Department of Medical Biochemistry, Kurume University School of Medicine
     
トップ 教室紹介 メンバー 教育活動 研究活動 論文発表 学会発表

2018

英文原著

Sakiyama M, Matsuo H, Nakaoka H, Kawamura Y, Kawaguchi M, Higashino T, Nakayama A, Akashi A, Ueyama J, Kondo T, Wakai K, Sakurai Y,
Yamamoto K, Ooyama H, Shinomiya N:
Common variant of BCAS3 is associated with gout risk in Japanese population : the first replication study after gout GWAS in Han Chinese.
BMC Med Genet. 2018 Jun 7; 19 (1): 96. doi: 10.1186/s12881-018-0583-z.

Mizoguchi T, Kinoshita Y,
Harada J, Ogasawara S, Tamiaki H:
Light-dependent accumulation of new bacteriochlorophyll-e bearing a vinyl group at the 8-position in the green sulfur bacterium Chlorobaculum limnaeum.
J Photochem Photobiol A Chem. 2018 May 1; 358: 356-361. doi.org/10.1016/j.jphotochem.2017.08.071.

Iwaya C, Kitajima H,
Yamamoto K, Maeda Y, Sonoda N, Shibata H, Inoguchi T:
DNA methylation of the Klf14 gene region in whole blood cells provides prediction for the chronic inflammation in the adipose tissue.
Biochem Biophys Res Commun. 2018 Mar 11; 497 (3): 908-915. doi: 10.1016/j.bbrc.2017.12.104.

Harada J
, Shibata Y, Teramura M, Mizoguchi T, Kinoshita Y, Yamamoto K, Tamiaki H:
In vivo Excited Energy Transfer of Bacteriochlorophyll c, d, e, or f to Bacteriochlorophyll a in the Wild-Type and Mutant Cells of the Green Sulfur Bacterium Chlorobaculum limnaeum
ChemPhotoChem. 2018 Mar; 2 (3): 190-195. doi.org/10.1002/cptc.201700164.

Teramura M,
Harada J, Tamiaki H:
In vitro enzymatic assays of photosynthetic bacterial 3-vinyl hydratases for bacteriochlorophyll biosyntheses.
Photosynth Res. 2018 Mar; 135 (1-3): 319-328. doi: 10.1007/s11120-017-0415-6.

総説・著書

山本 健:
疾患感受性遺伝子同定の方法論 ー連鎖解析からGWASへー
消化器病サイエンス 2018; 2 (2): 22-24.

2017

英文原著

Takahashi Y, Sugimachi K,
Yamamoto K, Niida A, Shimamura T, Sato T, Watanabe M, Tanaka J, Kudo S, Sugihara K, Hase K, Kusunoki M, Yamada K, Shimada Y, Moriya Y, Suzuki Y, Miyano S, Mori M, Mimori K:
Japanese genome-wide association study identifies a significant colorectal cancer susceptibility locus at chromosome 10p14.
Cancer Sci. 2017 Nov; 108 (11): 2239-2247. doi: 10.1111/cas.13391.

Takeuchi F, Katsuya T, Kimura R, Nabika T, Isomura M, Ohkubo T, Tabara Y,
Yamamoto K, Yokota M, Liu X, Saw WY, Mamatyusupu D, Yang W, Xu S; Japanese Genome Variation Consortium, Teo YY, Kato N:
The fine-scale genetic structure and evolution of the Japanese population.
PLoS One 2017 Nov 1; 12 (11): e0185487. doi: 10.1371/journal.pone.0185487.

Inoue C, Zhao C, Tsuduki Y, Udono M,
Wang L, Nomura M, Katakura Y:
SMARCD1 regulates senescence-associated lipid accumulation in hepatocytes.
NPJ Aging Mech Dis. 2017 Aug 30; 3: 11. doi: 10.1038/s41514-017-0011-1.

Higashino T, Takada T, Nakaoka H, Toyoda Y, Stiburkova B, Miyata H, Ikebuchi Y, Nakashima H, Shimizu S, Kawaguchi M, Sakiyama M, Nakayama A, Akashi A, Tanahashi Y, Kawamura Y, Nakamura T, Wakai K, Okada R, Yamamoto K, Hosomichi K, Hosoya T, Ichida K, Ooyama H, Suzuki H, Inoue I, Merriman TR, Shinomiya N, Matsuo H:
Multiple common and rare variants of ABCG2 cause gout.
RMD Open 2017 Aug 29; 3 (2): e000464. doi: 10.1136/rmdopen-2017-000464.

Mizoguchi T, Isaji M, Yamano N,
Harada J, Fujii R, Tamiaki H:
Molecular Structures and Functions of Chlorophylls-a Esterified with Geranylgeranyl, Dihydrogeranylgeranyl, and Tetrahydrogeranylgeranyl Groups at the 17-Propionate Residue in a Diatom, Chaetoceros calcitrans.
Biochemistry. 2017 Jul 18; 56 (28): 3682-3688. doi: 10.1021/acs.biochem.7b00381.

