Y, Kashiwase K, Onizuka M, Azuma F, Akatsuka Y, Ogino Y, Satake M, Sanada M, Chiba S, Saji H, Inoko H, Kennedy GC, Yamamoto K, Morishima S, Morishima Y, Kodera Y, Sasazuki T, Ogawa S: Genome wide surveillance of mismatched alleles for graft versus host disease in stem cell transplantation. Blood 2015 Dec 17; 126 (25): 2752-63. doi: 10.1182/blood-2015-03-630707. Saw WY, Liu X, Khor CC, Takeuchi F, Katsuya T, Kimura R, Nabika T, Ohkubo T, Tabara Y, Yamamoto K, Yokota M; Japanese Genome Variation Consortium, Teo YY, Kato N: Mapping the genetic diversity of HLA haplotypes in the Japanese populations. Sci Rep. 2015 Dec 9; 5: 17855. doi: 10.1038/srep17855. Mizoguchi T, Harada J, Yamamoto K, Tamiaki H: Inactivation of bciD and bchU genes in the green sulfur bacterium Chlorobaculum limnaeum and alteration of photosynthetic pigments in the resultant mutants. J Photochem Photobiol A Chem. 2015 Dec 1; 313: 52-9. doi: 10.1016/j.jphotochem.2015.06.012. Saga Y, Hayashi K, Hirota K, Harada J, Tamiaki H: Modification of the esterifying farnesyl chain in light-harvesting bacteriochlorophylls in green sulfur photosynthetic bacteria by supplementation of 9-decyn-1-ol, 9-decen-1-ol, and decan-1-ol. J Photochem Photobiol A Chem. 2015 Dec 1; 313: 44-51. doi:10.1016/j.jphotochem.2015.05.002. Harada J, Teramura M, Mizoguchi T, Tsukatani Y, Yamamoto K, Tamiaki H: Stereochemical conversion of C3-vinyl group to 1-hydroxyethyl group in bacteriochlorophyll c by the hydratases BchF and BchV: adaptation of green sulfur bacteria to limited-light environments. Mol Microbiol. 2015 Dec; 98 (6): 1184-98. doi:10.1111/mmi.13208. Nishida N, Ohashi J, Sugiyama M, Tsuchiura T, Yamamoto K, Hino K, Honda M, Kaneko S, Yatsuhashi H, Koike K, Yokosuka O, Tanaka E, Taketomi A, Kurosaki M, Izumi N, Sakamoto N, Eguchi Y, Sasazuki T, Tokunaga K, Mizokami M: Effects of HLA-DPB1 genotypes on chronic hepatitis B infection in Japanese individuals. Tissue Antigens 2015 Dec; 86 (6): 406-12. doi: 10.1111/tan.12684. Nakatochi M, Ichihara S, Yamamoto K, Ohnaka K, Kato Y, Yokota S, Hirashiki A, Naruse K, Asano H, Izawa H, Matsubara T, Yokota M: Epigenome-wide association study suggests that SNPs in the promoter region of RETN influence plasma resistin level via effects on DNA methylation at neighbouring sites. Diabetologia 2015 Dec; 58 (12): 2781-90. doi: 10.1007/s00125-015-3763-9. Kato N, Loh M, Takeuchi F, ~, ~, Yamamoto K, ~, ~, Chambers JC: Trans-ethnic genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation. Nat Genet. 2015 Nov; 47 (11): 1282-93. doi: 10.1038/ng.3405. Sato S, Yamamoto K, Matsushita T, Isobe N, Kawano Y, Iinuma K, Niino M, Fukazawa T, Nakamura Y, Watanabe M, Yonekawa T, Masaki K, Yoshimura S, Murai H, Yamasaki R, Kira J; Japan Multiple Sclerosis Genetics Consortium: Copy Number Variations in Multiple Sclerosis and Neuromyelitis Optica. Ann Neurol. 2015 Nov; 78 (5): 762-74. doi: 10.1002/ana.24511. Sano K, Miura S, Fujiwara T, Fujioka R, Yorita A, Noda K, Kida H, Azuma K, Kaieda S, Yamamoto K, Taniwaki T, Fukumaki Y, Shibata H: A novel missense mutation of RYR1 in familial idiopathic hyper CK-emia. J Neurol Sci. 2015 Sep 15; 356 (1-2): 142-7. doi: 10.1016/j.jns.2015.06.035. Tsukatani Y, Hirose Y, Harada J, Misawa N, Mori K, Inoue K, Tamiaki H: Complete Genome Sequence of the Bacteriochlorophyll b-Producing Photosynthetic Bacterium Blastochloris viridis. Genome Announc. 