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Hiroshi Watanabe, M.D., Ph.D.

Position title: Professor and Chairman             

Education
1988 Nagasaki University,　Nagasaki,　Japan　(M.D.)
2001 Nagasaki University,　Nagasaki,　Japan　(Ph.D.)


Certificate
Internal Medicine, Infectious Disease, Respiratory Disease, Infection Control Doctor, ISTM Certificate in Travel Health
Senior Editor: Journal of Infection and Chemotherapy
Editorial Board: Annals of Infection

Professional Experience

1988-1989     Nagasaki University Hospital 
1989-1989     Iki Public Hospital
1989-1990     Tagawa City Hospital 
1990-1991     Aino Memorial Hospital
1991-1993     Nagasaki University Hospital 
1993-1995     Kawatana National Hospital 
1995-1997     Kyorin Hospital 
1997-2001　  Department of Internal Medicine, Institute of Tropical Medicine, 
                     Nagasaki University, Assistant Professor
2001-2003     Department of Microbiology, The University of Iowa, USA
2003-2006　  Department of Internal Medicine, Institute of Tropical Medicine, 
                     Nagasaki University, Assistant Professor
2006-2014     Division of Infectious Diseases, Department of Infectious
                     Medicine, Kurume University School of Medicine, Professor and
                     Chairman                       
2007-            Division of Infection Control and Prevention, Kurume University
                     Hospital, Director               

2014-            Department of Infection Control and Prevention, Kurume
                     University School of Medicine, Professor and Chairman

2017- 　　 　 Vice-president of Kurume University Hospital

 

Field Experience

since 1997    Collaboration with Chiang Mai University, Chiang Mai, Thailand 
                    funded by Monbusho Grant-in-Aid for Scientic Research and
                    Japan Society for the Promotion of Science (JSPS)
1998             East Africa (Zambia, Malawi, Ethiopia, Sudan) Team,
                    International Medical Foundation of Japan 
2003             SARS Infection Control Team in China, short term consultancy,
                    WPRO, WHO 
2003-2006    Collaboration with National Institute of Hygiene and
                    Epidemiology, Hanoi, Vietnam funded by Core University
                    Program, JSPS 
2004-2006    Instructor, Training Course for Tropical Infectious Diseases,
                    21st Century Centers of Excellence Program, JSPS
2005             Collaboration with University of Peradeniya, Kandy, Sri Lanka
                    funded by Grant-in-Aid for Special Purposes, the Ministry of 
                    Education, Culture, Sport, Science and Technology, Japan
since 2007    Collaboration with Zhongshan Hospital of Fudan University,                     shanghai, China
2007             Register with WHO, GOARN (Global outbreak alert and response                     network) partner      

           

Publications

  1. Tanamachi C, Iwahashi J, Togo A, Ohta K, Miura M, Sakamoto T, Gotoh K, Horita R, Kamei K, and Watanabe H. Molecular analysis for potential hospital-acquired infection caused by Aspergillus tubingensis through the environment. Kurume Med J. 2024 Jan 16. doi: 10.2739/10.2739/ kurumemedj.MS6934013. 
  2. Miura M, Gotoh K, Tanamachi C, Katayama H, Fuketa H, Tomoike H, Kawamura N, Watanabe H, and Mihashi M. Microbiological analysis concerning the antibacterial effect of atomized Ionless® hypochlorous acid water in a nursery school environment. J Infect Chemother. 2023 Sep 26:S1341-321X(23)00234-9. doi: 10.1016/j.jiac.2023.09.024. 
  3. Miyake A, Gotoh K, Iwahashi J, Togo A, Horita R, Miura M, Kinoshita M, Ohta K, Yamashita Y, and Watanabe H. Characteristics of Biofilms Formed by C. parapsilosis Causing an Outbreak in a Neonatal Intensive Care Unit. J Fungi (Basel). 2022 Jul 1;8(7):700. doi: 10.3390/jof8070700. 
  4. Hachisu Y, Tamura K, Murakami K, Fujita J, Watanabe H, Tanabe Y, Kuronuma K, Kubota T, Oshima K, Maruyama T, Kasahara K, Nishi J, Abe S, Nakamura M, Kubota M, Hirai S, Ishioka T, Ikenoue C, Fukusumi M, Sunagawa T, Suzuki M, Akeda Y, Oishi K, and the Adult IHD Study Group. Invasive Haemophilus influenzae disease among adults in Japan during 2014-2018. Infection. 2022 Jul 28. doi: 10.1007/s15010-022-01885-w. 
  5. Sakamoto T, Gotoh K, Hashimoto K, Tanamachi C, and Watanabe H. Risk Factors and Clinical Characteristics of Patients with Ocular Candidiasis. J Fungi (Basel). 2022 May 11;8(5):497. doi: 10.3390/jof8050497.  