Nomura A, Won HH, Khera AV, Takeuchi F, Ito K, McCarthy S, Emdin CA, Klarin D, Natarajan P, Zekavat SM, Gupta N, Peloso GM, Borecki IB, Teslovich TM, Asselta R, Duga S, Merlini PA, Correa A, Kessler T, Wilson JG, Bown MJ, Hall AS, Braund PS, Carey DJ, Murray MF, Kirchner HL, Leader JB, Lavage DR, Manus JN, Hartze DN, Samani NJ, Schunkert H, Marrugat J, Elosua R, McPherson R, Farrall M, Watkins H, Juang JJ, Hsiung CA, Lin SY, Wang JS, Tada H, Kawashiri MA, Inazu A, Yamagishi M, Katsuya T, Nakashima E, Nakatochi M,
Yamamoto K, Yokota M, Momozawa Y, Rotter JI, Lander ES, Rader DJ, Danesh J, Ardissino D, Gabriel S, Willer CJ, Abecasis GR, Saleheen D, Kubo M, Kato N, Ida Chen YD, Dewey FE, Kathiresan S:
Protein-Truncating Variants at the Cholesteryl Ester Transfer Protein Gene and Risk for Coronary Heart Disease.
Circ Res. 2017 Jun 23; 121 (1): 81-88. doi: 10.1161/CIRCRESAHA.117.311145.

Nakatochi M, Ichihara S, Yamamoto K, Naruse K, Yokota S, Asano H, Matsubara T, Yokota M:
Epigenome-wide association of myocardial infarction with DNA methylation sites at loci related to cardiovascular disease.
Clin Epigenetics 2017 May 15; 9: 54. doi: 10.1186/s13148-017-0353-3.

Taniguchi I, Iwaya C, Ohnaka K, Shibata H,
Yamamoto K:
Genome-wide DNA methylation analysis reveals hypomethylation in the low-CpG promoter regions in lymphoblastoid cell lines.
Hum Genomics 2017 May 12; 11 (1): 8. doi: 10.1186/s40246-017-0106-6.

Nakayama A, Nakaoka H,
Yamamoto K, Sakiyama M, Shaukat A, Toyoda Y, Okada Y, Kamatani Y, Nakamura T, Takada T, Inoue K, Yasujima T, Yuasa H, Shirahama Y, Nakashima H, Shimizu S, Higashino T, Kawamura Y, Ogata H, Kawaguchi M, Ohkawa Y, Danjoh I, Tokumasu A, Ooyama K, Ito T, Kondo T, Wakai K, Stiburkova B, Pavelka K, Stamp LK, Dalbeth N; Eurogout Consortium., Sakurai Y, Suzuki H, Hosoyamada M, Fujimori S, Yokoo T, Hosoya T, Inoue I, Takahashi A, Kubo M, Ooyama H, Shimizu T, Ichida K, Shinomiya N, Merriman TR, Matsuo H; Eurogout Consortium:
GWAS of clinically defined gout and subtypes identifies multiple susceptibility loci that include urate transporter genes.
Ann Rheum Dis. 2017 May; 76 (5): 869-877. doi: 10.1136/annrheumdis-2016-209632.

Mizoguchi T, Kinoshita Y,
Harada J, Tamiaki H:
Supramolecular organogelation of bacteriochlorophyll-c possessing an isobutyl substituent at the 8-position in carbon tetrachloride.
ChemPlusChem. 2017 Apr; 82 (4): 595-597. doi: 10.1002/cplu.201600494.

Liu X, Lu D, Saw WY, Shaw PJ, Wangkumhang P, Ngamphiw C, Fucharoen S, Lert-Itthiporn W, Chin-Inmanu K, Chau TN, Anders K, Kasturiratne A, de Silva HJ, Katsuya T, Kimura R, Nabika T, Ohkubo T, Tabara Y, Takeuchi F,
Yamamoto K, Yokota M, Mamatyusupu D, Yang W, Chung YJ, Jin L, Hoh BP, Wickremasinghe AR, Ong RH, Khor CC, Dunstan SJ, Simmons C, Tongsima S, Suriyaphol P, Kato N, Xu S, Teo YY:
Characterising private and shared signatures of positive selection in 37 Asian populations.
Eur J Hum Genet. 2017 Apr; 25 (4): 499-508. doi: 10.1038/ejhg.2016.181.

Morimoto T, Mineharu Y, Ono K, Nakatochi M, Ichihara S, Kabata R, Takagi Y, Cao Y, Zhao L, Kobayashi H, Harada KH, Takenaka K, Funaki T, Yokota M, Matsubara T,
Yamamoto K, Izawa H, Kimura T, Miyamoto S, Koizumi A:
Significant association of RNF213 p.R4810K, a moyamoya susceptibility variant, with coronary artery disease.
PLoS One. 2017 Apr 17; 12 (4): e0175649. doi: 10.1371/journal.pone.0175649.

Takao H, Hirabayashi K, Nishigaya Y, Kouriki H, Nakaniwa T, Hagiwara Y,
Harada J, Sato H, Yamazaki T, Sakakibara Y, Suiko M, Asada Y, Takahashi Y, Yamamoto K, Fukuyama K, Sugishima M, Wada K:
A substrate-bound structure of cyanobacterial biliverdin reductase identifies stacked substrates as critical for activity.
Nat Commun. 2017 Feb 7; 8: 14397. doi: 10.1038/ncomms14397.