2015 Sep 3; 3 (5). pii: e01006-15. doi: 10.1128/genomeA.01006-15. Saga Y, Hirota K, Harada J, Tamiaki H: In Vitro Enzymatic Activities of Bacteriochlorophyll a Synthase Derived from the Green Sulfur Photosynthetic Bacterium Chlorobaculum tepidum. Biochemistry 2015 Aug 18; 54 (32): 4998-5005. doi:10.1021/acs.biochem.5b00311. Tsukatani Y, Harada J, Nomata J, Yamamoto H, Fujita Y, Mizoguchi T, Tamiaki H: Rhodobacter sphaeroides mutants overexpressing chlorophyllide a oxidoreductase of Blastochloris viridis elucidate functions of enzymes in late bacteriochlorophyll biosynthetic pathways. Sci Rep. 2015 May 15; 5: 9741. doi: 10.1038/srep09741. Tanimura K, Jin H, Suenaga T, Morikami S, Arase N, Kishida K, Hirayasu K, Kohyama M, Ebina Y, Yasuda S, Horita T, Takasugi K, Ohmura K, Yamamoto K, Katayama I, Sasazuki T, Lanier LL, Atsumi T, Yamada H, Arase H: β2-glycoprotein I/ HLA class II complexes are novel autoantigens in antiphospholipid syndrome. Blood 2015 Apr 30; 125 (18): 2835-44. doi: 10.1182/blood-2014-08-593624. Unno M, Ishikawa-Suto K, Kusaka K, Tamada T, Hagiwara Y, Sugishima M, Wada K, Yamada T, Tomoyori K, Hosoya T, Tanaka I, Niimura N, Kuroki R, Inaka K, Ishihara M, Fukuyama K: Insights into the proton transfer mechanism of a bilin reductase PcyA following neutron crystallography. J Am Chem Soc. 2015 Apr 29; 137 (16): 5452-60. doi: 10.1021/jacs.5b00645. Harada E, Sugishima M, Harada J, Noguchi M, Fukuyama K, Sugase K: Backbone assignments of the apo and Zn(II) protoporphyrin IX-bound states of the soluble form of rat heme oxygenase-1. Biomol NMR Assign. 2015 Apr; 9 (1): 197-200. doi:10.1007/s12104-014-9573-z. Fares-Taie L, Gerber S, Tawara A, Ramirez-Miranda A, Douet JY, Verdin H, Guilloux A, Zenteno JC, Kondo H, Moisset H, Passet B, Yamamoto K, Iwai M, Tanaka T, Nakamura Y, Kimura W, Bole-Feysot C, Vilotte M, Odent S, Vilotte JL, Munnich A, Regnier A, Chassaing N, De Baere E, Raymond-Letron I, Kaplan J, Calvas P, Roche O, Rozet JM: Submicroscopic deletions at 13q32.1 cause congenital microcoria. Am J Hum Genet. 2015 Apr 2; 96 (4): 631-9. doi:10.1016/j.ajhg.2015.01.014. Takeuchi F, Isono M, Yamamoto K, Yokota M, Akiyama K, Katsuya T, Kim HS, Park JE, Jang Y, Lee JY; AGEN
Consortium, Lee JY, Kato N: |
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| ----- ２０１４ 英文原著 Sugimachi K, Niida A, Yamamoto K, Shimamura T, Imoto S, Iinuma H, Shinden Y, Eguchi H, Sudo T, Watanabe M, Tanaka J, Kudo S, Hase K, Kusunoki M, Yamada K, Shimada Y, Sugihara K, Maehara Y, Miyano S, Mori M, Mimori K. Allelic imbalance at an 8q24 oncogenic SNP is involved in activating MYC in human colorectal cancer. Ann Surg Oncol. 2014 Dec;21 Suppl 4:S515-21. doi: 2. 10.1245/s10434-013-3468-6. Sato T, Nakagome S, Watanabe C, Yamaguchi K, Kawaguchi A, Koganebuchi K, Haneji K, Yamaguchi T, Hanihara T, Yamamoto K, Ishida H, Mano S, Kimura R, Oota H. Genome-wide SNP analysis reveals population structure and demographic history of the ryukyu islanders in the southern part of the Japanese archipelago. Mol Biol Evol. 2014 Nov;31(11):2929-40. doi: 10.1093/molbev/msu230. Wen W, Zheng W, Okada Y, Takeuchi F, Tabara Y, Hwang JY, Dorajoo R, Li H, Tsai FJ, Yang X, He J, Wu Y, He M, Zhang Y, Liang J, Guo X, Sheu WH, Delahanty R, Guo X, Kubo M, Yamamoto K, Ohkubo