  6. Tamura K, Chang B, Shimbashi R, Watanabe H, Tanabe Y, Kuronuma K, Oshima K, Maruyama T, Fujita J, Abe S, Kasahara K, Nishi J, Kubota T, Kinjo Y, Fujikura H, Fukusumi M, Shimada T, Sunagawa T, Suzuki M, Yamamoto Y, Oishi K, and the Adult IPD Study Group. Dynamic changes in clinical characteristics and serotype distribution of invasive pneumococcal disease among adults in Japan after introduction of the pediatric 13-valent pneumococcal conjugate vaccine in 2013-2019. Vaccine. 2022 May 26;40(24):3338-3344. doi: 10.1016/j.vaccine.2022.04.062. Epub 2022 Apr 28.  
  7. Hashimoto K, Gotoh K, Masunaga K, Iwahashi J, Sakamoto T, Miura M, Horita R, Sakai Y, Murotani K, and Watanabe H. Reducing the urine collection rate could prevent hospital-acquired horizontal transmission of multidrug-resistant Pseudomonas aeruginosa. J Infect Chemother, 28: 786-790, 2022.
  8. Chang B, Tamura K, Fujikura H, Watanabe H, Tanabe Y, Kuronuma K, Fujita J, Oshima K, Maruyama T, Abe S, Kasahara K, Nishi J, Kubota T, Kinjo Y, Serizawa Y, Shimbashi R, Fukusumi M, Shimada T, Sunagawa T, Suzuki M, Oishi K, and the Adult IPD Study Group. Pneumococcal meningitis in adults in 2014-2018 after introduction of pediatric 13-valent pneumococcal conjugate vaccine in Japan. Sci Rep. 2022 Feb 23;12(1):3066. doi: 10.1038/s41598-022-06950-w. 
  9. Chang B, Kinjo Y, Morita M, Tamura K, Watanabe H, Tanabe Y, Kuronuma K, Fujita J, Oshima K, Maruyama T, Abe S, Kasahara K, Nishi J, Kubota T, Ohnishi M, Suga S, Oishi K, and the Adult IPD Study Group. Distribution and Variation of Serotypes and Pneumococcal Surface Protein A Clades of Streptococcus pneumoniae Strains Isolated From Adult Patients With Invasive Pneumococcal Disease in Japan. Front Cell Infect Microbiol. 2021 Mar 19;11:617573. doi: 10.3389/fcimb.2021.617573. eCollection 2021.  
  10. Sakai Y, Gotoh K, Nakano R, Iwahashi J, Miura M, Horita R, Miyamoto M, Yano H, Kannae M, Takasu O, and Watanabe H. Infection control for a carbapenem-resistant Enterobacteriaceae outbreak in an advanced emergency medical services center. Antibiotics (Basel). 2021 Dec 15;10(12):1537. doi: 10.3390/antibiotics10121537. 
  11. Shimbashi R, Suzuki M, Chang B, Watanabe H, Tanabe Y, Kuronuma K, Oshima K, Maruyama T,Takeda H, Kasahara K, Fujita J, Nishi J, Kubota T, Tanaka-Taya K, Matsui T, Sunagawa T, Oishi K, and the Adult IPD Study Group. Effectiveness of 23-valent pneumococcal polysaccharide vaccine against invasive pneumococcal disease in adults, Japan, 2013-2017. Emerg Infect Dis, 26: 2378-2386, 2020.
  12. Iwahashi J, Kamei K, and Watanabe H. Disruption of Aspergillus Fumigatus Biofilm by Streptococcus Pneumoniae: Mycelial Fragmentation by Hydrogen Peroxide. J Infect Chemother, 26: 831-837, 2020.
  13. Sakai Y, Miwa R, Mitsuoka M, and Watanabe H. Combinatorial vancomycin and piperacillin/tazobactam results in elevated vancomycin trough concentration and acute kidney injury: a case report. YAKUGAKU ZASSHI 140, 751-754, 2020.
  14. Tatara K, Gotoh K, Okumiya K, Teramachi M, Ishimoto K, Tanaka Y, Iwahashi J, Shindou S, Yamashita Y, and Watanabe H. Molecular epidemiology, antimicrobial susceptibility, and characterization of fluoroquinolone non-susceptible Streptococcus pyogenes in Japan. J Infect Chemother, 26: 280-284, 2020.
  15. Hara K, Yaita K, Khamrin P, Kumthip K, Kashiwagi T, Eléouët JF, Rameix-Welti MA, and Watanabe H. A small fragmented P protein of respiratory syncytial virus inhibits virus infection by targeting P protein. J Gen Virol. 2020 Jan;101(1):21-32. doi: 10.1099/jgv.0.001350.
  16. Yaita K, Gotoh K, Nakano R, Iwahashi J, Sakai Y, Horita R, Yano H, and Watanabe H. Biofilm-forming by carbapenem resistant Enterobacteriaceae may contribute to the blood stream infection. Int J Mol Sci 2019 Nov 26;20(23). pii: E5954. doi: 10.3390/ijms20235954.