Oki R, Yamada K, Nakano S, Kimoto K,
Yamamoto K, Kondo H, Kubota T:
A Japanese Family With Autosomal Dominant Oculocutaneous Albinism Type 4.
Invest Ophthalmol Vis Sci. 2017 Feb 1; 58 (2): 1008-1016. doi: 10.1167/iovs.16-20612.

2016

英文原著

Maeki M, Yamazaki S, Pawate SA, Ishida A, Tani H, Yamashita K,
Sugishima M, Watanabe K, Tokeshi M, Kenis PJA, Miyazaki M:
A microfluidic-based protein crystallization method in 10 micrometer-sized crystallization space.
Cryst. Eng. Comm. 2016; 18: 7722-7727. doi: 10.1039/C6CE01671E

Teramura M,
Harada J, Tamiaki H:
In vitro stereospecific hydration activities of the 3-vinyl group of chlorophyll derivatives by BchF and BchV enzymes involved in bacteriochlorophyll c biosynthesis of green sulfur bacteria.
Photosynth Res. 2016 Dec;130(1-3):33-45. doi:10.1007/s11120-016-0220-7.

Hagiwara Y, Wada K, Irikawa T,
Sato H, Unno M, Yamamoto K, Fukuyama K, Sugishima M:
Atomic-resolution structure of the phycocyanobilin:ferredoxin oxidoreductase I86D mutant in complex with fully protonated biliverdin.
FEBS Lett. 2016 Oct;590(19):3425-3434. doi: 10.1002/1873-3468.12387.

Sakiyama M, Matsuo H, Nakaoka H,
Yamamoto K, Nakayama A, Nakamura T, Kawai S, Okada R, Ooyama H, Shimizu T, Shinomiya N:
Identification of rs671, a common variant of ALDH2, as a gout susceptibility locus.
Sci Rep. 2016 May 16; 6: 25360. doi: 10.1038/srep25360.

Sawada G, Niida A, Uchi R, Hirata H, Shimamura T, Suzuki Y, Shiraishi Y, Chiba K, Imoto S, Takahashi Y, Iwaya T, Sudo T, Hayashi T, Takai H, Kawasaki Y, Matsukawa T, Eguchi H, Sugimachi K, Tanaka F, Suzuki H,
Yamamoto K, Ishii H, Shimizu M, Yamazaki H, Yamazaki M, Tachimori Y, Kajiyama Y, Natsugoe S, Fujita H, Mafune K, Tanaka Y, Kelsell DP, Scott CA, Tsuji S, Yachida S, Shibata T, Sugano S, Doki Y, Akiyama T, Aburatani H, Ogawa S, Miyano S, Mori M, Mimori K:
Genomic Landscape of Esophageal Squamous Cell Carcinoma in a Japanese Population.
Gastroenterology 2016 May; 150 (5): 1171-82. doi: 10.1053/j.gastro.2016.01.035.

Teramura M,
Harada J, Mizoguchi T, Yamamoto K, Tamiak H:
In Vitro Assays of BciC Showing C132 -Demethoxycarbonylase Activity Requisite for 5 Biosynthesis of Chlorosomal Chlorophyll Pigments.
Plant Cell Physiol. 2016 May; 57 (5): 1048-57. doi: 10.1093/pcp/pcw045.

Nishida N, Ohashi J, Khor SS, Sugiyama M, Tsuchiura T, Sawai H, Hino K, Honda M, Kaneko S, Yatsuhashi H, Yokosuka O, Koike K, Kurosaki M, Izumi N, Korenaga M, Kang JH, Tanaka E, Taketomi A, Eguchi Y, Sakamoto N, Yamamoto K, Tamori A, Sakaida I, Hige S, Itoh Y, Mochida S, Mita E, Takikawa Y, Ide T, Hiasa Y, Kojima H, Yamamoto K, Nakamura M, Saji H, Sasazuki T, Kanto T, Tokunaga K, Mizokami M:
Understanding of HLA-conferred susceptibility to chronic hepatitis B infection requires HLA genotyping-based association analysis.

Sci Rep.
2016 Apr 19; 6: 24767. doi: 10.1038/srep24767.

Matsuo H, Yamamoto K, Nakaoka H, Nakayama A, Sakiyama M, Chiba T, Takahashi A, Nakamura T, Nakashima H, Takada Y, Danjoh I, Shimizu S, Abe J, Kawamura Y, Terashige S, Ogata H, Tatsukawa S, Yin G, Okada R, Morita E, Naito M, Tokumasu A, Onoue H, Iwaya K, Ito T, Takada T, Inoue K, Kato Y, Nakamura Y, Sakurai Y, Suzuki H, Kanai Y, Hosoya T, Hamajima N, Inoue I, Kubo M, Ichida K, Ooyama H, Shimizu T, Shinomiya N:
Genome-wide association study of clinically defined gout identifies multiple risk loci and its association with clinical subtypes.
Ann Rheum Dis. 2016 Apr; 75 (4): 652-9. doi: 10.1136/annrheumdis-2014-206191.