T, Go MJ, Liu JJ, Gan W, Chen CC, Gao Y, Li S, Lee NR, Wu C, Zhou X, Song H, Yao J, Lee IT, Long J, Tsunoda T, Akiyama K, Takashima N, Cho YS, Ong RT, Lu L, Chen CH, Tan A, Rice TK, Adair LS, Gui L, Allison M, Lee WJ, Cai Q, Isomura M, Umemura S, Kim YJ, Seielstad M, Hixson J, Xiang YB, Isono M, Kim BJ, Sim X, Lu W, Nabika T, Lee J, Lim WY, Gao YT, Takayanagi R, Kang DH, Wong TY, Hsiung CA, Wu IC, Juang JM, Shi J, Choi BY, Aung T, Hu F, Kim MK, Lim WY, Wang TD, Shin MH, Lee J, Ji BT, Lee YH, Young TL, Shin DH, Chun BY, Cho MC, Han BG, Hwu CM, Assimes TL, Absher D, Yan X, Kim E, Kuo JZ, Kwon S, Taylor KD, Chen YD, Rotter JI, Qi L, Zhu D, Wu T, Mohlke KL, Gu D, Mo Z, Wu JY, Lin X, Miki T, Tai ES, Lee JY, Kato N, Shu XO, Tanaka T. Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index. Hum Mol Genet. 2014 Oct 15;23(20):5492-504. doi:10.1093/hmg/ddu248. Kusano S, Kukimoto-Niino M, Satta Y, Ohsawa N, Uchikubo-Kamo T, Wakiyama M, Ikeda M, Terada T, Yamamoto K, Nishimura Y, Shirouzu M, Sasazuki T, Yokoyama S. Structural basis for the specific recognition of the major antigenic peptide from the Japanese cedar pollen allergen Cry j 1 by HLA-DP5. J Mol Biol. 2014 Aug 26;426(17):3016-27. doi: 10.1016/j.jmb.2014.06.020. Kida H, Takano Y, Yamamoto K, Mori M, Yanaga K, Tanaka J, Kudo SE, Mimori K. A single nucleotide polymorphism in fibronectin 1 determines tumor shape in colorectal cancer. Oncol Rep. 2014 Aug;32(2):548-52. doi: 10.3892/or.2014.3251. Mizoguchi T, Harada J, Tsukatani Y, Tamiaki H. Isolation and characterization of a new bacteriochlorophyll-c bearing a neopentyl substituent at the 8-position from the bciD-deletion mutant of the brown-colored green sulfur bacterium Chlorobaculum limnaeum. Photosynth Res. 2014 Jul;121(1):3-12. doi:10.1007/s11120-014-9977-8. Harada J, Mizoguchi T, Nomura K, Tamiaki H. Isolation and structural determination of C8-vinyl-bacteriochlorophyll d from the bciA and bchU double mutant of the green sulfur bacterium Chlorobaculum tepidum. Photosynth Res. 2014 Jul;121(1):13-23. doi: 10.1007/s11120-014-0007-7. Chen P, Takeuchi F, Lee JY, Li H, Wu JY, Liang J, Long J, Tabara Y, Goodarzi MO, Pereira MA, Kim YJ, Go MJ, Stram DO, Vithana E, Khor CC, Liu J, Liao J, Ye X, Wang Y, Lu L, Young TL, Lee J, Thai AC, Cheng CY, van Dam RM, Friedlander Y, Heng CK, Koh WP, Chen CH, Chang LC, Pan WH, Qi Q, Isono M, Zheng W, Cai Q, Gao Y, Yamamoto K, Ohnaka K, Takayanagi R, Kita Y, Ueshima H, Hsiung CA, Cui J, Sheu WH, Rotter JI, Chen YD, Hsu C, Okada Y, Kubo M, Takahashi A, Tanaka T, van Rooij FJ, Ganesh SK, Huang J, Huang T, Yuan J, Hwang JY; CHARGE Hematology Working Group, Gross MD, Assimes TL, Miki T, Shu XO, Qi L, Chen YT, Lin X, Aung T, Wong TY, Teo YY, Kim BJ, Kato N, Tai ES. Multiple nonglycemic genomic loci are newly associated with blood level of glycated hemoglobin in East Asians. Diabetes 2014 Jul;63(7):2551-62. doi: 10.2337/db13-1815. Akiyama K, Takeuchi F, Isono M, Chakrawarthy S, Nguyen QN, Wen W, Yamamoto K, Katsuya T, Kasturiratne A, Pham ST, Zheng W, Matsushita Y, Kishimoto M, Do LD, Shu XO, Wickremasinghe AR, Kajio H, Kato N. Systematic fine-mapping of association with BMI and type 2 diabetes at the FTO locus by integrating results from multiple ethnic groups. PLoS One 2014 Jun 30;9(6):e101329. doi:10.1371/journal.pone.0101329. Harada J, Mizoguchi