  17. Hoshino T, Takeuchi N, Ohkusu M, Hachisu Y, Hirose S, Fukasawa C, Kubota T, Ishida M, Watanabe H, Oishi K, and Ishiwada N. Identification of Haemophilus influenzae serotype e strains missing the fucK gene in clinical isolates from Japan. J Med Microbiol. 2019 Oct;68(10):1534-1539. doi: 10.1099/jmm.0.001055.
  18. Matsukawa M, Igarashi M, Watanabe H, Qin L, Ohnishi M, Terajima J, Iyoda S, Morita-Ishihara T, Tateda K, Ishii Y, Saga T, Aoki K, and Bonomo RA. Epidemiology and genotypic characterisation of dissemination patterns of uropathogenic Escherichia coli in a community. Epidemiol Infect 2019 Jan;147:e148. doi: 10.1017/S0950268819000426.
  19. Shimbashi R, Chang B, Tanabe Y, Takeda H, Watanabe H, Kubota T, Kasahara K, Oshima K, Nishi J, Maruyama T, Kuronuma K, Fujita J, Ikuse T, Kinjo Y, Suzuki M, Kerdsin A, Shimada T, Fukusumi M, Tanaka-Taya K, Matsui T, Sunagawa T, Ohnishi M, Oishi K, and the Adult IPD Study Group. Epidemiological and clinical features of invasive pneumococcal disease caused by serotype 12F in adults, Japan. PLoS One. 2019 Feb 21;14(2):e0212418. doi: 10.1371/journal.pone.0212418. eCollection 2019.
  20. Watanabe H, Mizuno T, Kikuchi H, Miyagi K, Takada K, Mishima N, and Okoshi H. An attempt to support by the Japanese society of travel and health for increasing travel clinics. J Infect Chemother, 24: 1024-1025, 2018.
  21. Yaita K, Sugi S, Hayashi M, Koga T, Ebata T, Sakai Y, Kaieda S, Ida H, and Watanabe H. The co-existence of Lemierre`s syndrome and Bezold`s abscesses due to Streptococcus constellatus: A case report. Medicine, 97: e11228, 2018.
  22. Yaita K, Yahara K, Hamada N, Sakai Y, Iwahashi J, Masunaga K, and Watanabe H. Typhoid Vaccination among Japanese Travelers to South Asia and the Factors Associated with Compliance. Intern Med, 57: 1071-1074, 2018.
  23. Yaita K, Akiyoshi H, Nakae I, Kawasaki Y, Nakama K, Sakai Y, Masunaga K, and Watanabe H. Disseminated Mycobacterium intracellulare infection with multiple intramuscular abscesses on extremities in a woman with chronic corticosteroid therapy. J Gen Fam Med, 18: 425-427, 2017.
  24. Yaita K, Oyama N, Sakai Y, Iwahashi J, Masunaga K, Hamada N, and Watanabe H. Typhoid fever: a rare cause of relative bradycardia in Japan. J Gen Fam Med, 18: 317-318, 2017.
  25. Miyamoto N, Yahara K, Horita R, Yano T, Tashiro N, Morii D, Tsutsui A, Yaita K, Shibayama K, and Watanabe H. Integration of DPC and clinical microbiological data in Japan reveals importance of confirming a negative follow-up blood culture in patients with MRSA bacteremia. J Infect Chemother, 23: 687-691, 2017.
  26. Yaita K, Yahara K, Sakai Y, Iwahashi J, Masunaga K, Hamada N, and Watanabe H. Hepatitis B vaccination status among Japanese travelers. Kurume Med J, 63: 69-76, 2017.
  27. Leder K, Borwein S, Chanthavanich P, Chatterjee S, Htun K, Marma ASP, Nakatani I, OK JJ, Pakasi L, Pandey P, Piyaphanee W, Rupali P, Schwartz E, Shinozuka T, Phu PTH, Watanabe H, Visser J, Wilder-Smith A, Zhang M, and McGuinness SL. Travel medicine perspectives of select travel medicine experts practicing in the Asia-Pacific region. J Travel Med, 24, 2017.
  28. Hara K, Kashiwagi T, Hamada N, and Watanabe H. Basic amino acids in the N-terminal half of the PB2 subunit of influenza virus RNA polymerase are involved in both transcription and replication. J Gen Virol, 98: 900-905, 2017.
  29. Fukusumi  M, Chang  B, Tanabe  Y, Oshima  K, Maruyama  T, Watanabe  H, Kuronuma  K, Kasahara  K, Takeda  H, Nishi  J, Fujita  J, Kubota  T, Sunagawa T, Matsui  T, Oishi  K, and the Adult IPD Study Group. Invasive pneumococcal disease among adults in Japan, April 2013 to March 2015: disease characteristics and serotype distribution. BMC Infectious Diseases, 17:2, DOI: 10.1186/s12879-016-2113-y, 2017.