Uchi R, Takahashi Y, Niida A, Shimamura T, Hirata H, Sugimachi K, Sawada G, Iwaya T, Kurashige J, Shinden Y, Iguchi T, Eguchi H, Chiba K, Shiraishi Y, Nagae G, Yoshida K, Nagata Y, Haeno H, Yamamoto H, Ishii H, Doki Y, Iinuma H, Sasaki S, Nagayama S, Yamada K, Yachida S, Kato M, Shibata T, Oki E, Saeki H, Shirabe K, Oda Y, Maehara Y, Komune S, Mori M, Suzuki Y,
Yamamoto K, Aburatani H, Ogawa S, Miyano S, Mimori K:
Integrated Multiregional Analysis Proposing a New Model of Colorectal Cancer Evolution.
PLoS Genet. 2016 Feb 18; 12 (2): e1005778. doi:10.1371/journal.pgen.1005778.

Yanagi T, Mizuochi T, Takaki Y, Eda K, Mitsuyama K, Ishimura M, Takada H, Shouval DS, Griffith AE, Snapper SB, Yamashita Y,
Yamamoto K:
Novel exonic mutation inducing aberrant splicing in the IL10RA gene and resulting in infantile-onset inflammatory bowel disease: a case report.
BMC Gastroenterol. 2016 Jan 28; 16 (1): 10. doi: 10.1186/s12876-016-0424-5.

Wen W, Kato N, Hwang JY, Guo X, Tabara Y, Li H, Dorajoo R, Yang X, Tsai FJ, Li S, Wu Y, Wu T, Kim S, Guo X, Liang J, Shungin D, Adair LS, Akiyama K, Allison M, Cai Q, Chang LC, Chen CH, Chen YT, Cho YS, Choi BY, Gao Y, Go MJ, Gu D, Han BG, He M, Hixson JE, Hu Y, Huang T, Isono M, Jung KJ, Kang D, Kim YJ, Kita Y, Lee J, Lee NR, Lee J, Wang Y, Liu JJ, Long J, Moon S, Nakamura Y, Nakatochi M, Ohnaka K, Rao D, Shi J, Sull JW, Tan A, Ueshima H, Wu C, Xiang YB,
Yamamoto K, Yao J, Ye X, Yokota M, Zhang X, Zheng Y, Qi L, Rotter JI, Jee SH, Lin D, Mohlke KL, He J, Mo Z, Wu JY, Tai ES, Lin X, Miki T, Kim BJ, Takeuchi F, Zheng W, Shu XO:
Genome-wide association studies in East Asians identify new loci for waist-hip ratio and waist circumference.
Sci Rep. 2016 Jan 20; 6: 17958. doi: 10.1038/srep17958.

総説・著書

海野昌喜、日下勝弘、玉田太郎、
杉島正一、和田啓、萩原義徳、福山恵一:
ビリン還元酵素PcyAと基質ビリベルジン複合体の中性構造解析から見えてきたもの
日本中性子科学会誌「波紋」 2016; 26: 130-134.

Unno M, Ishikawa-Suto K, Kusaka K, Tamada T, Hagiwara Y,
Sugishima M, Wada K, Ishikawa M, Fukuyama K:
Neutron Crystallography Reveals Two Protonation States of PcyA, a Bilin Reductase.
MLF Annual Reports 2014, 2016: 15-17.

杉島正一:
X線小角散乱によるNADPH-シトクロムP450還元酵素とヘムオキシゲナーゼの複合体の構造解析
九州シンクロトロン光研究センター年報2014、2016: 14-16.

杉島正一:
ヘム代謝系関連酵素の構造生物学的研究
生化学 2016 Apr; 88 (2): 171-81. doi: 10.14952/SEIKAGAKU.2016.880171.

2015

Sato-Otsubo A, Nannya Y, Kashiwase K, Onizuka M, Azuma F, Akatsuka Y, Ogino Y, Satake M, Sanada M, Chiba S, Saji H, Inoko H, Kennedy GC, Yamamoto K, Morishima S, Morishima Y, Kodera Y, Sasazuki T, Ogawa S:
Genome wide surveillance of mismatched alleles for graft versus host disease in stem cell transplantation.
Blood 2015 Dec 17; 126 (25): 2752-63. doi: 10.1182/blood-2015-03-630707.

Saw WY, Liu X, Khor CC, Takeuchi F, Katsuya T, Kimura R, Nabika T, Ohkubo T, Tabara Y,
Yamamoto K, Yokota M; Japanese Genome Variation Consortium, Teo YY, Kato N:
Mapping the genetic diversity of HLA haplotypes in the Japanese populations.
Sci Rep. 2015 Dec 9; 5: 17855. doi: 10.1038/srep17855.

Mizoguchi T,
Harada J, Yamamoto K, Tamiaki H:
Inactivation of bciD and bchU genes in the green sulfur bacterium Chlorobaculum limnaeum and alteration of photosynthetic pigments in the resultant mutants.
J Photochem Photobiol A Chem. 2015 Dec 1; 313: 52-9. doi: 10.1016/j.jphotochem.2015.06.012.

Saga Y, Hayashi K, Hirota K, Harada J, Tamiaki H:
Modification of the esterifying farnesyl chain in light-harvesting bacteriochlorophylls in green sulfur photosynthetic bacteria by supplementation of 9-decyn-1-ol, 9-decen-1-ol, and decan-1-ol.
J Photochem Photobiol A Chem. 2015 Dec 1; 313: 44-51. doi:10.1016/j.jphotochem.2015.05.002.