T, Tsukatani Y, Yokono M, Tanaka A, Tamiaki H. Chlorophyllide a oxidoreductase works as one of the divinyl reductases specifically involved in bacteriochlorophyll a biosynthesis. J Biol Chem. 2014 May 2;289(18):12716-26. doi: 10.1074/jbc.M113.546739. Yamaguchi T, Nakaoka H, Yamamoto K, Fujikawa T, Kim YI, Yano K, Haga S, Katayama K, Shibusawa T, Park SB, Maki K, Kimura R, Inoue I. Genome-wide association study of degenerative bony changes of the temporomandibular joint. Oral Dis. 2014 May;20(4):409-15. doi: 10.1111/odi.12141. DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium; Asian Genetic Epidemiology Network Type 2 Diabetes (AGEN-T2D) Consortium; South Asian Type 2 Diabetes (SAT2D) Consortium; Mexican American Type 2 Diabetes (MAT2D) Consortium; Type 2 Diabetes Genetic Exploration by Nex-generation sequencing in muylti-Ethnic Samples (T2D-GENES) Consortium, Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat Genet. 2014 Mar;46(3):234-44. doi: 10.1038/ng.2897. Sugishima M, Sato H, Higashimoto Y, Harada J, Wada K, Fukuyama K, Noguchi M. Structural basis for the electron transfer from an open form of NADPH-cytochrome P450 oxidoreductase to heme oxygenase. Proc Natl Acad Sci U S A 2014 Feb18;111(7):2524-9. doi: 10.1073/pnas.1322034111. Ueda S, Oryoji D, Yamamoto K, Noh JY, Okamura K, Noda M, Kashiwase K, Kosuga Y, Sekiya K, Inoue K, Yamada H, Oyamada A, Nishimura Y, Yoshikai Y, Ito K, Sasazuki T. Identification of independent susceptible and protective HLA alleles in Japanese autoimmune thyroid disease and their epistasis. J Clin Endocrinol Metab. 2014 Feb;99(2):E379-83. doi: 10.1210/jc.2013-2841. Wu Y, Gao H, Li H, Tabara Y, Nakatochi M, Chiu YF, Park EJ, Wen W, Adair LS, Borja JB, Cai Q, Chang YC, Chen P, Croteau-Chonka DC, Fogarty MP, Gan W, He CT, Hsiung CA, Hwu CM, Ichihara S, Igase M, Jo J, Kato N, Kawamoto R, Kuzawa CW, Lee JJ, Liu J, Lu L, McDade TW, Osawa H, Sheu WH, Teo Y, Vadlamudi S, Van Dam RM, Wang Y, Xiang YB, Yamamoto K, Ye X, Young TL, Zheng W, Zhu J, Shu XO, Shin C, Jee SH, Chuang LM, Miki T, Yokota M, Lin X, Mohlke KL, Tai ES. A meta-analysis of genome-wide association studies for adiponectin levels in East Asians identifies a novel locus near WDR11-FGFR2. Hum Mol Genet. 2014 Feb 15;23(4):1108-19. doi:10.1093/hmg/ddt488. Matsuo H, Nakayama A, Sakiyama M, Chiba T, Shimizu S, Kawamura Y, Nakashima H, Nakamura T, Takada Y, Oikawa Y, Takada T, Nakaoka H, Abe J, Inoue H, Wakai K, Kawai S, Guang Y, Nakagawa H, Ito T, Niwa K, Yamamoto K, Sakurai Y, Suzuki H, Hosoya T, Ichida K, Shimizu T, Shinomiya N. ABCG2 dysfunction causes hyperuricemia due to both renal urate underexcretion and renal urate overload. Sci Rep. 2014 Jan 20;4:3755. doi: 10.1038/srep03755. 総説・著書 Sugishima M, Fukuyama K, Noguchi M. Crystal structure of an associated form of NADPH-cytochrome P450 reductase with heme oxygenase. SPring-8 Research Frontiers 2014, 18-19. 杉島正一 ヘム鉄代謝の鍵となる電子伝達複合体の構造解析 日本結晶学会誌, 2014; 56, 393-398, DOI: 10.5940/jcrsj.56.393. 杉島正一 フェレドキシン依存性酸化還元酵素の構造と機能 日本の結晶学（II)－その輝かしい発展－ 日本結晶学会, 294, ISBN 978-4-9903861-2-2 |
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Copyright(C) Department of Medical Biochemistry, Kurume University School of Medicine. All Rights Reserved. 〒８３０－００１１ 福岡県久留米市旭町６７ 久留米大学医学部医化学講座 基礎２号館６階 |
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