  30. Qin L, Sakai Y, Bao R, Xie H, Masunaga K, Miura M, Hashimoto K, Tanamachi C, Hu B, and Watanabe H. Characteristics of multidrug-resistant Corynebacterium spp. isolated from blood cultures from hospitalized patients in Japan. Jpn J Infect Dis, 70: 152-157, 2017.
  31. Moorthy AN, Rai P, Jiao H, Wang S, Tan KB, Qin L, Watanabe H, Zhang Y, Teluguakula N, and Chow VT. Capsules of virulent pneumococcal serotypes enhance formation of neutrophil extracellular traps during in vivo pathogenesis of pneumonia. Oncotarget, 7: 19327-19340, 2016.
  32. Yaita K, Inoue S, Horinouchi T, Kinoshita M, Unno M, Iwata O, Tanaka Y, Gotoh K, Ishibashi M, Sakai Y, Masunaga K, Watanabe H, and Tominaga M. A Case of HIV-Infected Pregnant Female Treated with Long-Term Administration of Raltegravir-Included Antiretroviral Therapy. Intern Med, 55: 2727-2730, 2016.
  33. Yaita K, Ohshima H, Hayashi M, Nakamura M, Ueda S, Sakai Y, Masunaga K, Ohshima K, and Watanabe H. Miliary Tuberculosis noticed by the efficacy of levofloxacin monotherapy. Journal of General and Family Medicine, 17: 176-178, 2016.
  34. Yaita K, Matsunaga M, Tashiro N, Sakai Y, Masunaga K, Miyoshi H, Oshima K, Chikamatsu K, Takaki A, Mitarai S, and Watanabe H. Mycobacterium conceptionense bloodstream infection in a patient with advanced gastric carcinoma. Jpn J Infect Dis 2016 Mar 18. [Epub ahead of print]
  35. Sakai Y, Qin L, Miura M, Masunaga K, Tanamachi C, Iwahashi J, Kida Y, Takasu O, Sakamoto T, and Watanabe H. Successful infection control for a vancomycin-intermediate Staphylococcus aureus outbreak in an advanced emergency medical service centre. J Hosp Infect, 92: 385-391, 2016.
  36. Yaita K, Sakai Y, Iwahashi J, Masunaga K, Hamada N, and Watanabe H. Post-Travel Consultations in a Regional Hub City Hospital, Japan. Intern Med, 55: 739-743, 2016.
  37. Yaita K, Sakai Y, Masunaga K, and Watanabe H. A Retrospective Analysis of Drug Fever Diagnosed During Infectious Disease Consultation.Intern Med, 55: 605-608, 2016.
  38. Yonezawa Y, Yahara K, Miura M, Hieda F, Yamakawa R, Masunaga K, Mishima Y, and Watanabe H. Risk factors for and circumstances of needlestick and sharps injuries of doctors in operating rooms: A study focusing on surgeries using general anesthesia at Kurume University Hospital, Japan. J Infect Chemother, 21: 837-841, 2015.
  39. Sakai Y, Naito T, Arima C, Miura M, Qin L, Hidaka H, Masunaga K, Kakuma T, and Watanabe H. Potential drug interaction between warfarin and linezolid. Intern Med, 54: 459-464, 2015.
  40. Sato R, Hamada N, Kashiwagi T, Imamura Y, Hara K, Naito Y, Koga N, Nishimura M, Kamimura T, Takasaki T, Watanabe H, and Koga T. Dengue hemorrhagic fever in a Japanese traveler who had preexisting Japanese encephalitis virus antibody. Trop Med Health, 43: 85-88, 2015.
  41. Uemura Y, Kashiwagi T, Hara K, Nakazono Y, Hamada N, and Watanabe H. The N-terminal fragment of PA subunit of the influenza A virus effectively inhibits ribonucleoprotein (RNP) activity via supression of its RNP expression. J Infect Chemother, 21: 296-301, 2015.
  42. Kashiwagi T, Hara K, Nakazono Y, Uemura Y, Imamura Y, Hamada N, and Watanabe H. The N-terminal fragment of a PB2 subunit from the influenza A virus (A/Hong Kong/156/1997 H5N1) effectively inhibits RNP activity and viral replication. PLoS ONE, 9(12): e114502, 2014.
  43. Seki M, Yoshida H, Gotoh K, Hamada N,Motooka D, Nakamura S, Yamamoto N, Hamaguchi S, Akeda Y, Watanabe H, Iida T, and Tomono K. Severe respiratory failure due to co-infection with human metapneumovirus and Streptococcus pneumoniae. Respiratory Medicine Case Reports, 12: 13-15, 2014.
  44. Zhou ZY, Hu BJ, Qin L, Lin YE, Watanabe H, Zhou Q, and Gao XD. Removal of waterborne pathogens from liver transplant unit water taps in prevention of healthcare-associated infections: a proposal for a cost-effective, proactive infection control strategy. Clin Microbiol Infect, 20: 310-314, 2014.