Harada J, Teramura M, Mizoguchi T, Tsukatani Y, Yamamoto K, Tamiaki H:
Stereochemical conversion of C3-vinyl group to 1-hydroxyethyl group in bacteriochlorophyll c by the hydratases BchF and BchV: adaptation of green sulfur bacteria to limited-light environments.
Mol Microbiol. 2015 Dec; 98 (6): 1184-98. doi:10.1111/mmi.13208.

Nishida N, Ohashi J, Sugiyama M, Tsuchiura T,
Yamamoto K, Hino K, Honda M, Kaneko S, Yatsuhashi H, Koike K, Yokosuka O, Tanaka E, Taketomi A, Kurosaki M, Izumi N, Sakamoto N, Eguchi Y, Sasazuki T, Tokunaga K, Mizokami M:
Effects of HLA-DPB1 genotypes on chronic hepatitis B infection in Japanese individuals.
Tissue Antigens 2015 Dec; 86 (6): 406-12. doi: 10.1111/tan.12684.

Nakatochi M, Ichihara S,
Yamamoto K, Ohnaka K, Kato Y, Yokota S, Hirashiki A, Naruse K, Asano H, Izawa H, Matsubara T, Yokota M:
Epigenome-wide association study suggests that SNPs in the promoter region of RETN influence plasma resistin level via effects on DNA methylation at neighbouring sites.
Diabetologia 2015 Dec; 58 (12): 2781-90. doi: 10.1007/s00125-015-3763-9.

Kato N, Loh M, Takeuchi F, ~, ~,
Yamamoto K, ~, ~, Chambers JC:
Trans-ethnic genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation.

Nat Genet. 2015 Nov; 47 (11): 1282-93. doi: 10.1038/ng.3405.

Sato S,
Yamamoto K, Matsushita T, Isobe N, Kawano Y, Iinuma K, Niino M, Fukazawa T, Nakamura Y, Watanabe M, Yonekawa T, Masaki K, Yoshimura S, Murai H, Yamasaki R, Kira J; Japan Multiple Sclerosis Genetics Consortium:
Copy Number Variations in Multiple Sclerosis and Neuromyelitis Optica.
Ann Neurol. 2015 Nov; 78 (5): 762-74. doi: 10.1002/ana.24511.

Sano K, Miura S, Fujiwara T, Fujioka R, Yorita A, Noda K, Kida H, Azuma K, Kaieda S,
Yamamoto K, Taniwaki T, Fukumaki Y, Shibata H:
A novel missense mutation of RYR1 in familial idiopathic hyper CK-emia.
J Neurol Sci. 2015 Sep 15; 356 (1-2): 142-7. doi: 10.1016/j.jns.2015.06.035.

Tsukatani Y, Hirose Y,
Harada J, Misawa N, Mori K, Inoue K, Tamiaki H:
Complete Genome Sequence of the Bacteriochlorophyll b-Producing Photosynthetic Bacterium Blastochloris viridis.
Genome Announc. 2015 Sep 3; 3 (5). pii: e01006-15. doi: 10.1128/genomeA.01006-15.

Saga Y, Hirota K,
Harada J, Tamiaki H:
In Vitro Enzymatic Activities of Bacteriochlorophyll a Synthase Derived from the Green Sulfur Photosynthetic Bacterium Chlorobaculum tepidum.
Biochemistry 2015 Aug 18; 54 (32): 4998-5005. doi:10.1021/acs.biochem.5b00311.

Tsukatani Y,
Harada J, Nomata J, Yamamoto H, Fujita Y, Mizoguchi T, Tamiaki H:
Rhodobacter sphaeroides mutants overexpressing chlorophyllide a oxidoreductase of Blastochloris viridis elucidate functions of enzymes in late bacteriochlorophyll biosynthetic pathways.
Sci Rep. 2015 May 15; 5: 9741. doi: 10.1038/srep09741.

Tanimura K, Jin H, Suenaga T, Morikami S, Arase N, Kishida K, Hirayasu K, Kohyama M, Ebina Y, Yasuda S, Horita T, Takasugi K, Ohmura K,
Yamamoto K, Katayama I, Sasazuki T, Lanier LL, Atsumi T, Yamada H, Arase H:
β2-glycoprotein I/ HLA class II complexes are novel autoantigens in antiphospholipid syndrome.
Blood 2015 Apr 30; 125 (18): 2835-44. doi: 10.1182/blood-2014-08-593624.

Unno M, Ishikawa-Suto K, Kusaka K, Tamada T, Hagiwara Y,
Sugishima M, Wada K, Yamada T, Tomoyori K, Hosoya T, Tanaka I, Niimura N, Kuroki R, Inaka K, Ishihara M, Fukuyama K:
Insights into the proton transfer mechanism of a bilin reductase PcyA following neutron crystallography.
J Am Chem Soc. 2015 Apr 29; 137 (16): 5452-60. doi: 10.1021/jacs.5b00645.

Harada E,
Sugishima M, Harada J, Noguchi M, Fukuyama K, Sugase K:
Backbone assignments of the apo and Zn(II) protoporphyrin IX-bound states of the soluble form of rat heme oxygenase-1.
Biomol NMR Assign. 2015 Apr; 9 (1): 197-200. doi:10.1007/s12104-014-9573-z.

Fares-Taie L, Gerber S, Tawara A, Ramirez-Miranda A, Douet JY, Verdin H, Guilloux A, Zenteno JC, Kondo H, Moisset H, Passet B,
Yamamoto K, Iwai M, Tanaka T, Nakamura Y, Kimura W, Bole-Feysot C, Vilotte M, Odent S, Vilotte JL, Munnich A, Regnier A, Chassaing N, De Baere E, Raymond-Letron I, Kaplan J, Calvas P, Roche O, Rozet JM:
Submicroscopic deletions at 13q32.1 cause congenital microcoria.
Am J Hum Genet. 2015 Apr 2; 96 (4): 631-9. doi:10.1016/j.ajhg.2015.01.014.

Takeuchi F, Isono M, Yamamoto K, Yokota M, Akiyama K, Katsuya T, Kim HS, Park JE, Jang Y, Lee JY; AGEN Consortium, Lee JY, Kato N:
Heterogeneous effects of association between blood pressure Loci and coronary artery disease in East asian individuals.
Circ J. 2015 Mar 25; 79 (4): 830-8. doi: 10.1253/circj.CJ-14-0841.

He M, Xu M, Zhang B, Liang J, Chen P, Lee JY, Johnson TA, Li H, Yang X, Dai J, Liang L, Gui L, Qi Q, Huang J, Li Y, Adair LS, Aung T, Cai Q, Cheng CY, Cho MC, Cho YS, Chu M, Cui B, Gao YT, Go MJ, Gu D, Gu W, Guo H, Hao Y, Hong J, Hu Z, Hu Y, Huang J, Hwang JY, Ikram MK, Jin G, Kang DH, Khor CC, Kim BJ, Kim HT, Kubo M, Lee J, Lee J, Lee NR, Li R, Li J, Liu J, Longe J, Lu W, Lu X, Miao X, Okada Y, Ong RT, Qiu G, Seielstad M, Sim X, Song H, Takeuchi F, Tanaka T, Taylor PR, Wang L, Wang W, Wang Y, Wu C, Wu Y, Xiang YB,
Yamamoto K, Yang H, Liao M, Yokota M, Young T, Zhang X, Kato N, Wang QK, Zheng W, Hu FB, Lin D, Shen H, Teo YY, Mo Z, Wong TY, Lin X, Mohlke KL, Ning G, Tsunoda T, Han BG, Shu XO, Tai ES, Wu T, Qi L:
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
Hum Mol Genet. 2015 Mar 15; 24 (6): 1791-800. doi:10.1093/hmg/ddu583.

Oryoji D, Ueda S,
Yamamoto K, Yoshimura Noh J, Okamura K, Noda M, Watanabe N, Yoshihara A, Ito K, Sasazuki T:
Identification of a Hashimoto thyroiditis susceptibility locus via a genome-wide comparison with Graves' disease.
J Clin Endocrinol Metab. 2015 Feb; 100 (2): E319-24. doi: 10.1210/jc.2014-3431.

Oryoji D, Hisamatsu T, Tsuchiya K, Umeno J, Ueda S,
Yamamoto K, Matsumoto T, Watanabe M, Hibi T, Sasazuki T:
Associations of HLA class I alleles in Japanese patients with Crohn's disease.
Genes Immun. 2015 Jan-Feb; 16 (1): 54-6. doi:10.1038/gene.2014.61.

Mizoguchi T, Isaji M,
Harada J, Tsukatani Y, Tamiaki H:
The 17-propionate esterifying variants of bacteriochlorophyll-a and bacteriopheophytin-a in purple photosynthetic bacteria.
J Photochem Photobiol B. 2015 Jan; 142: 244-9. doi:10.1016/j.jphotobiol.2014.12.013.

Harada E,
Sugishima M, Harada J, Fukuyama K, Sugase K:
Distal regulation of heme binding of heme oxygenase-1 mediated by conformational fluctuations.
Biochemistry 2015 Jan 20; 54 (2): 340-8. doi: 10.1021/bi5009694.

総説・著書

福山恵一、和田啓、
杉島正一、海野昌喜:
光合成色素フィコシアノビリンを合成する酵素と基質ビリベルジンとの複合体の中性子結晶解析
生化学 2015 Dec; 87 (6): 753-7. doi: 10.14952/SEIKAGAKU.2015.870753.

海野昌喜、
杉島正一、和田啓、萩原義徳、日下勝弘、玉田太郎、福山恵一:
中性子結晶構造解析で明らかになったビリン還元酵素PcyA基質複合体の二つの水素化状態と構造的特徴
日本結晶学会誌、2015, 57 (5): 297-303. doi: 10.5940/jcrsj.57.297

山本 健:
ゲノム配列の個体差に基づく疾患関連遺伝子の同定
久留米医学会雑誌 2015年, 第78巻, 225-232.

Colvin H,
Yamamoto K, Wada N, Mori M:
Hereditary Gastric Cancer Syndromes.
Surg Oncol Clin N Am. 2015 Oct; 24 (4): 765-77. doi: 10.1016/j.soc.2015.06.002.


山本 健:
大腸癌の遺伝背景とゲノム構造異常
日本臨床 最新臨床大腸癌学 2015年増刊号, 95-99.