  45. Qin L, Kida Y, Ishiwada N, Ohkusu K, Kaji C, Sakai Y, Watanabe K, Furumoto A, Ichinose A, and Watanabe H. The relationship between biofilm formations and capsule in Haemophilus influenzae. J Infect Chemother, 20: 151-156, 2014.
  46. Hamada N, Hara K, Matsuo Y, Imamura Y,  Kashiwagi T, Nakazono Y, Gotoh K, Ohtsu Y, Ohtaki E, Motohiro T and Watanabe H. Performance of a rapid human metaneumovirus antigen test during an outbreak in a long-term care facility. Epidemiol Infect, 142: 424-427, 2014.
  47. Hara K, Nakazono Y, Kashiwagi T, Hamada N, and Watanabe H. Co-incorporation of the PB2 and PA polymerase subunits from human H3N2 influenza virus is a critical determinant of the replication of reassortant ribonucleoprotein complexes. J. Gen. Virol, 94: 2406-2416, 2013.
  48. Yano H, Yamazaki Y, Qin L, Okitsu N, Yahara K, Irimada M, Hirakata Y, Kaku M, Kobayashi T, and Watanabe H. Improvement rate of acute otitis media caused by Haemophilus influenzae at one week is significantly associated with the time to recovery. J Clin Microbiol, 51: 3542-3546, 2013.
  49. Uemura Y, Qin L, Gotoh K, Ohta K, Nakamura K, and Watanabe H. Comparison study of single and concurrent administrations of carbapenem, new quinolone, and macrolide against in vitro nontypeable Haemophilus influenzae mature biofilms. J Infect Chemother, 19: 902-908, 2013.
  50. Hidaka H, Miura M, Masunaga K, Qin L, Uemura Y, Sakai Y, Hashimoto K, Kawano S, Yamashita N, Sakamoto T, and Watanabe H. Infection control for a methicillin-resistant Staphylococcus aureus outbreak in an advanced emergency medical service center, as monitored by molecular analysis. J Infect Chemother, 19: 884-890, 2013.
  51. Umeyama T, Ohno H, Minamoto F, Takagi T, Tanamachi C, Tanabe K, Kaneko Y, Yamagoe S, Kishi K, Fujii T, Takemura H, Watanabe H, and Miyazaki Y. Determination of epidemiology of clinically isolated Cryptococcus neoformans strains in Japan by multilocus sequence typing. Jpn J Infect Dis 66: 51-55, 2013.
  52. Qin L, Kida Y, Imamura Y, Kuwano K and Watanabe H. Impaired capsular polysaccharide is relevant to enhanced biofilm formation and lower virulence in Streptococcus pneumoniae. J Infect Chemother, 19: 261-271, 2013.
  53. Hamada N, Imamura Y, Hara K, Kashiwagi T, Imamura Y, Nakazono Y, Chijiwa K, and Watanabe H. Intrahost emergent dynamics of oseltamivir-resistant virus of pandemic influenza A (H1N1) 2009 in a fatally immunocompromised patient. J Infect Chemother 18:865-871, 2012.
  54. Nakazono Y, Hara K, Kashiwagi T, and Watanabe H. The RNA polymerase PB2 subunit of influenza A/HongKong/156/1997(H5N1) restricts the replication of reassortant ribonucleoprotein complexes. PLoS ONE 7(2) e32634: 1-9, 2012.
  55. Qin L, Zhou Z, Hu B, Yamamoto T, and Watanabe H. Antimicrobial susceptibilities and genetic characteristics of Haemophilus influenzae isolated from community acquired respiratory tract infection patients in Shanghai City, China. J Infect Chemother, 18: 508-514, 2012.
  56. Toyotome T, Yamaguchi M, Iwasaki A, Watanabe A, Taguchi H, Qin L, Watanabe H, Kamei K. Fetuin A, a serum component, promotes growth and biofilm formation by Aspergillus fumigatus. Int J Med Microbiol, 302: 108-116, 2012.
  57. Masaki H, Qin L, Zhou Z, Onizuka T, Watanabe K, Hu B, and Watanabe H. A prospective study of intrafamilial transmission and antimicrobial susceptibility for Moraxella catarrhalis. Microbiol Immunol, 55(9): 599-604, 2011.
  58. Hara K, Yahara K, Gotoh K, Nakazono Y, Kashiwagi T, Imamura Y, Hamada N,   Khositsakulchai W, Sanchai T, Khantawa B, Tharavichitkul P, Maneekarn N,   Sirisanthana T, and Watanabe H. Clinical study concerning the relationship between community-acquired pneumonia and viral infection in northern Thailand. Intern Med, 50: 991-998, 2011.
  59. Yahara K, Miura M, Masunaga K, Matsumoto K, Miyao T, Tanimachi C, Hashimoto K, Sagawa K and Watanabe H. Comparison of two control measures of weatherstripping in reducing blowing dust during hospital renovations. J Infect Chemother, 16: 431-435, 2010.
  60. Kashiwagi T, Hara K, Nakazono Y, Hamada N and Watanabe H. Artificial 
    hybrids of influenza A virus RNA polymerase reveal PA subunit modulates its thermal sensitivity. PLoS ONE 5(12) e15140: 1-11, 2010.
  61. Morinaga Y, Yanagihara K, Masunaga K, Hashiguchi M, Okamura T, Watanabe 
    H, Kohno S, and Kamihira S. Invasive pneumococcal diseases in a traveler who returned from the philippines: A case report and in vivo study of the isolate. J Travel Med, 17: 63-65, 2010.
  62. Qin L, Masaki H, Gotoh K, Furumoto A, Terada M, Watanabe K, and Watanabe 
    H. Molecular epidemiological study of Moraxella catarrhalis isolated from nosocomial respiratory infection patients in a community hospital in Japan. Intern Med, 48:797-803, 2009.
  63. Kuroki R, Kawakami K, Qin L, Kaji C, Watanabe K, Kimura Y, Ishiguro C, 
    Tanimura S, Tsuchiya Y, Hamaguchi I, Sakakura M, Sakabe S, Tsuji K, Inoue M, and Watanabe H. Nosocomial bacteremia caused by biofilm-forming Bacillus cereus and Bacillus thuringiensis. Intern Med, 48:791-796, 2009.
  64. Gotoh K, Qin L, Watanabe K, Anh DD, Huong PLT, Anh NTH, Cat NDL, Ha LL,Ai  LTT, Tien NM, Minh TT, Oishi K, and Watanabe H. Prevalence of Haemophilus influenzae with resistant gene isolated from young children with  acute lower respiratory tract infections in Nha Trang, Vietnam. J Infect Chemother, 14: 349-53, 2008.
  65. Ogata K, Kashiwagi T, Iwahashi J, Hara K, Honda H, Ide T, Kumashiro R, Kohara M, Sata M, Watanabe H, and Hamada N. Amutational shift from domain Ⅲ to Ⅱ in the ribosomal entry site of hepatitis C virus with interferon-ribavirin therapy. Archives of Virology , 153: 1575-1579, 2008.
  66. Kaji C, Watanabe K, Apicella MA, and Watanabe H. Antimicrobial effect of
    fluoroquinolones for the eradication of nontypeable Haemophilus influenzae 
    isolates within biofilms. Tohoku J Exp Med, 214: 121-128, 2008.
  67. Hamada N, Gotoh K, Hara K, Iwahashi J, Imamura Y, Nakamura S, Taguchi C, 
    Sugita M, Yamakawa R, Etoh Y, Sera N, Ishibashi T, Chijiwa K, and Watanabe 
    H. A nosocomial outbreak of epidemic keratoconjunctivitis accompanying 
    environmental contamination with adenoviruses. J Hosp Infect, 68: 262-268, 2008.
  68. Watanabe H, Asoh N, Kobayashi S, Watanabe K, Oishi K, Kositsakulchai W,
    Sanchai T, Khantawa B, Tharavichitkul P, Sirisanthana T, and Nagatake T. Clinical and microbiological characteristics of community-acquired pneumonia among HIV-infected patients in northern Thailand. J Infect Chemother, 14: 105-109, 2008.
  69. Watanabe K, Anh DD, Huong PLT, Nguyet NT, Anh NTH, Thi NT, Dung NT, 
    Phong DM, Rusizoka OS, Nagatake T, Watanabe H, and Oishi K. Drug-resistant pneumococci in children with acute respiratory infections in Vietnam. Pediatr Int, 50: 514-518, 2008.
  70. Qin L, Masaki H, Watanabe K, Furumoto A, and Watanabe H. Antimicrobial 
    susceptibility and genetic characteristics of Streptococcus pneumoniae isolates indicating possible nosocomial transmission routes in a community hospital in Japan. J Clin Microbiol, 45: 3701-3706, 2007.
  71. Watanabe H, Batuwanthudawe R, Thevanesam V, Kaji C, Qin L, Nishikiori N, 
    Saito W, Saito M, Watanabe K, Oishi K, Abeysinghe N, Kunii O. Possible
    prevalence and transmission of acute respiratory tract infections caused by 
    Streptococcus pneumoniae and Haemophilus influenzae among the internally 
    displaced persons in tsunami disaster evacuation camps of Sri Lanka. Intern Med 46:1395-1402, 2007.
  72. Anh DD, Huong PLT, Watanabe K, Nguyet NT, Anh NTH, Thi NT, Dung NT, 
    Phong DM, Tanimura S, Ohkusa Y, Nagatake T, Watanabe H, and Oishi K. Increased rates of intense nasopharyngeal bacterial colonization of Vietnamese children with radiological pneumonia. Tohoku J Exp Med, 213:167-172, 2007.