2014

英文原著

Sugimachi K, Niida A,
Yamamoto K, Shimamura T, Imoto S, Iinuma H, Shinden Y, Eguchi H, Sudo T, Watanabe M, Tanaka J, Kudo S, Hase K, Kusunoki M, Yamada K, Shimada Y, Sugihara K, Maehara Y, Miyano S, Mori M, Mimori K.
Allelic imbalance at an 8q24 oncogenic SNP is involved in activating MYC in human colorectal cancer.
Ann Surg Oncol. 2014 Dec;21 Suppl 4:S515-21. doi: 2. 10.1245/s10434-013-3468-6.

Sato T, Nakagome S, Watanabe C, Yamaguchi K, Kawaguchi A, Koganebuchi K, Haneji K, Yamaguchi T, Hanihara T,
Yamamoto K, Ishida H, Mano S, Kimura R, Oota H.
Genome-wide SNP analysis reveals population structure and demographic history of the ryukyu islanders in the southern part of the Japanese archipelago.
Mol Biol Evol. 2014 Nov;31(11):2929-40. doi: 10.1093/molbev/msu230.

Wen W, Zheng W, Okada Y, Takeuchi F, Tabara Y, Hwang JY, Dorajoo R, Li H, Tsai FJ, Yang X, He J, Wu Y, He M, Zhang Y, Liang J, Guo X, Sheu WH, Delahanty R, Guo X, Kubo M,
Yamamoto K, Ohkubo T, Go MJ, Liu JJ, Gan W, Chen CC, Gao Y, Li S, Lee NR, Wu C, Zhou X, Song H, Yao J, Lee IT, Long J, Tsunoda T, Akiyama K, Takashima N, Cho YS, Ong RT, Lu L, Chen CH, Tan A, Rice TK, Adair LS, Gui L, Allison M, Lee WJ, Cai Q, Isomura M, Umemura S, Kim YJ, Seielstad M, Hixson J, Xiang YB, Isono M, Kim BJ, Sim X, Lu W, Nabika T, Lee J, Lim WY, Gao YT, Takayanagi R, Kang DH, Wong TY, Hsiung CA, Wu IC, Juang JM, Shi J, Choi BY, Aung T, Hu F, Kim MK, Lim WY, Wang TD, Shin MH, Lee J, Ji BT, Lee YH, Young TL, Shin DH, Chun BY, Cho MC, Han BG, Hwu CM, Assimes TL, Absher D, Yan X, Kim E, Kuo JZ, Kwon S, Taylor KD, Chen YD, Rotter JI, Qi L, Zhu D, Wu T, Mohlke KL, Gu D, Mo Z, Wu JY, Lin X, Miki T, Tai ES, Lee JY, Kato N, Shu XO, Tanaka T.
Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index.
Hum Mol Genet. 2014 Oct 15;23(20):5492-504. doi:10.1093/hmg/ddu248.

Kusano S, Kukimoto-Niino M, Satta Y, Ohsawa N, Uchikubo-Kamo T, Wakiyama M, Ikeda M, Terada T,
Yamamoto K, Nishimura Y, Shirouzu M, Sasazuki T, Yokoyama S.
Structural basis for the specific recognition of the major antigenic peptide from the Japanese cedar pollen allergen Cry j 1 by HLA-DP5.
J Mol Biol. 2014 Aug 26;426(17):3016-27. doi: 10.1016/j.jmb.2014.06.020.

Kida H, Takano Y,
Yamamoto K, Mori M, Yanaga K, Tanaka J, Kudo SE, Mimori K.
A single nucleotide polymorphism in fibronectin 1 determines tumor shape in colorectal cancer.
Oncol Rep. 2014 Aug;32(2):548-52. doi: 10.3892/or.2014.3251.

Mizoguchi T,
Harada J, Tsukatani Y, Tamiaki H.
Isolation and characterization of a new bacteriochlorophyll-c bearing a neopentyl substituent at the 8-position from the bciD-deletion mutant of the brown-colored green sulfur bacterium Chlorobaculum limnaeum.
Photosynth Res. 2014 Jul;121(1):3-12. doi:10.1007/s11120-014-9977-8.

Harada J, Mizoguchi T, Nomura K, Tamiaki H.
Isolation and structural determination of C8-vinyl-bacteriochlorophyll d from the bciA and bchU double mutant of the green sulfur bacterium Chlorobaculum tepidum.
Photosynth Res. 2014 Jul;121(1):13-23. doi: 10.1007/s11120-014-0007-7.

Chen P, Takeuchi F, Lee JY, Li H, Wu JY, Liang J, Long J, Tabara Y, Goodarzi MO, Pereira MA, Kim YJ, Go MJ, Stram DO, Vithana E, Khor CC, Liu J, Liao J, Ye X, Wang Y, Lu L, Young TL, Lee J, Thai AC, Cheng CY, van Dam RM, Friedlander Y, Heng CK, Koh WP, Chen CH, Chang LC, Pan WH, Qi Q, Isono M, Zheng W, Cai Q, Gao Y,
Yamamoto K, Ohnaka K, Takayanagi R, Kita Y, Ueshima H, Hsiung CA, Cui J, Sheu WH, Rotter JI, Chen YD, Hsu C, Okada Y, Kubo M, Takahashi A, Tanaka T, van Rooij FJ, Ganesh SK, Huang J, Huang T, Yuan J, Hwang JY; CHARGE Hematology Working Group, Gross MD, Assimes TL, Miki T, Shu XO, Qi L, Chen YT, Lin X, Aung T, Wong TY, Teo YY, Kim BJ, Kato N, Tai ES.
Multiple nonglycemic genomic loci are newly associated with blood level of glycated hemoglobin in East Asians.
Diabetes 2014 Jul;63(7):2551-62. doi: 10.2337/db13-1815.