  73. Koyama J, Ahmed K, Zhao J, Saito M, Onizuka S, Oma K, Watanabe K,           
    Watanabe H , and Oishi K. Strain-specific pulmonary defense achieved after 
    repeated airway immunizations with non-typeable Haemophilus influenzae in a mouse model. Tohoku J Exp Med, 211:63-74, 2007.
  74. Iwahashi J, Hamada N, and Watanabe H. Two hydrophobic segments of the RTN1 family determine the ER localization and retention. Biochem Biophys Res Commun, 355: 508-512, 2007.
  75. Qin L, Watanabe H, Asoh N, Watanabe K, Oishi K, Mizota T, and Nagatake T. 
    Antimicrobial susceptibility and genetic characteristics of Haemophilus influenzae isolated from patients with respiratory tract infections between 1987 and 2000, including beta-lactamase-negative ampicillin-resistant strains. Epidemiol Infect, 135: 665-668, 2007.
  76. Kurita S, Koyama J, Onizuka S, Motomura K, Watanabe H, Watanabe K, Senba M, Apicella MA, Murphy TF, Matsushima K, Nagatake T, and Oishi K. Dynamics of dendritic cell migration and the subsequent induction of protective immunity in the lung after repeated airway challenges by nontypeable Haemophilus influenzae outer membrane protein. Vaccine, 24: 5896-5903, 2006.
  77. Qin L, Watanabe H, Yoshimine H, Guio H, Watanabe K, Kawakami K, Iwagaki A, Nagai H, Goto H, Kuriyama T, Fukuchi Y, Matsushima T, Kudoh S, Shimada K, Matsumoto K, Nagatake T, Mizota T, and Oishi K. Antimicrobial susceptibility and serotype distribution of Streptococcus pneumoniae isolated from patients with community-acquired pneumonia and molecular analysis of multidrug-resistant serotype 19F and 23F pneumococci in Japan. Epidemiol Infect, 134: 1188-1194, 2006.
  78. Oishi K, Yoshimine H, Watanabe H, Watanabe K, Tanimura S, Kawakami K, 
    Iwagaki A, Nagai H, Goto H, Kudoh S, Kuriyama T, Fukuchi Y, Matsushima T, 
    Shimada S, Matsumoto K, and Nagatake T. Drug-resistant genes and serotypes of pneumococcal strains of community-acquired pneumonia among adults in Japan. Respirology, 11: 429-436, 2006.
  79. Masaki H, Nagatake T, Asoh N, Yoshimine H, Watanabe K, Watanabe H, Oishi 
    K, Rikitomi N, and Matsumoto K. Significant reduction of nosocomial pneumonia after introduction of disinfection of upper airways using povidone-iodine in geriatric wards. Dermatology, 212, suppl 1: 92-96, 2006.
  80. Jurcisek J, Greiner L, Watanabe H, Zaleski A, Apicella MA, and Bakaletz LO. Role of sialic acid and complex carbohydrate biosynthesis in biofilm formation by nontypeableHaemophilus influenzae in the chinchilla middle ear. Infect Immun, 73: 3210-3218, 2005.
  81. Watanabe H, Hoshino K, Sugita R, Asoh N, Guio H, Qin L, Kaji C, Watanabe K, Oishi K, and Nagatake T. Molecular analysis of intrafamiliar transmission in Moraxella catarrhalis. Int J Med Microbiol, 295: 187-191, 2005.
  82. Watanabe H, Kaji C, Anh DD, Huong PLT, Anh NTH, Huong VT, Phuong HVM, Thi NT, Suu PT, Nguyet NTT, Rusizoka OS, Watanabe K, Nagatake T, and Oishi K. A comparative molecular analysis of Haemophilus influenzae isolates from young children with acute lower respiratory tact infections and meningitis in Hanoi, Vietnam. J Clin Microbiol, 43: 2474-2476, 2005.
  83. Asoh N, Masaki H, Watanabe H, Watanabe K, Mitsusima H, Matsumoto K, Oishi K, and Nagatake T. Molecular characterization of the transmission between the colonization of methicillin-resistant Staphylococcus aureus to human and environmental contamination in geriatric long-term care wards. Intern Med, 44: 41-45, 2005.
  84. Greiner LL, Watanabe H, Phillips NJ, Shao J, Morgan A, Zaleski A, Gibson BW, 
    and Apicella MA. Nontyeable Haemophilus influenzae strain 2019 produces a 
    biofilm containing N-acetylneuraminic acid that may mimic sialylated O-linked glycans. Infect Immun, 72: 4249-4260, 2004.
  85. Ashizawa K, Watanabe H, Morooka H, and Hayashi K. Hyperbaric oxygen 
    therapy for air embolism complicating CT-guided needle biopsy of the lung. ALR Am J Roentgenol, 182: 1606-1607, 2004.
  86. Watanabe H, Hoshino K, Sugita R, Asoh N, Watanabe K, Oishi K, and 
    Nagatake T. Possible high rate of transmission of nontypeable Haemophilus 
    influenzae     including beta-lactamase-negative ampicillin-resistant strains between children and their parents. J Clin Microbiol, 42: 362-365, 2004.
  87. Watanabe H, Asoh N, Hoshino K, Watanabe K, Oishi K, Kositsakulchai W, 
    Sanchai T, Kunsuikmengrai K, Kahintapong S, Khantawa B, Tharavichitkul P, 
    Sirisanthana T, and Nagatake T. Antimicrobial susceptibility and serotypedistribution of Streptococcus pneumoniae and molecular characterization of multi-drug resistant serotype 19F, 6B and 23 F pneumococci in northern Thailand. J Clin Microbiol, 41: 4178-4183, 2003.
  88. Masaki H, Asoh N, Kawazoe K, Watanabe K, Onizuka T, Shimogama S, 
    Yamaryo T, Watanabe H, Oishi K, and Nagatake T. Possible relationship of PFGE patterns of Moraxella catarrhalis between hospital- and community-acquired respiratory infections in a community hospital. Microbiol Immunol, 47: 379-385, 2003.
  89. Asoh N, Watanabe H, Fines-Guyon M, Watanabe K, Oishi K, Kositsakulchai W, 
    Sanchai T, Kunsuikmengrai K, Kahintapong S, Khantawa B, Tharavichitkul P, 
    Sirisanthana T, and Nagatake T. Emergence of rifampin-resistant Rhodococcus equi with several types of mutations in the rpoB gene among AIDS patients in northernThailand. J Clin Microbiol, 41:2337-2340, 2003.
  90. Masaki H, Asoh N, Watanabe H, Tao M, Watanabe K, Ikeda H, Matsumoto K, Oishi K, and Nagatake T. Possible relationship between Staphylococcus aureus colonizing the respiratory tract and rectum and S. aureus isolated in a geriatric hospital environment. Intern Med, 42:281-282, 2003.
  91. Hoshino K, Watanabe H, Sugita R, Asoh N, Ntabaguzi AS, Watanabe K, Oishi K, and Nagatake T. High rate of transmission of penicillin-resistant Streptococcus pneumoniae between parents and children. J Clin Microbiol, 40: 4357-4359, 2002.
  92. Masaki H, Watanabe H, Degawa S, Yoshimine H, Asoh N, Rikitomi N, 
    Matsumoto K, Ahmed K, Watanabe K, Oishi K, and Nagatake T. Significant 
    reduction of methicillin-resistant Staphylococcus aureus bacteremia in geriatric wards after introduction of infection control measures against nosocomial infections. Intern Med, 40: 214-220, 2001.
  93. Watanabe H, Masaki H, Asoh N, Watanabe K, Oishi K, Kobayashi S, Sato A, 
    Sugita R, and Nagatake T. Low concentrations of mupirocin in the pharynx following intranasal application may contribute to mupirocin resistance in methicillin-resistantStaphylococcus aureus. J Clin Microbiol, 39: 3775-3777, 2001.
  94. Watanabe H, Masaki H, Asoh N, Watanabe K, Oishi K, Kobayashi S, Sato A, and Nagatake T. Enterocolitis caused by methicillin-resistant Staphylococcus 
    aureus    : molecular characterization of respiratory and digestive tract isolates. 
    Microbiol Immunol, 45: 629-634, 2001.
  95. Watanabe H, Masaki H, Asoh N, Watanabe K, Oishi K, Furumot A, Kobayashi 
    S, Sato A, and Nagatake T. Emergence and spread of low-level mupirocin 
    resistance in MRSA isolated from a community hospital in Japan. J Hosp Infect, 47: 294-300, 2001.
  96. Watanabe H, Masaki H, Asoh N, Watanabe K, Oishi K, Kobayashi S, Sato A, 
    and Nagatake T. Molecular analysis of MRSA as a causative agent of bronchopulmonary infection: relation to colonization in the upper respiratory tract. J Clin Microbiol, 38:3867-3869, 2000.
  97. Watanabe H, Kobayashi S, Watanabe K, Oishi K, Sanchai T, Kositsakulchai 
    W,Kunsuikmengrai K, Kahintapong S, Tharavichitkul P, Sirisanthana T, and 
    Nagatake T. Pulmonary infection caused by Rhodococcus equi in HIV-infected 
    patients: report of four patients from northern Thailand. J Infect Chemother, 6: 229-232, 2000. 24.
  98. Watanabe H, Sato S, Kawakami K, Watanabe K, Oishi K, Rikitomi N, Ii T, Ikeda H, Sato A, and Nagatake T.  A comparative clinical study of pneumonia by penicillin-resistant and-sensitive Streptococcus pneumoniae in a community hospital. Respirology, 5: 59-64, 2000.