Akiyama K, Takeuchi F, Isono M, Chakrawarthy S, Nguyen QN, Wen W,
Yamamoto K, Katsuya T, Kasturiratne A, Pham ST, Zheng W, Matsushita Y, Kishimoto M, Do LD, Shu XO, Wickremasinghe AR, Kajio H, Kato N.
Systematic fine-mapping of association with BMI and type 2 diabetes at the FTO locus by integrating results from multiple ethnic groups.
PLoS One 2014 Jun 30;9(6):e101329. doi:10.1371/journal.pone.0101329.

Harada J, Mizoguchi T, Tsukatani Y, Yokono M, Tanaka A, Tamiaki H.
Chlorophyllide a oxidoreductase works as one of the divinyl reductases specifically involved in bacteriochlorophyll a biosynthesis.
J Biol Chem. 2014 May 2;289(18):12716-26. doi: 10.1074/jbc.M113.546739.

Yamaguchi T, Nakaoka H,
Yamamoto K, Fujikawa T, Kim YI, Yano K, Haga S, Katayama K, Shibusawa T, Park SB, Maki K, Kimura R, Inoue I.
Genome-wide association study of degenerative bony changes of the temporomandibular joint.
Oral Dis. 2014 May;20(4):409-15. doi: 10.1111/odi.12141.

DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium; Asian Genetic Epidemiology Network Type 2 Diabetes (AGEN-T2D) Consortium; South Asian Type 2 Diabetes (SAT2D) Consortium; Mexican American Type 2 Diabetes (MAT2D) Consortium; Type 2 Diabetes Genetic Exploration by Nex-generation sequencing in muylti-Ethnic Samples (T2D-GENES) Consortium, 
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
Nat Genet. 2014 Mar;46(3):234-44. doi: 10.1038/ng.2897.

Sugishima M, Sato H, Higashimoto Y, Harada J, Wada K, Fukuyama K, Noguchi M.
Structural basis for the electron transfer from an open form of NADPH-cytochrome P450 oxidoreductase to heme oxygenase.
Proc Natl Acad Sci U S A 2014 Feb18;111(7):2524-9. doi: 10.1073/pnas.1322034111.

Ueda S, Oryoji D,
Yamamoto K, Noh JY, Okamura K, Noda M, Kashiwase K, Kosuga Y, Sekiya K, Inoue K, Yamada H, Oyamada A, Nishimura Y, Yoshikai Y, Ito K, Sasazuki T.
Identification of independent susceptible and protective HLA alleles in Japanese autoimmune thyroid disease and their epistasis.
J Clin Endocrinol Metab. 2014 Feb;99(2):E379-83. doi: 10.1210/jc.2013-2841.

Wu Y, Gao H, Li H, Tabara Y, Nakatochi M, Chiu YF, Park EJ, Wen W, Adair LS, Borja JB, Cai Q, Chang YC, Chen P, Croteau-Chonka DC, Fogarty MP, Gan W, He CT, Hsiung CA, Hwu CM, Ichihara S, Igase M, Jo J, Kato N, Kawamoto R, Kuzawa CW, Lee JJ, Liu J, Lu L, McDade TW, Osawa H, Sheu WH, Teo Y, Vadlamudi S, Van Dam RM, Wang Y, Xiang YB,
Yamamoto K, Ye X, Young TL, Zheng W, Zhu J, Shu XO, Shin C, Jee SH, Chuang LM, Miki T, Yokota M, Lin X, Mohlke KL, Tai ES.
A meta-analysis of genome-wide association studies for adiponectin levels in East Asians identifies a novel locus near WDR11-FGFR2.
Hum Mol Genet. 2014 Feb 15;23(4):1108-19. doi:10.1093/hmg/ddt488.

Matsuo H, Nakayama A, Sakiyama M, Chiba T, Shimizu S, Kawamura Y, Nakashima H, Nakamura T, Takada Y, Oikawa Y, Takada T, Nakaoka H, Abe J, Inoue H, Wakai K, Kawai S, Guang Y, Nakagawa H, Ito T, Niwa K,
Yamamoto K, Sakurai Y, Suzuki H, Hosoya T, Ichida K, Shimizu T, Shinomiya N.
ABCG2 dysfunction causes hyperuricemia due to both renal urate underexcretion and renal urate overload.
Sci Rep. 2014 Jan 20;4:3755. doi: 10.1038/srep03755.

総説・著書

Sugishima M, Fukuyama K, Noguchi M.
Crystal structure of an associated form of NADPH-cytochrome P450 reductase with heme oxygenase.
SPring-8 Research Frontiers 2014, 18-19.

杉島正一
ヘム鉄代謝の鍵となる電子伝達複合体の構造解析
日本結晶学会誌, 2014; 56, 393-398, DOI: 10.5940/jcrsj.56.393.

杉島正一
フェレドキシン依存性酸化還元酵素の構造と機能 日本の結晶学(II)-その輝かしい発展-
日本結晶学会, 294, ISBN 978-4-9903861-2-2


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